• 대한전자공학회논문지SP
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• 제38권5호
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• pp.567-575
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• 2001

본 논문에서는 음성신호의 발성길이와 상관없이 일정한 크기의 파라미터를 얻을 수 있는 새로운 방법을 제안하였다. 음성인식기의 성능은 음성신호에서 추출된 파라미터간의 유사도(패턴간의 거리)를 어떻게 비교하는지에 따라 결정된다. 그러나 화자에 따른 음성신호의 변이나 발성속도의 차이는 음성신호에서 일정한 크기의 파라미터 추출을 어렵게 한다. 제안한 방법은 음성신호에서 얻어진 파라미터를 스펙토그램의 형태로 표현한 뒤 2차원 DCT(Discrete Cosine Transform)를 이용해 일정한 크기의 파라미터로 정규화시키는 방법이다. 제안한 방법의 유효성을 입증하기 위해 청각세포를 모델링한 32개의 대역통과 필터로부터 얻어진 음성신호의 파라미터를 2차원 DCT 방법으로 가공한 후, 신경 회로망의 입력으로 사용하였다. 또한 기존 방법과의 인식률 비교를 위해 기존의 정규화된 입력을 구하는 방법 중 하나를 선택하여 비교 실험을 수행하였다. 실험결과 제안한 방법은 기존 방법에 비해 화자종속 및 화자독립 고립단어 인식에서 더 높은 인식률과 빠른 인식속도를 얻을 수 있었다.

• 한국결정성장학회지
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• 제12권2호
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• pp.87-90
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• 2002

$LiCoO_{2}$ powders were synthesized at various temperatures using lithium hydroxide and cobalt hydroxide as precursors prepared by precipitation process and freeze-drying. In this study, the$LiCoO_{2}$ samples were synthesized via a solid state reaction with various LiOH concentration between 10 % and 30 % excess. And $LiCoO_{2}$powders were calcined at 600~$800^{\circ}C$ in a short time. Measurements of XRD and SEM were performed to characterize the properties of the prepared materials. The effect of amount of Li ions on the structural change in powder has been examined using the XRD analysis. For the not added excess of LiOH, CoOOH phase presented in the XRD pattern of $LiCoO_{2}$ due to loss of Li ions during firing. The morphology and particle size of the powders were examined using SEM. The obtained powders are high temperature-$LiCoO_{2}$HT-LiCoO$_{2}$) and homogeneous with the range of grain size in the order of hundreds of nanometers. The effects of variation of LiOH concentration on the structural change in powder were investigated using the Rietveld analysis. As an analysis result, c/a is constant by 4.99 on all occasions. Finally, the structure of HT-$LiCoO_{2}$ was simulated by the commercial software $Creius^{2}$(Molecular Simulations, Inc.) from the results of Rietveld analysis.

• The Korean Journal of Physiology and Pharmacology
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• 제6권3호
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• pp.143-147
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• 2002

Granule cells in dentate gyrus of hippocampus relay information from entorhinal cortex via perforant fiber to pyramidal cells in CA3 region. Their electrical activities are known to be closely associated with seizure activity as well as memory acquisition. Since action potential is a stereotypic phenomena which is based on all-or-none principle of $Na^+$ current, the neuronal firing pattern is mostly dependent on afterpotentials which follows the stereotypic $Na^+$ spike. Granule cells in dentate gyrus show afterdepolarization (ADP), while interneurons in dentate gyrus have afterhyperpolarizaton. In the present study, we investigated the ionic mechanism of afterdepolarization in hippocampal dentate granule cell. Action potential of dentate granule cells showed afterdepolarization, which was characterized by a sharp notch followed by a depolarizing hump starting at about $-49.04{\pm}1.69\;mV\;(n=43,\;mean{\pm}SD)$ and lasting $3{\sim}7$ ms. Increase of extracellular $Ca^{2+}$ from 2 mM to 10 mM significantly enhanced the ADP both in amplitude and in duration. A $K^+$ channel blocker, 4-aminopyridine (4-AP, 2 mM), enhanced the ADP and often induced burst firings. These effects of 10 mM $Ca^{2+}$ and 4-AP were additive. On the contrary, the ADP was significantly suppressed by removal of external $Ca^{2+},$ even in the presence of 4-AP (2 mM). A $Na^+$ channel blocker, TTX (100 nM), did not affect the ADP. From these results, it is concluded that the extracellular $Ca^{2+}$ influx contributes to the generation of ADP in granule cells.

• 대한약리학회지
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• 제19권1호
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• pp.77-84
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• 1983

The behavioral pattern of an animal is influenced by endogenous and endogenous stimuli such as humoral secretion, neurohumoral transmitters, drugs, light and environmental change. It has teen known that adenosine is a normal constituent of brain, and has sedative or hypnotic effects and anticonvulsant effects, inhibiting the spontaneous firing of cells in the brain via membrane adenosine receptors. Recent studies suggest that the excitatory responses to xanthines in the CNS might be related to the competitive antagonism of xanthines to adenosine. This study was undertaken to Investigate the effects of adenosine and the CNS stimulants such as picrotoxin, strychnine and caffeine on the spontaneous activity of mire, and to examine the influence of adenosine on the seizures induced by large doses of CNS stimulants. Subjects were $20{\sim}30\;g$ adult mice, and the spontaneous activity was measured using the Selective Activity Meter after intraperitoneal injection of adenosine (10 mg/kg), caffeine (100 mg/kg), strychnine(0.2 mg/kg) or picrotoxin(0.5 mg/kg) with or without adenosine pretreatment. The seizures were induced with caffeine(200, 250 and 300 mg/kg), strychnine(1.25 and 1.5 mg/kg) or picrotoxin(10 and 15 mg/kg). The results are summarized as follows : 1) The spontaneous activity in mite was significantly inhibited between 10 and 20 minutes after adenosine treatment. 2) Caffeine and picrotoxin increased the motor activity significantly while strychnine had no effect on the activity. 3) The ambulatory activity in the caffeine, strychnine and picrotoxin treated groups was significantly inhibited by adenosine pretreatment. 4) The seizures were observed with caffeine(200, 250 and 300 m9/kg), strychnine(1.25 and 1.5 mg/kg) or picrotoxin(10 and 15 mg/kg). The caffeine induced seizures were inhibited by adenosine pretreatment, but the strychnine or picrotoxin induced seizures were not affected.

• 대한수의학회지
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• 제40권2호
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• pp.275-282
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• 2000

Substantia nigra is known to highly express glibenclamide binding site, a protein associated to ATP-sensitive $K^{+}$ ($K_{ATP}$) channel in the brain. However, the functional expression of $K_{ATP}$ channels in the area is not yet known. In this work, we attempted to estimate the functional expression of $K_{ATP}$ channels in neurons of the substantia nigra pars compacta (SNC) in young rats using slice patch clamp technique. Membrane properties and whole cell currents attributable to $K_{ATP}$ channel were examined by the current and voltage clamp method, respectively. In SNC, two sub-populations of neurons were identified. Type I (rhythmic) neurons had low frequency rebound action potentials ($4.5{\pm}0.25Hz$, n=75) with rhythmic pattern. Type II (phasic) neurons were characterized by faster firing ($22.7{\pm}3.16Hz$, n=12). Both time constants and membrane capacitance in rhythmic neurons ($34.0{\pm}1.27$ ms, $270.0{\pm}11.83$ pF) and phasic neurons ($23.7{\pm}4.16$ ms, $184{\pm}35.2$ pF) were also significantly different. The current density of $K_{ATP}$ channels was $6.1{\pm}1.47$ pA/pF (2.44~15.43 pA/pF, n=8) at rhythmic neurons of young rats. Our data show that in SNC there are two types of neurons with different electrical properties and the density of $K_{ATP}$, channel of rhythmic neuron is about 600 channels per neuron.

• 대한간호학회지
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• 제24권2호
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• pp.313-318
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• 1994

To build a suitable National Health Care System for the coming 21s1 century, Nursing must also be renewed. The future Korea will be united and the majority of its population will raidly consist of the aged. Economically standing on the same level with developed countries the growth of scientific technologies will foster communications, firing astounding changes in the medical field. While the overall life style pattern of Koereans not to mention the structure of diseases undergo change, the possibility that the reckless induction of high-tech health care may only cause medical fees to eascafate. It can전so be expected that the health care system will evolve towards the consumers. Nursing in the 21s1 century will be of two scenarios according to WHO, which presents the role of the nurse. The first scenario is that "a gen-eric health care work force" namely a "care giver" will replace all other health professions. If Nursing does not become the compatent profession fitting to this purpose it will eventually dei out. The second scenario is that nurses who are educated in a well grounded and extensive general background and have command of a specialized area will undertake services varying from health pro-motion to treatment and rehabilitation both direct and indirectly, while supervising other personnel. The nurse here would become the "care giver". To become the necessary health care profession in the 21s1 century, nurses should be provided with more educational opportunities, variating in its con-tents, course, and system, enabling them to grow. Clair Faign points out that the minimal educational entry for the nursing profession is a 4 year undergraduate education in this aspect, now in the time to set the future of Nursing into the course of the first scenario. A new educational system stipulating a baccalaureate nursing degree is in urgent need, and aside from govermental actions nurse themseives should formaily officiallze this process, striving for quality assurance. While considering 6 years nursing education programs, multifarious degree courses for existing 3 years educated nurse should be provided Junior nursing schools must devise measures to grow into baccalaucate institutions, also. Among the existing courses, the Self Study Degree Program should be converted into RN, BSN courese provided by universities, and clinical training for the University on the Air must be supplimented, The possibility of establishing nursing courses into commercial high school programs only jeopardizes the development of the nursing profession.

• 보존과학회지
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• 제6권1호
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• pp.3-14
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• 1997

15세기 말과 16세기 초에 철화분청을 생산했던 곳으로 잘 알려진 공주 학봉리에서 수습된 12 도편의 분청사기를 과학적으로 분석하였다. 태토와 유약의 성분은 각각 X선 형광분석기와 전자현미분석장치로 분석하였고, 미세구조분석은 광학현미경, 편광현미경, 전자현미분석장치, 그리고 X선회절분석기를 이용하였다. 태토와 유약의 성분은 학봉리에서 지리적으로 가까운 곳에 위치한 보령 용수리분청과 비교하여 통계분석을 하였으며, SPSS프로그램을 사용하였다 태토는 보령 송수리 분청에 비해 실리카와 용융제는 높게 나타났으나, 알루미나는 낮은 수치를 보였고, 유약은 실리카, 소다. 철산화물은 높은 반면, 알루미나와 칼슘산화물의 양은 낮게 나타났다. 학봉리 분청 자체도 두 그룹으로 나뉘었다. 유약은 라임계열이었으며, 태토내에는 석영, 둘레가 일부 녹은 큰 장석덩어리, 사장석, 흑운모와 철산화물과 같은 결정들이 많이 남아있음을 관찰할 수 있었다. 이러한 미세구조로 보아 원료의 수비상태가 좋지 않았고, 번조온도도 비교적 낮았음을 예측할 수 있다. 철화안료의 원료는 성분과 X선 회절분석에 의해 Mg/Fe/Al 스피넬로 확인되었다.

• 대한치과보철학회지
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• 제45권2호
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• pp.203-215
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• 2007

Statement of problem: Titanium and its alloy, with their excellent bio-compatibility and above average resistance to corrosion, have been widely used in the field of dentistry. However, the excessive oxidization of titanium which occurs during the process of firing on porcelain makes the bonding of titanium and porcelain more difficult than that of the conventional metal-porcelain bonding. To solve this problem related to titanium-porcelain bonding, several methods which modify the surfaces, coat the surfaces of titanium with various pure metals and ceramics, to enable the porcelain adhesive by limiting the diffusion of oxygen and forming the adhesive oxides surfaces, have been investigated. Purpose: The purpose of this study was to know whether the titanium-porcelain bonding strength could be enhanced by treating the titanium surface with gold and TiN followed by fabrication of clinically applicable porcelain-fused-to-titanium crown Material and method: The porcelain-fused-to-titanium crown was fabricated after sandblasting the surface of the casting titanium coping with $Al_2O_3$ and treating the surface with gold and TiN coating followed by condensation and firing of ultra-low fusing porcelain. To compare with porcelain-fused-to-titanium crowns, porcelain-fused-to-gold crowns were fabricated and used as control groups. The bonding strengths of porcelain-fused-to-gold crowns and porcelain-fused-totitanium crowns were set for comparison when the porcelain was fractured on purpose to get the experimental value of fracture strength. Then, the surface were examined by SEM and each fracturing pattern were compared with each other Result:Those results are as follows. 1. The highest value of fracture strength of porcelain-fused-to-titanium crowns was in the order of group with gold coating, group with TiN coating, group with $Al_2O_3$ sandblasting. No statistically significant difference was found among the three (P>.05). 2. The porcelain-fused-to-gold crowns showed the highest value in bonding strength. The bonding strength of crowns porcelain-fused-to-titanium crowns of rest groups showed bonding strength reaching only 85%-94% of that of PFG, though simple comparision seemed unacceptable due to the difference in materials used. 3. The fracturing patterns between metal and porcelain showed mixed type of failure behavior including cohesive failure and adhesive failure as a similar patterns by examination with the naked eye and SEM. But porcelain-fused-to-gold crowns showed high incidence of adhesive failure and porcelain-fused-to-titanium crowns showed high incidence of cohesive failure. Conclusion: Above results proved that when fabricating porcelain-fused-to-titanium crowns, treating casting titanium surface with gold or TiN was able to enhance the bonding strength between titanium and porcelain. Mean value of masticatory force was found to showed clinically acceptable values in porcelain bonding strength in all three groups. However, more experimental studies and evaluations should be done in order to get better porcelain bonding strength and various surface coating methods that can be applied on titanium surface with ease.

• 헤리티지:역사와 과학
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• 제41권2호
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• pp.61-78
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• 2008

철화(鐵畵) '성(成)' 명청자(銘靑瓷)는 전라남도(全羅南道) 강진군(康津郡) 대구면(大口面) 사당리(沙堂里) 7호 가마터에서만 출토되는 특징적 청자로 붓을 이용하여 굽안바닥 중앙에 명문(銘文)을 쓰고 있다. 명문이 눈에 잘 띄지 않은 곳에 표기되어 있으며, 필체가 다양하여 생산에 여러 사람이 참여하였음을 알 수 있어 제작자보다는 공방(工房)을 표기하였던 것으로 추정된다. 또한 유약(釉藥)과 태토(胎土), 기형(器形), 문양(文樣), 번법(燔法) 등 품격(品格)이 동일(同一)하여 같은 제작기법을 사용하여 같은 시기에 제작되었음을 쉽게 알 수 있다. 기종(器種)은 ${\Box}$과 대${\Box}$(大), ${\Box}$시(匙), 잔(盞), 합(盒), 병(甁) 등 일상(日常) 생활용기(生活容器)가 중심을 이루고 있다. 시문기법(施文技法)은 음각(陰刻)과 상감(象嵌)보다 압출양각(壓出陽刻) 기법을 특히 선호하였으며, 음각보다 상감의 예가 적어 이 시기 상감기법이 보편화되지 않았음을 알 수 있다. 문양은 국화문(菊花文)과 모란문(牡丹文), 앵무문(鸚鵡文), 연판문(蓮瓣文), 연당초문(蓮唐草文) 등으로 권위나 위엄의 의미를 갖는 특별한 문양은 확인되지 않는다. 굽은 합과 접시의 일부를 제외하고 대부분 'U'자형으로 성형하였으며, 번법(燔法)은 내화토(耐火土) 비짐이 일부 있으나 전면(全面) 시유(施釉) 후 굽 안바닥 3~4 곳에 규석(硅石)을 받쳐 굽고 있다. 생산시기(生産時期)는 현재 사당리 7호 가마터 이외의 유적에서는 확인되지 않아 유사한 성격을 갖는 유적 출토품과의 비교를 통해 13세기(世紀) 2/4분기(分期)에 생산되었음을 알 수 있었다. 그리고 고품격의 양질청자에 비해 상대적으로 품질이 떨어지는 일반적인 양질청자가 중심을 이루고 있어 왕실(王室) 등의 최상류층보다 한 단계 낮은 계층에 공급되었던 것으로 추정된다. '성(成)' 명청자(銘靑瓷)는 그동안 전성기(全盛期) 음 양각 기법의 청자를 모두 12세기대로 편년하면서 발생하였던 13세기 전반의 공백을 보완할 수 있는 편년 자료로 그 중요성이 매우 크다고 하겠다.

• The Journal of Advanced Prosthodontics
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• 제1권3호
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• pp.129-135
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• 2009

STATEMENT OF PROBLEM. Zirconia-based restorations have the common technical complication of delamination, or porcelain chipping, from the zirconia core. Thus the shear bond strength between the zirconia core and the veneering porcelain requires investigation in order to facilitate the material's clinical use. PURPOSE. The purpose of this study was to evaluate the bonding strength of the porcelain veneer to the zirconia core and to other various metal alloys (high noble metal alloy and base metal alloy). MATERIAL AND METHODS. 15 rectangular ($4\times4\times9mm$) specimens each of zirconia (Cercon), base metal alloy (Tillite), high noble metal alloy (Degudent H) were fabricated for the shear bond strength test. The veneering porcelain recommended by the manufacturer for each type of material was fired to the core in thickness of 3mm. After firing, the specimens were embedded in the PTFE mold, placed on a mounting jig, and subjected to shear force in a universal testing machine. Load was applied at a crosshead speed of 0.5mm/min until fracture. The average shear strength (MPa) was analyzed with the oneway ANOVA and the Tukey's test ($\alpha$= .05). The fractured specimens were examined using SEM and EDX to determine the failure pattern. RESULTS. The mean shear strength ($\pm\;SD$) in MPa was 25.43 ($\pm\;3.12$) in the zirconia group, 35.87 ($\pm\;4.23$) in the base metal group, 38.00 ($\pm\;5.23$) in the high noble metal group. The ANOVA showed a significant difference among groups, and the Tukey' s test presented a significant difference between the zirconia group and the metal group. Microscopic examination showed that the failure primarily occurred near the interface with the residual veneering porcelain remaining on the core. CONCLUSION. There was a significant difference between the metal ceramic and zirconia ceramic group in shear bond strength. There was no significant difference between the base metal alloy and the high noble metal alloy.