• Journal of Veterinary Science
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• v.21 no.1
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• pp.7.1-7.13
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• 2020

Aging triggers cellular and molecular alterations, including genomic instability and organ dysfunction, which increases the risk of disease in mammals. Recently, due to the markedly growing number of aging dogs in the world, as much as 49% in total number of pet dogs, it is necessary to improve and maintain their quality of life by understanding of the biological effects of aging. Therefore, the aim of this study was to determine specific biomarkers in aging dogs as a means of defining a set of hematological/biochemical biomarkers that influence the aging process. Blood samples were collected from younger (1-3 years) and older (7-10 years) dogs of middle/large size. The hematological/biochemistry analysis was performed to evaluate parameters significantly associated with age. Enzyme-linked immunosorbent assay was used to target growth hormone (GH)/insulin growth factor-1 (IGF-1), one of the main regulators of the aging process. Declining levels of total protein and increased levels of glucose in young dogs was observed regardless of their body size. Notably, a significantly high concentration of GH and IGF-1 in the younger dogs compared to the older dogs was found in middle/large-sized dogs. GH and IGF-1 were also found at significantly high levels in large-sized dogs compared to middle-sized dogs, suggesting a similar trend to that of elderly humans. Consequently, glucose, total protein, GH, and IGF-1 were identified as potential biomarkers for regulating the aging process in large/middle-sized dogs. These findings provide an invaluable insight into the mechanism of aging for the field of aging research.

• Journal of Electrical Engineering and Technology
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• v.9 no.2
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• pp.635-642
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• 2014

The space charge behaviors of oil-paper insulation affect the stability and security of oil-filled converter transformers of traditional and new energies. This paper presents the results of the electrical aging of oil-impregnated paper under AC-DC combined voltages by the pulsed electro-acoustic technique. Data mining and feature extractions were performed on the influence of electrical aging on charge dynamics based on the experiment results in the first stage. Characteristic parameters such as total charge injection and apparent charge mobility were calculated. The influences of electrical aging on the trap energy distribution of an oil-paper insulation system were analyzed and discussed. Longer electrical aging time would increase the depth and energy density of charge trap, which decelerates the apparent charge mobility and increases the probability of hot electron formation. This mechanism would accelerate damage to the cellulose and the formation of discharge channels, enhance the acceleration of the electric field distortion, and shorten insulation lifetime under AC-DC combined voltages.

• Transactions on Electrical and Electronic Materials
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• v.11 no.5
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• pp.216-221
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• 2010

The microstructure, electrical properties, and DC-accelerated aging behavior of the Zn-Pr-Co-Cr-Y-Er (ZPCC-YE) varistors were investigated for different amounts of erbium oxide ($Er_2O_3$). The microstructure consisted of zinc oxide grain and an intergranular layer ($Pr_6O_{11}$, $Y_2O_3$, and $Er_2O_3$-rich phase) as a secondary phase. The increase of $Er_2O_3$ amount decreased the average grain size and increased the sintered density. As the $Er_2O_3$ amount increased, the breakdown field increased from 5094 V/cm to 6966 V/cm and the nonlinear coefficient increased from 27.8 to 45.1. The ZPCC-YE varistors added with 0.5 to 1.0 mol% $Er_2O_3$ are appropriate for high voltage, with high nonlinearity and stability against DC-accelerated aging stress.

• BMB Reports
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• v.50 no.4
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• pp.164-174
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• 2017

Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms. However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.

• Transactions of the Korean Society of Automotive Engineers
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• v.9 no.2
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• pp.202-209
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• 2001

As a part of stringent emission regulations, OBD on a converter is requested by EU and CARB. It demands that MIL is light-on to inform the failure to the driver when the converter is failed in its function. Usually dual oxygen sensor method is used for converter OBD. For this, detail methods, like amplitude ratio, time delay and frequency ratio methods are adapted for vehicle application. Actually, the cars produced later than MY94 for US market are using one of these methods. In this study, OSCs of converters are investigated with an absolute measuring method. The converters are aged with a furnace aging, an engine bench aging and vehicle aging method to represent various aging condition in field applications. An OBD index that is used for TLEVs regulation is also investigated to find a relation between two parameters. The relations of these parameters with THC emission on vehicle are evaluated.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2016.05a
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• pp.170-171
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• 2016

The unity of korean peninsula have traditionally been established as major policy in korea government. Present government also set Trust Process on the Korean Peninsula as national high-level strategies for unity, and construction field related directly to living of north korean as major industry which would be implemented in early stage. Deterioration level of architectural facilities in north korea is known as very high, so a huge budget would be required to improve aging architectural facilities for stability of social and living of north korean. Therefore the purpose of this study deduct financing plan for improving aging architectural facilities in north korea and selection of optimal alternative securing effectiveness. The results of this study could be utilized as preliminary data for establishment of master plan and policy for improving deteriorated facilities in situation of united korean peninsula.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.3 s.52
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• pp.213-218
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• 2005

Recently, with the remarkable increase in elderly persons and improvement of skin care technique, the requirements of customer for anti-aging care have become very important. Also, after cosmeceutical-product law was done in 2001, the major interesting field in cosmetic industry has been focused to developing anti-aging materials having safety and efficacy by basic science. In this review, we ill introduce the trend of anti-aging research and materials to prevent wrinkle or improve elasticity of skin.

• KIEAE Journal
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• v.7 no.1
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• pp.5-13
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• 2007

Since aging has become one of most hot and serious issues in the whole global world, universal design as a strategic concept to enable the elderly age in place has received much attention and its importance is getting recognized. Japan has undergone the Aging phenomenon much earlier than Korea and other countries. During that time, through much trials and errors, it accumulated the wisdoms and techniques to precede aging friendly environment and products. Therefore current Japan house is a comprehensive setting which embraces lots of universal design features that has a valuable implication for Korean development that faces fast aging future. The purpose of this study was to delineate characteristics of universal design features appeared in Japanese Model houses. One site of housing park in the city where various model houses of representative housing construction companies was selected as a cluster area for data collecting. Data were collected mainly through field survey at the housing park of Tokyo during November, 2006, and additional data were collected through website and company information of relevant company. Universal design features were extracted for 17 houses of the housing park and sorted and analyzed according to the analysis frame. The frame were made using 2 major clusters; space area, and 8 universal design principle. Results showed a range of universal design feature and its detail universal design principle satisfied. The 8 principle currently developed became to house realistic practical examples and theory became proved its impractical power. The academic, educational and industrial implication were documented.

• Journal of The Korea Institute of Healthcare Architecture
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• v.20 no.4
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• pp.81-89
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• 2014

Purpose : An aging phenomenon was recognized as only negative aspect, which impediment a development with the decrease of a developing population and increase of social burden. Nevertheless, the problem of aging cannot be treated as a problem of individuals or social burden. Because Every mankind sometime will be the person directly involved the aging. Methods : Korea, predict to reach the aging society with over 20 percent of elderly in the whole population in 2020, should find an active political plan for responding. Because a previous discussion about the aging phenomenon focused on social welfare, the housing plan for the elderly with a consideration of the physical environment for sustaining elderly's life with happiness will be primary task. Results : This research considers housing policy, focusing on the medical service. It is because statistics, which 85 percent of elderly people suffer from chronic diseases because of physical aging signify the importance of medical service to the elderly in every-day-life. Implications : We prescribe the elderly as a population over 65. In this duration, the elderly retirees from the workplace e and spend the majority of time in their home. Thus, for the elderly, the residential space is a field of action and passageway connecting with the surroundings For the solution of physical space preparing the aging phenomenon, the combination of residential and medical function creates a new type of a lifestyle.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.11 no.2
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• pp.82-89
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• 1998

The experimental results using the X -ray technique, the position and structure of mica crystal are not observed the phase change of aging and sound specimen respectively. However, We could observe the intensity difference of crystal element in both atmospheres. The analysis of mica-epoxy materials by optical microscope are shown that the each surface of sound and aging specimens are different in both atmospheres Also, the experimental results have shown that the potassium ions of mica cristal are substituted by hydrogen ions at boundary area of mica-epoxy and/or mica-mica. On components made of mica, a potassium ion of big atomic radius, is replaced by hydrogen ion of small atomic radius. The voids are created by the difference of radius progressed by combined stresses. Through these phenomena, it has been proposed that the conductive layers made of potassium enable the voids to form and the cracks to create by high electric field.