• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.6 no.3
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• pp.135-140
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• 2013

In this paper, novel PWM generation method for cascaded H-bridge PWM converter is proposed. The proposed method can solve the unvalancing problem between H-bridges which consist cascade PWM converter without any injection of redundancy switching pattern for solving the load of switches forced from voltage reference of controller.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.39 no.6
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• pp.568-576
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• 1990

Recently, streaming electrification in forced oil cooled power transformer has been taken up as a serious problem. In this paper, the charging tendency of various insulation oils, such as mineral oil, polybutene and silicone oil has been measured by means of an injection type charging tendency measuring apparatus under various condition. The experimental data of the dependence of the leakage current on flow velocity and temperature of oil can be explained by considering the flow state such as laminar and turbulent flow. The effect of additives on the charging tendency of mineral oil has been investigated. BTA is regarded as the most effective retardant to electrification of oil among the additives chose for this investigation.

• Journal of Mechanical Science and Technology
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• v.14 no.12
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• pp.1376-1385
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• 2000

This study investigates spray characteristics before and after wall impingingment of gasoline spray in suction air flow. For this study, a rectangular model intake port was made of acrylic glass, and suction air was generated by using the forced air blower contrariwise. The injector for this study was a pintle-type port gasoline injector in which an air-assist adaptor is installed to supply assisted air. A PDPA system was employed to simultaneously measure the size and velocity of droplets near the wall. Measured droplets are divided into "pre-impinging droplets"with positive normal velocity and "post-impinging droplets"were negative normal velocity for the suction flow. The velocities, size distributions and Sauter mean diameter(SMD) of pre-and post-impinging droplets for varions injection angles and air-assists are comparatively analyzed.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.04a
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• pp.256-260
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• 2013

The fan-shroud plays the important role in cooling down the engine heat by the forced convection. As the fan-shroud is made by injection molding, the unbalance of the fan blades is inevitable, and its low frequency characteristics makes it easy to excite the resonances of the environmental structures. So controlling its vibration, specially the dominant vibration source of unbalance vibration, is one of key factor to improve the sound and vibration quality of the modern vehicles. This paper introduces the plane balancing method, the most appropriate way of controlling the fan-shroud by generating the acceleration orbit measured from 2 accelerometers, and proves its balancing effect by the experiment.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.9
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• pp.1780-1787
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• 1992

Experiments have been performed on the thermal behavior in a liquid saturated porous medium in a system to simulate a single well aquifer thermal energy storage system. The principal interests in this study are the combined effects of forced and natural convection. Significant buoyancy flow due to natural convection is developed quickly as the temperature difference between the injection and original aquifer temperature increases. Theoretical model under simplified assumptions (called simple buoyancy flow model in this study) has been developed. The results of this model agree well with the experiments. The effects of buoyancy flow on the recovery factor are also examined in this study.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.2082-2087
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• 2004

In this study, the variation of spark plug location in the combustion chamber was investigated for the sake of emission characteristics from SI engine by using PDA valve. The swirl is ong of the important parameters that effects emission characteristics. PDA valve has been used to satisfy the requirements of sufficient swirl generation to improve combustion and emission reduction to effect on flow profile on a combustion chamber. Especially, the variation of spark plug location have an important effect to analyze exhaust gas and the early flame propagative process. Therefore, this test is forced that injection timing, spark timing and intake air motion govern the stable combustion. From the results, it showed that the variable spark plug location and PDA valve can be reduced exhaust gas.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.328-332
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• 2002

Cordyceps is reputed for its broad biological activities and as a tonic for replenishing vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the development of new type Cordyceps, the effects of the fruiting bodies of cultivated fungus of Paecilomyces japonica grown on silkworm larvae on fatigue and hematotoxicity were investigated. The antifatigue activity of dongchongxiacao (Paecilomyces japonica) was studied in mice using weight loaded forced swimming performance method. The water extract of dongchongxiacao(25 mg/kg of body weight, intraperitoneal injection at 12 and 36 hours before irradiation and 30 minute and 24 hours after irradiation) showed a significant antifatigue effect in normal mice and radiation-induced fatigue mice (p<0.0005). In the experiment on the improvement of hematotoxicity, a significant difference from the irradiated controls was seen at day 3 of the group treated with dongchongxiacao and substantial differences from the irradiated controls at day 7 was also detected.

• Journal of Ginseng Research
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• v.44 no.4
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• pp.644-654
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• 2020

Background: Posttraumatic stress disorder (PTSD), a mental disorder induced by traumatic stress and often accompanied by depression and/or anxiety, may involve an imbalance in the neurotransmitters associated with the fear response. Korean Red Ginseng (KRG) has long been used as a traditional medicine and is known to be involved in a variety of pharmacological activities. We used the open field test and forced swimming test to examine the effects of KRG on the depression-like response of rats after exposure to single prolonged stress (SPS), leading to activation of the serotonergic system. Methods: Male rats received KRG (30, 50, and 100 mg/kg, intraperitoneal injection) once daily for 14 days after exposure to SPS. Results: Daily KRG administration significantly improved depression-like behaviors in the forced swimming test, increased the number of lines crossed and time spent in the central zone in the open field test, and decreased freezing behavior in contextual and cued fear conditioning. KRG treatment attenuated SPS-induced decreases in serotonin (5-HT) tissue concentrations in the hippocampus and medial prefrontal cortex. The increased 5-HT concentration during KRG treatment may be partially attributable to the 5-hydroxyindoleacetic acid/5-HT ratio in the hippocampus of rats with PTSD. These effects may be caused by the activation of hippocampal genes encoding tryptophan hydroxylase-1 and 2 mRNA levels. Conclusion: Our findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD.

• Korean Journal of Biological Psychiatry
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• v.27 no.1
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• pp.27-35
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• 2020

Objectives Ketamine has been reported to have antidepressant effects or psychotomimetic effects. The aim of this study was to investigate the behavioral effects of ketamine treatment at various sub-anesthetic doses in adolescent and adult naïve mice. Methods In each experiment for adolescent and adult mice, a total of 60 male Institute of Cancer Research mice were randomly divided into 6 groups, which were intraperitoneally treated with physiological saline, 10, 20, 30, 40, and 50 mg/kg ketamine for consecutive 3 days. At 1 day after last injection, the locomotor and depressive-like behaviors were evaluated in mice, using open field test (OFT) and forced swim test (FST), respectively. Results In case of adolescent mice, ketamine dose was negatively correlated with total distance traveled in the OFT (Spearman's rho = -0.27, p = 0.039). In case of adult mice, we found significant positive correlation between ketamine dose and duration of immobility in the FST (Spearman's rho = 0.45, p < 0.001). Immobility time in the 50 mg/kg ketamine-treated mice was significantly higher compared to the saline-treated mice (Dunnett's post-hoc test, p = 0.012). Conclusions We found that the repeated treatment with ketamine could decrease the locomotor or prolong the duration of immobility in mice as the dose of ketamine increased. Our findings suggest that sub-anesthetic doses of ketamine might induce schizophrenia-like negative symptoms but not antidepressant effects in naïve laboratory animals.

• Tuberculosis and Respiratory Diseases
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• v.67 no.6
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• pp.569-573
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• 2009

Idiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by surfactant component accumulation in the alveolar space. Idiopathic PAP has recently been recognized as a autoimmune disease of impaired alveolar macrophage function caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). While whole lung lavage has been the standard treatment, not every patient shows a complete response. Subcutaneous injection or inhalation of GM-CSF is another promising treatment option for PAP. A 45-year-old patient visited our hospital for dyspnea, he was diagnosed as PAP and underwent whole lung lavage. Eighteen months later, the patient had not achieved complete remission in despite of initial response. After then he was administered with GM-CSF (5 ${mu}g/kg/day$, subcutaneous injection) for fivetimes a week during 2 months. Nine months later, the abnormal shadows in high-resolution computed tomography (HRCT) decreased and the patient fully recovered in forced vital capacity. After 60 months, the HRCT scan showed complete remission of PAP.