• Journal of fish pathology
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• v.30 no.2
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• pp.115-134
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• 2017

A total number of 668 apparently healthy fish were obtained from farm to study the effect of two heavy metals (Copper and Mercury) on histopathology of liver, kidney, spleen, gills and muscles also residues in muscles. The $LC_{50}$/96 hr. of Cu and Hg were estimated and fish exposed to 1/2 $LC_{50}$ for 7 days and for 1/10 $LC_{50}$ for 8 weeks from each product separately. Histopathological findings in acute and chronic mercuric chloride toxicity revealed degeneration and necrosis in the glomeruli, interstitium tissue and epithelium lining renal tubules. The tubular epithelium became necrotic at several places. Eosinophilic hyaline droplets is exist in the cytoplasm of the necrosed cells. Degenerative changes and hyperactivity in melanomachrophage center was seen in the spleen together with some necrotic areas. Necrosis and aggregation of melanomachrophage were seen in the hepatic cells, Hepatic cells showed vacuolar degeneration in the hepatic cells. Gills showed loss in the lamellae of the filaments associated with edema, inflammatory cells infiltration and haemorrhages in the arch. The sarcoplasm of the bundles of the skeletal muscle showed granular degeneration and focal inflammatory cells infiltration between the hyalinized bundles. Mercury residues obtained from these studies in the acute toxicity were 0.22 ppm/gm in the 2nd day, 0.411 ppm/gm in the $5^{th}$ day ended with 0.96 ppm/gm in the $7^{th}$ day. In chronic toxicity it was 1.1320, 1.7140, 2.3620 and 3.5640 ppm/gm respectively from the $2^{nd}$ to the $8^{th}$ week of exposure. In acute and chronic copper toxicity, there was degenerative changes in renal tubules. Melanophores aggregation in the wall of the blood vessels of the spleen and depletion of some of the melanophores in the melanomachrophage were seen together with necrosis in some areas. Congested Mvs (Micro vessels) and vacuolation of hepatocytes were observed. Some areas of hemorrhage and melanophores vacuolar degeneration in the liver were seen. There was mitosis in some areas with displesia of hepatopancreatic cells and eosinophilic granular cells aggregation. Zymogen granules disappeared and there were dyplastic hepatocytes. Congestion in the blood vessels of the gill filaments, associated with massive number of granular eosinophilic cells infiltration were seen in the base of the filaments. There were sever vacuolization and hyalinization in the skeletal muscle bundles. Detection of residues of copper sulfate revealed increase of the amount of copper measured in ppm/gm comparing to the normal control starting from 0.60 ppm/g in the $2^{nd}$ day, 0.67 ppm/g in the $5^{th}$ day and 0.67 ppm/g in the $7^{th}$ day. Result obtained in chronic copper sulfate toxicity revealed gradual increase of the amount of copper which ranged from 0.18 ppm/g at the $2^{nd}$ week to 0.21 ppm/g in the $8^{th}$ week of exposure.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4491-4501
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• 2016

Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Apart from virus-associated lesions, VPLs harboring malignant potential or behaviour such as verrucous carcinoma, proliferative verrucous leukoplakia, oral verrucous hyperplasia (OVH), oral papillary squamous cell carcinoma (PSCC) and oral conventional squamous cell carcinoma with papillary features (CSCC) need to be further clarified for better understanding of their predictable biologic behavior and appropriate treatment. Current understanding of potentially malignant VPLs is perplexing and is primarily attributed to the use of confusing and unsatisfactory terminology. In particular, the condition referred to as oral verrucous hyperplasia (OVH) poses a major diagnostic challenge. OVH represents a histopathological entity whose clinical features are not well recognised and is usually clinically indistinguishable from a verrucous carcinoma and a PSCC or a CSCC. A consensus report published by an expert working group from South Asia as an outcome of the 'First Asian Regional Meeting on the Terminology and Criteria for Verruco-papillary Lesions of the Oral Cavity' held in Kuala Lumpur, Malaysia, recognised the clinical description of these OVH as a new entity named 'Exophytic Verrucous Hyperplasia'. Previously described clinical features of OVH such as the 'blunt' or 'sharp' variants; and the 'mass' or 'plaque' variants can now collectively fall under this newly described entity. This paper discusses in detail the application of the standardized criteria guidelines of 'Exophytic Verrucous Hyperplasia' as published by the expert group which will enable clinicians and pathologists to uniformly interpret their pool of OVH cases and facilitate a better understanding of OVH malignant potential.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.15-23
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• 2017

The purpose of this study is to examine the issues of digital textbook policy in Korea, using the four dimensional model of Cooper, Fusarelli, & Randall(2004). Building upon systematic review of the policy documents, journals, and articles, I found some issues and implications for the betterment of the policy: From normative dimension, it is important to overcome widespread view of textbook based on positivist epistemology. From structural dimension, we need to move to curriculum-based textbook system and stabilize the organization in authority within the Ministry of Education. From constituentive dimension, much more consideration and support within the authority are to be provided to teachers and students. Lastly, it is critical to develop and disseminate an effective instructional model and build capacity of teachers' ICT from technical dimension. Building upon the results, clarification of policy objectives, establishment of priorities for school grades and subjects in the mid- to long-term perspective, and the establishment of communicative venue for the gathering of opinions of teachers and students who are key participants and activation of operations.

• Korean Journal of Environment and Ecology
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• v.26 no.6
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• pp.941-951
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• 2012

The changes of forest habitats and maeulsoops(village forests) in Jinan-gun, Jeollabuk-do, South Korea are examined using landscape indices and morphological pattern analysis, and their landscape-ecological implications on conserving biological diversity are presented. We used FRAGSTATS and GUIDOS software, as well as land cover maps(of 1989 and 2006) to analyze the spatial and temporal patterns of habitat composition and configuration in surrounding landscapes of 34 representative maeulsoops and Jinan-gun. The results showed decreases in the amount of core habitats and corridors and habitat connectivity at a regional scale since 1989. In addition, multi-scale habitat analysis at a focal scale revealed that the structural and functional connectivity between forest habitats surrounding maeulsoops of the year 2006 was lower than that of the year 1989. In order to reduce forest fragmentation and to enhance the connectivity among habitats, it is necessary to provide the additional habitat corridors as well as preserving existing corridors and surrounding landscapes of maeulsoops. We also suggest that a combination of landscape indices and morphological spatial pattern analysis can provide an effective tool to assess the habitat functions and configuration in a rapidly changing landscape.

• Korean Journal of Optics and Photonics
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• v.23 no.5
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• pp.189-196
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• 2012

A floating optical system is a system that moves more than 2 groups to focus at the camera lens. At the camera optics, the floating system that is mainly used is an optical system such as a macro lens which changes magnification very much. When the floating system is assembled and fabricated in the factory, there are differences between the image plane of the sensor and the focal plane of the infinity or macro state. Therefore, in a considerable proportion of cases, the focus adjustment to minimize the difference of BWD(Back Working Distance) is carried out in the process of manufacturing. In this paper, in order to decide the movement of each group in a floating system, we evaluated the rotation angle of CAM for the focus adjustment. We know that the maximum magnification of macro state is corrected by this numerical method for the focus adjustment, too. We investigated the limit of CAM rotation angle of the system by using statistical analysis for CAM rotation angle, which uses the focus adjustment of the floating system with symmetric error factors.

• Economic and Environmental Geology
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• v.39 no.5 s.180
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• pp.615-626
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• 2006

The natural resources and material life-cycle include all human activities related to resources and material extraction, transportation, processing, use, recovery and disposal. Sustainable material management (SMM) is an integrated set of policy approaches targeted on economic agents throughout the material life-cycles and designed to result in economically efficient and environmentally effective material use. The material flows of industrial mineral, ores and fossil fuels have also long been a focal area for environmental policies because of the high environmental pressures associated with extraction, processing, consumption, and final disposal of these materials. OECD work on material flow is to improve the quantitative and analytical knowledge bases about natural resource and material flows within and among countries, so as to better understand the importance of material resources in member countries' economies. In several EU Member States, material flow accounts are part of official statistics. Material flow analysis (MFA) is a valuation method which assesses the efficiency of use of materials using information from material flow accounting. Material flow analysis helps to identify waste of natural resources and other materials in the economy which would otherwise go unnoticed in conventional economic monitoring systems. Resource use and resource efficiency has emerged as a major issue for long-term sustainability and environmental policy.

• Journal of Internet Computing and Services
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• v.14 no.4
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• pp.63-72
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• 2013

Business Process Intelligence (BPI) is one of the emerging technologies in the knowledge discovery and analysis area. BPI deals with a series of techniques from discovering knowledge to analyzing the discovered knowledge in BPM-supported organizations. By means of the BPI technology, we are able to provide the full functionality of control, monitoring, prediction, and optimization of process-supported organizational knowledge. Particularly, we focus on the focal organizational knowledge, which is so-called the BPM activity-performer affiliation networking knowledge that represents the affiliated relationships between performers and activities in enacting a specific business process model. That is, in this paper we devise a statistical analysis method to be applied to the BPM activity-performer affiliation networking knowledge, and dubbed it the activity-performer correspondence analysis method. The devised method consists of a series of pipelined phases from the generation of a bipartite matrix to the visualization of the analysis result, and through the method we are eventually able to analyze the degree of correspondences between a group of performers and a group of activities involved in a business process model or a package of business process models. Conclusively, we strongly expect the effectiveness and efficiency of the human resources allotments, and the improvement of the correlational degree between business activities and performers, in planning and designing business process models and packages for the BPM-supported organization, through the activity-performer correspondence analysis method.

• Proceedings of the KSEG Conference
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• 2005.04a
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• pp.101-106
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• 2005

The three-dimensional Tomography developed by Kim and Bae(2004) was applied to 64,024 P and 64,618 S wave arrival times observed at 238 seismic stations for 4050 local earthquakes in the depth range from 0 to 300 km in and around Hokkaido, Japan. High and low velocity zones for Vp/Vs were clearly imaged in and around Hokkaido. The upper seismic planes of the double seismic zone (DSZ) were found in the subducted Pacific Plate beneath Hokkaido at depth of 40- 80 km, which produced high seismicity around Hokkaido. The findings of high Vp/Vs anomalies beneath the Moho discontinuity supports an evidence of a surface triple-collision hypothesis prepared by Moriya(1994) that the Kuril Arc(Okhotsk Plate or North American Plate) is colliding against the NE Japanese Arc(Amurian Plate or Eurasian Plate), along and beneath the Hidaka Mountain Range, and at the same time the Pacific Plate is subducting into these two plates, making an equilibrium of tectonic forces along the Hikada Mountain Range (HMR) corner and the central tectonic axis(142 ~ 143E) in Hokkaido. The low Vp and Vs were also found in east and west along the central tectonic axis in which the focal mechanism represents the extensional forces. These phenomena are also consistent with low Bouguer gravity anomalies in this region. It is understood why most of great earthquakes occurred outside Hokkaido where the balance of tectonic forces are breaking from the triple junction of three tectonic forces in Hokkaido.

• Applied Microscopy
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• v.17 no.1
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• pp.98-114
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• 1987

Degranulation of the rat peritoneal mast cell induced by intraperitoneal injection of horseradish peroxidase(HRP) was studied using light and electron microscopes. 1. Rat peritoneal mast cells in the Tyrode's buffered salt solution injected control group did not show any particular morphological changes following the specified time course. 2. Under the light microscope, the majority of mast cells observed 10 minutes after HRP injection were nearly the same as those of the control group. However, after 30 minutes, granule densities or staining properties of certain cells began to decrease and these appearances increased gradually until 12 hours after injection, at which time small groups of granules being stained pale-red or pink with toluidine blue were easily identified in the cytoplasm of many cells, and numerous extruded granuleg were scattered around these cells. 3. In the mast cells representing the early stage of degranulation induced by HRP, the electron densities of certain granules decreased as the size enlarged, and perigranular cavities were formed by perigranular membrane expansion. As a result, a thin cytoplasmic septum was formed between the expanded perigranular membrane and the cytoplasmic membrane in the cell periphery, and fusion of the adjacent perigranular membranes was observed in the inner side of the cell. 4. In some mast cells, one or two changes in the peripheral cytoplasmic septum could be seen. One was a focal rupture of the peripheral septum and the other was the formation of a saccule containing one or more vesicles. This saccule was thought to be used for granule-extrusion site and/or material absorptive apparatus judging from the morphological characteristics. 5. As the degranulation proceeded, the granule was extruded from the cell after partial rupture of the peripheral cytoplasmic septum. This phenomenon proceeded to-ward the inner side of the cell through the fused perigranular cavities, and consequently several distinct cavities containing a few unextruded membrane-free granules were formed throughout the cytoplasm after 12 hours. As a rule, the granule-extrusion sites were relatively fewer while the cytoplasmic cavities resulting from degranulation were more numerously observed. Thus, it was thought that the granule-extrusion sites tended to be restricted in the HRP-induced degranulation.

• Journal of the Korean Society for Nondestructive Testing
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• v.23 no.1
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• pp.21-29
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• 2003

It is very important to reduce the computational time in estimating the parameters of vision control algorithm for robot's position control in real time. Unfortunately, the batch estimation commonly used requires too murk computational time because it is iteration method. So, the batch estimation has difficulty for robot's position control in real time. On the other hand, the Extended Kalman Filtering(EKF) has many advantages to calculate the parameters of vision system in that it is a simple and efficient recursive procedures. Thus, this study is to develop the EKF algorithm for the robot's vision control in real time. The vision system model used in this study involves six parameters to account for the inner(orientation, focal length etc) and outer (the relative location between robot and camera) parameters of camera. Then, EKF has been first applied to estimate these parameters, and then with these estimated parameters, also to estimate the robot's joint angles used for robot's operation. finally, the practicality of vision control scheme based on the EKF has been experimentally verified by performing the robot's position control.