• Biomolecules & Therapeutics
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• 제13권2호
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• pp.95-100
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• 2005

This study was performed to investigate the mechanism of cerebral blood flow of adenosine $A_{2B}$ receptor agonist in the rats, and to define whether its mechanism is mediated by nitric oxide (NO) and guanylate cyclase. In pentobarbital-anesthetized, pancuronium-paralyzed and artificially ventilated male Sprague-Dawley rats, all drugs were applied topically to the cerebral cortex. Blood flow from cerebral cortex was measured using laser-doppler flowmetry. Topical application of an adenosine $A_{2B}$ receptor agonist, 5'-N-ethylcar-boxamidoadenosine (NECA; $4{\mu}mol/l$) increased cerebral blood flow. This effect of NECA ($4{\mu}mol/l$) was blocked by pretreatment with NO synthase inhibitor, $N^G$-nitro-L-argine methvlester (L-NAME; $40{\mu}mol/l$) and guanylate cyclase inhibitor, LY-83,583 ($10{\mu}mol/l$). These results suggest that adenosine $A_{2B}$ receptor increases cerebral blood flow. It seems that this action of adenosine $A_{2B}$ receptor is mediated via the NO and the activation of guanylate cyclase in the cerebral cortex of the rats.

• 대한기계학회논문집A
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• 제28권1호
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• pp.63-69
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• 2004

It is of great interest to enhance mixing performance in a microchannel in which the flow is usually characterized as a low Reynolds number (Re) so that good mixing is quite difficult to be achieved in this laminar flow regime. In this regard, we present a new chaotic passive micromixer, named Barrier Embedded Micromixer (BEM), of which the mixing mechanism is based on chaotic flows. In BEM, chaotic flow is induced by periodic perturbation of the velocity field due to periodically inserted barriers along the channel wall while a helical type of flow is obtained by slanted grooves on the bottom surface of the channel in the pressure driven flow. To experimentally compare the mixing performance, a T-microchannel and a microchannel with only slanted grooves were also fabricated. All microchannels were made of PDMS (Polydimethylsiloxane) from SU-8 masters that were fabricated by conventional photolithography. Mixing performance was experimentally characterized with respect to an average mixing intensity by means of color change of phenolphthalein as pH indicator. It was found that mixing efficiency decreases as Re increases for all three micromixers. Experimental results obviously indicate that BEM has better mixing performance than the other two. Chaotic mixing mechanism, suggested in this study, can be easily applied to integrated microfluidic systems , such as Micro-Total-Analysis-System, Lab-on-a-chip and so on.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2006년 제4회 한국유체공학학술대회 논문집
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• pp.191-194
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• 2006

In this paper, we present a detailed mechanism of drag reduction by dimples and roughness on a sphere by measuring the streamwise velocity above the dimpled and roughened surfaces, respectively. Dimples cause local flow separation and trigger the shear layer instability along the separating shear layer, resulting in generation of large turbulence intensity. With this increased turbulence, the flow reattaches to the sphere surface with high momentum near the wall and overcomes strong adverse pressure gradient formed in the rear sphere surface. As a result, dimples delay main separation and reduce drag significantly. The present study suggests that generation of a separation bubble, i.e. a closed-loop streamline consisting of separation and reattachment, on a body surface is an important flow-control strategy for drag reduction on a bluff body such as the sphere and cylinder. In the case of roughened sphere, the boundary layer flow is directly triggered by roughness and changes to a turbulent flow. Due to this change, the drag significantly decreases. As the Reynolds number further increases, transition to turbulence occurs earlier on the sphere surface. Because of faster growth of turbulent boundary layer by roughness, earlier transition thickens the boundary layer, resulting in earlier separation and drag increase with increasing Reynolds number

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.843-846
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• 2004

Cavity tone is generated due to the feedback between flow and acoustic wave. It is recognized that the period is determined by the time required for the flow convection in one direction, the time required for the acoustic propagation in the other direction and the time for phase shift depending on the flows and mode. Most of the phenomena have been investigated by experiments and a simple but fundamental theory. But the cause of the phase shift and the correctness of the theory have not been clearly explained so far. In this paper, the phenomena are calculated numerically to obtain detail information of flow and acoustic wave to explain the mechanism including the phase. High order high resolution scheme of optimized high order compact is used to resolve the small acoustic quantities and large flow quantities at the same time. The data are reduced using cross correlation function in space and time and cross spectral density function which has phase information. Abrupt change in pressure near corner in cavity is observed and is relate to phase variation. The time required for the feedback between the flow and acoustic wave is calculated after the numerical simulation f3r various modes. The periods based on the time calculated using the above method and direct observation from the acoustic waves generated and propagated in the numerical simulation are compared. It is found that no phase shift is required if we examine the time required carefully. Rossiter's formula for the cavity tone used for quick estimation needs to be modified far some modes.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.419-426
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• 2004

A three-dimensional computation was conducted to understand effects of the inlet boundary layer thickness on the loss mechanism in a low-speed axial compressor operating at the design condition(${\phi}=85\%$) and near stall condition(${\phi}=65\%$). At the design condition, the flow phenomena such as the tip leakage flow and hub comer stall are similar independent of the inlet boundary layer thickness. However, when the axial compressor is operating at the near stall condition, the large separation on the suction surface near the casing is induced by the tip leakage flow and the boundary layer on the blade for thin inlet boundary layer but the hub corner stall is enlarged for thick inlet boundary layer. These differences of internal flows induced by change of the boundary layer thickness on the casing and hub enable loss distributions of total pressure to be altered. When the axial compressor has thin inlet boundary layer, the total pressure loss is increased at regions near both casing and tip but decreased in the core flow region. In order to analyze effects of inlet boundary layer thickness on total loss in detail, using Denton's loss models, total loss is scrutinized through three major loss categories in a subsonic axial compressor such as profile loss, tip leakage loss and endwall loss.

• 한국유체기계학회 논문집
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• 제10권5호
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• pp.41-45
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• 2007

The effects of channel area on the performance of regenerative type fuel pump were numerically studied by commercial CFD code (ANSYS CFX-10). To examine the effects of channel area, the shapes of the side channel and blade were simplified. The channel area affected the flow characteristics of the internal recirculation flow between the side channel and the blade groove and also made a difference in the overall performance. These loss mechanism with circulation flow were adopted as a loss coefficient in the performance prediction program. The loss coefficient was newly derived from the results of calculations with different channel area, and compared with the experimental results in the reference paper and used to modify the performance prediction program. The circulation flow characteristics with different channel area, which is related with loss mechanism, were also discussed with the results of 3-dimensional flow calculations.

• 한국기계가공학회지
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• 제21권6호
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• pp.15-21
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• 2022

This study considered the internal flow considering the internal shape of the CNG filling nozzle, which is widely distributed in Korea. The CNG filling nozzle is the last part to pass through in the CNG filling process and has a significant influence on the filling efficiency. The mechanism was identified by disassembling the CNG filling nozzle and performing a flow analysis according to the mechanism. Consequently, the energy loss owing to eddy currents in the flow was determined, and modeling was proposed to reduce the energy loss by simplifying the shape and parts.

• 한국콘텐츠학회논문지
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• 제8권8호
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• pp.57-64
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• 2008

지연시간으로 인한 부정확한 네트워크 상태정보로 발생되는 문제점을 해결하기 위해 단방향 지연시간을 이용하여 정확한 지연정보로 네트워크 상황을 판단하고 TFRC 흐름제어를 기반으로 네트워크 상태변화에 따란 실시간 멀티미디어 데이터의 전송율을 적절하게 조절할 수 있는 흐름제어 기법을 제안한다. 본 논문의 시뮬레이션 결과, 네트워트 상태 정보 측정을 위해 RTT와 $OWD{\times}2$를 비교하여 평균적으로 약 12% 차이를 보였다. RTT를 사용하였을 경우 TFRC가 TCP보다 약 32%정도 더 많은 대역폭을 사용하였으며, OWD를 사용하였을 경우 3%정도의 오차를 보이고 링크의 공정한 대역폭을 사용할 수 있다. 네트워크 상황을 판단하고 TFRC 기반으로 네트워크 상태변화에 따라 TCP와 공정한 대역폭을 사용하면서 실시간 데이터 전송에 맞게 전송율을 적절하게 조절하여 사용자들에게 고품질의 서비스를 제공할 수 있다.

• 한국전산유체공학회지
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• 제10권3호
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• pp.43-47
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• 2005

In this study, the numerical and dynamic simulation on staging problem including forward jet mechanism is conducted. The forward jet plays a vital role in staging, which jets out from aftbody. This staging environment needs full dynamic characteristics study and flow analysis for securing staging safety. Present study performs dynamic simulation of forebody and aftbody with flow analysis using the Chimera grid scheme which is usually used for moving body simulations. As a result, the separation mechanism using forward jet well work in staging for given initial conditions and reverse thrust, chamber pressure variation from experiments. Furthermore, it is found that the technique using forward jets for staging is excellent for securing the separation safety.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2000년도 제20회 KOSCO SYMPOSIUM 논문집
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• pp.35-44
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• 2000

It was numerically studied that NOx emission characteristics of confined $CH_{4}$ jet flames with the variation of the diameter of inner fuel nozzle, the flow rate of $CH_{4}$ and equivalence ratio. Parabolic type equations were adopted in the calculation and GRI-2.1I mechanism was used for the chemical reaction. NOx emission index (EINOx) was introduced to evaluate NOx emission quantitatively in parametrically varied flames and the contribution of Thermal and Prompt NO mechanism was discussed. The results showed that Total EINOx varied sensitively with the variation of the flow rate of$CH_{4}$ but it was not sensitive to the variation of the diameter of inner fuel nozzle. Thermal EINOx showed the similar tendency to total EINOx and Prompt EINOx showed insensitivity to the variation of the diameter of inner fuel nozzle and the flow rate of $CH_{4}$.