Journal of mucopolysaccharidosis and rare diseases

  • 제1권1호
  • /
  • Pages.15-18
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  • 2015
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  • 2465-8936(pISSN)
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  • 2465-9452(eISSN)
뮤코다당증연구학회 (Association for Research of MPS and Rare Diseases)
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Improving Patient Compliance with Biopharmaceuticals by Reducing Injection-Associated Pain

  • So, Jineon (Biopharmceutical R&D, LG Life Sciences)
  • 투고 : 2015.06.12
  • 심사 : 2015.06.22
  • 발행 : 2015.06.30
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초록

Biopharmaceuticals, with their ability to treat many unmet needs, are seen as promising medications in diabetes mellitus, growth hormone deficiency, chronic renal failure, cancer, and rheumatoid arthritis. However, almost all biopharmaceuticals should be administrated by injection; IV, IM, and SC. In addition, these treatments are long term, and patients should receive frequent injections for many years. Patient compliance is therefore of critical importance to ensure treatment benefits. Therefore, the goal of drug product development should be focused on improving patient compliance by reducing injection-associated pain as well as stable formulation development. This review will suggest the kinds of factors that should be considered to minimize injection pain with regard to formulation, device, and injection procedures focused on SC injections.

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참고문헌

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피인용 문헌

  1. Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection vol.11, pp.None, 2019, https://doi.org/10.1177/2515841419861856
  2. Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site vol.36, pp.11, 2015, https://doi.org/10.1007/s12325-019-01101-6
  3. Understanding and Minimising Injection-Site Pain Following Subcutaneous Administration of Biologics: A Narrative Review vol.7, pp.4, 2020, https://doi.org/10.1007/s40744-020-00245-0