• Journal of Ginseng Research
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• v.48 no.2
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• pp.211-219
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• 2024

Background: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. Methods: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 10⁹ particles/mL), and followed by UVB irradiation or H₂O₂ exposure. In addition, the antioxidant activity of GrDENs was measured using a fluorescence microscope or flow cytometry. Finally, molecular mechanisms were examined with immunoblotting analysis. Results: GrDENs contained detectable levels of ginsenosides (Re, Rg1, Rb1, Rf, Rg2 (S), Gyp17, Rd, C-Mc1, C-O, and F2). In UVB-irradiated HaCaT cells, GrDENs protected cells from death and reduced ROS production. GrDENs downregulated the mRNA expression of proapoptotic genes, including BAX, caspase-1, -3, -6, -7, and -8 and the ratio of cleaved caspase-8, -9, and -3 in a dose-dependent manner. In addition, GrDENs reduced the mRNA levels of aging-related genes (MMP2 and 3), proinflammatory genes (COX-2 and IL-6), and cellular senescence biomarker p21, possibly by suppressing activator protein-1 signaling. Conclusions: This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng. In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.

• Journal of Venture Innovation
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• v.1 no.2
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• pp.47-59
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• 2018

With the recent, rapid changes in the socio-economic environment, organizations of today are now required to present a framework of realistic consumer behaviors based on psychology, economy, and finance, in order to understand their investing customers. Stock investors show differences in terms of their decisions or evaluations in the process of investing. This is due to what is called the 'framing effect.' The decision frames of the investors are defined differently, and, as a result, this affects the decisions made by the investors. Preceding studies on stock investment rarely touched the topic of the effect of message framing on market participants in their stock investment, especially regarding the differences in terms of their risk management behaviors based on the message framing in stock investment. Therefore, the purpose of this study is to examine the influence of stock investment message framing on market participants in their investment decision making and empirically validate whether this message framing effect has a moderating effect on the factors of investment satisfaction. For this, 494 participants with stock investment experiences were interviewed from May 1 to 26, 2018, and the results were used as the data for the empirical analysis. The analysis of the data was conducted using SPSS 22.0 statistical analysis software. The results of this study were as follows; First, of the stock investment behavioral factors, the stock comprehension, recommendation by others for a stock, and the degree of risks of a stock affected stock investment satisfaction in a positive manner. And, of the behavioral factors of stock investment, stock comprehension, stock brand, recommendation on the stocks from others, past performances, and risk levels of stocks affected the intent of continued stock investment in a positive manner. Second, message framing turned out to affect stock investment satisfaction in a positive manner, and it also had a significant moderating effect to the relationship between the stock investment behavior and stock investment satisfaction. Third, message framing was found to affect continued stock investment intent significantly, with a significant moderating effect in the relationship between stock investment behavioral factor and continued stock investment intent.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.39 no.4
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• pp.99-110
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• 2021

This study intends to examine the characteristics of the construction method of the urban water system in the historical cities of Korea, focusing on Gyeongju, Gyeongju, Goryeo, Hanyang, and Suwon Hwaseong, which were created as new towns in the late Joseon Dynasty. It examines the meaning of waterways in connection with the urban skeletal structure, focusing on the location of cities, roads, and arrangement of urban facilities, and analyzes the compositional form of the water system. We tried to derive the relationship with the structure. In particular, it can be seen that water and natural water systems act as key factors in determining the location of a city, and have a close relationship with the urban structure, urban development process, and urban structure. In addition to the symbolic meaning of water in harmony with the geographical concept, realistic demands in terms of water level and water retention are an important background. In order to respond to various demands related to water space, various planning and technical elements for managing water space were introduced in the process of city formation and development. The planning elements of the urban water system in the process of urban formation and development are summarized as follows through the analysis of the research site. First, in the process of building the urban water system in Gyeongju, Goryeo, Goryeo, Hanyang, and Hwaseong, Suwon, which were selected as the research destinations, the water system in consideration of drainage and disaster is common, but the water system construction method and usability are common. shows the difference. Second, water and natural water systems act as symbolic elements to secure the legitimacy of the city location, and as a key factor in determining the location of the city in harmony with the geographical concept and determining the left direction of the city. Third, the natural water system prior to the formation of a city works as a basis for determining the compositional form of the urban water system constructed in the process of urban formation and development in harmony with the topographical conditions. Fourth, the urban water system built on the basis of natural water systems is constructed by linking natural waterways and planned artificial waterways. Fifth, the urban water system is being built in a planned manner in consideration of the utility in connection with the urban structure, such as securing of urban land, arrangement of urban facilities and areas, composition of functional areas, and land division, in addition to the perspective of drainage system and flood control in consideration of disasters.

• Journal of the Korean Professional Engineers Association
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• v.29 no.2
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• pp.15-23
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• 1996

With the ever-increasing importance of high-speed information in society as we move towards the 21 st century, telecommunication laboratories of advanced nations are pressing forward with research and development aimed at implementing its W & P(Visual Intelligent and Personal) services and construction of a new network to support them. In legals to the former, based on a long-term view of technological and market trends, those laboratories are researching and developing services that will make possible an effective progression from the development of services that answer to potential needs towards the full-scale implementation of VI & P services. In regards to the latter, these laboratories are responding in a flexible manner to the increasing diversity and disposal of the communications environment by separating the network into a transmission system and a versatile information control/conversion -ion system and laboratories are working at enhancing the performance of both. Within these board aims, the laboratories are currently focusing our attention in three areas : the technology for a high-speed broadband transmission system featuring optical frequency multiplexing and ATM techniques, network and software technologies for advanced information control and conversion, and technology for constructing a new access network that can provide a comprehensive range of multimedia services. This article describes the laboratories' concept of how VI & P services will develop in the future, and the latest trends in the field of communications. It also describes the ideal configuration of the new network and discusses the important technological aspects of how it is to be constructed. Finally, it presents the results of the laboratories'recent research which include some innovative work, point out the areas requiring future investigation.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.133-141
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• 2020

Currently, companies are focusing on how they make their members have change-oriented organizational citizen behavior in the era of fierce competition due to the 4th industrial revolution. Therefore, this study verified how the flexible culture of adhocracy-clan plays a role in positive psychological capital and change-oriented organizational citizen behavior. A survey was conducted for employees in companies located in Daejeon-si, Sejong-si, Chungcheongnam-do, and Chungcheongbuk-do, and 394 valid questionnaires were used for analysis. The concrete analysis results are obtained from the study as follows. First, among the flexible cultures of adhocracy-clan, the innovation culture was found to have a significant effect on change-oriented organizational citizenship behavior while relationship culture was found to not directly affect change-oriented organizational citizenship behavior. Second, the flexible cultures of adhocracy-clan, the innovation culture was found to have a significant effect on the positive psychological capital. Third, the positive psychological capital was found to have a significant effect on the change-oriented organizational citizenship behavior. Fourth, the positive psychological capital was found to play a mediating role in the relation between the recognition of flexible cultures of adhocracy-clan and the change-oriented organizational citizenship behavior. Therefore, it can be said to find out the fact that the change-oriented organizational citizen behavior can appear under the fierce competition as nowadays only when the organization should establish the organization culture of innovation-relation or the members are in the positive psychological state. We expect that the future study on the type of subculture and new organizational citizen behavior will be made in the manner of classifying the unit of organizational culture into a headquarter or team for measurement.

• Journal of Distribution Science
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• v.13 no.9
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• pp.81-93
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• 2015

Purpose - "Showrooming" refers to the phenomenon where a shopper visits a store to see and compare products but makes the purchase online at a lower price. Surveys on showrooming activities at home and abroad indicate that a significant number of consumers pursue showrooming activities. The advent of "showroomers," who engage in buying activities, hovering both on and offline, while selectively choosing sales channels to suit their needs, is powerful enough to erode the borders between channels and bring about seismic changes in the distribution industry. However, surprisingly, there has been no in-depth discussion on showrooming. This study seeks to theoretically investigate what impact personal characteristics have on showrooming preferences and attitudes in a multi-channel environment. Specifically, assumptions have been made that price perception, perceived performance risk, and trust in online shopping not only have a direct impact on showrooming attitudes but also indirectly affect it through the means of contact motivation. Research design, data, and methodology - To test the hypotheses, this study conducted a survey of male and female shoppers, ages 20 through 40s, who live in metropolitan areas, and have actively showroomed fashion items in the last six months. A clothing item usually purchased after a careful decision-making process was chosen as the target product of the study. The survey was conducted between October and November 2014, using a professional survey service provider. A total of 200 surveys were collected, of which 198 were used for analysis. Conceptual model Structural Equation Modeling (SEM) and Amos 18.0 were employed for data analysis and model verification. In addition, following the confirmatory factor analysis and measurement model analysis, the theoretical model that corresponds to the research model was analyzed. Results - Analysis results show that price perception, perceived performance risk, and trust in online shopping have a statistically significant and positive (+) impact on showrooming attitudes. In addition, in terms of the indirect influence of price perception and perceived performance risk on showrooming attitudes through means of contact motivation, price perception had a statistically significant and positive impact on means of contact motivation, whereas perceived performance risk did not have a statistically significant impact on it, with the relevant hypothesis rejected. Conclusions - These analysis results imply that the ultimate goal of consumers is to maximize their shopping benefits by selectively and strategically taking advantage of different channels in a complementary manner. This study presents many implications for distributors to encourage a deep understanding of showrooming consumers who have complicated consumption behaviors and to build channel integration strategies. This study has limitations in theoretical and practical implications. Therefore, subsequent studies need to focus on verifying that showrooming activities are based on reasonable and planned decisions by applying the theory of reasoned or planned behavior. In addition, the scope of the study should expand to include web showrooming, where consumers conduct product research online and purchase offline.

• Journal of the Korea Convergence Society
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• v.7 no.6
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• pp.259-266
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• 2016

The purpose of this study is to explore the feasibility of establishing the elderly protection system for the elderly in the local community, and to explore the linkage model and action strategy. In Korea, there is a need to build a comprehensive elderly care system so that elderly people can have appropriate counseling and support programs in the community, as the elderly increase their diverse needs (leisure, housing, employment). In this study, we set up a linkage model of elderly care system and suggested two ways to practice it. First, it is suggested that it is desirable to focus on the formation of the elderly protection system in the community, and divide the practice process into three stages: organization, practice, and organization. Second, it is necessary to apply the long-term care professional manpower which can play a central role such as care manager and nursing care provider in order to apply the community organizing model of the elderly protection system and stable operation of long-term care insurance for the elderly. In addition, a social welfare council and a private network should be established to form a social welfare council, the establishment of related legal provisions, and the education of care managers. Therefore, it is necessary to establish basic data through this study, to establish diverse strategies and plans for the elderly protection system, and to promote it in a phased manner.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.803-810
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• 2007

An analytical method capable of predicting various stress-strain responses in axially loaded concrete confined with FRP (fiber reinforced polymers) composites in a rational manner is presented. Its underlying idea is that the volumetric expansion due to progressive microcracking in mechanically loaded concrete is an important measure of the extent of damage in the material microstructure, and can be utilized to estimate the load-carrying capacity of concrete by considering the corresponding accumulated damage. Following from this, an elastic modulus expressed as a function of area strain and concrete porosity, the energy-balance equation relating the dilating concrete to the confining device interactively, the varying confining pressure, and an incremental calculation algorithm are included in the solution procedure. The proposed method enables the evaluation of lateral strains consecutively according to the related mechanical model and the energy-balance equation, rather than using an empirically derived equation for Poisson's ratio or dilation rate as in other analytical methods. Several existing analytical methods that can predict the overall response were also examined and discussed, particularly focusing on the way of considering the volumetric expansion. The results predicted by the proposed and Samaan's bilinear equation models correlated with observed results with a reasonable degree, however it can be judged that the latter is not capable of predicting the response of lateral strains correctly due to incorporating the initial Poisson's ratio and the final converged dilation rate only. Further, the proposed method seems to have greater benefits in other applications by the use of the fundamental principles of mechanics.

• Journal of Life Science
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• v.24 no.2
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• pp.209-217
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• 2014

In a variety of eukaryotic cells, autophagy sequesters a portion of the cytoplasm and targets it to a lytic compartment for degradation in bulk. Autophagy is a dynamic process for degrading cytoplasmic cargoes with various degrees of selectivity, and its activity is tightly regulated in a nutrient- and development-dependent manner. Autophagy research has drawn much attention since autophagy not only is an interesting cell biological phenomenon but also has great potential for medical and agricultural applications. For example, autophagy is associated with cancers and neurodegenerative diseases in human and mammalian cells and is also suggested in remobilization of nutrients during the senescence of plant leaves. In this general review, we describe genetic components of the core autophagic machinery conserved among yeast, animals, and plants and briefly explain how these components are responsible for major steps in plant autophagy. We discuss four common features of autophagic processes: (i) autophagy as a degradation pathway, (ii) the concept of flux in autophagy research, (iii) dependency on developmental and nutritional cues, and (iv) diversity of autophagy, focusing on selective types of autophagy. We also summarize cell biological and physiological functions of plant autophagy. Our intention is to provide a quick guide to autophagy for those who are new to autophagy research.

• The Korean Society of Law and Medicine
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• v.9 no.1
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• pp.385-411
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• 2008

The goal of medicine is to contribute to promoting national health by preventing diseases and providing treatment. The scope of modern medicine isn't merely confined to disease testing, treatment and prevention in accordance to that, and making experiments by using the human body is widespread. The advance in modern medicine has made a great contribution to valuing human dignity and actualizing a manly life, but there is a problem that has still nagged modern medicine: treatment and healing for terminal patients including cancer patients. In advanced countries, pain care and hospice medicine are already universal. Offering a helping hand for terminal patients to lead a less painful and more manly life from diverse angles instead of merely focusing on treatment is called the very hospice medicine. That is a comprehensive package of medical services to take care of death-facing terminal patients and their families with affection. That is providing physical, mental and social support for the patients to pass away in peace after living a dignified and decent life, and that is comforting their bereaved families. The National Hospice Organization of the United States provides terminal patients and their families with sustained hospital care and home care in a move to lend assistance to them. In our country, however, tertiary medical institutions simply provide medical care for terminal patients to extend their lives, and there are few institutional efforts to help them. Hospice medicine is offered mostly in our country by non- professionals including doctors, nurses, social workers, pastors or physical therapists. Terminal patients' needs cannot be satisfied in the same manner as those of other patients, and it's needed to take a different approach to their treatment as well. Nevertheless, the focus of medical care is still placed on treatment only, which should be taken seriously. Ministry for Health, Welfare & Family Affairs and Health Insurance Review & Assessment Service held a public hearing on May 21, 2008, on the cost of hospice care, quality control and demonstration project to gather extensive opinions from the academic community, experts and consumer groups to draw up plans about manpower supply, facilities and demonstration project, but the institutions are not going to work on hospice education, securement of facilities and relevant legislation. In 2002, Ministry for Health, Welfare & Family Affairs made an official announcement to introduce a hospice nurse system to nurture nurse specialists in this area. That ministry legislated for the qualifications of advanced nurse practitioner and a hospice nurse system(Article 24 and 2 in Enforcement Regulations for the Medical Law), but few specific plans are under way to carry out the regulations. It's well known that the medical law defines a nurse as a professional health care worker, and there is a move to draw a line between the responsibilities of doctors and those of nurses in association with medical errors. Specifically, the roles of professional hospice are increasingly expected to be accentuated in conjunction with treatment for terminal patients, and it seems that delving into possible problems with the job performance of nurses and coming up with workable countermeasures are what scholars of conscience should do in an effort to contribute to the development of medicine and the realization of a dignified and manly life.