• 제목/요약/키워드: First line

검색결과 4,582건 처리시간 0.028초

Second-Line Irinotecan after Cisplatin, Fluoropyrimidin and Docetaxel for Chemotherapy of Metastatic Gastric Cancer

  • Kucukzeybek, Yuksel;Dirican, Ahmet;Erten, Cigdem;Somali, Isil;Can, Alper;Demir, Lutfiye;Bayoglu, Ibrahim Vedat;Akyol, Murat;Medeni, Murat;Tarhan, Mustafa Oktay
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제13권6호
    • /
    • pp.2771-2774
    • /
    • 2012
  • Aim: Tumors of upper gastrointestinal tract are among the cancers that have a quite lethal course. Cytotoxic chemotherapy is the most efficient therapeutic modality for metastatic gastric cancer. In patients who do not respond to first-line treatment, the response rate to second-line therapies is generally low and the toxicity rates high. This study concerned the efficacy and the side effect profile of second-line therapy with irinotecan in the patients who were being followed-up with the diagnosis of metastatic gastric cancer in $\dot{I}$zmir, Turkey. Materials and Methods: We retrospectively evaluated the efficacy and toxicity in 31 patients with metastatic gastric adenocarcinoma who presented to the polyclinic of Medical Oncology of Izmir Ataturk Education and Research Hospital between May 2008 and July 2011. All received chemotherapy regimens containing cisplatin, fluoropyrimidine (5-FU) and docetaxel as the first-line therapy for late stage disease. Irinotecan as a single agent was given at a dose of 210 mg/$m^2$ on each 21 days. Irinotecan (180 mg/$m^2$ on day 1), 5-FU (500 mg/$m^2$ on days 1-2) and leucovorin (LV; 60 mg/$m^2$ on days 1-2) as a combined regimen were given over a 14 day period. Results: Median age was 54 (range, 31-70). Irinotecan was given as a combined regimen for median 6 cycles (range, 3-12) and as a single agent for median 3 cycles (range, 1-10). Metastases were detected in one site in six patients (19%), in two different sites in 17 patients (55%) and in three or more sites in eight patients (26%). Four patients (12.9%) showed partial response and six patients (19.3%) showed stable disease. Progression-free survival (PFS) was found to be 3.26 months (95% CI, 2.3-4.2). Median overall survival (OS) was found to be 8.76 months (95% CI, 4.5-12.9). The most commonly seen grade 3/4 side effect was neutropenia but the the therapy was generally well-tolerated. Conclusions: In this study, it was demonstrated that second-line therapy with irinotecan given following the first-line therapy with cisplatin, fluoropyrimidine (5-FU) and docetaxel was efficient and safe. Further studies are needed for confirmation.

장애물 위치 정보를 이용한 모바일 로봇의 2차원 지도 작성에 관한 연구 (Using the obstacle position information of the mobile robot in the two-dimensional cartography Study)

  • 이준호;홍현주;강석주
    • 한국기계가공학회지
    • /
    • 제13권1호
    • /
    • pp.30-38
    • /
    • 2014
  • The purpose of this study is to build and manage environment models with line segments from sonar range data on obstacles in unknown and varied environments. The proposed method therefore employs a two-stage data-transform process in order to extract environmental line segments from range data on obstacles. In the first stage, the occupancy grid extracted from the range data is accumulated to form a two-dimensional local histogram grid. In the second stage, a line histogram extracted from a local histogram grid is based on a Hough transform, and matching serves as a means of comparing each of the segments on a global line segments map against the line segments to detect the degree of similarity in the overlap, orientation, and arrangement. Each of these tests is formulated by comparing one of the parameters in the segment representation. After the tests, new line segments can be found at maximum-density cells in the line histogram, and they are composed onto the global line segment map. The proposed technique is demonstrated in experiments in an indoor environment.

765kV 수직2회선 6도체 현수형 철탑에서 직접활선작업의 안전성 평가분석 (Analysis of Electrical Safety Level Test for Barehand Work at 765kV Vertical Double Circuit Six Bundle Conductors on the Suspension String Tower Type)

  • 김대식;한상옥
    • 전기학회논문지P
    • /
    • 제57권3호
    • /
    • pp.275-278
    • /
    • 2008
  • It has been issued that the necessity of Live line work for 765kV vertical double circuit six bundle conductors transmission line when the characteristics of transmission line, the composition of T/L and near the T/L circumstances etc. Others are considered. The Barehand method of UHV T/L is extremely dangerous work and especially it is directly related with lineman life so it is very dangerous. It should be performed several technology developments for live-line work on the UHV T/L, that should be considered such as the electrical influence on workers near the T/L, development of live-line facilities, guarantee of safety, the technical rules of live-line work, the safe method of live-line work and etc. In order to maintain the 765kV transmission lines safely by barehand work, first of all, we should know the analysis of electrical safety level test in live-line work at 765kV vertical double circuit six bundle conductors on the suspension string tower type.

A-line Skirt의 Marking 효율에 관한 연구 (A Study on the Marking Efficiency of A-line Skirt)

  • 어미경
    • 한국의상디자인학회지
    • /
    • 제8권1호
    • /
    • pp.69-79
    • /
    • 2006
  • The purpose of this study is to find the proper width of fabric which can bring high efficiency on productivity. We focus on the marking method by comparing and analyzing the marking efficiency of A-line skirt. This study employs 4 criteria to mark the A-line skirt, which are cutting method, angle, width, and direction, respectively. There can be 2 different cutting methods(fold pattern and add seam pattern at the front and back center line), and 2 different angles(warp angle and bias angle). Also, width of the fabric can be classified into 2 groups(110cm, 150cm), and marking direction can be grouped into 2(one direction marker and one direction per each size marker). These 4 criteria make 16($2^*2^*2^*2$) cases for this study. Main findings are follows. First, the skirt with folded at the center line had higher efficiency rate than the skirt with add seam at the center line. Second, the skirt with the 150cm width has higher efficiency rate than that of 110cm. Third, fixing the warp angle has higher efficiency rate than that of fixing the bias angle at the front and back center line. Finally, one direction per each size marker has much higher efficiency than the one direction marker.

  • PDF

주성분 분석을 이용한 직선 검출에 대한 분석 (Analysis of Straight Line Detection Using PCA)

  • 오정수
    • 한국정보통신학회논문지
    • /
    • 제19권9호
    • /
    • pp.2161-2166
    • /
    • 2015
  • 본 논문은 주성분 분석을 이용한 직선 검출 알고리즘을 분석하여 새로운 두 기능이 추가된 개선된 알고리즘을 제안한다. 첫 번째 기능은 검출된 직선을 통해 무효 화소를 제거하고 다시 직선을 검출하는 것이고, 두 번째 기능은 겹치지 않는 블록들에서 직선 검출을 통해 후보 직선들 선택하고, 각 후보 직선의 주변 화소들을 이용해 유효 직선을 검출하는 것이다. 제안된 알고리즘은 정제된 직선 영상에서는 기존 알고리즘보다 적은 계산량으로 더 정확한 직선을 검출하고 있다.

장거리 345kV XLPE 케이블 지중송전선로의 준공 (The first installation of long-distance underground transmission line with 345kV XLPE Cable in Korea)

  • 신희덕;박근룡
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
    • /
    • pp.376-378
    • /
    • 2003
  • Since the first underground transmission line of Korea was installed between Danginri and Yongsan substations in 1974, the two types of underground transmission power cables, oil-filled and XLPE, have been applied for underground transmission lines. As the manufacturing technologies of XLPE cable have been improved and the simplicity of installation and maintenance has been focused on, the installations of XLPE cables have been largely increased since the mid 1990's. For the first time, in Korea, the 345kV XLPE cable was installed between Youngseo and Youngdeungpo substations in 2003, June. So, this paper introduces the project profile, the design of cable and its accessory, the cable system design, installation and site test.

  • PDF

345kV XLPE 케이블 선로의 준공 (The first installation of underground transmission line with 345kV XLPE cable in Korea)

  • 신희덕;김화종;김현주;박근룡;송재혁
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2003년도 하계학술대회 논문집 C
    • /
    • pp.1815-1817
    • /
    • 2003
  • Since the first underground transmission line in Korea was installed in 1974, the two types of underground transmission power cables, oil-filled and XLPE, have been applied for underground transmission lines. As the manufacturing technologies of XLPE cable have been improved and the simplicity of installation and maintenance has been focused on, the installations of XLPE cables have been largely increased since the mid 1990's. For the first time, in Korea, the 345kV XLPE cable was installed at Pyungtaek thermal power plant in 2003, February. So, this paper introduces the project profile, the design of cable and its accessory, the cable system design, installation and site test.

  • PDF

Comparison of Efficacy and Toxicity of First Line Chemotherapy with or without Epirubicin for Patients with Advanced Stage Soft Tissue Sarcoma

  • Cao, Jie;Huang, Xin-En;Liu, Jin;Wu, Xue-Yan;Lu, Yan-Yan
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제14권12호
    • /
    • pp.7171-7177
    • /
    • 2013
  • Purpose: To compare the safety and efficacy of first-line chemotherapy regimen with or without doxorubicin in treating patients with advanced soft tissue sarcoma (STS). Patients and Methods: We retrospectively analyzed a cohort of 56 patients histologically confirmed with STS who were treated at Jiangsu Cancer Hospital and Research Institute from July 2011 to June 2012.The basic element of first line chemotherapy contained epirubicin in group B and lacked epirubicin in group A. Response was assessed using RECIST criteria. The Kaplan-Meier method was used to estimate progress free survival (PFS). Results: According to RECIST criteria, patients in group treated by chemotherapy without epirubicin, the objective response (OR) ratio was 6.5 % (CR0%+PR6.5%). Disease control rate (DCR=CR+PR+SD) was 25.8% with a median follow-up of 14.6 months, including 2 patients achieving a partial response (PR 6.5%) and a stable response (SD 19.4%) in 6. In group B with epirubicin based regimens, no patient had complete response, PR (28 %) was observed in 7 and SD (24 %) in 6. DCR was observed in 13 patients (52%). By Fisher's exact test, the DCR difference between the two groups was statistically significant (p=0.046). In group A, median PFS was 3.0 months (95%CI:2.1-3.8), compared with 4.0 months (95% CI:3.03-4.97) in group B (p=0.0397 by log-rank test). Epirubicin based chemotherapy and ECOG performance status 0-1 were identified as favorable factors for progression in our cohort of patients. Differences of nonhematologic and hematologic toxicities were not statistically significant between the two groups, and the addition of epirobicin was not associated with cardiac toxicity (p=0.446). Conclusion: Our study demonstrates that epirubicin-based chemotherapy is effective and well tolerated, and is superior to chemotherapy without epirubicin regarding efficacy. Therefore it is recommended that epirubicin-based chemotherapy should be considered as first line for patients with advanced STS.

수직선 표기법에 대한 분석 연구 (An Analytic Study on the Figure of Number Line)

  • 서보억;신현용;나준영
    • 대한수학교육학회지:수학교육학연구
    • /
    • 제23권2호
    • /
    • pp.135-152
    • /
    • 2013
  • 본 연구의 목적은 중학교 교과서에 나타난 수직선 표기법에 대한 체계적인 분석을 통해 수직선 및 좌표평면 표기의 가장 바람직한 방향을 탐색하는 것이다. 이를 위해 본 연구에서는 첫째, 우리나라 중학교 수학교과서와 외국의 수학교과서에 나타난 수직선 기호 표기에 대해 비교하였다. 둘째, 수직선 표기가 역사적으로 어떻게 변화되었는지 두 가지 관점에서 분석하였다. 하나는 제1차 교육과정부터 2007개정 교육과정까지의 교과서를 분석하였고, 다른 하나는 1637년 Descartes 이래 출판된 문헌에 대한 분석을 실시하였다. 셋째, 수직선 표기의 타당한 방법을 제시하였다. 기호언어학적 측면에서 수직선 기호를 분석한 결과 수직선 표기는 한쪽 화살표만을 사용하는 것이 옳은 표기로 판단된다. 본 연구의 결과로부터 수직선 및 좌표평면의 올바른 사용법에 대한 충분한 논의가 있기를 기대된다.

  • PDF

온라인과 오프라인의 신뢰의 영향변수와 결과변수에 관한 연구 (Antecedents and Consequences of Trusts in On and Off Line in Internet Banking)

  • 김경훈;여일구;김동율
    • 마케팅과학연구
    • /
    • 제13권
    • /
    • pp.159-181
    • /
    • 2004
  • 본 연구의 목적은 인터넷뱅킹과 지점뱅킹을 동시에 사용하고 있는 고객들을 대상으로 하여 그들의 인터넷채널에 대한 충성도를 향상시키는데 있어 중요한 변수인 신뢰와 관계결속과 그것의 영향변수인 공유가치, 커뮤니케이션, 기회주의와의 관계를 온라인과 오프라인 채널을 통하여 동시에 고찰하고, 온라인과 오프라인 채널에 대한 신뢰의 상호작용과 그 역할을 고찰하는 것이다. 변수들간의 인과관계를 검정하기 위하여 LISREL 분석을 실시한 결과 다음과 같은 결론을 얻을 수 있었다. 첫째, 온라인 환경에서는 공유가치, 커뮤니케이션, 기회주의 모두 관계결속에 중요한 영향변수로 나타났다. 둘째, 온라인 채널과 오프라인 채널에 대한 신뢰는 서로 밀접한 관계가 있는 것으로 나타났다. 셋째, 온라인 채널에 대한 고객 충성도에 온라인 채널에 대한 신뢰뿐만 아니라 오프라인 채널에 대한 신뢰도 영향을 미치는 것으로 나타났다.

  • PDF