• Journal of Technology Innovation
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• v.15 no.2
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• pp.41-59
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• 2007

This paper analyzes interactive activities of foreign R&D centers operating in Korea. Interactive activities refer to collaborative R&D activities, R&D outsourcing, and formation of communities between foreign R&D centers and Korean firms and institutions. Active interactions between foreign R&D centers and their Korean partners (Korean firms and universities, research institutes etc.) are essential in promoting spillover effects from foreign R&D centers. Using the survey of 76 foreign R&D centers operating in Korea, this paper found the intensity of interplay between foreign R&D centers and the Korean firms and institutions was not so high. And the partners of foreign R&D centers with the mission of finding new technologies in Korea are mainly customers rather than universities and research institutes. This result is markedly different from previous studies focused on the cases of western countries, where the partners of foreign R&D centers that have the mission of finding new technologies were mainly local universities and research institutes.

• 한국가스학회:학술대회논문집
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• 1997.09a
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• pp.247-252
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• 1997

• Toxicological Research
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• v.13 no.3
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• pp.303-306
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• 1997

Antigenic potential of genetically engineered human granulocyte colony-stimulating factor (CJ-50001) was assessed in guinea pigs and mice. In active systemic anaphylaxis (ASA) test, although CJ-50001 at 50 $\mu\textrm{g}$ /head induced anaphylactic responses, CJ-50001 5 $\mu\textrm{g}$ /head alone or 50 $\mu\textrm{g}$ / head with adjuvant did not induce anaphylactic responses. In passive systemic anaphylaxis test (PCA) or passive hemagglutination test (PHA), CJ-50001 did not induce positive responses. It is concluded that, in light of the fact that CJ-50001 was antigenic only in ASA but not in PCA or PHA and also that CJ-50001 is a foreign human recombinant protein to guinea pigs, CJ-50001 may not induce systemic allergic react-ion in its clinical use in human.

• Journal of the Korean Magnetic Resonance Society
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• v.14 no.2
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• pp.88-104
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• 2010

Human melanocortin-4 receptor (hMC4R) has a critical role in part of energy homeostasis, and their heterozygous mutations related in genetic cause of severe human obesity. In order to study the structure and function of these membrane proteins, it is important to prepare the samples. However, the preparation of transmembrane peptide is seriously difficult and time-consuming. Overexpression and purification of membrane proteins was reported to be difficult due to their innate insoluble and toxic properties. Among the many difficulties, the most important is the difficulty in obtaining sufficient quantities of purified protein. Recently, we succeed to produce large amounts of the second transmembrane domain from the wild-type hMC4R (wt-TM2) and D90N mutant hMC4R (m-TM2) and proposed the structural difference of them in membrane-like environments. In this paper, we demonstrate the optimization procedures to express and purify wt-TM2 or m-TM2 peptides, and solution NMR studies in different detergents to get high-resolution spectra were also described.

• Journal of Korean Institute of Industrial Engineers
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• v.43 no.2
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• pp.83-89
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• 2017

This study aims to investigate the compatibility between 'quality' and 'R&D' and to ascertain what methodology can be applied. To consider the compatibility, this study discussed whether quality management can expand into R&D area in future and whether the quality management principles in ISO9000 can work well in R&D environment. Our conclusion is that the application of the quality management in R&D is valid and can serve as a new paradigm for improving R&D performance. In addition, this study divided the quality concept in R&D into several types from the viewpoints of quality definition and suggested quality methodologies for each type.

• Journal of Microbiology and Biotechnology
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• v.5 no.5
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• pp.285-291
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• 1995

Saccharide utilizations for the growth by Bifidobacterium longum and Bifidobacterium breve were compared. B. longum fermented glucose more rapidly than lactose as a carbon source whereas B. breve fermented lactose at a rate higher than that of glucose. The highest cell concentration, in the case of B. longum, was obtained when cultivated in a jar fermentor that contained modified MRS medium that half the beef extract was replaced by the same amount of tuna extract, and that pH was controlled at 6.0. B. breve showed the best growth when grown in a jar fermentor containing the MRS medium with lactose instead of glucose, controlled at pH 6.0. The optimal concentration of peptone in MRS medium for the growth of B. breve was 5 g/l.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.1
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• pp.11-17
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• 2001

To enhance the productivity and activity of nitrile hydratase in Rhodococcus rhodochrous M33, a glucose-limited fed-batch culture was performed. In a fed-batch culture where the glucose was controlled at a limited level and cobalt was supplemented during the fermentation period, the cell mass and total activity of nitrile hydratase both increased 3.3-fold compared to that in the batch fermentation. The productivity of nitrile hydratase also increased 1.9-fold compared to that in the batch fermentation. The specific activity of nitrile hydratase in the whole cell preparation when using a fed-batch culture was 120 units/mg-DCW, which was similar to that in the batch culture.

• Journal of Aerospace System Engineering
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• v.15 no.5
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• pp.16-23
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• 2021

Domestic and foreign manufacturers are developing VTOL UASs in various shapes in line with demand for future technologies. UASs have been developed in a shape classified as fixed/rotary wing, and verified by appropriate certification standards. However, airworthiness certification of recent VTOL UASs is strict with the absence of VTOL-specific certification standards. In this paper, criteria applicable to VTOL UAS were presented through analysis of STANAG-4671 and STANAG-4702, which are certification standards for fixed/rotary wing UAS of the North Atlantic Treaty Organization (NATO) and the Special Condition for VTOL Aircraft (SC-VTOL) of European Aviation Safety Agency (EASA). For this, the categorization criteria of general/fixed-wing/VTOL characteristics were established for each standard item and utilized for analysis.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.919-920
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• 2007

Currently national High Voltage Gas Insulated Switchgear (GIS) operating mechanism is made up of spring operating mechanism or hydraulic operating mechanism. On the contrary, advanced technology trend in foreign countries replace current mechanical mechanism with electrical motor-drive mechanism that leads to participate GIS bid and increase sales with the point of simplification of driving system and IT application. Therefor it is essential to develop high voltage GIS using the motor-drive system to develop national heavy electric machine industries and catch up the technology to the advanced level. This paper therefore presents design and analysis of permanent synchronous motor for high voltage GIS, verifies the performance by the experimental test.

• Journal of Biomedical Engineering Research
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• v.40 no.5
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• pp.197-205
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• 2019

The existing Extracorporeal membrane oxygenation(ECMO) and Cardiopulmonary bypass system(CPB) have been developed and applied to various devices according to their respective indications. However, due to the complicated configuration and difficult usage method, it causes inconvenience to users and there is a risk of an accident. Therefore, smart all-in-one cardiopulmonary circulation device is being developed recently. The smart all-in-one cardiopulmonary assist device consists of a blood pump for cardiopulmonary bypass, a blood oxidizer for cardiopulmonary bypass, a blood circuit for cardiopulmonary bypass, and an artificial cardiopulmonary device. It is an integrated cardiopulmonary bypass device that can be used for a variety of purposes such as emergency, intraoperative, post-operative intensive care, and long-term cardiopulmonary assist, combined with CPB used in open heart surgery and ECMO used when patient's cardiopulmonary function does not work normally. The smart all-in-one cardiopulmonary assist device does not exist as a standard and international standard applicable to advanced medical devices. Therefore, in this study, we will refer to the International Standard for Blood Components, the International Standard for Blood, the Guideline for Blood Products, and prepare applicable performance and safety guidelines to help quality control of medical devices, and contribute to the improvement of the health of people. The guideline, which is the result of conducted a survey of the method of safety and performance test, is based on the principle of all-in-one cardiopulmonary aiding device, related domestic foreign standards, the status of domestic and foreign patents, related literature, blood pump(ISO 18242), blood oxygenator (ISO 7199), and blood circuit (ISO 15676) for cardiopulmonary bypass.The items on blood safety are as follows: American Society for Testing and Materials ASTM F1841-97R17), and in the 2010 Food and Drug Administration's Safety Assessment Guidelines for Medical Assisted Circulatory Devices. In addition, after reviewing the guidelines drawn up through expert consultation bodies including manufacturers / importers, testing inspectors, academia, etc. the final guideline was established through revision and supplementation process. Therefore, we propose guidelines for evaluating the safety and performance of smart all-in-one cardiopulmonary assist devices in line with growing technology.