• Phonetics and Speech Sciences
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• 제4권2호
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• pp.61-70
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• 2012

The current study observes the durational interaction of tautosyllabic consonants and vowels in the word-initial position of English and Korean child-directed speech (CDS). The effect of phonological laryngeal contrasts in stops on the following vowel duration, and the effect of the intrinsic vowel duration on the release duration of preceding stops in addition to the acoustic realization of the contrastive segments are explored in different prosodic contexts - phrase-initial/medial, focal accented/non-focused - in a marked speech style of CDS. A trade-off relationship between Voice Onset Time (VOT), as consonant release duration, and voicing phonation time, as vowel duration, reported from adult-to-adult speech, and patterns of durational variability are investigated in CDS of two languages with different linguistic rhythms, under systematically controlled prosodic contexts. Speech data were collected from four native English mothers and four native Korean mothers who were talking to their one-word staged infants. In addition to the acoustic measurements, the transformed delta measure is employed as a variability index of individual tokens. Results confirm the durational correlation between prevocalic consonants and following vowels. The interaction is revealed in a compensatory pattern such as longer VOTs followed by shorter vowel durations in both languages. An asymmetry is found in CV interaction in that the effect of consonant on vowel duration is greater than the VOT differences induced by the vowel. Prosodic effects are found such that the acoustic difference is enhanced between the contrastive segments under focal accent, supporting the paradigmatic strengthening effect. Positional variation, however, does not show any systematic effects on the variations of the measured acoustic quantities. Overall vowel duration and syllable duration are longer in English tokens but involve less variability across the prosodic variations. The constancy of syllable duration, therefore, is not found to be more strongly sustained in Korean CDS. The stylistic variation is discussed in relation to the listener under linguistic development in CDS.

• The Bulletin of The Korean Astronomical Society
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• 제36권2호
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• pp.126.1-126.1
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• 2011

The SPICA (SPace Infrared Telescope for Cosmology & Astrophysics) project is a next-generation infrared space telescope optimized for mid- and far-infrared observation with a cryogenically cooled 3m-class telescope. Owing to unique capability of focal plane instruments onboard SPICA, it will enable us to resolve many astronomical key issues from the star-formation history of the universe to the planetary formation. The FPC (Focal Plane Camera) is a Korean-led near-infrared instrument as an international collaboration. Korean consortium for FPC proposed a key instrument responsible for a fine guiding (FPC-G). The back-up of FPC-G will make scientific observations as well. We have examined the legacy science programs for FPC and performed the feasibility study for the fine guiding system. Recently, the international review process is now in progress, in order to make a selection of the focal plane instruments. Here, we report the current status of SPICA/FPC project.

• Korean Journal of Optics and Photonics
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• 제9권6호
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• pp.362-367
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• 1998

Center Distance Finding (CDF) is a technique to find the sphere diameter by measuring the distance between two contacting spheres. The focal spots of the sphere clusters are formed in the back-focal plane by the transmission-mode optical microscope with the pseudothermal illumination source. Digital images taken by the CCD camera were processed by the software called Global Lab Image. The centers of the focal spots are found and the spot positions are expressed in terms of the CCD pixel elements, whose coordinate are calibrated by a heterodyne interferometer. The new CDF measurement system has been developed, which are more advantageous in time and convenience than the existing system, while the measurement uncertainly remains sufficient for its use as a magnification standard for optical microscopy. Two kinds of polystyrene spheres whose nominal diameters 3 and 10 $\mu\textrm{m}$ (NIST SRM 1962 and 1960) are measured with the uncertainly less than 1% at the confidence level of 99%, and the results are compared with the results of National Institute of Standards and Technology.

• Korean Journal of Optics and Photonics
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• 제22권5호
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• pp.230-238
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• 2011

There are many types of interchangeable zoom lens in the digital single lens reflex camera and the compact digital still camera system in order to meet various specifications such as the field angle. Thus special cases for which the focus adjustment using only an auto-focus group is not available in the focal point correction (that is, the focus adjustment) of both wide and tele-zoom positions are sometimes generated. In order to make each BFL(back focal length, BFL) coincide at wide and tele-zoom positions with each designed BFL, focus adjustment processes must be performed at least in these two points within the zoom lens system. In this paper, we propose a method of focus adjustment by using the concept of focus sensitivity, and we calculate a limit on focus adjustment distance by means of statistical analysis.

• Journal of Veterinary Clinics
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• 제26권3호
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• pp.259-262
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• 2009

Focal adnexal dysplasia(FAD) is a rare non-neoplastic lesion of adnexal appendages that occurs in dogs and has good prognosis. We report a case in which FAD diagnosis was favored by its histopathological features. A 8-year-old, castrated male American cocker spaniel dog presented with papillomatous masses on the distal phalanx of left forelimb. Histopathologically, the stroma was sharply demarcated from the adjacent dermis and subcutis. The adnexa was surrounded and interspersed with abundant, hyalinized collagen and the numerous sebaceous lobules distributed haphazardly around hair follicles, which is thickened, dilated and tortuous with abundant keratin. Epidermis was acanthotic. Proliferative lesions of the skin region are very common with similar gross features, thus the basic histopathological examination supported by additional diagnostic methods allow to establish the definitive diagnosis in most cases of cutaneous tumor or tumor-like lesions. And it is important that physicians and pathologists are aware of this unusual tumour-like nonneoplastic lesion.

• The Korean Journal of Physiology and Pharmacology
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• 제11권3호
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• pp.85-88
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• 2007

Matrix metalloproteinases (MMPs) can degrade a wide range of extracellular matrix components. It has been reported that MMP-9 are activated after focal ischemia in experimental animals. (-)-Epigallocatechin-3-gallate (EGCG), a major constituent of green tea polyphenols, is a potent free radical scavenger and reduces the neuronal damage caused by oxygen free radicals. And it has been known that EGCG could reduce the infarction volume in focal brain ischemia and inhibit MMP-9 activity. To delineate the relationship between the anti-ischemic action and the MMP-9-inhibiting action of EGCG, we investigated the effect of EGCG on brain infarction and the activity of matrix metalloproteinase-9 induced by permanent middle cerebral artery occlusion (pMCAO) in ICR mice. EGCG (40 mg/kg, i.p. $15{\sim}30min$ prior to MCAO) significantly decreased infarction volume at 24 hr after MCAO. GM 6001 (50 mg/kg, i.p. $15{\sim}30min$ prior to MCAO), a MMP inhibitor, also significantly reduced infarction volume. In zymogram, MMP-9 activities began to increase at ipsilateral cortex at 2 hr after MCAO, and the increments of MMP-9 activities were attenuated by EGCG treatment. Western blot for MMP-9 also showed patterns similar to that of zymogram. These findings demonstrate that the anti-ischemic action of EGCG ire mouse focal cerebral ischemia involves its inhibitory effect on MMP-9.

• Journal of the Economic Geographical Society of Korea
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• 제18권2호
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• pp.206-223
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• 2015

Korea government has established 67 agri-food clusters for 10 years. In recent years, the criticism of this policy has significantly increased due to trials and errors. The purpose of this study is to suggest some policy implications for the focal firm and governance mechanism through the case study of Muan Loess Sweet Potato Cluster. The concept of netchain was used as an analysis framework. Muan Loess Sweet Potato Cluster doesn't operate an integrated production organization and focal firm doesn't exercise its influence as well. The cluster agency, focal firm of Cluster, is important for a Agri-food Cluster to grow continuously. it must have a great influence on organizing networks and an enough capacity for forming coordination mechanism. Also, Local governments must actively be involved in the network formation and coordination and inform the vision and plan for development.

• Journal of the Institute of Electronics Engineers of Korea SP
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• 제42권4호
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• pp.87-94
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• 2005

3D image mosaicking is useful for 3D visualization of the roadside scene of urban area by projecting 2D images to the 3D planes. When a sequence of images are filmed from a side-looking video camera passing long distance areas, the ghost effect in which same objects appear repeatively occurs. To suppress such ghost effect, the long distance range areas are detected by using the distance between the image frame and the 3D coordinate of tracked optical flows. The ghost effects are suppressed by projecting the part of image frames onto 3D multiple planes utilizing vectors passing the focal point of frames and a virtual focal point. The virtual focal point is calculated by utilizing the first and last frames of the long distance range areas. We demonstrate algorithm that creates efficient 3D Panoramic mosaics without the ghost effect at the long distance area.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.149-157
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• 2017

The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley rats, focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 1 h. The rats simultaneously received 50 mg/kg human IL-1RA through the intranasal (IN group) or intraperitoneal route (IP group). The other rats were given 0.5 mL/kg normal saline (EC group). Neurobehavioral function, infarct size, and the concentration of the administered human IL-1RA in the brain tissue were assessed. In addition, the cellular distribution of intranasal IL-1RA in the brain and its effect on proinflammatory cytokines expression were evaluated. Intranasal IL-1RA improved neurological deficit and reduced infarct size until 7 days after MCAO (p<0.05). The concentrations of the human IL-1RA in the brain tissue 24 h after MCAO were significantly greater in the IN group than in the IP group (p<0.05). The human IL-1RA was confirmed to be co-localized with neuron and microglia. Furthermore, the IN group had lower expression of $interleukin-1{\beta}$ and tumor necrosis $factor-{\alpha}$ at 6 h after MCAO than the EC group (p<0.05). These results suggest that intranasal IL-1RA can reach the brain parenchyma more efficiently and provide superior neuroprotection in the transient focal cerebral ischemia.

• Journal of Korean Neurosurgical Society
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• 제56권3호
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• pp.248-253
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• 2014

Objective : Cortical dysplasia (CD) is one of the common causes of epilepsy surgery. However, surgical outcome still remains poor, especially with frontal lobe epilepsy (FLE), despite the advancement of neuroimaging techniques and expansion of surgical indications. The aim of this study was to focus on surgical strategies in terms of extent of resection to improve surgical outcome in the cases of FLE with CD. Methods : A total of 11 patients of FLE were selected among 67 patients who were proven pathologically as CD, out of a total of 726 epilepsy surgery series since 1992. This study categorized surgical groups into three according to the extent of resection : 1) focal corticectomy, 2) regional corticectomy, and 3) partial functional lobectomy, based on the preoperative evaluation, in particular, ictal scalp EEG onset and/or intracranial recordings, and the lesions in high-resolution MRI. Surgical outcome was assessed following Engel's classification system. Results : Focal corticectomy was performed in 5 patients and regional corticectomy in another set of 5 patients. Only 1 patient underwent partial functional lobectomy. Types I and II CD were detected with the same frequency (45.45% each) and postoperative outcome was fully satisfactory (91%). Conclusion : The strategy of epilepsy surgery is to focus on the different characteristics of each individual, considering the extent of real resection, which is based on the focal ictal onset consistent with neuroimaging, especially in the practical point of view of neurosurgery.