• Proceedings of the PSK Conference
• /
• 2003.10a
• /
• pp.44-46
• /
• 2003

Although Cyclosporin A (CsA) is a powerful immunosuppresant with little adverse effect on the bone marrow, CsA administered orally in the general formulation cannot obtain high bioavailability due to its poor aqueous solubility. To improve the solubility and enhance the bioavailability of poorly water-soluble CsA, many different approaches have been made in our laboratory. (omitted)

• 제어로봇시스템학회:학술대회논문집
• /
• 2003.10a
• /
• pp.2566-2569
• /
• 2003

An alternative optimal control law formulation is introduced and compared with two different control law, a conventional linear quadratic regulator and the control law based on game theory. This formulation eliminates the undesired modes of the system by the projection of a controller onto the subspace orthogonal to that of the bad modes. In conventional LQR control law, the control performance can be improved only by using proper weighting matrices in performance index, normally, with high cost. The control law formulation by game theory may provide various ways to obtain the desired performance. The control law modified by the elimination of bad modes provides efficient ways to get rid of an undesired performance since it eliminates the exact modes which cause the bad control performance.

• Journal of mucopolysaccharidosis and rare diseases
• /
• v.1 no.1
• /
• pp.15-18
• /
• 2015

Biopharmaceuticals, with their ability to treat many unmet needs, are seen as promising medications in diabetes mellitus, growth hormone deficiency, chronic renal failure, cancer, and rheumatoid arthritis. However, almost all biopharmaceuticals should be administrated by injection; IV, IM, and SC. In addition, these treatments are long term, and patients should receive frequent injections for many years. Patient compliance is therefore of critical importance to ensure treatment benefits. Therefore, the goal of drug product development should be focused on improving patient compliance by reducing injection-associated pain as well as stable formulation development. This review will suggest the kinds of factors that should be considered to minimize injection pain with regard to formulation, device, and injection procedures focused on SC injections.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2010.11a
• /
• pp.652-655
• /
• 2010

BBU attached to the 155mm is the weapon system for the extension of range through the reduction of base drag. This research focus on the development of inhibitor formulation changing cure agent from DDI to IPDI. Development process is as follows. First, the formulation test about basic property Second, the study on the application of process. Third, the tests for the quality and aging properties. The test results are satisfied with the all of the requirments. In results, this research is contributed to the stable manufacturing in the instability of supplying of cure agent.

• Journal of Mechanical Science and Technology
• /
• v.19 no.spc1
• /
• pp.312-319
• /
• 2005

For real time dynamic simulation, two different subsystem synthesis methods with independent generalized coordinates have been developed and compared. In each formulation, the subsystem equations of motion are generated in terms of independent generalized coordinates. The first formulation is based on the relative Cartesian coordinates with respect to moving subsystem base body. The second formulation is based on the relative joint coordinates using recursive formulation. Computational efficiency of the formulations has been compared theoretically by the arithmetic operational counts. In order to verify real-time capability of the formulations, bump run simulations of a quarter car model with SLA suspension subsystem have been carried out to measure the actual CPU time.

• Nuclear Engineering and Technology
• /
• v.43 no.6
• /
• pp.477-488
• /
• 2011

A formulation is proposed for modelling the process of intra-granular diffusion of fission gas during irradiation of $UO_2$ under both normal operating conditions and power transients. The concept represents a simple extension of the formulation of Speight, including an estimation of the contribution of bubble motion to fission gas diffusion. The resulting equation is formally identical to the diffusion equation adopted in most models that are based on the formulation of Speight, therefore retaining the advantages in terms of simplicity of the mathematical-numerical treatment and allowing application in integral fuel performance codes. The development of the new model proposed here relies on results obtained by means of molecular dynamics simulations as well as finite element computations. The formulation is proposed for incorporation in the TRANSURANUS fuel performance code.

• Journal of the Korean Graphic Arts Communication Society
• /
• v.27 no.1
• /
• pp.49-58
• /
• 2009

Computer to plate technology(CTP) have become fully commercial. The current wide range of computer to plate system and plate makes many potential customers insecure. This process which began around 1995 has now been successfully completed, so that a wide variety of high performance systems is available. The computer to plate method of producing printing plates eliminates films from the production process, thus reducing costs and shortening production times. To discover the optimization formulation of sensitized materials we were changed formulation of resin and violet solution in thermal sensitizers. Also we were analyzed the CTP plate's surface and the result of coating and development at each sample. we were analyzed the effects of development condition as temperature and speed, the plate wear of printing test in C, M, Y, Bk ink. This paper aims to find out suitable ways that we can develop a domestic CTP plate.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.9 no.5
• /
• pp.484-491
• /
• 2017

Recent research has shown that quadrupole noise has a significant influence on the overall characteristics of flow-induced noise and on the performance of underwater appendages such as sonar domes. However, advanced research generally uses the Ffowcs Williams-Hawkings analogy without considering the quadrupole source to reduce computational cost. In this study, flow-induced noise is predicted by using an LES turbulence model and a developed formulation, called the formulation Q1As method to properly take into account the quadrupole source. The noise around a circular cylinder in an underwater environment is examined for two cases with different velocities. The results from the method are compared to those obtained from the experiments and the permeable FW-H method. The results are in good agreement with the experimental data, with a difference of less than 1 dB, which indicates that the formulation Q1As method is suitable for use in predicting quadrupole noise around underwater appendages.

• The Plant Pathology Journal
• /
• v.22 no.3
• /
• pp.303-308
• /
• 2006

Ethaboxam is a fungicide controlling plant diseases caused by Oomycetes. Efforts were made to improve its fungicidal activity applying formulation technology. Fungicidal activity of ethaboxam against cucumber downy mildew caused by Pseudoperonospora cubensis was improved by incorporating polyoxyethylene cetyl ether (PCE) in a wettable powder formulation. It was found that the optimum combination ratio of PCE and ethaboxam was 3:1, and a tank-mix of $150{\mu}g/ml$ of ethaboxam and $450{\mu}g/ml$ of PCE would be as good as the standard 25 % WP formulation diluted to $250{\mu}g/ml$ ethaboxam without PCE in controlling cucumber downy mildew. Based on this results, a wettable powder (WP) co-formulation containing 15% of ethaboxam and 45% of PCE was developed in this study, and tested for its performance in the fields. This co-formulation showed significant improvement in persistence of fungicidal activity and curative efficacy of ethaboxam against cucumber downy mildew. The improved control efficacy was also confirmed for control of grape downy mildew caused by Plasmopara viticola and potato late blight caused by Phytophthora infestans in the field tests.

• The KIPS Transactions:PartB
• /
• v.9B no.4
• /
• pp.437-444
• /
• 2002

There are some important that development of tools to retrieve information by simple operation in large of nave users in the world wide web. In general, query formulation method and operators are variety, not easy to formulate query in information retrieval system or web based retrieval engine. In this paper, we propose "Concept Wizard" to support query formulation with concept term expansion in natural language query information retrieval system. The Concept Wizard are interactively supporting query formulation using thesaurus and Providing plug-in on the web.