• Journal of Biomedical Engineering Research
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• v.42 no.6
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• pp.251-258
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• 2021

Hyaluronic acid (HA) microspheres (MSs) crosslinked with polyethylene glycol diglycidyl ether (PEGDE) are prepared using a simple fluidic device (SFD) to investigate the optimized parameters. A solution mixture of PEGDE in 2-methyl-1-propanol was prepared as a continuous phase in SFD. HA solutions of 1 wt% concentration were introduced into SFD as a discontinuous phase. The HA solution prepared by stirring for more than 48 h exhibited spherical MSs at the needle tip inside the ring cap. As the flow rate of the continuous phase increased from 0.7 to 1.9 mL/min, the diameter of the MS decreased from 173±36 ㎛ to 129±13 ㎛. Although the PEGDE concentration in the range of 0.2 to 1.8 vol% did not affect the diameter of the MS, the microstructure of MS, consisting of inner hollow void and wall, was changed. The inner void and wall size decreased and increased from 79.5 ㎛ to 57.2 ㎛ and from 10.3 ㎛ to 21.4 ㎛, respectively, with increasing PEGDE concentration from 0.2 vol% to 1.8 vol%. FT-IR peaks located around 2867 cm^-1 and 1088 cm^-1 indicated that the HA MS prepared at different PEGDE concentrations were chemically crosslinked. The HA MSs containing different PEGDE concentrations exhibited quantitative cell viability of more than 98%. L-929 cells adhered well to the HA MSs and proliferated continuously with increasing culture time to 48 h regardless of PEGDE concentration, implying that the HA MSs are clinically safe and effective.

• Advances in aircraft and spacecraft science
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• v.4 no.2
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• pp.145-167
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• 2017

The presented paper gives an overview of several projects addressing the experimental characterization and control of the buffet phenomenon on 3D turbulent wings in transonic flow conditions. This aerodynamic instability induces strong wall pressure fluctuations and therefore limits flight domain. Consequently, to enlarge the latter but also to provide more flexibility during the design phase, it is interesting to try to delay the buffet onset. This paper summarizes the main investigations leading to the achievement of open and closed-loop buffet control and its experimental demonstration. Several wind tunnel tests campaigns, performed on a 3D half wing/fuselage body, enabled to characterize the buffet aerodynamic instability and to study the efficiency of innovative fluidic control devices designed and manufactured by ONERA. The analysis of the open-loop databases demonstrated the effects on the usual buffet characteristics, especially on the shock location and the separation areas on the wing suction side. Using these results, a closed-loop control methodology based on a quasi-steady approach was defined and several architectures were tested for various parameters such as the input signal, the objective function, the tuning of the feedback gain. All closed-loop methods were implemented on a dSPACE device able to estimate in real time the fluidic actuators command calculated mainly from the unsteady pressure sensors data. The efficiency of delaying the buffet onset or limiting its effects was demonstrated using the quasi-steady closed-loop approach and tested in both research and industrial wind tunnel environments.

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.245-246
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• 2004

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.453-454
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• 2004

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.244-249
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• 2007

Fluidic conditions for the separation of phases were surveyed in a microfluidic aqueous two-phase extraction system. The infusion ratio between polyethylene glycol (PEG) and dextran solution defines the concentrations of each polymer in micro-channel, which determine the phase-separation. The appropriate ratio between PEG (M.W. 8000, 10%, w/v) and dextran T500 (M.W. 500000, 5%, w/v) in order to perform the separation of phases of both polymers was observed as changing the mixed ratio of both polymers. Based on the fluidic conditions, stable two-phase solutions were obtained within 4% to 8% and 3% to 1% of PEG and dextran, respectively. In addition, the characteristics of the two-phase were discussed. The separation technique studied in the paper can be applied for the implementation of a lab-on-a chip which can detect various biological entities such cells, bacterium, and virus in an integrated manner using built in a biosensor inside the chip.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.11a
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• pp.395-400
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• 1996

Scoping analyses for the Safety Injection System (SIS) configuration for Korean Next Generation Reactor (KNGR) are peformed in this study. The KNGR SIS consists of four mechanically separated hydraulic trains. Each hydraulic train consisting of a High Pressure Safety Injection (HPSI) pump and a Safety Injection Tank (SIT) is connected to the Direct Vessel Injection (DVI) nozzle located above the elevation of cold leg and thus injects water into the upper portion of reactor vessel annulus. Also, the KNGR is going to adopt the advanced design feature of passive fluidic device which will be installed in the discharge line of SIT to allow more effective use of borated water during the transient of large break LOCA. To determine the feasible configuration and capacity of SIT and HPSI pump with the elimination of the Low Pressure Safety Injection (LPSI) pump for KNGR, licensing design basis evaluations are performed for the limiting large break LOCA. The study shows that the DVI injection with the fluidic device SIT enhances the SIS performance by allowing more effective use of borated water for an extended period of time during the large break LOCA.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.3
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• pp.338-345
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• 2000

A model testing has been performed to investigate the flow characteristics of a vortex chamber, which plays a role of a flow switch and passively controls the discharge flow rate. This method of passive flow control is a matter of concern in the design of advanced nuclear reactor systems as an alternative to the active flow control to provide emergency water to the reactor core in case of postulated accidents like LOCA (Loss-Of-Coolant Accident). By changing the inflow direction in the vortex chamber and varying the flow resistance inside the chamber, the vortex chamber can control passively the injection flowrate. Fundamental characteristics such as discharge flow rate and pressure drop of the vortex chamber are measured, and its parametric effects on the performance of the vortex chamber are also systematically investigated.

• Nuclear Engineering and Technology
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• v.39 no.4
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• pp.299-312
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• 2007

The program on thermal-hydraulic evaluation by testing and analysis (THETA) for the development and licensing of the new design features in the APR1400 (Advanced Power Reactor-1400) is briefly introduced with a presentation on the research motivation and typical results of the separate effect tests and analyses of the major design features. The first part deals with multi-dimensional phenomena related to the safety analysis of the APR1400. One research area is related to the multidimensional behavior of the safety injection (SI) water in a reactor pressure vessel downcomer that uses a direct vessel injection type of SI system. The other area is associated with the condensation of steam jets and the resultant thermal mixing in a water pool; these phenomena are relevant to the depressurization of a reactor coolant system (RCS). The second part describes our efforts to develop new components for safety enhancements, such as a fluidic device as a passive SI flow controller and a sparger to depressurize the RCS. This work contributes to an understanding of the new thermal-hydraulic phenomena that are relevant to advanced reactor system designs; it also improves the prediction capabilities of analysis tools for multi-dimensional flow behavior, especially in complicated geometries.

• Design & Manufacturing
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• v.7 no.1
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• pp.55-59
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• 2013

A Light Emitting Diode(LED) is a semiconductor device which converts electricity into light. LEDs are widely used in a field of illumination, LCD(Liquid Crystal Display) backlight, mobile signals because they have several merits, such as low power consumption, long lifetime, high brightness, fast response, environment friendly. In general, LEDs production does die bonding and wire bonding on board, and do silicon and phosphor dispensing to protect LED chip and improve brightness. Then lens molding process is performed using mixed liquid silicon rubber(LSR) by resin and hardener. A mixture of resin and hardener affect the optical characteristics of the LED lens. In this paper, computational design of static mixer was performed for mixing of liquid silicon. To evaluate characteristic of mixing efficiency, finite element model of static mixer was generated, and fluidic analysis was performed according to length of mixing element. Finally, optimal condition of length of mixing element was applied to static mixer from result of fluidic analysis.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.2
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• pp.100-106
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• 2004

Micro-fluidics is one of the major technologies used in developing micro-total analytical systems (${\mu}$-TAS), also known as “lab-on-a-chip”. With this technology, the analytical capabilities of room-size laboratories can be put on one small chip. In this paper, we will briefly introduce materials that can be used in micro-fluidic systems and a few modules (mixer, chamber, and sample prep. modules) for lab-on-a-chip to analyze biological samples. This is because a variety of fields have to be combined with micro-fluidic technologies in order to realize lab-on-a-chip.