• Korean Chemical Engineering Research
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• v.61 no.4
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.

• Analytical Science and Technology
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• v.23 no.2
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• pp.216-223
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• 2010

In previous research, results on efficiency versus size and type of Ag particles showed similarity of detection efficiency comparing the particles of flake and spherical type with the gray particle on the market and in the case of nAg (rod, $0.9\;{\mu}m$) particle, relatively good results was given in the various evaluation methods for detection efficiency of latent fingerprint. However, oxidation was occurred when nAg particles laying on nature condition for a month and due to water absorption, detection efficiency was decreased. Therefore, with need to prevent oxidation and water absorption, more research is necessary. In this research, surface modification on nAg particles using silicon oil was conducted in various methods for complementing weakness of oxidation and water absorption. Then detection efficiency of nAg particles and surface modified nAg particles was evaluated by the number of feature points on the surface of non-porous materials (glass, plastic etc.) and degree of particle adhesion with ridges and contrast of detected fingerprint. Improvement of preventing oxidation and water absorbtion was given by surface modification using silicon oil (DC200, 0.5%) on the surface of non-porous materials.

• Journal of Oral Medicine and Pain
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• v.24 no.4
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• pp.397-410
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• 1999

In order to obtain the basic data concerning the optimal parameters in using Nd:YAG laser as a therapeutic modality to dentinal hypersensitivity, the author prepared 3 sections of sound dentin and 10 sections of sclerotic dentin with thickness of $0.5mm{\pm}0.1mm$ from human extracted teeth of anteriors and premolars, and applied the laser energy from a fiberoptic delivered, free running, pulsed Nd:YAG laser (wavelength 1064nm, pulse duration $120{\mu}sec$, fiber diameter $320{\mu}m$) to surfaces of sound and sclerotic dentin sections for 1 second with contact/unidirectional moving mode of the fiber under speed of 3mm~4mm/sec and parameters of 0.5W/10Hz, 1.0W/10Hz, 1.5W/10Hz, 2.0W/10Hz: $62J/cm^2$, $124J/cm^2$, $187J/cm^2$, $249J/cm^2$. The author comparatively evaluated the characteristics of ultrastructural changes on surfaces of sound and sclerotic dentin sections irradiated by the pulsed Nd:YAG laser using the scanning electron microscopy. A fairly ill-defined bordered surface of partially closed and melted dentinal tubules can be seen on the scanning electron microscopic feature of the sound dentin surface irradiated by the pulsed Nd:YAG laser with energy density of $62J/cm^2$. The physical modification of sound dentin surface extensively occurred depended on the increase of energy density from $62J/cm^2$ to $124J/cm^2$, $187J/cm^2$, $249J/cm^2$. While, a fairly well-defined bordered surface of partially closed and melted dentinal tubules with thickened peritubular dentin can be seen on the scanning electron microscopic feature of the sclerotic dentin surface irradiated by the pulsed Nd:YAG laser with energy density of $62J/cm^2$. The physical modification of sclerotic dentin surface of a fairly rough, shallow depression with many cracks, thickened peritubular dentin and structureless dentinal tubules extensively occurred depended on the increase of energy density from $62J/cm^2$ to $124J/cm^2$, $187J/cm^2$, $249J/cm^2$ compared to those of sound dentin surface irradiated by the pulsed Nd:YAG laser under the same parameters. Therefore, it is recommended that the pulsed Nd:YAG laser as a therapeutic modality to dentinal hypersensitivity should be applied with the less energy density than $62J/cm^2$ on the sound dentin surface, and its energy density on the partially sclerotic dentin surface should be lower than that on the sound dentin surface to preserve tooth from unnecessary excessive structural destruction.

• Journal of Satellite, Information and Communications
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• v.9 no.3
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• pp.109-115
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• 2014

This paper suggest meteorological satellite processing software's structure that reduces time and efforts of modification/upgrade. This structure's key feature is "algorithm component" that works within framework and eventually to a complete Meteorological satellite processing system. Most of existing Meteorological satellite system is designed around specific function and data sets which limits range of modification and upgrade. In addition, re-use of current algorithms become difficult although re-use of similar algorithm is the case in many occasions. This inefficiency can be resolved by designing a new framework as a result of detail analysis of collected requirements. A new framework and system architecture has been designed. In addition, operational flow of Satellite image processing framework has been described.

• The Transactions of the Korea Information Processing Society
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• v.6 no.7
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• pp.1832-1840
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• 1999

Since the existed Korean Web IR systems generally use boolean system, it is difficult to retrieve the information to be wanted at one time. Also, because of the feature that web documents have the frequent abbreviation and many links, the keyword extraction using the inverted document frequency extracts the improper keywords for adding ambiguous meaning problem. Therefore, users must repeat the modification of the queries until they get the proper information. In this paper, we design and implement the relevance feedback agent system for resolving the above problems. The relevance feedback agent system extracts the proper information in response to user's preferred keywords and stores these keywords in preference DB table. When users retrieve this information later, the relevance feedback agent system will search it adding relevant keywords to user's queries. As a result of this method, the system can reduce the number of modification of user's queries and improve the efficiency of the IR system.

• Journal of Korea Society of Industrial Information Systems
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• v.13 no.2
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• pp.69-79
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• 2008

Due to popularization of the wireless Internet and mobile devices the infrastructure of the ubiquitous environment, where users can get information whatever they want anytime and anywhere, is created. Therefore, a variety of fields including the education studies methods for efficiency of information transmission using on-line and off-line contents. In this paper, we propose the Mixed Mobile Education system(MME) that improves educational efficiency using on-line and off-line contents on mobile devices. Because it is hard to input new data and cannot use similar off-line contents in systems used additional tags, the proposed system does not use additional tags but recognizes of-line contents as we extract feature points in the input image using the mobile camera. We use the Scale Invariant Feature Transform(SIFT) algorithm to extract feature points which are not affected by noise, color distortion, size and rotation in the input image captured by the low resolution camera. And we use the client-server architecture for solving the limited storage size of the mobile devices and for easily registration and modification of data. Experimental results show that compared with previous work, the proposed system has some advantages and disadvantages and that the proposed system has good efficiency on various environments.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1D
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• pp.157-167
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• 2006

During the first and second NGIS projects by the Korean government, The first one (1995~2000) was limited on constructing geographic information and the second (2001~2005) was focused on circulation and practical use of geoinformation from the result of the first project. In the latter half of 2nd NGIS project, However, the geographic information from the NGIS projects have not been renewed even though there were significant geographical changes. The accurate renewal of geoinformation is a matter of great importance to the next generation industry (e.g. LBS, Ubiquitous, Telematics). In this respect, it is time to update the geographic information in the latter half of the second NGIS project. Therefore, It is not only important to build an accurate geoinformation but also rapid and correct renewal of the geoinformation. NGII (National Geographic Information Institute) has been studying for improvement of digital map that was constructed by the result of the 1st NGIS project. Through the construction of clean digital map, NGII constructed Framework Data to three kinds of formats (NGI, NDA, NRL). Framework Data was contained to other database, and provided the reference system of location or contents for combining geoinformation. Framework Data is consist of Data Set, Data Model and UFID (Unique Feature Identifier). It will be achieved as national infrastructure data. This paper attempts to explore a method of the update to practical framework data with realtime geoinformation on feature's creation, modification and destruction managed by 'Feature management agency' using UFID's process. Furthermore, it suggests a method which can provide important data in order to plan the Framework update with the land change ratio.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.3
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• pp.81-88
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• 2012

In this paper, we propose a novel speech enhancement algorithm for effective noise suppression in various noisy environments. In the proposed method, to result in improved decision performance for speech and noise segments, local speech absence probability (LSAP, local SAP) based on Teager energy of noisy speech is used as the feature parameter for voice activity detection (VAD) in each frequency subband instead of conventional LSAP. In addition, The presented method utilizes global SAP (GSAP) derived in each frame as the weighting parameter for the modification of the adopted TE operator to improve the performance of TE operator. Performances of the proposed algorithm are evaluated by objective test under various environments and better results compared with the conventional methods are obtained.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.5
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• pp.400-404
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• 2009

Native Command Queueing is a technology to maximize throughput of disk system by reordering requests in its command queue. Recent S-ATA 2 standard specifies a protocol for the purpose of dealing with NCQ feature, making most vendors implementing it in their disk devices. However, the new feature, NCQ, may lead to information gap between OS and disk drive. 05 considers that disk will service I/O requests in the order as OS has dispatched. Unfortunately, it isn't true any more since NCQ would simply ignore the policy of OS and reorder the sequence OS has expected. Let us define the term as expectation-discord. Due to the discord, serious performance anomalies or starvation of requests may occur in I/O subsystem. In this paper, we confirm that the expectation-discord actually brings about starvation of requests. We propose a solution to settle it. Our solution is very simple, effective, cheap(not requiring any hardware modification) and portable across various OS. Experimental results show that our solution can balance throughput and response time very well.

• Journal of the Korea Society of Computer and Information
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• v.25 no.11
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• pp.147-155
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• 2020

System support software is one of the software that makes up ship combat management system and has the characteristics of being mounted in the combat management systems of all ships but with little functional change. However, despite these characteristics, software modifications due to equipment, etc. are inevitable in the application of new ships. Modification of software causes software reliability testing which is a key factor in increasing development costs. In this paper, the structure of the existing system support software was analyzed to identify and supplement the code change factors, and the system support standardization architecture was designed. The feature model elicited common and variable elements of system support software, and applied white-box reuse to improve software design. In addition, the results of comparing existing system support software with the new architecture in terms of development elements and time to perform reliability test were presented to verify the effectiveness of the new one.