• Applied Microscopy
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• v.51
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• pp.6.1-6.9
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• 2021

Histopathology is a well-established standard diagnosis employed for the majority of malignancies, including breast cancer. Nevertheless, despite training and standardization, it is considered operator-dependent and errors are still a concern. Fractal dimension analysis is a computational image processing technique that allows assessing the degree of complexity in patterns. We aimed here at providing a robust and easily attainable method for introducing computer-assisted techniques to histopathology laboratories. Slides from two databases were used: A) Breast Cancer Histopathological; and B) Grand Challenge on Breast Cancer Histology. Set A contained 2480 images from 24 patients with benign alterations, and 5429 images from 58 patients with breast cancer. Set B comprised 100 images of each type: normal tissue, benign alterations, in situ carcinoma, and invasive carcinoma. All images were analyzed with the FracLac algorithm in the ImageJ computational environment to yield the box count fractal dimension (Db) results. Images on set A on 40x magnification were statistically different (p = 0.0003), whereas images on 400x did not present differences in their means. On set B, the mean Db values presented promising statistical differences when comparing. Normal and/or benign images to in situ and/or invasive carcinoma (all p < 0.0001). Interestingly, there was no difference when comparing normal tissue to benign alterations. These data corroborate with previous work in which fractal analysis allowed differentiating malignancies. Computer-aided diagnosis algorithms may beneficiate from using Db data; specific Db cut-off values may yield ~ 99% specificity in diagnosing breast cancer. Furthermore, the fact that it allows assessing tissue complexity, this tool may be used to understand the progression of the histological alterations in cancer.

• Journal of the Korean Association of Geographic Information Studies
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• v.8 no.3
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• pp.1-10
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• 2005

The purpose of this paper is to conduct an experimental measurement and analysis of cities' morphology. Fractal theory that is an effective tool for evaluating self-similarity and complexity of objects was applied. For the comparative analysis of fractailities and computational verification, two totally different cities in Japan were selected. They are Kitakyushu City, which is a big and fully developed city, and Jinguu Machi of which almost all the area is covered with agricultural land use. After converting vector data to raster data within GIS, fractal dimensions of two cases in Kitakyushu City and one case in Jinguu Machi were calculated. The calculation showed that two parts of Kitakyushu City were already fractal. Jinguu Machi, however, was difficult to find fractality. As a conclusion, fractal was proved to be an useful tool to estimate the shape of cities reflecting their internal spatial structure, that is self-similarity and complexity.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1996.10a
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• pp.96-100
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• 1996

So far the analysis and modeling of cutting process is studied commonly assumed as being linear stochastic or chaotic without experimental verification. So we verified force signals of cutting process(ball end-milling) is low-dimensional chaos by calculating Lyapunov Exponents. reconstructing attractor using time delay coordinates and calcula-ting it's fractal dimension.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.04a
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• pp.385-388
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• 2005

Through the regional lineament analysis in Korea peninsula, the statistical distribution of regional lineament is investigated. We also analyze the lineaments pattern using the fractal dimension. These results are the preliminary study for a understanding of the deep ground geological structure in Korea. For the investigations of the average block scale, we use the Dershowitz and Herda(1992)'s method. At result, the average spacing between the regional lineaments is about 10km.

• Journal of Korean Society on Water Environment
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• v.21 no.5
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• pp.500-504
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• 2005

Water samples were collected at 7 sites located along the River Nakdong on 30 occasions. Water qualities, size and fractal dimension ($d_F$) of suspended particles were measured. Laser light scattering method was used to obtain the size and $d_F$ of suspended particles. The average size of particles in this river ranged from $89{\mu}m$ and $169{\mu}m$, which appears to be relatively coarse compared with other rivers worldwide. The average $d_F$ of suspended particles in this study ranged from 1.8 to 1.9. The correlation analysis showed that DO, TN, $NO_3$ and chlorophyll-${\alpha}$ had significant positive relationships with particles size, whereas flow rates and TSS had negative relationships. Interestingly, the factors of which had positive relationships with particles size showed negative relationship with the fractal dimension ($d_F$) of suspended particles. Generally, as the size of particles increased, the fractal dimension of particles decreased which was indicating the shape of the larger particles became more irregular.

• The Journal of Engineering Geology
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• v.9 no.2
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• pp.101-118
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• 1999

The pumping test analysis on 28 pumping test data in Duksan hot-spring area was performed using the fractal model, the leaky fractal model, and the steady-state dual-porosity fractal model. The fractional flow dimension 1.9 or 2.0 was determined in the central put of the hot spring and the fractional flow dimension 1.5-1.7 in the marginal area. For the flow dimension 2.0, the correlation between the transmissivity and the productivity index by the aquifer loss was much better than that between the transmissivity and the specific yield by the total drawdown. On the other hand, for the flow dimension 1.9, the correlation between the generalized transmissivity and the productivity index was very similar to that between the generalized transmissivity and the specific yield.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.971-976
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• 2005

In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to $1.85\;g/1^{-1}$ at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.

• Imaging Science in Dentistry
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• v.37 no.2
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• pp.79-82
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• 2007

Purpose: The purpose of this study was to investigate whether panoramic radiographs were useful in predicting osteoporosis. Materials and Methods: 50 postmenoposal women between the age of 41.8 and 78.5 were classified as normal and osteoporosis groups according to the bone mineral density of lumbar vertebrae. Panoramic radiographs were taken. Age, body mass index, remaining mandibular teeth, mandibular cortical thickness and morphology, and fractal dimensions at periapical areas of mandibular first molars were evaluated to differentiate the two groups. Results: The age of osteoporotic group was statistically significantly higher than that of normal group (p<0.05), but not the body mass index or number of remaining mandibular teeth. The mean fractal dimension of osteoporotic group was $1.391{\pm}0.085$, and was significantly lower than that of the normal group, which was $1.523{\pm}0.725$ (p<0.01). Thick mandibular cortical thickness was common in normal group, whereas thin or very thin mandibular cortical thickness was common in osteoporotic group and the difference was significant (p < 0.05). C2 pattern was common in normal group followed by C1, whereas C2 was common in osteoporotic group followed by C3. The difference was statistically significant (p< 0.0 1). Conclusion: Age, mandibular cortical thickness and shape, fractal dimension on panoramic radiographs were useful in predicting osteoporosis.

• Journal of the Korean Society for Railway
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• v.2 no.2
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• pp.21-30
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• 1999

This study proposes the analysis and evaluation method of time series ultrasonic signal using the phase space-frequency domain. Features extracted from time series signal analyze quantitatively characteristics of weld defects. For this purpose, analysis objectives in this study are features of time domain and frequency domain. Trajectory changes in the attractor indicated a substantial difference in fractal characteristics resulting from distance shifts such as parts of head and flange even though the types of defects are identified. These differences in characteristics of weld defects enables the evaluation of unique characteristics of defects in the weld zone. In quantitative fractal feature extraction, feature values of 3.848 in the case of part of head(crack) and 4.102 in the case of part of web(side hole) and 3.711 in the case of part of flange(crack) were proposed on the basis of fractal dimension. Proposed phase space-frequency domain method in this study can integrity evaluation for defect signals of rail weld zone such as side hole and crack.

• Korean Journal of Ecology and Environment
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• v.44 no.1
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• pp.58-65
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• 2011

This study aims to investigate the settling velocity of aggregates of cohesive sediment (floc) and its relationship with sediment size, density and fractal dimension. A system of commercial camera and macro-lens is used for the experiment. Through the image-analysis technique, the image taken by the camera system is analyzed. For the experiment, kaolinite and a natural sediment sampled at Lake Apopka in Florida have been tested. From this study, it is known that kaolinite and Lake Apopka sediments show different behaviors mainly depending on the organic matter content. Samples of kaolinite with less organic contents show a more definite trend to follow a fractal theory and relatively strong relationships between the settling velocity, density, fractal dimension and floc size compared to the Lake Apopka sediments rich in organics.