• Archives of Plastic Surgery
• /
• 제34권5호
• /
• pp.557-561
• /
• 2007

Purpose: Malignant melanoma is a fatal tumor arising in the melanocytic systems of the skin. The incidence of malignant melanoma, formerly considered a rare tumor in Korea, is observed to increase. The aim of this study is to analyze the clinical and histopathological pattern of malignant melanoma in one institute. Methods: Thirty patients with ages ranging from 33 to 80 years, diagnosed as malignant melanoma at our skin tumor department, were enrolled in a retrospective study over a 6 year period(2000. 9-2006. 7). The analyzed data included age, sex, location, duration before diagnosis, clinical type, level of invasion, and stage. Results: The cases were identified and analyzed by clinical and histopathologic study. The male to female ratio was 1:1.7. Lower extremities(especially, feet) were favored sites. The majority of cases were acral lentiginous melanoma(40%), followed by nodular melanoma (36.7%), superficial spreading melanoma(20%) in this study. Clark level IV was predominant in histopathologic study. There was merely narrow gap among each stage by AJCC. Conclusion: The clinicopathological characteristic of melanoma in our patients is quite different with that in the West. In this retrospective study, primary lesions of the foot were predominant with melanoma, and a high percentage of these were classified pathologically as acral lentiginous melanomas. Patients had a more advanced stage of disease at first presentation and a more deeply invasive primary lesion than Western patients. These suggest that malignant melanoma has a worse prognosis in our patients than in the West. So, further organized prospective studies are needed to approach the prudent and accurate diagnosis and management of melanoma in Korea.

• 대한지구과학교육학회지
• /
• 제7권1호
• /
• pp.75-90
• /
• 2014

The purpose of this study was to explore the characteristics of STEAM program developed and implemented by two docents and its educational impact for the use of natural history museum. Two docents developed this program with the help of science educators who ran five times of workshop during five months. The STEAM program implemented in the natural history museum demonstrated the following characteristics. The exhibitions in museum were reached by visitors only for learning science concepts (S) out of five components in STEAM. The other components, T (technology) and E (engineering), were delivered through lectures in the room, not exhibition hall. M (Mathematics)was achieved by guessing the animal's size, or calculating the walking or running speed with the clue of foot prints. The three phases of STEAM program (presentation of context, creatively design the investigation, and emotional touch) were explicitly implemented but partially successful. Two docents participating in this study responded that they formed new or extended the understandings about STEAM education, but they had the difficulties in implementing STEAM program for various type of visitors. All visitors who participated in this study displayed the favorable responses in educational impact by STEAM program in natural history museum. The heavier emphasis on E and T of STEAM program is recommended through community-based learning. In addition, educator professional program through which docents can bridge theory into practice is suggested for revitalization of STEAM education.

• Journal of Microbiology and Biotechnology
• /
• 제28권1호
• /
• pp.109-114
• /
• 2018

Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes various diseases such as myocarditis and hand-foot-mouth disease. However, an effective antiviral drug is still not developed. In this study, we looked for potential inhibitors of CVB3 replication by examining the survival of CVB3-infected HeLa cells. We detected an antiviral effect by cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps the digestion and absorption of lipids in the small intestine. HeLa cells were cultured in 12-well plates and treated with cholic acid (1 and $10{\mu}g/ml$) and $10^6PFU/ml$ of CVB3. After 16 h post-infection, the cells were lysed and subjected to western blot analysis and RT-PCR. The production of the viral capsid protein VP1 was dramatically decreased, and translation initiation factor eIF4G1 cleavage was significantly inhibited by treatment with $10{\mu}g/ml$ cholic acid. Moreover, cholic acid inhibited ERK signaling in CVB3-infected HeLa cells. RT-PCR showed that the amounts of the CVB3 RNA genome and mRNA for the ER stress-related transcription factor ATF4 were significantly reduced. These results showed that cholic acid strongly reduced ER stress and CVB3 proliferation. This compound can be developed as a safe natural therapeutic agent for enterovirus infections.

• 한국운동역학회지
• /
• 제15권2호
• /
• pp.1-10
• /
• 2005

G. B. LEE, A. S. GWON, The Research for Using methodof GRF (Ground Reaction Force) on Rotational Movement in Arabesque. Korean Journal of Sport Biomechanics, Vol. 15, No. 2, pp.1-10, 2005. As, in relation to all movements of a human being, the movements such as mutually walking, running, rotating, and jumping are attained endlessly through the ground amid the interaction with the ground, in terms of the harmonious movement of the upper limbs and the lower limbs, related to the basic movement in ballet, the type of a movement depends on the size and direction of the force that presses down the ground (Fz, Fx, Fy) amid the interaction with the ground. Therefore, aiming to correctly and efficiently perform a rotational movement in Arabesque, this study analyzed factors of the force manifestation through GRF (Ground Reaction Force), by dividing into preparing, stepping, standing, rotating, and finishing stages (events (1) ${\sim}$ (5)), targeting the subjects of 4 elite female students who majored in ballet. 1. At the No.5 position of the preparing stage, It is necessary that support the ground with left and right foot balance, 2. As the stepping stage is the phase ranging from the event (2), in which a plie movement of bending a knee is started, to the event (3) of stretching a knee, Rebunding motion is not good, and One have a position with ankle and knee flextion condition in order to stretch strengthly in event (3) position 3. At the event (1) position, It is necessary that exert the Fz reaction force at the event (3) position. Because large stretch force help to have a toe on position easily and show a active motion 4. In order to have a stand and rotation motion smoothly, One need a muscle strength training for ankle extension, knee extension, control horizental force

• Journal of Trauma and Injury
• /
• 제28권3호
• /
• pp.158-169
• /
• 2015

Purpose: Frostbite can affect still soldiers. Initial clinical manifestations are similar for superficial and deep frostbite, so early treatment is identical. It is under-estimated by physicians. We try to identify the challenges of managing these complex tissue injuries. Methods: A retrospective analysis of 84 patients hospitalized at AFCH from 2009 to 2015 was conducted. We investigated differences of epidemiological characteristics, identification of soft tissue injury, treatment and complications between superficial (SF: 43; 51.2%) and deep (DF: 41; 48.8%) frostbite. Results: The major (94.0%) developed frostbite in dry circumstances (89.3%). Wet circumstances (66.7%) were more susceptible to DF rather than dry (46.7%). The 38 (45.2%) arrived to specialist within 7days. Most prone sites were feet, followed by hands. Toes had more deep injuries. DF presented more increased levels of ALT, CPK, CKMB, CRP. The bone scan of W+S+ was 48.3%, 87.1% and W+S- was 20.7%, 12.9%, respectively. The treatment resulted in improved or normalized perfusion scan with matching clinical improvement. It was a good tool to assess treatment response. Eighteen normal and 8 stenotic type of PCR resulted in normal with matching clinical improvement. One continuous obstructive waveform led to minor amputation. Twelve underwent both PCR and MRA. Among 6 normal PCR, 5 showed normal and one stenosis in MRA. All 5 stenosis and one obstruction showed the same findings in MRA. It was a good tool to evaluate vascular compromise. They were treated with rapid rewarming (11.6%, 22.0%), hydrotherapy (16.3%, 29.3%), respectively. Six (14.6%) underwent STSG, 2 (4.9%) had digital amputation in DF. Berasil, Ibuprofen, Trental were commonly administered. PGE1 was administered selectively for 6.8, 10.8 days, respectively. Raynaud's syndrome (16.3%), CRPS (4.7%), LOM (14.6%) and toe deformity (4.9%) were specific sequelae. Conclusion: We should recommend intensive foot care education, early rewarming and evacuation to specialized units. The bone scanning and PCR should allow for a more aggressive and active approach to the management of tissue viability.

• 한국균학회지
• /
• 제29권1호
• /
• pp.75-78
• /
• 2001

2000년 경상남도농업기술원 창원화훼시험장 스타티스포장에서 흰가루병이 발생하여 병원균의 형태, 병원성, 분류학적인 특성을 조사를 하였다. 병징은 이병엽 앞뒷면과 잎자루, 줄기에 전형적인 흰가루 모양의 균총이 많이 형성되었고, 병징이 심하게 진전될 경우 잎에 황화되고 갈색 또는 암갈색으로 되며 결국 말라죽는다. 병반부에서 분생포자, 분생자병이 형성되었다. 분생포자는 분생자병의 끝에 형성되고 단상으로 원통형 또는 장타원형의 무색, 단포이다. 크기는 25.3{\sim}49.4{\times}12.3{\sim}17.2{\mu}m$이며, Fibrosin body는 없었다. 부착기는 손바닥 또는 가느다란 실모양이었다. 분생자병은 $2{\sim}4$개의 격막으로 되어있고 길이는 $65.7{\sim}124.8{\mu}m$이었다. Foot cell은 원통형이었다. 포장에서나 접종시 나타난 이병엽 병반부에서 자낭각은 관찰되지 않았다. 이상과 같은 본 병원균은 Oidium sp.에 의한 스타티스 흰가루병으로 동정되었으므로 국내에서 처음 확인된 새로운 병으로 보고한다.

• The Korean Journal of Pain
• /
• 제25권4호
• /
• pp.245-253
• /
• 2012

Background: Prevalence of chronic pain and its association with demographic characteristics have been reported by different studies from different geographical regions in the world. However, data from many Middle East countries including Iran (especially southern Iran) are scare. The aim of the present study was to demonstrate the prevalence of chronic pain and its association with demographic, psychological and socioeconomic factors in an Iranian population. Methods: In this population-based survey, the target population was comprised of subjects aged 20 to 85 years residing in Jahrom, southern Iran during 2009-2011. All eligible subjects were invited to participate in the study. Before a detailed questionnaire was given; face to face interviews were done for each individual. Results: There were 719 men and 874 women with an average age of 40.5 years at the onset of the study. Among the study population, 38.9% (620/1,593) complained of chronic pain, of whom 40.8% (253/620) were men and 59.2% (367/620) were women. Foot and joint pain were observed in 31.9%. Hip and spine pain, migraine and tension headaches, heart pain, and abdomen pain were observed in 21.5%, 15.5%, 9.5%, and 8.0% of chronic pain cases, respectively. There was a significant association among the covariables age, sex, overweight, educational level, income, and type of employment with chronic pain as the dependent variable (P < 0.0001). Conclusions: Our findings show the prevalence of chronic pain and its association with demographic, psychological and socioeconomic factors. Individuals with low incomes and less education became accustomed to pain due to a lack of knowledge.

• 한국농공학회논문집
• /
• 제54권1호
• /
• pp.63-72
• /
• 2012

In livestock industry, damage caused by the epidemic diseases such as Foot-and-Mouth Disease (FMD), Highly-Pathogenic-Avian-Influenza (HPAI) and Porcine-Reproductive-and-Respiratory-Syndrome (PRRS) was very serious. The financial loss incurred from FMD alone which occurred on Nov. 2011 in Korea was estimated at 3 billion won, 23 % of annual livestock industry production. The livestock industry in Korea has greater risk of disease infection because of high density production, etc. Investigating the spread of livestock diseases should consider both direct and indirect contact as well as other various factors including airborne. Airborne infection of livestock disease was first hypothesised in the early 1900s, however, field experimental studies are still limited. Furthermore, no protocol is available in detecting airborne viruses in the field. In this study, effective virus samplers were investigated by comparative analysis of the type of samplers used detect to airborne virus. Laboratory experiments were conducted to compare virus samplers such as Bio-sampler, Dust-sampler, Compact-Cascade-Impactor (CCI) and Microflow in detecting PRRSV. Samples were analyzed by Reverse-Transcription PCR to assess the efficiency of the instrument in detecting the airborne virus. First, samples were classified into five levels according to light intensity of gel images and then the classified results were normalized. In every case, Bio-sampler and Dust-sampler were comparable with each other and have shown to be more effective than CCI and Microflow samplers.

• 산업경영시스템학회지
• /
• 제42권4호
• /
• pp.1-7
• /
• 2019

The customer of massage chair is expanding day by day from middle age to all ages. In 2018, the market size was 700 billion KRW, an increase of 30 times over 10 years. However, most related SMEs suffer from excessive competition by the market monopoly of some major companies. In this situation, in order for a related company to survive, it is necessary to steadily research and develop new products. Founded in 2009, company L produces massage chairs for health and relaxation of customers. L's products use a sound wave vibration module that is favorable for human body, unlike other products that use vibration motor type. However, frequent breakdowns of massage chair due to the vulnerability of plate (leaf) springs, which play an important role in sound wave vibration modules, made sap its competitiveness. In this paper, we propose a method to design desirable plate spring structure by sequentially experimenting with five different plate springs. The results of this study are expected to contribute to improve the quality of plate spring and the reliability of sound wave vibration module. In the future, it is necessary to find a way to use it in the development of foot massage or scalp management device as well as continuous research to find optimal plate spring structure through various analysis.

• 대한기계학회논문집B
• /
• 제20권9호
• /
• pp.2944-2952
• /
• 1996

In this paper the CSCM type upwind flux difference splitting Navier-Stokes method has been applied to study the ARL-SL19 transoni $c^ersonic compressor cascade flow. First, the general characteristics of baseline cascade flow were analyzed. At freestream Mach n.1.612 and exit/inlet pressure ratio 2.15, the results from current laminar flow were compared well in suction surface with the experiment; however, not well in pressure surface. Second, numerical study of the transoni $c^ersonic compressor cascade flow demonstrated the effectiveness of a passive control by the various size cavities. A cavity under the shock foot point at the suction surface of the blades was used as a passive control. The passive control of shock-boundary layer interaction by a cavity reduced total pressure losses. The effect of cavity length and depth was studied. The total pressure loss was reduced by about 10% and the isentropic efficiency was improved slightly. The effect of cavity depth in current study(d/l = 0.05, 0.02) was not found strong. Further adequate turbulence modeling and TVD schemes would help to capture the shock more accurately and increase the effectiveness of the current shock-boundary layer interaction study using upwind flux difference splitting computational methods.thods.