• Journal of Pharmaceutical Investigation
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• v.36 no.1
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• pp.39-44
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• 2006

Tamsulosin or a salt thereof such as its hydrochloride salt has been known to have an adrenaline ${\alpha}$ receptor blocking action for urethra and prostate areas. It has been widely used as a drug which lowers the prostate pressure and improves urinary disturbance accompanied by prostate-grand enlargement, thus for the treatment of prostatic hyperplasia. To avoid dose-dependent side effects of tamsulosin upon oral administration, the development of sustained-release delivery system is essentially required, that can maintain therapeutic drug levels for a longer period of time. The aim of this study was therefore to formulate sustained-release tamsulosin granules and assess their formulation variables. We designed entric coated sustained-release tamsulosin granules for this purpose. Nano-pores in the outer controlled release membrane were needed in order to obtain initial tamsulosin release even in an acidic environment such as gastric region. In our sustained release osmotic granule system, hydroxypropylmethylcellulose in a drug-containing layer was used as a rate controller. The drug-containing granules were coated with hydroxypropylmethylcellulose phthalate (HPMCP) and Eudragit, along with glycerol triacetate as an aqueous nano-pore former. The release of tamsulosin depended heavily on the type of Eudragit such as RS, RL, NE 30D, used in the formulation of controlled release layer. These results obtained clearly suggest that the sustained-release oral delivery system for tamsulosin could be designed with satisfying drug release profile approved by the Korean Food and Drug Administration.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1057-1061
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• 2008

For the purpose of investigating the reasonable logics contained in physiognomy of east and old western medicine. hypothetical researches based on hydromechanics theory were performed concerning facial types of form and pathologic features, especially 4 types of Dr. Jisan-Essence, Qi energy. Emotional Activity and Blood(EQAB). In order to infer the functional relation between facial type forming and EQAB factors, EQAB were supposed as fluid grounded on their continual flowing or periodical change and pressure effect from its congestion. and a premise that there's a linear corresponding relationship between the appearance of organ and its physical conditions of its inner vessels is formed too. Through this work, the unit fluid model(UFM) of Essence can be assumed as circle shape formed by the high viscosity and surface tension, the UFM model of Qi energy as quadrangular shape by the scattering features to outer four directions, and the UFM of emotional activity as inverted triangular shape by the flippant and uprising features, and the UFM of blood as ellipsoid triangle by the heavy and descending features in spite of circulation. The shapes made from each UFM are reproduced in the process of human development and manifest respective facial shape through the self-reproduction method like fractal theory in the last. Conclusively. it is said that the facial form analysis method like EQAB type theory can be the useful methodology to understand the human pathological and physiological features in view of hydromechanics.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.1
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• pp.178-189
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• 1989

An experimental study has been performed to study the effect of the base slant angle of a 1/10 scale two-dimensional vehicle-like body on its wake flow including the recirculating region, where the simplified shape of the body has been originated from a profile of a domestic passenger car. In the case of a Reynolds number based on the length of the model R=7.96*10$^{5}$ , the surface pressure coefficient, the mean velocity and the turbulent stresses have been measured, while the flow visualization technique using wool tuft has been adopted as well. When the base slant angle of the model is 15.deg., the free stream flowing parallel to the slant is observed to be separated from the lower edge of the slant, thus forming the smallest recirculating region. When the base slant angles are 30.deg. and 45.deg., the free streams are separated from the upper edge of the slant and the sizes of the recirculating zones are observed to be almost the same as when the base slant angle is 0.deg. From these observations, it is conjectured that between the base slant angles of 15.deg. and 30.deg. there exists a critical angle at which the size of the recirculating region becomes minimum and as the slant angle becomes larger than this critical angle the separation line moves along the slant towards the rear edge of the roof. Through the flow visualization technique, the existence of the two counter-rotating bubbles in the recirculating region has been clearly observed and verified.

• Fire Science and Engineering
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• v.26 no.3
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• pp.8-13
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• 2012

This study suggests the water curtain nozzles as the way to protect important wooden cultural properties from an adjacent building fire or a forest fire. They are designed to block off the pyrolysis of timbers which occurs at $200{\sim}250^{\circ}C$ by forming a water curtain with the flow of water that spouts over a certain pressure from the bottom. The existing water curtain nozzles installed at the following sites were examined: NakSan-sa (Temple) in Gangwon-do (Province) and in Muwisa (Temple) in Jeollanam-do (South Province). As a way to improve and complement the system, this study designed nozzles with covers in order not to disrupt the landscape. Connected pipes are elevated and jet water when they are in use. Possible ways to install the connected elevating pipes to jet water effectively were investigated.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.4
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• pp.35-40
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• 2005

There are many methods to reinforce the cylindrical structure for light weight design like skin-stringer and semi-monocoque. Isogrid is one of the reinforced structures to improve buckling load. Isogrid has many advantages for complex load case, internal pressure and concentrated load.In this paper, compressive buckling test and non-linear FE analysis of the isogrid panel are described. Diameter of panel is 2.4m and thickness of plate is 11.43mm. The angle which the panel accomplish is about 70 degrees and, its height is about 660mm. Local buckling, global buckling and variation of stiffness after local buckling were observed during buckling test of the panel. MSC/MARC is used for non-linear FE analysis. When analysis, initial imperfection of panel which occurred during plastic forming is considered. The results of analysis for buckling mode and buckling load have good agreements with test.

• Korean Journal of Optics and Photonics
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• v.13 no.6
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• pp.559-563
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• 2002

We measure the 3-dimensional temporal behavior of the light emitted from the discharge cell of a plasma display panel (PDP) by using a scanned point detecting system. The light signal detected by a PM tube is sent to the oscilloscope, and the oscilloscope is connected to a PC with GPIB. From the resultant temporal behaviors, we could analyze the discharge characteristics of the panel with a Ne-Xe (4%) mixing gas at a 400 torr pressure. The top view of the panel shows that discharge moves from the inner edge of the cathode electrode to the outer cathode electrode, forming an arc shape. The side view of the panel shows that the light is detected up to 150 $\mu\textrm{m}$ up the barrier rib. After a trigger pulse is applied, peak intensity is detected at 730 ns and peak intensity position is located at the center of the ITO electrodes.

• Corrosion Science and Technology
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• v.2 no.3
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• pp.141-147
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• 2003

Sputter-deposited Nb-Al-Cr alloys. $3-5{\mu}m$ thick, have been prepared on quartz substrates as oxidation-and sulfidation-resistant materials at high temperatures. The oxidation or the alloys in the $Ar-O_2$ atmosphere of an oxygen partial pressure of 20 kPa follows approximately the parabolic rate law, thus being diffusion controlled. Their oxidation rates are almost the same as or even lower than those ofthc typical chromia-forming alloys. The multi-lavered oxide scales are formed on the ternary alloys. The outermost layer is composed of $Cr_2O_3$, which is"mainly responsible for the high oxidation'resistance of these alloys. In contrast to sputter-deposited Cr-Nb binary alloys reported previously, the inner layer is not porous. TEM observation as well as EDX analysis indicates that the innermost layer is a mixture of $Al_2O_3$ and niobium oxide. The dispersion of $Al_2O_3$ in niobium oxide may be attributable to the prevention of the formation of the porous oxide layer. The sulfidation rates of the present ternary alloys arc higher than those of the sputter-deposited Nb-AI binary alloys, but still several orders of magnitude lower than those of conventional high temperature alloys. Two-layered sulfide scales are formed, consisting of an outer $Al_2S_3$ layer containing chromium and an inner layer composed of $NbS_2$ and a small amount of $Cr_2S_3$. The presence of $Cr_2S_3$ in the inner protective $NbS_2$ layer may be attributed to the increase in the sulfidation rates.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.3
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• pp.103-111
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• 2006

The spray behavior of direct-injection spark-ignition(DISI) engines is crucial for obtaining the required mixture distribution for optimal engine combustion. The spray characteristics of DISI engines are affected by many factors such as piston bowl shape, air flow, ambient temperature, injection pressure and fuel temperature. In this study, the effect of fuel temperature on the spray and combustion characteristics was partially investigated for the wall-guided system. The effect of fuel temperature on the fan spray characteristics was investigated in a steady flow rig embodied in a wind tunnel. The shadowgraphy and direct imaging methods were employed to visualize the spray development at different fuel temperatures. The microscopic characteristics of spray were investigated by the particle size measurements using a phase Doppler anemometry(PDA). The effect of injector temperature on the engine combustion characteristics during cold start and warming-up operating conditions was also investigated. Optical single cylinder DISI engine was used for the test, and the successive flame images captured by high speed camera, engine-out emissions and performance data have been analyzed. This could give the way of forming the stable mixture near the spark plug to achieve the stable combustion of DISI engine.

• Journal of Korea Foundry Society
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• v.31 no.5
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• pp.274-283
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• 2011

The vacuum die casting is a promising candidate of the stamping process for fabrication of fuel cell bipolar plate due to its advantages, such as precision casting, mass production and short production time. This study proposes vacuum die casting process to fabricate bipolar plates in fuel cell. Bipolar plates were fabricated under various injection conditions such as molten metal temperature and injection velocity. Also, according to injection velocity conditions, simulation results of MAGMA soft were compared to the experimental results. In case of melt temperature $650^{\circ}C$, misrun occurred. When the melt temperature was $730^{\circ}C$, mechanical properties were low due to dendrite microstructure. Injection velocity has to set at more than 2.0 m/s to fabricate the sound sample. When melt temperature, injection velocity (Fast shot), and vacuum pressure are $700^{\circ}C$, 2.5 m/s and 30 kPa respectively, sample had good formability and few casting defects. Simulation results are mostly in agreement with experimental results.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.1532-1548
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• 2008

The tunnel type spillways is under construction to increasing water reservoir capacity in Dae-am dam. The tunnel outlet was planned to be made after installing slope stabilization system on natural slope there. Generally, the tunnel outlet is made perpendicularly to the slope, but in this case, it had to be made obliquely to the slope for not interrupting flow of river. Because of excavation in condition of natural slope caused to deflecting earth pressure, the outlet couldn't be made. So, artificial ground made with concrete that it was constructed in the outside of tunnel for producing the arching effect which enables to make a outlet. We were planned tunnel excavation was carried out after artificial ground made. Artificial ground made by poor mix concrete of which it was planned that the thickness was at least 3.0m height from outside of tunnel lining and 30cm of height per pouring. Spreading and compaction was planned utilized weight of 15 ton roller machine. In order to access of working truck, slope of artificial ground was designed 1:1.0 and applied 2% slope in upper pert of it for easily drainage of water. In addition to, upper pert of artificial ground was covered with soil, because of impaction of rock fall from upper slope was made minimum. The tunnel excavation of the artificial ground was designed application with special blasting method that it was Super Wedge and control blasting utilized with pre-percussion hole.