• Journal of Preventive Medicine and Public Health
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• 제57권4호
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• pp.370-378
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• 2024

Objectives: Comorbidities increase susceptibility to severe coronavirus disease 2019 (COVID-19) infections, but limited information has been published regarding human immunodeficiency virus (HIV) and COVID-19 co-infections. This study explored the relationships among socioeconomic characteristics, sexual behaviors, and COVID-19 infection rates among Korean men who have sex with men (MSM) who are also living with HIV. Methods: Data were collected through a web survey aimed at members of the largest gay portal site in Korea, supported by the National Research Foundation of Korea (n=1005). The primary independent variables included COVID-19-related vaccinations and sexual behaviors. The dependent variable was the incidence of COVID-19 infection among respondents during the pandemic. For statistical analysis, hierarchical multiple logistic regression was performed, controlling for potential confounding variables. Results: Model I indicated that older MSM were less likely to contract COVID-19 (adjusted odds ratio [aOR], 0.98; 95% confidence interval [CI], 0.96 to 0.99). Model II demonstrated that HIV-positive MSM were nearly twice as likely to be infected with COVID-19 compared to their HIV-negative counterparts (aOR, 1.97; 95% CI, 1.14 to 3.41). Furthermore, even after accounting for COVID-19 vaccination status in model III, HIV-positive MSM continued to show a higher risk of infection (aOR, 1.93; 95% CI, 1.12 to 3.35). Conclusions: The findings of this study indicate that HIV-positive MSM are at an increased risk of contracting COVID-19, even when their vaccination status is considered. Therefore, it is essential to prioritize the prevention of COVID-19 infections in HIV-positive individuals by administering appropriate antiretroviral therapy and ensuring adherence to public health guidelines.

• Journal of Pharmaceutical Investigation
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• 제37권4호
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• pp.255-261
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• 2007

A bioequivalence study of $Nimegen^{TM}$ soft capsule (Medica Korea Pharma. Co., Ltd.) to $RoAccutane^{(R)}$ soft capsule (Roche Korea Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Thirty healthy male Korean volunteers received each medicine at the isotretinoin dose of 60 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of isotretinoin were monitored by a high performance liquid chromatography (HPLC) for over a period of 48 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48 hr) was calculated by the linear trapezoidal rule method. $C_{MAX}$ (maximum plasma drug concentration) and $T_{MAX}$ (time to reach $C_{MAX}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{MAX}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{MAX}$ ratio for $Nimegen^{TM}/RoAccutane^{(R)}$ were $log0.860{\sim}log0.98\;and\;log0.85{\sim}log1.00$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Nimegen^{TM}\;and\;RoAccutane^{(R)}$ with respect to the rate and extent of absorption.

• 한국콘텐츠학회논문지
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• 제16권5호
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• pp.229-241
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• 2016

본 연구는 사회적 기업 CEO을 대상으로 직무스트레스가 경영성과에 미치는 영향과 이들 간에 사회적 지원, 정부지원제도의 조절역할을 탐구하는데 목적이 있다. 사회적 목적 실현을 위하여 설립한 사회적 기업의 CEO는 기업윤리성, 기업수익성, 정체성 혼란 및 경영 어려움 등으로 직무스트레스를 받고 있다. 이러한 CEO의 직무스트레스를 표출시킴으로 지역사회 내에서 함께 풀어나갈 방안을 모색하여 사회적 기업이 경영 성과를 성장시킴으로 지속적으로 지역사회 내에서 사회적 목적을 수행할 수 있는 기반을 마련하고자 한다. 본 연구의 이론적 배경은 ISR 직무스트레스모델 이론을 주근거로 적용하였다. 직무스트레스 요인과 직무 스트레스 영향을 독립변수로 그리고 경영성과를 종속변수로, 그리고 사회적 지원, 정부지원제도를 조절변수로 상호간의 유의성에 관하여 분석하고자 한다. 연구 방법은 우리나라에 소재하고 있는 사회적 기업 223명 CEO을 대상으로부터 구조화된 설문지를 사용하여 수집하였다. 자료 분석은 IBM SPSS Statristics 20.0 프로그램을 사용하여 표본의 일반적 특성, 신뢰도 검증, 요인분석, 상관관계 분석, 연구 가설 검증을 통하여 다음과 같은 결과를 도출하였다. 첫째, 직무스트레스 요인 및 영향은 경영성과에 부정적인 영향을 미치는 것으로 조사되었다. 둘째, 사회적 지원은 직무스트레스 요인과 영향을 낮추고 경영성과를 높이는 것으로 조사되었다. 셋째, 정부지원제도는 직무스트레스 요인과 영향을 낮추고 경영성과를 높이는 것으로 조사되었다.

• Journal of Preventive Medicine and Public Health
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• 제42권5호
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• pp.331-336
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• 2009

Objectives : The objectives of this study were to determine the relationship between lifestyle-implementation and metabolic syndrome in an electronics research and development company, and to provide a foundation for health providers of health management programs for setting priorities. Methods : From July 1 to July 16, 2008 we carried out a descriptive cross-sectional survey. Consecutive workers of one R & D company in Seoul, Korea (N=2,079) were enrolled in study. A checklist for lifestyle (from the National Health Insurance Corporation) consisted of questions regarding diet, drinking, smoking and exercise. After the survey, researchers obtained data from health profiles for metabolic syndrome(waist-circumference, triglycerides, HDL cholesterol, blood pressure and fasting blood sugar level). Lifestyle was recorded as good or not good. Statistical analysis of metabolic syndrome and the lifestyle of subjects was done using multiple logistic regression analysis. Results : The prevalence of metabolic syndrome in our study gropu was 13.3% (N=277). After adjustment for age, the adjusted odds ratios (odds ratio, 95% confidence intervals) for metabolic syndrome increased in proportion to the number of bad habits: two (1.72, 1.23-2.44), three (2.47, 1.73-3.56), and four (3.63, 2.03-6.34). Relative to subjects eating both vegetables and meat', the OR for 'meat' eaters was 1.66 (1.18-2.31). Compared with 'nonsmokers and ever-smoker', the OR for 'current-smoker' was 1.62 (1.25-2.10). Compared with 'Healthy drinker', the OR for 'unhealthy drinker' was 1.38 (1.05-1.83). Conclusions : Poor lifestyle was associated with an increased likelihood of metabolic syndrome. These findings suggest that lifestyle-based occupational health interventions for young employees should include a specific diet, smoking cessation, and healthy-drinking programs.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3545-3549
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• 2016

Background: The incidence of bladder cancer is lower in Asian than in Western countries. However, the crude incidence and mortality of bladder cancer have recently increased in Japan because of the increased number of senior citizens. We have already reported risk factors for urothelial cancer in a large population-based cohort study in Japan (JACC study). However, we did not evaluate the cancer risk in the upper and lower urinary tract separately in our previous study. Materials and Methods: Here we evaluated the risk of cancer death in the upper and lower urinary tracts, separately, using the database of the JACC study. The analytic cohort included 46,395 males and 64,190 females aged 40 to 79 years old. The Cox proportional hazard model was used to determine hazard ratios and their 95% confidence intervals. Results: Current smoking increased the risk of both upper and lower urinary tract cancer deaths. A history of kidney disease was associated with an increased risk of bladder cancer death, even after controlling for age, sex and smoking status. Conclusions: The present study confirmed that current smoking increases the risk of both upper and lower urinary tract cancer deaths and indicated the possibility that a history of kidney disease may be a risk factor for bladder cancer death in the Japanese population.

• 한국도로학회논문집
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• 제8권4호
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• pp.125-133
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• 2006

본 논문은 KS의 침입도 등급 체계에 대한 통계적 타당성을 검토하였다. 각 등급의 범위는 신뢰구간에 근거하여 설정되어야 하며, 최대한 인접 등급과의 중복을 피하도록 해야 한다. 그러나 통계적 이론에 근거해 검토한 결과 KS 침입도 등급 체계에는 각 등급 사이에 간격(Gap)이 없어서 범위를 벗어나는 것은 바로 다른 바인더의 등급을 침범한다는 점을 알 수 있었다. 따라서 많은 바인더 제품들의 침입도 평균값이 규정한계 내에 있을지라도 인접한 등급과 유사한 특성을 가질 수 있다. 또한 침입도 40-60, 60-80, 80-100과 같이 등급의 범위를 모두 20으로 규정한 것은 통계적 타당성이 없다. KS 침입도 등급은 각 등급 간에 간격이 없기 때문에 생산자는 제품의 품질관리 규정을 만족하기 위하여 ASTM 체계의 제품보다 변동계수를 더 낮게 유지해야 한다. 게다가 침입도평균이 상 하한선 쪽으로 치우친다면 재료의 품질 불확실성 때문에 바인더의 1/2 또는 그 이상이 인접 바인더와 중복된 것이다. 그러므로 KS침입도 등급은 통계적으로 타당토록 바로 수정되어야 한다.

• 한국치위생학회지
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• 제12권1호
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• pp.93-101
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• 2012

Objectives : The purpose of this study was to examine the educational effect of cooperative learning, which enables learners to make portfolio by taking advantage of their knowledge and skills acquired through practice, on an oral prophylaxis practice course in an attempt to stir up the spontaneous learning of learners, their learning interest and problem-solving skills. Methods : The selected dental hygiene students engaged in cooperative learning in oral prophylaxis practice III class in the second semester of their sophomore year by utilizing portfolio that was prepared by altering an inclusive dental hygiene practice model. They completed all the 15-week practice course, and then their portfolio was evaluated. They were divided into eight nonequivalent groups whose members were all different in academic standing, and their learning strategies and academic self-efficacy were checked before and after the instruction was provided. And their satisfaction with the class was investigated after the instruction was provided. Results : 1. There were significant gaps to $0.36{\pm}0.07$ in the charge of learning strategies after they engaged in cooperative learning(p<0.01). There were the broadest differences in cognitive strategies to 3.61, followed by metacognitive strategies to 3.19, and significant differences were found in all the subfactors(p<0.01). 2. There were significant gaps in the charge of self-efficancy to $0.13{\pm}0.06$ after they engaged in cooperative learning(p<0.01). There were the widest differences in self-regulating efficancy to 3.49, followed by confidence to 3.03 and task difficulty preference to 2.97, and significant differences were found in all the subfactors(p<0.01). 3. When their satisfaction level was analyzed after engaging in cooperative learning, there were significant gaps to 3.94 in the satisfaction level with all of the lectures(p<0.01). There were significant gaps in the satisfaction level with lecture to 4.20, with ensuring academic achievement to 4.13 and with cooperative learning to 3.48 (p<0.01). Conclusions : The above-mentioned findings indicated that cooperative learning had a positive impact on the learning strategies, academic self-efficacy and class satisfaction of the learners, and this study is expected to lay the foundation for the development of new teaching methods for dental hygiene.

• 통상정보연구
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• 제16권2호
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• pp.113-129
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• 2014

본 연구는 중소기업에 있어 외부의 지식서비스 활용이 경영성과에 미치는 영향을 검정하고자 진행하였다. 지식서비스 활용을 경험한 중소기업을 대상으로 설문조사를 실시하여 분석하였으며 연구 결과는 다음과 같다. 첫째, 중소기업을 대상으로 한 정부지원 지식서비스 제공 사업에 있어 지식서비스 전문가 집단의 역량과 정부지원정책은 지식서비스품질에 정(+)의 유의한 영향을 미치며, 지식서비스 전문가 집단의 역량이 정부 지원정책보다 지식서비스품질에 크게 영향을 미치는 것으로 확인되었다. 둘째, 지식서비스품질은 경영성과에 정(+)의 유의한 영향을 미치며, 확신성과 관련한 지식서비스품질 요인이 고객과의 관계성 강화와 지식정보화 부문에 유의하게 작용하는 것으로 확인되었다. 본 연구의 시사점과 의의는 다음과 같다. 본 연구 결과는 정부의 지식서비스산업 육성 정책에 있어 중소기업에 대한 지식서비스 지원 사업, 지원체계 등 개별기업에의 지식서비스 지원과 더불어 지식서비스 제공 회사 및 전문가 집단을 위한 제도적 지원 등 지식서비스산업 기반조성 정책을 강화할 필요가 있음을 시사하고 있으며, 이는 정부의 지식서비스 제공 사업에 대한 효과적이고 효율적인 정책 방향성을 제시하였다는데 의의가 있다.

• Journal of Preventive Medicine and Public Health
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• 제52권6호
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• pp.405-415
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• 2019

Objectives: The aim of this study was to evaluate the associations of frailty with perceived neighborhood walkability and environmental pollution among community-dwelling older adults in rural areas. Methods: The participants were 808 community-dwelling men and women aged 65 years and older in 2 rural towns. Comprehensive information, including demographics, socioeconomic status, grip strength, polypharmacy, perceived neighborhood environment (specifically, walkability and environmental pollution), and frailty, was collected from participants using face-to-face interviews conducted between June and August 2018. Perceived neighborhood walkability was measured using 20 items that were selected and revised from the Neighborhood Environment Walkability Scale, the Neighborhood Walkability Checklist from the National Heart Foundation of Australia, and the Physical Activity Neighborhood Environment Survey. The Kaigo-Yobo Checklist was used to assess participants' frailty. Results: The overall prevalence of frailty in this community-dwelling population was 35.5%. Sex, age, cohabitation status, educational attainment, employment status, grip strength, and polypharmacy were significantly associated with frailty. In the logistic regression analysis, frailty was associated with low perceived neighborhood walkability (adjusted odds ratio [aOR], 0.881; 95% confidence interval [CI], 0.833 to 0.932; p<0.001) and severe perceived neighborhood environmental pollution (aOR, 1.052; 95% CI, 1.017 to 1.087; p=0.003) after adjusting for sex, age, cohabitation status, educational attainment, employment status, monthly income, grip strength, and polypharmacy. Conclusions: More studies are warranted to establish causal relationships between walkability and environmental pollution and frailty.

• Asian Spine Journal
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• 제12권6호
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• pp.1085-1091
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• 2018

Study Design: Case-control. Purpose: To determine optimal cut-off value for body mass index (BMI) in predicting surgical success in patients with lumbar spinal canal stenosis (LSCS). Overview of Literature: BMI is an essential variable in the assessment of patients with LSCS. Methods: We conducted a prospective study with obese and non-obese LSCS surgical patients and analyzed data on age, sex, duration of symptoms, walking distance, morphologic grade of stenosis, BMI, postoperative complications, and functional disability. Obesity was defined as BMI of ${\geq}30kg/m^2$. Patients completed the Oswestry Disability Index (ODI) questionnaire before surgery and 2 years after surgery. Surgical success was defined as ${\geq}30%$ improvement from the baseline ODI score. Receiver operating characteristic (ROC) analysis was used to estimate the optimal cut-off values of BMI to predict surgical success. In addition, correlation was assessed between BMI and stenosis grade based on morphology as defined by Schizas and colleague in total, 189 patients were eligible to enter the study. Results: Mean age of patients was $61.5{\pm}9.6years$. Mean follow-up was $36{\pm}12months$. Most patients (88.4%) were classified with grades C (severe stenosis) and D (extreme stenosis). Post-surgical success was 85.7% at the 2-year follow-up. A weak correlation was observed between morphologic grade of stenosis and BMI. Rates of postoperative complications were similar between patients who were obese and those who were non-obese. Both cohorts had similar degree of improvement in the ODI at the 2-year followup. However, patients who were non-obese presented significantly higher surgical success than those who were obese. In ROC curve analysis, a cut-off value of ${\leq}29.1kg/m^2$ for BMI in patients with LSCS was suggestive of surgical success, with 81.1% sensitivity and 82.2% specificity (area under the curve, 0.857; 95% confidence interval, 0.788-0.927). Conclusion: This study showed that the BMI can be considered a parameter for predicting surgical success in patients with LSCS and can be useful in clinical practice.