• 제목/요약/키워드: Fear Memory

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한의학 신(腎) 기능계에 관한 분자생리학적 고찰 (A Review on "Kidney" Functional System in Korean Medicine : From the Perspective of Molecular Physiology)

  • 박미소;조정효;허왕정;류호룡
    • 동의생리병리학회지
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    • 제36권5호
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    • pp.169-174
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    • 2022
  • In Korean medicine, the "five viscera" theory develops into the theory of homeostasis, in which the dynamic equilibrium state of the yin yang and five elements in the body maintain the balance of the physiological functions. The "five viscera" of the "five elements" can also be referred to as the "functional system," a conceptual system that includes all functional interactions mediated by the organ as well as the organ itself. Nowadays, the structure and function of the organs and tissues in the body are being re-examined, and there is now enough evidence that organs, structures, and their functions that belong to the same "element" are all connected in terms of energy metabolism. The functional system of the "kidney" includes the kidney itself, as well as other components that belong to "water" of the five elements such as bladder, bone, ear, essence, memory, and fear. The authors will discuss the latest findings in science and medicine to expand the understanding of the "Kidney" functional system to the level of molecular physiology.

뇌조직내 Benzodiazepine 유사물질과 스트레스-불안 반응 (Brain Benzodiazepine-like Molecules and Stress-anxiety Response)

  • 하정희
    • Journal of Yeungnam Medical Science
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    • 제16권1호
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    • pp.25-33
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    • 1999
  • 세계적으로 그 처방률이 높은 약물들 중 하나인 benzodiazepine계 약물은, 강력한 불안해소작용, 항경련작용, 최면작용 및 근이완작용을 가지고 있다. Benzodiazepine계 약물의 약리작용기전과 관련하여 불안장애의 병인에서 각종 신경전달계의 역할은 밝혀지고 있다. Benzodiazepine 약물은 편도체와 같은 변연계, 우측 시상하부 및 raphe nuclei에서 GALA성 신경전달을 조절함으로써 불안해소 작용을 나타내는 것으로 보고되었으며, 공포와 스트레스로 인해 유발되는 행동에 있어서 편도체의 역할은 이미 여러 보고를 통해 시사된 바 있다. 본 종설에서는 GABA성 신경전달 조절작용이 있다고 보고된 내인성 benzodiazepine 수용체 배위자의 불안 및 스트레스 반응의 인지 조절작용 및 기억 형성과정 조절작용 등에 관한 연구결과들을 종합하여 본 결과 내인성 benzodiazepine 수용체 배위자들이 불쾌한 학습과정에 동반되는 스트레스와 불안의 정도에 영향을 미침으로써 기억 형성과정을 조절한다는 생각을 뒷받침해 주었다. 또한 각종 행동 검사후 나타나는 뇌조직의 benzodiazepine 유사 물질의 부위별(편도체, 해마, 중격) 농도 감소는 행동 검사에 수반되는 스트레스 및 불안 정도에 비례하므로, 이러한 물질의 감소는 스트레스 및 불안에 대한 변연계의 일반적인 반응으로 생각된다. 부가적으로 이러한 결과는 변연계의 $GABA_A$/benzodiazepine 수용체 복합체는 생체의 스트레스 및 불안반응의 생리, 생화학적 면에서 중추적인 역할을 한다는 생각을 할 수 있게 하는 결과라 할 수 있다.

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개심술 환자의 퇴원후 간호요구에 대한 조사연구 (Post Discharge Nursing Needs of Patients with Open Heart Surgery)

  • 김명희
    • 대한간호학회지
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    • 제23권4호
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    • pp.664-677
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    • 1993
  • The purpose of this study was to provide basic data for the development of educational material in Korean for patient3 being discharge after open heart surgery. The subjects were 45 adult patients who were seen in the out -patient department of the thoracic surgery unit of P University hospital between February 1993 and May 1993. The data were collected through a chart review and interview. Nursing needs, and the patients status related to diet, activity, medication, physical and psychoemotional limitations were analyzed. The results are summarized as follows ; 1. Mitral valve replacement was the most frequent type of surgery(91.2%). In most cases, a mechanical valve was used (91.0%) . The duration of admission after the operation was two to four weeks for most of the patients(48.9%). The follow-up period was between one and two years for 28.9% of the patients and below 6 years for all of the patients. 2. Many Patients didn’t know the importance of a low salt diet(57.8%), and did not get any education on low salt diet (66.7%). Gimchi was included as one of the most commonly ingested foods (77.8%). All of the patients indicated nursing needs related to education about low salt diets and further they indicated a major interest in foods that are harmful (57.7%) or foods that are safe(51.1% ). 3. Most patients did not recognize the need for limitations on physical activity(84.4%). Further, 31.1% of them could not return to work at the time of the study. All patients had nursing needs related to physical activity, with the most frequent questions being about the permissble degree of activity and special cautions dictated by their illness (60.0%). 4. Many patients were ignorant of the necessity of medication(55.6%) . Forty percent of the patients were taking additional drugs, usually herb drugs. The time and duration of medication and the side effects of drugs were common concerns (57.7%) related to nursing. needs about medication and were mentioned by all of the patients. 5. All of the patients complained of physical discomfort including the following : memory disturbance(62.2%), weight gain(60.0%), chest tightness (55.6%), hair loss(51.1%), sleep disturbance(46.7%) and other symptoms in that order of frequency. Nursing needs related to physical condition were a concern for all of them. The viability and function of the replaced valve(53.3%) and weight gain(60.0%) were mal or concerns. 6. Looking at their psychoemotional condition it was found that 36 patients(80.0%) were emotionally unstable. The causes were physical discomfort(17 patients), insufficient knowlege of open heart surgery(6 patients), fear of death(6 patients), familial over protection(2 patients ) and lack of support (5 patients).

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Usefulness of Intravenous Anesthesia Using a Target-controlled Infusion System with Local Anesthesia in Submuscular Breast Augmentation Surgery

  • Chung, Kyu-Jin;Cha, Kyu-Ho;Lee, Jun-Ho;Kim, Yong-Ha;Kim, Tae-Gon;Kim, Il-Guk
    • Archives of Plastic Surgery
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    • 제39권5호
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    • pp.540-545
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    • 2012
  • Background Patients have anxiety and fear of complications due to general anesthesia. Through new instruments and local anesthetic drugs, a variety of anesthetic methods have been introduced. These methods keep hospital costs down and save time for patients. In particular, the target-controlled infusion (TCI) system maintains a relatively accurate level of plasma concentration, so the depth of anesthesia can be adjusted more easily. We conducted this study to examine whether intravenous anesthesia using the TCI system with propofol and remifentanil would be an effective method of anesthesia in breast augmentation. Methods This study recruited 100 patients who underwent breast augmentation surgery from February to August 2011. Intravenous anesthesia was performed with 10 mg/mL propofol and 50 ${\mu}g/mL$ remifentanil simultaneously administered using two separate modules of a continuous computer-assisted TCI system. The average target concentration was set at 2 ${\mu}g/mL$ and 2 ng/mL for propofol and remifentanil, respectively, and titrated against clinical effect and vital signs. Oxygen saturation, electrocardiography, and respiratory status were continuously measured during surgery. Blood pressure was measured at 5-minute intervals. Information collected includes total duration of surgery, dose of drugs administered during surgery, memory about surgery, and side effects. Results Intraoperatively, there was transient hypotension in two cases and hypoxia in three cases. However, there were no serious complications due to anesthesia such as respiratory difficulty, deep vein thrombosis, or malignant hypertension, for which an endotracheal intubation or reversal agent would have been needed. All the patients were discharged on the day of surgery and able to ambulate normally. Conclusions Our results indicate that anesthetic methods, where the TCI of propofol and remifentanil is used, might replace general anesthesia with endotracheal intubation in breast augmentation surgery.

한국무속의 신격 연구1 - 서울과 고성의 재수굿을 중심으로 - (The Study on the Divinity of Korean Shamanism 1)

  • 심상교
    • 공연문화연구
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    • 제36호
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    • pp.365-414
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    • 2018
  • 본고는 한국무속에 나타난 신격의 유형과 성격을 연구하는 과정의 하나로 서울과 강원도 고성의 재수굿에 나타난 신격에 대해 연구하였다. 신격에 대한 연구란 무속신이 각 굿에서 의미하는 바, 무속신의 위계, 무속신 상호간의 관계, 무속신의 각 지역 간 대비점 등에 대한 고찰을 의미한다. 본고의 무속 신격 연구는 채록된 무가를 근간으로 하였다. 서울의 재수굿은 논자에 따라 10거리에서 18거리까지 다양하지만 대체로 10거리 내외다. 본고에서는 김태곤이 채록한 12거리 무가를 근간으로 한다. 12거리는 부정거리, 가망거리, 말명거리, 상산거리, 별상거리, 대감거리, 제석거리, 호구거리, 군웅거리, 성주거리, 창부거리, 뒷전거리 등이다. 강원도 고성의 재수굿은 8거리로 부정굿, 서낭굿, 조상굿, 성주굿, 지신굿, 칠성굿, 말명굿, 거리풀이로 구성되었다. 말명거리는 독립굿이 아니라는 견해도 있지만 분석텍스트에 의거하여 본고에서는 독립된 거리로 본다. 그리고 상산 별상 신장 대감을 분리하기도 하고 묶어 대안주로 보기도 하지만 역시 김태곤무가집의 텍스트대로 분리하여 고찰한다. 재수굿의 핵심은 이성과 과학으로 설명되지 않는 세계를 이용해서 개인의 평안을 기원한 측면이 강하다. 인간의 기억에 저장된 경험의 세계를 이성과 과학이 모두 설명할 수 없는 측면이 반영된 것이고 인간 삶의 넓고 다양한 측면에 대해 해명하고자하는 탐구와 정리가 재수굿에 반영된 것으로 생각된다. 서울의 재수굿 각 굿에는 그 굿의 근간이 되는 주신이 있고 주신의 의미를 분명히 하려는 종신, 속신이 있다. 한 굿의 주신은 다른 굿에서 종신이나 속신이 되기도 한다. 각 신격들은 상하관계로 존재하지 않고 평등하게 존재하는 것이다. 재수기원의 신들은 기본적으로 나라안위${\rightarrow}$지역안위${\rightarrow}$가정안위 순으로 굿을 받게 된다. 국태민안${\rightarrow}$안과태평${\rightarrow}$부귀공명${\rightarrow}$재수소망의 순서가 되는 것이다.