• Title/Summary/Keyword: Fragile

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Elucidation of Anti-tumor Initiator and Promoter Derived from Seaweed-2: Investigation of Seaweed Extracts Suppressing Mutagenic Activity of PhIP and MeIQx (해조류 중의 anti-tumor initiator 및 promoter의 해석-2: PhIP와 MeIQx의 돌연변이원성을 억제하는 해조 추출물 소재의 연구)

  • PARK Young-Beom;KIM In-Soo;YOO Sung-Jae;AHN Jong-Khan;LEE Tae-Gee;PARK Douck-Chon;KIM Seon-Bong
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.31 no.4
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    • pp.581-586
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    • 1998
  • The present study was conducted to prepare seaweed extracts suppressing mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine ( PhIP ) ana 2-amino-3,8-dimethylmidazo[4,5-f]quinoxaline (MeIQx) derived from cooked meat produce. The tumor initiation activity of PhIP and MeIQx was assayed with Ames method using Salmonella typhimurium TA98 in the presence of S-9 mixtures before and after addition of methanol-solubles of seaweed, such as, Phaeophyta; Undaria pinnatifida, Ecklonia stolonifera Ecklonia cava, Laminaia japonica Sargassum fulvellum, Sargassum hornezi, Sargassum miyabei, Sargassum thunbergii, Agarum cribrosum and Hizikia fusifomis, Rhodophpei Porphyra yezoensis, Grateloupia eiliptiut Lomentraria catenata, Ploemium telfairiae and Glarilaria verrucosa, Chlorophyta; Codium fragile, Enteromorpha compresa and Ulva pertusa. Among seaweed tested, Phaeophyta was shown the higher desmutagenic activity than Rhodophyta and Chlorophyta. E. stolonifera, E. cava and S. miyabei, among Phaeophyta exerted the stronger desmutagenic activity (above $90\%$/2 mg). The ethyl acetate, diethyl ether and chlomform extracts except water extracts from E. stolonifera exhibited a high desmutagenic activity. The ethyl acetate extract of E. stolonifera which showed highest activity was fractionated with Sephadex LH20 column chromatography to give active fraction A-7, which showed desmutagenicity of $90\%$/mg against PhIP and $80\%$/mg against MeIQx. The active fraction had the absorbance at 207.7 and 232nm.

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Direct and indirect effects of social support on young children's behavior problems and cognitive development in single-mother families with low income (미국 저소득 미혼모가구의 사회적 지지가 아동의 문제행동과 인지능력에 미치는 영향)

  • Pyun, Ho-Soon;Choi, Jeong-Kyun
    • Journal of the Korean Society of Child Welfare
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    • no.36
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    • pp.133-163
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    • 2011
  • The aim of this study is to examine the relationships between social support and child behavior problems and cognitive development in low income female-headed families. Informed by the stress-coping theory, family process model, and theoretical perspectives related to social support, this study estimates both direct and indirect effects of social support on child behavior problems and cognitive development. In particular, we focus on how the relationship between child outcomes and social support is mediated by mothers' parenting stress. The first three waves of longitudinal data from a subsample of 1,315 single and non-cohabiting low-income mothers in the Fragile Families and Child Wellbeing Study were utilized in this study. Results suggest that social support is directly associated with child behavior problems and also indirectly associated with child behavior problems mediated by mothers' parenting stress. Social support did not have a direct effect on children's cognitive development but rather had an indirect effect, which was mediated by mothers' parenting stress. The policy and practice implications of these findings are discussed.

Balancing Water Supply Reliability, Flood Hazard Mitigation and Environmental Resilience in Large River Systems

  • Goodwin, Peter
    • Proceedings of the Korea Water Resources Association Conference
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    • 2016.05a
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    • pp.1-1
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    • 2016
  • Many of the world's large ecosystems are severely stressed due to population growth, water quality and quantity problems, vulnerability to flood and drought, and the loss of native species and cultural resources. Consequences of climate change further increase uncertainties about the future. These major societal challenges must be addressed through innovations in governance, policy, and ways of implementing management strategies. Science and engineering play a critical role in helping define possible alternative futures that could be achieved and the possible consequences to economic development, quality of life, and sustainability of ecosystem services. Science has advanced rapidly during the past decade with the emergence of science communities coalescing around 'Grand Challenges' and the maturation of how these communities function has resulted in large interdisciplinary research networks. An example is the River Experiment Center of KICT that engages researchers from throughout Korea and the world. This trend has been complemented by major advances in sensor technologies and data synthesis to accelerate knowledge discovery. These factors combine to allow scientific debate to occur in a more open and transparent manner. The availability of information and improved communication of scientific and engineering issues is raising the level of dialogue at the science-policy interface. However, severe challenges persist since scientific discovery does not occur on the same timeframe as management actions, policy decisions or at the pace sometimes expected by elected officials. Common challenges include the need to make decisions in the face of considerable uncertainty, ensuring research results are actionable and preventing science being used by special interests to delay or obsfucate decisions. These challenges are explored in the context of examples from the United States, including the California Bay-Delta system. California transfers water from the wetter northern part of the state to the drier southern part of the state through the Central Valley Project since 1940 and this was supplemented by the State Water Project in 1973. The scale of these activities is remarkable: approximately two thirds of the population of Californians rely on water from the Delta, these waters also irrigate up to 45% of the fruits & vegetables produced in the US, and about 80% of California's commercial fishery species live in or migrate through the Bay-Delta. This Delta region is a global hotspot for biodiversity that provides habitat for over 700 species, but is also a hotspot for the loss of biodiversity with more than 25 species currently listed by the Endangered Species Act. Understanding the decline of the fragile ecosystem of the Bay-Delta system and the potential consequences to economic growth if water transfers are reduced for the environment, the California State Legislature passed landmark legislation in 2009 (CA Water Code SS 85054) that established "Coequal goals of providing a more reliable water supply for California and protecting, restoring, and enhancing the Delta ecosystem". The legislation also stated that "The coequal goals shall be achieved in a manner that protects and enhances the unique cultural, recreational, natural resource, and agricultural values of the Delta as an evolving place." The challenges of integrating policy, management and scientific research will be described through this and other international examples.

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Effect of the U.S. Monetary Policy on the Real Economy of the Asia: Focusing on the impact of the exchange rate in Korea, China and Japan (미국의 통화정책이 아시아 실물경제에 미치는 영향: 한국, 중국, 일본의 환율충격을 중심으로)

  • Choi, Nam-Jin
    • International Area Studies Review
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    • v.20 no.2
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    • pp.3-23
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    • 2016
  • In this study, we used actual proof analysis, based on SVAR model according to economy theory, to observe the impact of actual and financial market of Korea, Japan, and China that have adopted quantitative easing export based strategy of growth, an unconventional monetary policy of the U.S. As a result of estimation, it appears that real effective exchange rate rise shock of Korea, Japan, and China against U.S. dollar has a negative influence on current account and index of industrial product, which are real economy. It can be implied that the result is driven from the fact that strong home currency of Korea, Japan, and China decreases price competitiveness of exports, causing negative influence on real economy. The real effective exchange rate shock against U.S. dollar appeared to decrease national bond rate of Korea and Japan, while increasing that of China. In instances of Korea and Japan, it is implied that national bond rate decreases as foreigner investment funds flow in, considering foreign-exchange profit through advanced financial market with high opening extent. On the other hand, because there are strong regulation on opening extent of Chinese financial markets, the influence seems to be greater for domestic policy, rather than a foreign influence. Lastly, Korea showed a more dramatic variable reaction to exchange rate shock compared to Japan or China. It is implied from the result that Korea is relatively more susceptible and fragile in regards of international status of economic size and currency.

Physical Restraints Use and Associated Factors Among Elderly Patients in Long-term Care Hospitals (요양병원 재원 노인의 신체적 억제대 사용과 관련 요인)

  • Ko, Yeong Ju;Ha, Sun-Mi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.9
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    • pp.167-174
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    • 2019
  • The propose od this study was to examine the extent of using physical restraint on elderly patients (over 65 years old) and who were patients in long-term care hospitals. The data was collected, from March 3 2018 to March 29 2018, from the electronic nursing records by using a recording tool, and clinical observation was also used for assessing the use of physical restraint and the related factors. Descriptive statistics, Pearson correlation coefficients and logistic regression were then performed. The usage rate for physical restraints in long-term care hospital was 83.7%, and the most common type of physical restraint was side rails. The use of physical restraints showed a positive correlation with the fall risk scores and a negative correlation with the MMSE. Logistic regression analysis showed that the Fall Risk Score (OR=1.02, 95% CI=1.01~1.03), MMSE (OR=0.94, CI=0.88~0.99) and the use of medical devices (OR=0.80, 95% CI=0.65~0.98) were related with using physical restraints. Therefore, it was confirmed that physical restraint was used in cases of a high risk of falling, severe cognitive impairment and the use of complex and fragile medical devices to treat the patient. Clinical nursing practice should be changed so that treatment alternatives can be applied for elderly patients rather than using too many physical restraints.

A Study on the Conservation and culturalization of Archaeological Heritage - On the emphasis of ordering better legitimacy and management system - (고고 유산의 보호 원리와 보존 활용 방안에 대하여 - 법(法)과 제도의 비교 고찰을 중심으로 -)

  • Jang, Ho-su
    • Korean Journal of Heritage: History & Science
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    • v.40
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    • pp.5-34
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    • 2007
  • Archaeological Heritage is material testimony of national and regional history, and it is one of the tourist's attractions. So it has very important meaning and identical value for a local residents. Public concern on the heritage site elevate higher day by day. They are willing to use it for a multiful purpose, cultural, educational, and even commercial one. But Archaeological Heritage is fragile, and visitors can impact negatively for protection and management of the authenticity on the heritage site. In this research I try to compare legal and administrative measure for the protection, management, and culturalization of Archaeological Heritage in many countries. And I suppose sustainable and practical strategies for keeping integrity of heritage.

Spatial and seasonal distributions of the phototrophic dinoflagellate Biecheleriopsis adriatica (Suessiaceae) in Korea: quantification using qPCR

  • Kang, Hee Chang;Jeong, Hae Jin;Ok, Jin Hee;You, Ji Hyun;Jang, Se Hyeon;Lee, Sung Yeon;Lee, Kyung Ha;Park, Jae Yeon;Rho, Jung-Rae
    • ALGAE
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    • v.34 no.2
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    • pp.111-126
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    • 2019
  • The phototrophic dinoflagellate Biecheleriopsis adriatica is a small suessioid species characterized by a fragile thin wall. Although the morphology of this dinoflagellate is well established, there is currently little information available on its distribution and the environmental factors that influence this distribution. Thus, to investigate the spatial and seasonal distributions of the vegetative cells of B. adriatica in Korean waters, surface water samples were collected on a seasonal basis from 28 stations in the East, West, and South Sea of Korea and Jeju Island from April 2015 to October 2018, and abundances of the vegetative cells of B. adriatica were quantified using quantitative real-time polymerase chain reactions, for which we developed the species-specific primer and probe set. Simultaneously, major environmental parameters, including temperature, salinity, nutrient concentrations, and dissolved oxygen concentrations were measured. The vegetative cells of B. adriatica were detected at 20 of the 28 sampling stations: 19 stations in summer and 6 in autumn, although from no stations in either spring or winter. The ranges of water temperature and salinity at sites where this species was detected were $17.7-26.4^{\circ}C$ and 9.9-34.3, respectively, whereas those of nitrate and phosphate concentrations were not detectable-96.2 and $0.18-2.66{\mu}M$, respectively. Thus, the sites at which this species is found are characterized by a narrow range of temperature, but wide ranges of salinity and concentrations of nitrate and phosphate. The highest abundance of the vegetative cells of B. adriatica was $41.7cells\;mL^{-1}$, which was recorded in Jinhae Bay in July 2018. In Jinhae Bay, the abundance of vegetative cells was significantly positively correlated with the concentration of nitrate, but was negatively correlated with salinity. On the basis of these findings, it appears that the abundance of B. adriatica vegetative cells shows strong seasonality, and in Jinhae Bay, could be affected by the concentrations of nitrate.

Seismic Performance Evaluation of Multi-Story Piping Systems using Triple Friction Pendulum Bearing (지진격리장치를 적용한 복층구조파이핑 시스템의 내진성능평가)

  • Ryu, Yonghee;Ju, Buseog;Son, Hoyoung
    • Journal of the Society of Disaster Information
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    • v.14 no.4
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    • pp.450-457
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    • 2018
  • Purpose: The evaluation of seismic performance of critical structures has been emerging a key issue in Korea, since a magnitude 5.8 earthquake, the worst in Koran history, struck Gyeongju, southern area in Korea on september 12th, 2016. In particular, the catastrophic failure of nonstructural components such as sprinkler piping systems can cause significant economic loss or loss of life during and after an earthquake. The nonstructural components can be more fragile than structural components in seismic behavior. Method: This study presents the seismic performance evaluation of fire protection piping system, using coupled building-piping system installed with Triple Friction Pendulum Bearings (TPBs). Kobe (Japan), Kocaeli (Turkey), and GyeongJu (Korea) were selected to consider the uncertainty of ground motions in this study. Result: In the simulation results, it was observed that the reduction of maximum displacements of the piping system with the TPBs' system was significant: Kobe, Kocaeli, and Gyeongju cases were 49%, 14.4% and 21.5%, respectively. Conclusion: Therefore, using seismically isolated system in a building-piping system can be more effective to reduce the seismic risk than a normally installed building-piping systems without TPBs in strong earthquakes.

Glass Fiber Composite Material with Polyurethane Toughener in Unsaturated Polyester Resin (UPR) (불포화 폴리에스터 (UPR)에 폴리우레탄을 첨가하여 강인성을 부여한 유리섬유 복합소재)

  • Baek, Chang Wan;Jang, Tae Woo;Kim, Taehee;Kim, Hye Jin;Kim, Hyeon-Gook;Kim, Changyoon;Seo, Bongkuk;Lim, Choong-Sun
    • Journal of Adhesion and Interface
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    • v.22 no.2
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    • pp.63-68
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    • 2021
  • Unsaturated Polyester Resin (UPR) is in general used as a resin to prepare for composite materials with reinforcing materials such as glass fibers. UPR, a thermosetting resin, is used in industry to prepare for sheet molding compound (SMC) molding prepreg that has excellent productivity and is advantageous for mass production among various molding methods of composite materials. The fiber-reinforced composite material using UPR as a matrix material is light and has the advantage of excellent physical properties, but it is weak against impact and is fragile. Four types of polyurethane were synthesized and added to UPR resin to overcome the shortcomings.

A Study on the Deriving of Areas of Concern for Crime using the Mental Map (멘탈 맵을 이용한 범죄발생 우려 지역 도출에 관한 연구)

  • Park, Su Jeong;Shin, Dong Bin
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.37 no.3
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    • pp.177-188
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    • 2019
  • Recently, citizens are feeling anxious as 'Motiveless Crime' increases. The quality of citizens life is degraded and the degree of crime fear is increasing. In this study, based on various variables related to crime other than actual crime occurrence status, crime occurrence points (point line polygon) felt by citizens are created by using mental map methodology. And the purpose of this study is to derive the area of concern for crime through spatial overlap analysis using kernel density estimation analysis. It also uses spatial overlay analysis using kernel density estimation to derive areas of concern for crime occurrence. As a result, the local residents' request point and the areas of concern for crime were overlapped. In addition, the mental map indicating the fear of crime was constructed by mapping mainly the areas between the facilities, the non-construction area such as the narrow area, the security CCTV, the streetlight. This study is meaningful in that it tried to derive a crime occurrence concern area by using mental map method unlike the previous study related to crime. The results of this study, such as mental map, could be used in various fields such as construction of fragile crime map, guideline of crime prevention through environment design.