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Heat Acclimatization in Hot Summer for Ten Weeks Suppress the Sensitivity of Sweating in Response to Iontophoretically-administered Acetylcholine

  • Lee, Jeong-Beom
    • The Korean Journal of Physiology and Pharmacology
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    • v.12 no.6
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    • pp.349-355
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    • 2008
  • To determine the peripheral mechanisms involved in thermal sweating during the hot summers in July before acclimatization and after acclimatization in September, we evaluated the sweating response of healthy subjects (n=10) to acetylcholine (ACh), a primary neurotransmitter involved in peripheral sudomotor sensitivity. The quantitative sudomotor axon reflex test (QSART) measures sympathetic C fiber function after iontophoresed ACh evokes a measurable reliable sweat response. The QSART, at 2 mA for 5 min with 10% ACh, was applied to determine the directly activated (DIR) and axon reflex-mediated (AXR) sweating responses during ACh iontophoresis. The AXR sweat onset-time by the axon reflex was $1.50{\pm}0.32$ min and $1.84{\pm}0.46$ min before acclimatization in July and after acclimatization in September, respectively (p<0.01). The sweat volume of the AXR(l) [during 5 min 10% iontophoresis] by the axon reflex was $1.45{\pm}0.53\;mg/cm^2$ and $0.98{\pm}0.24\;mg/cm^2$ before acclimatization in July and after acclimatization in September, respectively (p<0.001). The sweat volume of the AXR(2) [during 5 min post-iontophoresis] by the axon reflex was $2.06{\pm}0.24\;mg/cm^2$ and $1.39{\pm}0.32\;mg/cm^2$ before and after acclimatization in July and September, respectively (p<0.001). The sweat volume of the DIR was $5.88{\pm}1.33\;mg/cm^2$ and $4.98{\pm}0.94\;mg/cm^2$ before and after acclimatization in July and September, respectively (p<0.01). These findings suggest that lower peripheral sudomotor responses of the ACh receptors are indicative of a blunted sympathetic nerve response to ACh during exposure to hot summer weather conditions.

Lambs Infected with UV-Attenuated Sporocysts of Sarcocystis ovicanis Produced Abnormal Sarcocysts and Induced Protective Immunity against a Challenge Infection

  • Abdel-Baki, Abdel-Azeem;Allam, Gamal;Sakran, Thabet;El-Malah, El-Mahy
    • Parasites, Hosts and Diseases
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    • v.47 no.2
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    • pp.131-138
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    • 2009
  • The present study surveyed the prevalence of natural infection of the sheep esphagus muscle with sarcocysts of Sarcocystis ovicanis and examined induction of protective immunity using UV-attenuated sporocysts. The overall prevalence of natural infection of the sheep was 95%. Infectivity of the collected sarcocysts was confirmed by shedding of sporulated oocysts after feeding infected esophageal tissues to dogs. To induce protective immunity, lambs were immunized 3 times (once a week) with $1.5{\times}10^4$ sporocysts exposed to UV-light for 30min (UV-30 group) or 60 (UV-60 group) min and then challenged with $1.5{\times}10^4$ normal sporocysts at the 3rd week post the 1st vaccination. These lambs showed high survival and less clinical signs of sarcocystosis than normal infected lambs. The attenuated sporocysts produced abnormal cysts; small in size and detached from the muscle fiber. These abnormalities were more obvious in UV-60 group than UV-30 group. Also, the $IFN-{\gamma}$ level and lymphocyte percentage were increased while the total leukocyte count was decreased in the UV-60 group compared with other groups. The high level of $IFN-{\gamma}$ may be an evidence for the induction of Th1 responses which may have protective effect against a challenge infection.

Genetic Analysis and Characterization of a Bacteriophage ØCJ19 Active against Enterotoxigenic Escherichia coli

  • Kim, Gyeong-Hwuii;Kim, Jae-Won;Kim, Jaegon;Chae, Jong Pyo;Lee, Jin-Sun;Yoon, Sung-Sik
    • Food Science of Animal Resources
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    • v.40 no.5
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    • pp.746-757
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    • 2020
  • Enterotoxigenic Escherichia coli (ETEC) is the major pathogenic E. coli that causes diarrhea and edema in post-weaning piglets. In this study, we describe the morphology and characteristics of ØCJ19, a bacteriophage that infects ETEC, and performed genetic analysis. Phage ØCJ19 belongs to the family Myoviridae. One-step growth curve showed a latent phase of 5 min and burst size of approximately 20 phage particles/infected cell. Phage infectivity was stable for 2 h between 4℃ and 55℃, and the phage was stable between pH 3 and 11. Genetic analysis revealed that phage ØCJ19 has a total of 49,567 bases and 79 open reading frames (ORFs). The full genomic sequence of phage ØCJ19 showed the most similarity to an Escherichia phage, vB_EcoS_ESCO41. There were no genes encoding lysogeny, toxins, virulence factors, or antibiotic resistance in this phage, suggesting that this phage can be used safely as a biological agent to control ETEC. Comparative genomic analysis in terms of the tail fiber proteins could provide genetic insight into host recognition and the relationship with other coliphages. These results showed the possibility to improve food safety by applying phage ØCJ19 to foods of animal origin contaminated with ETEC and suggests that it could be the basis for establishing a safety management system in the animal husbandry.

A Study on the Dyeing of Silk Fabrics Treated with Aplysia kurodai Extract (군소 추출색소를 이용한 견직물의 염색성에 관한 연구)

  • Kim, Hyun-Mi;Kim, Sang-Bum;Jang, Ae-Ran
    • Korean Journal of Human Ecology
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    • v.21 no.4
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    • pp.791-803
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    • 2012
  • This study intends to identify applicability of natural dye extracted from Aplysia kurodai, aiming to standardization of Aplysia kurodai natural dyeing through scientific validation by analyzing characteristics of pigment elements to review dyeability, colorfastness and antibacterial activity. Such material as silk fabrics that is animal fiber were used for this purpose, and derived following summarized results. UV/VIS spectrum analysis on the pigment of Aplysia kurodai that was extracted from purple gland showed that maximum absorbtion was near 540 nm. The silk fabric optimal dyeing can be achieved at a temperature of $55^{\circ}C$ with a colorant concentration of 5%. Dyed at $55^{\circ}C$ with interval of 10~90 minutes for identifying dye uptake over time to observed slow increase of dye uptake over time, and equilibrium occurred at 50 minutes. For dye uptake according to pH, while dye uptake was superior in acidity, it decreased rapidly in a base after pH 7. For color changes according to pH variation, it was reddish purple in acidity and was purplish red in a base. For color changes according to mordanting method, more clear color change had been obtained when process with aluminium pre-mordanting than non-mordanting and post-mordanting. The colorfastness to light, perspiration and washing was 1, 4~5, and 3~4 ratings respectively. The silk fabric dyed with Aplysia kurodai demonstrated excellent antimicrobial activity to Staphylococcus aureus and Klebsiella pneumoniae. The Aplysia kurodai can be used as a new colorant for the natural dyeing of silk.

CLINICAL EFFORTS FOR TECHNICAL IMPROVEMENT IN TOOTH FRAGMENTATION (초기 영구 전치 파절시의 치아 재부착술의 임상 증례)

  • Choi, Sung-Chul;Lee, Keung-Ho;Choi, Yeong-Chul
    • Journal of the korean academy of Pediatric Dentistry
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    • v.29 no.1
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    • pp.125-131
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    • 2002
  • When a tooth is fracture with the pulp exposure, and if a fragment is large enough to save, reattachment of the fragment would be a choice of treatment and reattachment of the fragment provides several advantages over other forms of dental restoration following crown fracture. For the purpose of tooth reattachment, it is important to preserve the sound enamel around fracture area. For young patients, tooth reattachment has more advantages in the sense that they recover faster and that it enables other treatments at the same time. Through the continuous advancement in adhesion technology and the effort for aestheticism, various reattachment methods have been practiced and more efforts are considered necessary. The presented cases are that we had practiced in our department in Kyung Hee Medical center, I may address that fragmentation has been successfully done with aesthetically fine results, and no pathologic changes were found in short term follow-ups.

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Experimental Study of Thermal Conductivity for Glass Wool by Inserted Dissimilar Materials based on Structural Composites (구조 복합재료 기반 이종재료 첨가시의 유리섬유의 열적 성능 평가에 대한 실험적 연구)

  • Bae, Jin-Ho;Oh, Jong-Ho;Byun, Jun-Seok;Lee, Jae-Myung
    • Journal of the Society of Naval Architects of Korea
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    • v.55 no.5
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    • pp.448-455
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    • 2018
  • Glass wool is an eco-friendly materials that is manufactured through a continuous process by processing waste glass. This materials is low cost compared with another materials and has excellent thermal conductivity. For this reason, glass wool is installed as insulation system for LNG carriers and as insulation of building wall as well as various industries. The mechanism of insulation of glass wool is the conduction of the wool itself and convection by space between fibers. Therefore, in order to develop the enhanced thermal conductivity of glass wool is necessary to reduce its own conduction or to insert additional material after manufacturing as well as prevent convection. In this respect, many researchers have been actively studying to decrease thermal conductivity of polyurethane foam using by inserted glass wool or change the chemical component of glass wool. However, many research are aiming reduction of glass wool itself. This study focus on post-processing and inserted different materials; silica-aerogel, kevlar fiber 1mm, 6mm and glass bubble. Experimental results show that the thermal conductivity almost decreases with the addiction of glass bubble and silica aerogel.

Nonlinear Biaxial Shear Model for Fiber-Reinforced Cementitious Composite Panels (섬유보강 고인성 시멘트 복합체 패널의 2축 전단 비선형 모델)

  • Cho, Chang-Geun;Kim, Yun-Yong
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.22 no.6
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    • pp.597-605
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    • 2009
  • The present study has been proposed a model for the in-plane shear behavior of reinforced(Engineered Cementitious Composite(ECC) panels under biaxial stress states. The model newly considers the high-ductile tensile characteristic of cracked ECC by its multiple micro-cracking mechanism, the compressive strain-softening characteristic of cracked ECC, and the shear transfer mechanism in the cracked interface of ECC element. A series of numerical analyses were performed, and the predicted curves were compared with experimental results. The proposed in-plane shear model, R-ECC-MCFT, was found to be well matched with the experimental results, and it was also demonstrated that reinforced ECC panel showed more improved in-plane shear strength and post peak behavior, in comparing with the conventional reinforced concrete panel.

Growth and gut performance of young pigs in response to different dietary cellulose concentration and rearing condition

  • Cho, Hyun Min;Kim, Eunjoo;Wickramasuriya, Samiru Sudharaka;Shin, Taeg Kyun;Heo, Jung Min
    • Animal Bioscience
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    • v.34 no.10
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    • pp.1653-1662
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    • 2021
  • Objective: This experiment was conducted to investigate the effect of insoluble cellulose supplementation to diets on the growth performance, intestinal morphology, the incidence of diarrhea, nutrients digestibility, and inflammatory responses in altering environmental conditions of animals housing. Methods: A total of 108 male pigs (Duroc×[Yorkshire×Landrace]) were randomly allocated to one of three dietary treatments (cellulose 0%, 1%, 2%) and two environmental conditions (good sanitary condition vs. poor sanitary condition) to give 6 replicate pens per treatment with three pigs per each pen at 14 days post-weaning. Results: Pigs were in good sanitary condition had higher average daily gain (p<0.01) and improved feed efficiency (p<0.05) from day 1 to 14 after weaning compared to their counterparts. The interactions were found between environmental conditions and dietary treatments (day 7: crypt depth [p<0.01], villous height to crypt depth [p<0.001]; day 14: crypt depth [p<0.001], villous to crypt ratio [p<0.01]) in ileum morphology. Crypt depth was decreased (p<0.05), and villous to crypt ratio was increased (p<0.05) only in poor sanitary conditions. Pigs exposed to the good sanitary condition had higher (p<0.05) apparent ileal digestibility (day 7, gross energy; day 14, dry matter), apparent total tract digestibility (day 14, dry matter and crude protein) compared to pigs housed in the poor sanitary condition. Meanwhile, pigs fed a diet supplemented with 2% cellulose had decreased (p<0.05) apparent ileal digestibility (day 7, dry matter; day 14, crude protein), apparent total tract digestibility (day 7, dry matter; day 14, crude protein, gross energy) compared to pigs fed a diet supplemented with 0% or 1% cellulose. Conclusion: Our results indicated that a diet supplemented with 1% cellulose increased villous to crypt ratio, however feeding a diet containing cellulose (1% or 2%) impaired nutrient digestibility for 14 day after weaning in both good sanitary and poor sanitary conditions.

Improvement of Strain Detection Accuracy of Aircraft FBG Sensors Using Stationary Wavelet Transform (정상 웨이블릿 변환을 이용한 항공기 FBG 센서의 변형률 탐지 정확도 향상)

  • Son, Yeong-Jun;Shin, Hyun-Sung;Hong, Gyo-Young
    • Journal of Advanced Navigation Technology
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    • v.23 no.4
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    • pp.273-280
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    • 2019
  • There are many studies that use structure health monitoring to reduce maintenance costs for aircraft and to increase aircraft utilization. Many studies on FBG sensors are also being conducted. However, if the FBG sensor is installed inside the composite, voids will occur between the layers of the composite, resulting in signal split problem. In addition, the FBG sensor is not affected by electromagnetic waves, but will produce electromagnetic noise caused by electronic equipment during post-processing. In this paper, to reduce the error caused by these noises, the stationary wavelet transform, which has the characteristics of movement immutability and is efficient in nonlinear signal analysis, is presented. And in the above situation, we found that noise rejection performance of stationary wavelet transform was better compared with the wavelet packet transform.

Experimental behavior of VHSC encased composite stub column under compression and end moment

  • Huang, Zhenyu;Huang, Xinxiong;Li, Weiwen;Mei, Liu;Liew, J.Y. Richard
    • Steel and Composite Structures
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    • v.31 no.1
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    • pp.69-83
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    • 2019
  • This paper investigates the structural behavior of very high strength concrete encased steel composite columns via combined experimental and analytical study. The experimental programme examines stub composite columns under pure compression and eccentric compression. The experimental results show that the high strength encased concrete composite column exhibits brittle post peak behavior and low ductility but has acceptable compressive resistance. The high strength concrete encased composite column subjected to early spalling and initial flexural cracking due to its brittle nature that may degrade the stiffness and ultimate resistance. The analytical study compares the current code methods (ACI 318, Eurocode 4, AISC 360 and Chinese JGJ 138) in predicting the compressive resistance of the high strength concrete encased composite columns to verify the accuracy. The plastic design resistance may not be fully achieved. A database including the concrete encased composite column under concentered and eccentric compression is established to verify the predictions using the proposed elastic, elastoplastic and plastic methods. Image-oriented intelligent recognition tool-based fiber element method is programmed to predict the load resistances. It is found that the plastic method can give an accurate prediction of the load resistance for the encased composite column using normal strength concrete (20-60 MPa) while the elastoplastic method provides reasonably conservative predictions for the encased composite column using high strength concrete (60-120 MPa).