• Korean Journal of Clinical Laboratory Science
• /
• v.51 no.3
• /
• pp.323-328
• /
• 2019

Tuberculosis, a chronic bacterial infection caused by Mycobacterium tuberculosis (MTB), differs in its status latency and activity because of the characteristics of MTB, immune status of the host, and genetic susceptibility. The host defense mechanism against MTB is caused mainly by interactions between macrophages, T cells, and dendritic cells. CD44 is expressed in activated T cells when infected with MTB and regulates lymphocyte migration. In addition, CD44 mediates leukocyte adhesion to the ECM and plays a role in attracting macrophages and $CD4^+$ T cells to the lungs. Therefore, genetic polymorphism of the CD44 gene will inhibit the host cell immune mechanisms against MTB. This study examined whether the genetic polymorphism of the CD44 gene affects the susceptibility of tuberculosis. A total of 237 SNPs corresponding to the CD44 genes were analyzed using the genotype data of 443 tuberculosis cases and 3,228 healthy controls from the Korean Association Resource (KARE). Of these, 17 SNPs showed a significant association with the tuberculosis case. The most significant SNP was rs75137824 (OR=0.231, CI: 1.51~3.56, $P=1.3{\times}10^{-4}$). In addition, rs10488809, one of the 17 significant SNPs, is important for the tuberculosis outbreak can bind to the JUND and FOS transcription factors and can affect CD44 gene expression. This study suggests that polymorphism of the CD44 gene modulates the host susceptibility to tuberculosis in a variety of ways, resulting in differences in the status of tuberculosis.

• The Bulletin of The Korean Astronomical Society
• /
• v.44 no.1
• /
• pp.57.2-57.2
• /
• 2019

The NISS (Near-infrared Imaging Spectrometer for Star formation history) onboard NEXTSat-1 was successfully launched on last December and is now under the operation phase. The capability of both imaging and spectroscopy is a unique function of the NISS. It has realized the imaging spectroscopy (R~20) with a wide field of view of $2{\times}2deg$. in a wide near-infrared range from 0.95 to $2.5{\mu}m$. The major scientific mission is to study the cosmic star formation history in the local and distant universe. It also demonstrated the space technologies related to the infrared spectro-photometry in space. The NISS is performing the imaging spectroscopic survey for local star-forming galaxies, clusters of galaxies, star-forming regions, ecliptic deep fields and so on. As an extension of the NISS, the SPEHREx (Spectro-Photometer for the History of the Universe Epoch of Reionization, and Ices Explorer) was selected as the NASA MIDEX (Medium-class Explorer) mission (PI Institute: Caltech). As an international partner, KASI will participate in the development and the science for SPHEREx. It will perform the first all-sky infrared spectro-photometric survey to probe the origin of our Universe, to explore the origin and evolution of galaxies, and to explore whether planets around other stars could harbor life. Compared to the NISS, the SPHEREx is designed to have a much wider FoV of $3.5{\times}11.3deg$. as well as wider spectral range from 0.75 to $5.0{\mu}m$. Here, we introduce the status of the two space missions.

• Phonetics and Speech Sciences
• /
• v.12 no.4
• /
• pp.91-98
• /
• 2020

This study investigated the acoustic characteristics of sustained vowel /a/ and sentence utterance produced by patients with muscle tension dysphonia (MTD) using cepstrum-based acoustic variables. 36 women diagnosed with MTD and the same number of women with normal voice participated in the study and the data were recorded and measured by ADSVTM. The results demonstrated that cepstral peak prominence (CPP) and CPP_F0 among all of the variables were statistically significantly lower than those of control group. When it comes to the GRBAS scale, overall severity (G) was most prominent, and roughness (R), breathiness (B), and strain (S) indices followed in order in the voice quality of MTD patients. As these characteristics increased, a statistically significant negative correlation was observed in CPP. We tried to classify MTD and control group using CPP and CPP_F0 variables. As a result of statistic modeling with a Random Forest machine learning algorithm, much higher classification accuracy (100% in training data and 83.3% in test data) was found in the sentence reading task, with CPP being proved to be playing a more crucial role in both vowel and sentence reading tasks.

• (The)Study of the Eastern Classic
• /
• no.59
• /
• pp.387-404
• /
• 2015

A great number of philosophers during 'Six's Dynasty'(六朝) had the most active and furthest discussion throughout the history of China to study the concerns; Having a question such as "Where the body and the soul come out around us?", "What is the essence of complicated and delicate mental operation?" "Are there any relationships between the body and the soul?" and then "How do the human soul exist after death?" First, during 'Don-Jin' period as body and soul theory was based on 'Yin'(陰) and 'Yang'(陽). 'He Cheng Tian' said that everything which was burn on earth should die because the soul couldn't stay the dead body longer. In the same age, 'Ming Fo Run' and 'Da Xing Run' which denied that the soul couldn't exist forever were main topics of the discuss among the distinguished philosophers. Next, during 'Northern & Southern dynasty', body and soul theory was divided into two. First of all, body and soul of 'Heng Cun' might be harmonized, however, that was not perfectly put together. Because, after human death, even if the body of human might be existed, the soul left elsewhere but always stayed around us. The body was the soul which meant that the soul was to the nature of the body and the body was to the usage of soul. Many philosophers insisted that nobody meant no soul according to 'Shen Bu Mie Run' and 'Shen Mie Run'which was the main topic as an academic argument in those days. Finally, during Dong-Jin dynasty covered the significance of Body and Soul theory and analyzed the influence into the history of the history philosophy in china.

• (The)Study of the Eastern Classic
• /
• no.73
• /
• pp.415-444
• /
• 2018

This study was designed to analyze the delivery patterns of early(1900-1945) letters from the beginning of the postal service in order to examine the process of establishing the modern postal system after the constitution of the Postal Service(1884). In Chapter 2, we examined the 'change of the way letters are delivered', Chapter 3 is about the 'change of expression' and Chapter 4 is about 'double-faced of the post'. In the examination of aspects of changing the way letters were delivered, the phase of postal delivery by personal delivery to postal delivery were divided into three phases: [the period of personal delivery delivery] > [the coexistence period of personal delivery and postal deliveryy] > [the period of postal delivery]. In particular, it was interesting to see that the same sender and receiver mixed up postal delivery and personal delivery by the case in the second period. In addition, the functional differences between the express, telegram and particular post were found in the examination fo contents of the letter. In the examination of aspects of changing in expression, a change of common expression in 'greeting, ending, and receiving expressions' were confirmed. Also, it was confirmed that 'woo-pyeon' was not used as the basic term, but instead replaced with various terms, and that 'woo' was used independently and productively. In the double-faced aspects of post, there were disadvantages of the postal delivery such as 'discontent of the lost' and 'security of confidentiality', despite the advantages of 'economic, rapid, and long-distance delivery'. Because the disadvantage of postal delivery could be supplemented by personal delivery, postal delivery and personal delivery could coexist for a considerable period of time.

• Membrane Journal
• /
• v.31 no.1
• /
• pp.16-34
• /
• 2021

Water supplies are decreasing in comparison to increasing clean water demands. Using nanofiltration is one of the most effective and economical methods to meet the need for clean water. Common methods for desalination are reverse osmosis and nanofiltration. However, pristine membranes lack the essential features which are, stability, economic efficiency, antibacterial and antifouling performances. To enhance the properties of the pristine membranes, graphene oxide (GO) is a promising and widely researched material for thin film composites (TFC) membrane due to their characteristics that help improve the hydrophilicity and anti-fouling properties. Modification of the membrane can be done on different layers. The thin film composite membranes are composed of three different layers, the top filtering active thin polyamide (PA) layer, supporting porous layer, and supporting fabric. Forward osmosis (FO) process is yet another energy efficient desalination process, but its efficiency is affected due to biofouling. Incorporation of GO enhance antibacterial properties leading to reduction of biofilm formation on the membrane surface. Pressure retarded osmosis (PRO) is an excellent process to generate clean energy from sea water and the biofouling of membrane is reduced by introduction of GO into the active layer of the TFC membrane. Different modifications on the membranes are being researched, each modification with its own advantages and disadvantages. In this review, modifications of nanofiltration membranes and their composites, characterization, and performances are discussed.

• Journal of the Korean Society of Radiology
• /
• v.16 no.2
• /
• pp.177-184
• /
• 2022

The purpose of this study is surveyed diagnostic radiography (DR) examination in veterinary hospital (VC) including non-ionization radiation such as ultra-sonography and magnetic resonance imaging. From June 1 to June 20. 2021, we surveyed the VC in 00 metropolitan city by using a structural questionnaire which are location of VC and X-ray unit et al.. Data are expressed as a mean with standard deviation for continuous variable or percent for categorical variable using SPSS ver. 26.0. As the first animal to be visited, dogs were the highest with 61.9%, followed by cats with 12.9%. In 87.1% fo cases, DR units were used, and 4 VCs did not. In 27 VCs using DR units, 48.1% separated examination room and control room, 19.8% examined in animal visited, protective clothing was in all VCs, 55.6% were measured radiation exposure dose, 92.6% was responded a necessary for examination education. From the above results, it will help to revise the guidelines for DR units and examination in korea VCs.

• Journal of Life Science
• /
• v.32 no.12
• /
• pp.997-1004
• /
• 2022

To verify the nutritional superiority and safety of Protaetia brevitarsis larvae fed a food source containing soybean curd cake, the nutrients and harmful substances of larvae reared only with fermented oak sawdust and a food source containing soybean curd cake were comparatively analyzed. The crude protein content was 50.0% in the larvae fed with a food source containing soybean curd cake (SCC), which was 1.1 times higher than that of the larvae fed with fermented oak sawdust (FOS) at 44.7%. Potassium, which showed the highest content among macrominerals, was 2.5 times higher in SCC (3,169.6 mg/100 g) than in FOS (1,245.9 mg/100 g). Among trace minerals, zinc showed 12.6 times higher content than FOS (8.2 mg/100 g) in SCC (103.0 mg/100 g). As a result of the analysis of harmful substances, all heavy metals met the edible insect control standards, and pathogenic microorganisms, such as E. coli and Salmonella spp, were not detected. According to the above study, the larvae of P. brevitarsis fed soybean curd cake contain various nutrients, and safety has also been confirmed, so it is judged to be suitable for use as food.

• Journal of Korea Entertainment Industry Association
• /
• v.13 no.3
• /
• pp.231-248
• /
• 2019

The purpose of this study was to implement a cognitive stimulation activity program and examine its effects elderly people who is capable of daily life and community activities but suffering from per sistent cognitive decline on the elderly's cognitive function, self-efficacy, and depression. The purpose of this study was to help elderly people who is capable of daily life and community activities but suffering from persistent cognitive decline improve their ability to perform and adapt to activity-based tasks incorporating a variety of actions of different subdomains and difficulty levels, ac cording to their characteristics and cognitive levels. The aim of the program created was to systemati cally improve the subdomains of cognitive functions and eventually preventing these conditions develo ping into dementia in those affected. This study also enabled the subjects to improve their self-effica cy through newly gained positive perceptions and attitudes toward their own abilities by successfully expressing their experience or thoughts about circumstantially and relationally meaningful events and memories, and performing activities that promote sensory stimulations. The group activities conducted as part of the study helped the subjects reduce their symptoms of depression not only by expressing their thoughts and emotions, but also by encouraging empathy with, understanding of, and caring for others. Given that this study confirmed the potential of the cognitive stimulation program designed fo r it as a clinical intervention for elderly people with cognitive impairment, it is suggested as a useful preventive program for early stage dementia.

• Research in Community and Public Health Nursing
• /
• v.33 no.1
• /
• pp.13-31
• /
• 2022

Purpose: This study conducted a job analysis of visiting nurses in the process of change. Methods: Participants were the visiting nurses working for the Seoul Metropolitan city. On the basis of the Public Health Intervention Wheel model, two times of the focus group interview (FGI) with seven visiting nurses and one time of the Developing a Curriculum (DACUM) with 34 visiting nurses were performed. A questionnaire survey of 380 visiting nurses was conducted to examine the frequency, importance and difficulty levels of the tasks created by using the FGI and DACUM. Results: Visiting nurses' job was derived as the theme of present versus transitional roles. The present role was categorized as 'providing individual- and group-focused services' and 'conducting organization management', while the transitional role was categorized as 'providing district-focused services' and 'responding to new health issues'. The job generated 13 duties, 28 tasks, and 73task elements. The tasks showed the levels of frequency (3.65 scores), importance (4.27 scores), and difficulty (3.81 scores). All the tasks were determined as important, exceeding the average 4.00 scores. The group- and district-focused services of the tasks were recognized as more difficult but less frequent tasks. Conclusion: The visiting nurses exert both present and transitional roles. The transitional roles identified in the present study should be recognized as an extended role of visiting nurses in accordance with the current changing healthcare needs in South Korea. Finally, the educational curriculum for visiting nurses that reflects the transitional roles from the present study is needed.