• Neonatal Medicine
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• v.18 no.1
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• pp.6-13
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• 2011

All newborn infants with clinically significant bleeding should be evaluated for a hemostatic deficit. Medical history should include the following data: familial bleeding disorders, maternal illness and medication, age of bleeding onset, and prophylactic administration of vitamin K. The first essential step for evaluating bleeding neonates is determining whether the baby is sick or well. The physician should also evaluate the extent of the bleeding, features of bleeding lesions, and other abnormal findings from the physical examination. Skeletal anomalies may provide diagnostic clues. Depending on the clinical features and results of screening tests, other tests including coagulation factors may be useful for determining the diagnosis. All laboratory results must be considered in the context of age-related reference values. The platelet function analyzer provides a promising alternative to bleeding time. Fibrin degradation products and D-dimers are used for screening and specially testing fibrinolytic activity, respectively. The Apt test may help to rule out factors derived from maternal blood. Radiologic imaging studies are important because asymptomatic intracranial hemorrhages are common in neonates.

• Clinical and Experimental Pediatrics
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• v.56 no.11
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• pp.459-464
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• 2013

Improving mental health and reducing the burden of mental illness are complementary strategies which, along with the treatment and rehabilitation of people with mental disorders, significantly improve population health and well-being. A Institute of Medicine report describes a range of interventions for mental disorders that included treatment and maintenance, reserving the term "prevention" for efforts that occur before onset of a diagnosable disorder. Mental health problems affect 10-20% of children and adolescents worldwide. Despite their relevance as a leading cause of health-related disability and their long lasting consequences, the mental health needs of children and adolescents are neglected. Early intervention can help reduce the significant impacts that children and adolescents with serious mental health problems may experience. Screening is the first step in early intervention, recognizing emotional and behavioral problems and providing help at an early stage. It is essential to implement early intervention in a sensitive and ethical manner to avoid any of the negative outcomes.

• 한국전산유체공학회:학술대회논문집
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• 1997.10a
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• pp.120-125
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• 1997

In the present work the influence of various physical parameters on the two-phase flow behavior in a self-heated porous medium has been studied using a numerical model, that is, the effects of heat generation rate, of porosity, of particle size, and of system pressure on the dryout process. To analyze the effect of these parameters, the variation of both liquid volumetric fraction (i.e., liquid saturation) and liquid axial velocity is evaluated at the steady state or at the onset of a first boiled-out region. The analysis of computational results indicate that a qualitative tendency exists between the parameters such as heat generation rate, porosity, effective particle diameter and the temporal development of the liquid volumetric fraction field up to dryout. In addition to these parameters, a variation of fluid properties such as phase density, phase viscosity due to a change of system pressure can be used for gaining insight into the nature of two-phase flow behavior up to dryout.

• Korean Journal of Microbiology
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• v.15 no.2
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• pp.63-76
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• 1977

Irradiation with high doses of gamma rays induced the reduction of mycelial weight and anaylase activity, and increased relative amylase activity in surface cultures. Biphase in growth curves was shown in aeration-agitation cultures but the behavior of the first phase of growth could be eliminated by replacing the amylasehydrolysed starch substrates, so that enzyme production was shortened ca. 40 hours and relative amylase activity was increased about 3 times higher before onset of autolysis. In the effect of gibberellin on amylase production, the positive stimulation was appeared to only surface culturs of the liquid medium and the negative effect to shake-cultures in a mutant. Trials of various continuous culture were resulted not only the approalch to the value of amylase activity in surface cultures of liquid medium, but also higher productivity than in batch cultures. The culture-degeneration was observed in two-stage continuous culture, but did not appear in continuous elevation culture.

• Advances in Traditional Medicine
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• v.10 no.2
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• pp.86-89
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• 2010

Two common Indian spices Carum copticum Karst (ajowan) and Cinnamomum tamala T.Nees. (bay leaves) has been investigated first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extracts further quicken the onset and increased the duration of pentobarbital induced sleeping time.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2003.11a
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• pp.74-77
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• 2003

A new health paradigm may be evolving that would place emphasis on the positive aspects of diet, identifying components that are physiologically active and that contribute to the prevention of disease onset. It has been increasingly difficult to evaluate the impact of new bioactive materials and food products on the well being of society. Thus, testing systems for both health function and toxicity have become very elaborate, complex, and interrelated, making their interpretation difficult and open to controversy. To select the proper starting materials, to screen the appropriate health functionality and to determine the efficacy of product, a reliable, reproducible, sensitive and predictive assay is required. Particularly, in uitro assay is the first stage in preclinical test on physiologically active materials and have many advantages in terms of time, cost and convenience. However, several factors as well as some limitations should be considered in this assay system. This presentation, therefore, will address the use of in uitro assays for evaluating physiological functionality of foods coupled with general consideration.

• International Journal of Automotive Technology
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• v.8 no.1
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• pp.33-38
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• 2007

Since it is difficult to analytically express the Melnikov function when a dynamic system possesses multiple saddle fixed points with homoclinic and/or heteroclinic orbits, this paper investigates a vehicle model with nonlinear suspension spring and hysteretic damping element, which exhibits multiple heteroclinic orbits in the unperturbed system. First, an algorithm for Melnikov integrals is developed based on the Melnikov method. And then the amplitude threshold of road excitation at the onset of chaos is determined. By numerical simulation, the existence of chaos in the present system is verified via time history curves, phase portrait plots and $Poincar{\acute{e}}$ maps. Finally, in order to further identify the chaotic motion of the nonlinear system, the maximal Lyapunov exponent is also adopted. The results indicate that the numerical method of estimating chaotic threshold is an effective one to complicated vehicle systems.

• Proceedings of the KOSOMBE Conference
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• v.1989 no.05
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• pp.13-14
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• 1989

Prolongation in QT corrected interval (QTc), measured in surface ECG, has been shown in the majority af patients to be marker of bad prognosis in postmyocardial infarction patients (PMIP). Hence it would seem logical that dynamic QTc interval measurement can be a very usefull indicator to stratify prognosis in PMIP. We present a new algorithm for QT as well as for QTP (distance value from Q wave onset to T wave peak) intervals measurement in 24 hour ECG Holter tapes. Validation of the algorithm by hand measurement has been done on first beats of 18 Holter tapes, resulting in a magnitude of deviations between 10 and 15 ms. Application on 24 hour Holter ECG signal has also been done.

• Journal of Astronomy and Space Sciences
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• v.17 no.2
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• pp.141-146
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• 2000

Some observational features on the July 5, 1995 substorm event are presented using the data from the Geotail satellite which was located at near-Earth plasma sheet, ${X}_{GSE}$ ∼ $-9.6R_{E}$, and quite close to the onset sector. Near-tail magnetic field reveals the typical dipolarizations starting ar ∼ 11-4 UT until ∼ 1113 UT. During the interval, two dipolarizations occur: First dipolarization is not strong and accompanies only weak(<150km/s) earthward/dawnward plasma flows, and in the second dipolarization that follows shortly, rather large amplitude magnetic fluctuations are seen, but it initiates with no significant earthward flow. The earthward bursty flow with a maximum speed of > 450km/s was observed, but delayed by ∼ 1 min with respect to the second dipolarization initiation. These features are in conflict with the flow-braking scenario for the substorm. Rather they fit better in the near-tail current disruption scenario.

• The Korean Journal of Pain
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• v.8 no.1
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• pp.117-119
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• 1995

Writer's cramp is a gradual onset and the disorder shows itself at first only when the patient is fatigued or stressed, or when a difficulty in controlling the pen leads to inaccurate writing. The prognosis is poor and treatment is often difficult and unsatisfactory. Case 1: A-30-year old male, who had a difficulty in writing with palpitation for 10 years in front of the other men. After 5 times of stellate ganglion block, palpitation during writing did not appear and after 15 times, he could write with a slight spasm of hand muscles. Case 2: A-40-year old male, who had a difficulty in writing in a stressful situation. After 28 times of stellate ganglion block, he could write in normal work except in the strong stressful situation. From our experience, we recommend the stellate ganglion block may be an effective treatment for a writer's cramp.