• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.3 s.258
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• pp.380-387
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• 2007

We carried out an image analysis of living cells forming their contacts at the bottom of the cell culturing substrate. In order to visualize the contact area selectively, we adopted total-internal-reflection-fluorescence (TIRF) method, which can illuminate the specimen volume within only several hundred nano-meters above the substrate. From the fluorescent intensity of the TRF image, we could calculate the distance of the cell surface from the substrate. As a result, we visualized the origin of cell contacts, their movements, and the change of cell-contact type from the close-contact into focal-contact with information of its vertical displacement representing the temporal evolution process of the three-dimensional cell-surface-profile near the contact area during this metamorphosis.

• Economic and Environmental Geology
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• v.11 no.1
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• pp.11-20
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• 1978

This paper examines the seismicity of the offshore area of western Canada in the light of findings from a detailed study of an earthquake swarm which occurred in the area during November-December in 1971. The distribution of epicenters and focal mechanism solutions of a few main events suggest that the seismicity of the area may largely be interpreted in terms of plate interactions among the Pacific, Juan de Fuca, Explorer and North American plates. Differences between the patterns of seismicity along the transform fracture zones and at their junctions with the ridges were also observed.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.4 s.304
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• pp.87-94
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• 2005

3D image mosaicking is useful for 3D visualization of the roadside scene of urban area by projecting 2D images to the 3D planes. When a sequence of images are filmed from a side-looking video camera passing long distance areas, the ghost effect in which same objects appear repeatively occurs. To suppress such ghost effect, the long distance range areas are detected by using the distance between the image frame and the 3D coordinate of tracked optical flows. The ghost effects are suppressed by projecting the part of image frames onto 3D multiple planes utilizing vectors passing the focal point of frames and a virtual focal point. The virtual focal point is calculated by utilizing the first and last frames of the long distance range areas. We demonstrate algorithm that creates efficient 3D Panoramic mosaics without the ghost effect at the long distance area.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.11 no.3
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• pp.94-106
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• 2008

As populations inhabiting in natural ecosystem are fragmented by artificial barriers and habitats are destructed by development, extinction possibility of species is getting higher. It is necessary to design and to manage conservation areas and corridors considering animals' movement and migration for sustainable species diversity in present circumstances. 'Least-cost modeling' is one commonly employed approach in which dispersal costs are assigned to distinct habitat types and the last-costly dispersal paths among habitat patches are calculated using a geographical information system (GIS). This study aims to design ecological corridor using least-cost path method and to apply it to a regional ecological network considering movability of medium-large size mammals. This study was carried out over the metropolitan area, which has been deforested by rapid urbanization. Nevertheless there is connected with Gangwon province, Baekdudaegan mountain range and DMZ, considered where many forest species can migrate to this region. This study employs such an approach to develop least-cost path models for medium-large size mammals, have inhabited for this entire region. Considering those species, two forest areas as a source of species supply and forest areas more than 1,000ha are selected as focal forest areas. Movement and migration paths from species supply sources to focal forest areas are calculated by applying landscape permeability theory using land cover map, road density map and land slope map. Results showed least-cost paths from species supply sources to focal forest areas on two species. Wildcat and roe deer are different in some least-cost paths caused by their landscape permeability but paths show generally same specifics. The result of considering regional distribution of expected movement and migration paths to regional ecological network, low altitude mountains of western metropolitan area are evaluated important area for species connectivity. In national or regional levels ecological connectivity is essential to promote species diversity and to preserve integrated ecosystem. This study concludes that developing least-cost models from similar empirical data could significantly improve the utility of these tools.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.369-369
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• 2016

A nanostructure composite is a highly suitable substance for photoacoustic ultrasound generation. This allows an input laser beam (typically, nanosecond pulse duration) to be efficiently converted to an ultrasonic output with tens-of-MHz frequency. This type of energy converter has been demonstrated by using a carbon nanotube (CNT)-polydimethylsiloxane (PDMS) composite film that exhibit high optical absorption, rapid heat transition, and mechanical durability, all of which are necessary properties for high-amplitude ultrasound generation. In order to develop the CNT-PDMS composite film, a high-temperature chemical vapor deposition (HTCVD) method has been commonly used so far to grow CNT and then produce a CNT-PDMS composite structure. Here, instead of the complex HTCVD, we use a mixed solution of hydrophobic multi-walled CNT and dimethylformamid (DMF) and fabricate a solution-processed CNT-PDMS composite film over a spherically concave substrate, i.e. a focal energy converter. As the solution process can be applied over a large area, we could easily fabricate the focal transmitter that focuses the photoacoustic output at the moment of generation from the CNT-PDMS composite layer. With this method, we developed photoacoustic energy converters with a large diameter (>25 mm) and a long focal length (several cm). The lens performance was characterized in terms of output pressure amplitude for an incident pulsed laser energy and focal spot dimension in both lateral and axial. Due to the long focal length, we expect that the new lens can be applied for long-range ultrasonic treatment, e.g. biomedical therapy.

• Journal of architectural history
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• v.11 no.3 s.31
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• pp.21-34
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• 2002

This study is to analyse the transformation process of spatial structure of traditional small city structure in Jeollabuk-Do in the process of modern urbanization between 19th century and the year 2000. The small cities, IM-PI, YONG-AN, YEO-SAN, OK-GOO, GO-SAN, MU-JANG, GUM-MA, GO-BU, which have been local administrative center in CHO-SUN dynasty, have role of local administrative center of subdivision of country-myon, except OK-GOO. The method of this study is to investigate the transformation process of spatial structural elements of with the actual field surveys, the analysis of Gunhyun map made in 1872, land registration maps in 1910s and 2000, and various topological maps. The elements of analysis are the topological site and geographical situation conditions, the urbanized areas, the street systems, the function of streets, the focal points of urban land use, the land use systems, and the location of major facilities such as administration facilities, markets, bus terminals. The analytical point of view and the results are as follows. There is strong relationship between the transformation of internal matrix route system and the growth pattern of urbanized areas, Especially on the contrary to the matrix route with East-West direction which has the role of checking the growth of urbanized area, the South-North direction route acts as the leading line of the growth. The focal points structure of urban land use shows transformation process from the point of central space of administrative district in front of Nae-A, to the access point to administrative district or to the access point to housing and neighborhood commercial area. From the point of functional area structure and major facilities location, line-type commercial area is developed along the line of central axis route and access route to administrative district. Especially direction of the growth of commercial area is strongly connected with the interrelationship between the study area and its neighboring cities. Pattern of commercial district development is varied with the direction of matrix route. That is, commercial district, which shows one side development pattern along the East-West direction route, is developed on both sides of street along the South-North direction route.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.199-204
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• 2013

Syntenin is an adaptor molecule containing 2 PDZ domains which mediate molecular interactions with diverse integral or cytoplasmic proteins. Most of the results on the biological function of syntenin were obtained from studies with malignant cells, necessitating exploration into the role of syntenin in normal cells. To understand its role in normal cells, we investigated expression and function of syntenin in human lymphoid tissue and cells in situ and in vitro. Syntenin expression was denser in the germinal center than in the extrafollicular area. Inside the germinal center, syntenin expression was obvious in follicular dendritic cells (FDCs). Flow cytometric analysis with isolated cells confirmed a weak expression of syntenin in T and B cells and a strong expression in FDCs. In FDC-like cells, HK cells, most syntenin proteins were found in the cytoplasm compared to weak expression in the nucleus. To study the function of syntenin in FDC, we examined its role in the focal adhesion of HK cells by depleting syntenin by siRNA technology. Knockdown of syntenin markedly impaired focal adhesion kinase phosphorylation in HK cells. These results suggest that syntenin may play an important role in normal physiology as well as in cancer pathology.

• Childhood Kidney Diseases
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• v.20 no.2
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• pp.83-87
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• 2016

Congenital chloride diarrhea (CLD) is a rare autosomal recessive disease that is difficult to diagnose. CLD requires early treatment to correct electrolyte imbalance and alkalosis and to prevent severe dehydration. Renal injury is clearly associated with defective electrolyte balance induced by CLD, particularly during the first months or years of life. A 7-year-old boy was diagnosed with CLD following detection of a homozygous mutation (c.2063-1G>T) in SLC26A3 at 6 months of age. During treatment with electrolyte supplements, mild proteinuria was detected at 8 months of age, and is still present. Renal biopsy showed the presence of focal renal dysplasia, with metaplastic cartilage and mononuclear cell infiltration, calcification, and fibrosis in the interstitium. Up to two-thirds of the glomeruli exhibited global obsolescence, mostly aggregated in the dysplastic area. In nondysplastic areas, the glomeruli were markedly increased in size and severely hypercellular, with increased mesangial matrix, and displayed segmental sclerosis. The marked glomerular hypertrophy with focal segmental glomerulosclerosis suggested a compensatory reaction to the severe nephron loss or glomerular obsolescence associated with renal dysplasia, with superimposed by CLD aggravating the tubulointerstitial damage.

• Journal of the Optical Society of Korea
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• v.16 no.1
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• pp.22-28
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• 2012

We report a focal-length tunable liquid lens based on thermopneumatically driven fluidic pressure. The fluidic pressure is generated by deformation of an elastomeric diaphragm induced by thermopneumaticity from a laterally integrated microheater sealed within an air chamber. The pressure is transmitted by a confined liquid to a lens diaphragm through an internal fluid channel. The liquid filling under the lens diaphragm functions as a liquid lens for dynamic focusing with properties depending on the curvature of the deformed diaphragm. The diaphragm area of the air chamber is designed five times larger than that of the lens cavity to yield high focal-length tunability by amplified deflection of the lens diaphragm. With our method, we achieved excellent focal-length tunability from infinity (without an input current) to 4 mm (with an input current of 12 mA) with a lens aperture diameter of 2 mm.

• The Korean Journal of Nuclear Medicine
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• v.19 no.1
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• pp.145-148
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• 1985

A small number of pathologic entities such as Budd-Chiari Syndrome, cirrhosis, focal nodular hyperplasia, and superior and inferior vena cava obstruction has been reported to result in focal areas of increased uptake of radiocolloid on the hepatoscintigram. We recently studied a patient with focal accumulation of $^{99m}Tc-phytate$ at the inferior aspect of the liver, at the junction of the right and left lobe. The superior vena cava scintiangiogram was taken for the evaluation of the superior vena cava obstruction and collateral circulations. As a result of superior vena caval obstruction a considerable amount of blood flowed to the liver through the anterior parietal and periumblical venous channels. A certain fraction of radiocolloid delivered by the rete mirabile perfused to a localized area of the liver. This would explain the hot spot around the porta hepatis in this case.