• 대한한방성인병학회지
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• 제10권1호
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• pp.32-38
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• 2005

Scrub typhus is a acute febrile illness by Orientia tsutsugamushi that is endemic in Asian-Pacific areas. It is characterized by fever, rash, eschar, lymphadenopathy. Therapy with Tetracycline, Doxycycline, Chloramphenicol is currently recommended. Here we report a case of tsutsugamushi disease in a 66 year old man had fever, nausea, vommitting, dyspnea, who was successfully treated with East-West intergrative medicine therapy - Antibiotics therapy and Korean traditional medicine(Sasang medicine and acupuncture treatment) - and symptoms improved.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.18-26
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• 2010

The clinical picture in severe cases of pandemic (H1N1) 2009 influenza is markedly different from the disease pattern seen during the epidemics of seasonal influenza as many of those affected were previously healthy young people. Current predictions estimate that during a pandemic wave, 12~30% of the population will develop clinical influenza (compared with 5~15% for seasonal influenza) with 4% of those patients requiring hospital admissions and one in five requiring critical care. Until July 6, 94,512 people have been infected in 122 countries, of whom 429 have died with an overall case-fatality rate of <0.5%. Most of the confirmed cases of S-OIV (Swine-Origin Influenza A Virus) infection have been characterized by a self-limited, uncomplicated febrile respiratory illness and 38% of the cases have also included vomiting or diarrhea. Efforts to control these outbreaks are based on our understanding of novel S-OIV (Swine-Origin Influenza A Virus) and the previous influenza pandemics. So, this review covers the experience with S-OIV (Swine-Origin Influenza A Virus) for the admission and background data and the clinical presentation, diagnosis and treatment of H1N1 in pediatric patient with S-OIV (Swine-Origin Influenza A Virus) at YUMC, 2009.

• 대한수의학회지
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• 제57권1호
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• pp.37-42
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• 2017

Getah virus (GETV) infection causes sporadic outbreaks of mild febrile illness in horses and reproductive failure in pigs. In this study, we established a reverse transcription polymerase chain reaction (RT-PCR) method to detect GETV from suspected virus-infected samples. The reaction conditions were optimized and validated by using RNA extracted from GETV propagated in cell culture. A GETV-specific GED4 primer set was designed and used to amplify a 177 bp DNA fragment from a highly conserved region of the E1 glycoprotein gene in the GETV genome. RT-PCR performed with this primer set revealed high sensitivity and specificity. In the sensitivity test, the GED4 primer set detected GETV RNA at the level of $10^{2.0}\;TCID_{50}/mL$. In the specificity test, the GED4 primer set amplified only a single band of PCR product on the GETV RNA template, without non-specific amplification, and exhibited no cross-reactivity with other viral RNAs. These results suggest that this newly established RT-PCR method is useful for accurate identification of GETV infection in animals.

• Childhood Kidney Diseases
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• 제10권1호
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• pp.72-76
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• 2006

신 주위 농양은 증상이 비특이적이고 다양하여 임상적으로 진단이 어렵고 치료가 늦어지기 쉬워 합병증과 사망률이 높은 질환이므로, 발열이 지속되는 경우에 감별 진단해야 하는 질환이다. 초음파 촬영술, 전산화 단층 촬영술 등은 신 주위 농양을 조기에 진단하고 적절한 치료 방향을 정하는데 유용하며, 치료 방법으로 항생제 외에 경피적 농흡인, 배농 및 수술 등의 처치가 필요하다. 저자들은 발열이 9일 동안 지속된 환아에서 경피적 배농술로 치료한 신 주위 농양 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Child Health Nursing Research
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• 제20권2호
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• pp.113-122
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• 2014

목적 일 지역 소아청소년과 외래를 방문한 부모들의 자녀의 발열에 대한 발열공포의 수준 및 부모의 발열염려 정도와 대상자의 특성 간의 관련성을 파악하고자 함이다. 방법 소아청소년과 외래를 방문한 부모 151명을 대상으로 구조화된 자기기입식 설문지를 이용하여 자료를 수집하였다. 수집된 자료는 기술통계 및 카이제곱 검정을 통해 분석하였다. 결과 약 50%의 대상자들이 $37.8^{\circ}C$를 발열의 최저기준 체온으로 그리고 $38.9^{\circ}C$를 고열의 최저기준 체온으로 정의했다. 약 3/4의 대상자들이 발열의 해로운 효과로 경련과 뇌손상을 언급했으며, 발열에 대해 '매우 염려'를 하였고, 자녀의 발열 시 1시간 이내에 체온을 다시 측정하였고, 미온수 목욕을 제공했으며, 열성질환이 있는 경우 잠자는 아동을 해열제를 주기 위해 깨웠다. 부모의 자녀 발열에 대한 염려는 이전 열성 경련 경험 여부와 한 자녀 가정의 부모와 통계적으로 유의한 관련성이 있었다. 결론 소아청소년과 외래를 방문한 부모들에게도 발열공포가 광범위하게 존재하고 있었다. 부모들을 위한 발열 및 발열 관리 교육 프로그램의 개발과 평가가 요구된다. 의사와 간호사가 부모들의 발열관련 정보의 1차적 근원임을 고려할 때 건강관리제공자들은 부모들의 발열에 대한 비현실적인 공포를 경감시키는 데 중요한 역할을 하여야 할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.556-559
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• 2009

Acute eosinophilic pneumonia (AEP) is characterized by idiopathic acute febrile illness, diffuse pulmonary infiltration, severe hypoxemia, and pulmonary eosinophilia. We report a case of AEP associated with intramuscular administration of progesterone as luteal phase support after in vitro fertilization. A 33-year-old woman presented to our emergency room with tachypnea and hypoxemia, complaining of fever and cough for 4 days, and dyspnea for 2 days. The symptoms began 9 days after the first injection of progesterone. Chest radiograph showed bilateral infiltrates, located predominantly in the periphery of the lungs, with blunting of the costophrenic angle. Symptoms and chest radiograph dramatically improved after corticosteroid therapy and shifting the progesterone from an intramuscular form of administration to a vaginal form of administration.

• Parasites, Hosts and Diseases
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• 제56권5호
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• pp.521-525
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• 2018

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Following euthanasia, liver and kidney tissues were removed and tested using PCR for Orientia tsutsugamushi and other bacterial and rickettsial pathogens causing bartonellosis, borreliosis, human monocytic ehrlichiosis, human granulocytic anaplasmosis, leptospirosis, and rickettsiosis. A phylogenetic analysis was performed on all rodent species captured and pathogens detected. Four out of the 12 rodents (33.3%) tested positive by PCR for zoonotic pathogens. Anaplasma phagocytophilum, Bartonella grahamii, and B. queenslandensis were identified for the first time in Bhutan. Leptospira interrogans was also detected for the first time from rodents in Bhutan. The findings demonstrate the presence of these zoonotic pathogens in rodents in Bhutan, which may pose a risk of disease transmission to humans.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권4호
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• pp.223-231
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• 2014

Purpose: With previous methods based on only age and location, there are many difficulties in identifying the etiology of acute abdominal pain in children. We sought to develop a new systematic classification of acute abdominal pain and to give some helps to physicians encountering difficulties in diagnoses. Methods: From March 2005 to May 2010, clinical data were collected retrospectively from 442 children hospitalized due to acute abdominal pain with no apparent underlying disease. According to the final diagnoses, diseases that caused acute abdominal pain were classified into nine groups. Results: The nine groups were group I "catastrophic surgical abdomen" (7 patients, 1.6%), group II "acute appendicitis and mesenteric lymphadenitis" (56 patients, 12.7%), group III "intestinal obstruction" (57 patients, 12.9%), group IV "viral and bacterial acute gastroenteritis" (90 patients, 20.4%), group V "peptic ulcer and gastroduodenitis" (66 patients, 14.9%), group VI "hepatobiliary and pancreatic disease" (14 patients, 3.2%), group VII "febrile viral illness and extraintestinal infection" (69 patients, 15.6%), group VIII "functional gastrointestinal disorder (acute manifestation)" (20 patients, 4.5%), and group IX "unclassified acute abdominal pain" (63 patients, 14.3%). Four patients were enrolled in two disease groups each. Conclusion: Patients were distributed unevenly across the nine groups of acute abdominal pain. In particular, the "unclassified abdominal pain" only group was not uncommon. Considering a systemic classification for acute abdominal pain may be helpful in the diagnostic approach in children.

• Clinical and Experimental Pediatrics
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• 제58권10호
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• pp.398-401
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• 2015

Tularemia is a potentially severe zoonotic disease caused by Francisella tularensis. A lack of awareness about tularemia can be embarrassing and could result in delayed treatment because of improper diagnosis. The diagnosis of tularemia is difficult, because the infections are rare and the clinical spectrum is broad. As only 1 adult case has been reported in Korea thus far, pediatricians in Korea may be unfamiliar with tularemia. We report our experience with a 14-year-old male adolescent with tularemia who presented with atypical pneumonia and possible infective endocarditis. Although the infectivity and mortality rates for tularemia are very high if left untreated, we did not suspect tularemia in this case until the incidental isolation of F. tularensis. The present case suggests that clinicians in Korea should be more aware of tularemia. This case also suggests that tularemia should be considered in undetermined cases of atypical pneumonia or acute febrile illness without local signs.

• IMMUNE NETWORK
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• 제2권4호
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• pp.202-207
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• 2002

Background: Kawasaki disease is an acute febrile illness with systemic vasculitis which primarily affects children, We examined the production of leptin in plasma and gene expressions of CXC chemokines in peripheral blood mononuclear cells from patients with Kawasaki disease. Methods: Consecutive 39 samples from 13 patients according to the different clinical stages (acute, subacute, convalescent) of Kawasaki disease were collected. The plasma leptin levels according to clinical stages of Kawasaki disease were examined by ELISA and the expression of IP-10, Mig and IL-8 mRNAs in 39 samples (13 samples of each stage) from 13 cases were examined by RT-PCR. Results: There were not significant changes of plasma leptin levels according to the clinical stages of Kawasaki disease. The mean values of plasma leptin concentrations during each of the stages (n=13, p>0.05, pg/ml) were $335.8{\pm}549.0$ in acute, $358{\pm}347.6$ in subacute, and $443.6{\pm}645.9$ in convalescent stage. The mRNAs of IP-10, Mig, and IL-8 were expressed in 13/13 (100%), 2/13 (15%), 9/13 (69%) during acute stage, 13/13 (100%), 6/13 (46%), 13/13 (100%) during subacute stage, and 13/13 (100%), 4/13 (31%), 10/13 (77%) during the convalescent stage, respectively. In three patients, the production of leptin and expression of IP-10 mRNA were dramatically decreased according to the process of the clinical stages. In five patients with prominent cervical lymphadenopathy, the expression of IL-8 mRNA during the subacute stage was more elevated than the acute and convalescent stages. Conclusion: This data suggests that the production of leptin and the gene expressions of IP-10, Mig and IL-8 seem to have no significant correlation to the clinical stages of Kawasaki disease. However, expression patterns of IP-10, Mig and IL-8 mRNA may be related to the specific clinical manifestations, and the expression of IP-10 may also be correlated to leptin levels with pericardial involvement.