• 대한한의진단학회지
• /
• 제19권3호
• /
• pp.159-171
• /
• 2015

Objectives: Lately, non alcoholic fatty liver patients are increasing rapidly and the average age of patients are getting younger. Non alcoholic fatty liver often represents asymptomatic and korean pattern diagnosis is difficult to implement without symptoms. This study aimed to analyze interrelationship between non alcoholic fatty liver disease and Injinho-tang. Methods The AHP is a systematic procedure for analyzing the elements of any problem hierarchically. Based on survey of expertise, as series of pairwise comparison judgements is performed to evaluate the various elements in the hierarchy. We are expected to use the AHP analysis that would apply to oriental doctor's diagnostic process analysis. Results and conclusion Non-alcoholic fatty liver disease induced complex causes of the metabolic syndrome. Injinho-tang has been widely used disease that causes jaundice and liver biliary disease. According to AHP analysis, LFT is the most important facor in choosing Injinho-tang on non alcoholic fatty liver disease. BMI and body composition by bioelectrical impedance analysis are the next important factors. Personal hot temper also gives a big impact on choicing Injinho-tang on non alcoholic fatty liver disease.

• 한국방사선학회논문지
• /
• 제17권5호
• /
• pp.735-742
• /
• 2023

비알콜성 지방간은 심혈관계 질환, 당뇨병, 고혈압 및 신장질환의 발생에 있어 독립적인 위험인자에 해당하며, 최근에는 비알콜성 지방간에 대한 임상적 중요성이 증가하고 있다. 본 연구에서는 비알콜성 지방간 환자의 초음파영상에 대하여 질감분석 방법인 GLCM을 적용하여 특징값을 추출하고자 한다. 추출된 특징값들을 이용한 인공신경망 모델의 적용을 통하여 비알콜성 지방간의 지방침착 정도를 정상 간(normal), 경도 지방간(mild), 중등도 지방간(moderate), 중증 지방간(severe)으로 분류를 하고자 한다. GLCM알고리듬 적용 결과 Autocorrelation, Sum of squares, Sum average, Sum variance 파라미터 값들은 경도 지방간, 중등도 지방간을 거쳐 중증 지방간으로 갈수록 특징값의 평균값이 증가하는 경향성을 나타내었다. 인공신경망 모델의 입력은 비알콜성 지방간질환의 초음파영상에 GLCM 알고리듬을 적용하여 추출한 Autocorrelation, Sum of squares, Sum average, Sum variance의 4개의 파라미터들을 인공신경망 모델의 입력값으로 적용하였다. 비알콜성 지방간질환의 초음파영상에 GLCM 알고리듬을 적용하여 추출한 영상을 인공신경망에 적용하여 분류 정확도를 평가한 결과 92.5%의 높은 정확도를 나타내었다. 이러한 결과를 통하여 비알콜성 지방간 환자의 초음파 영상에 대한 질감 분석 GLCM 연구 시 본 연구의 결과를 기초자료로 제시를 하고자 한다.

• 동의생리병리학회지
• /
• 제26권6호
• /
• pp.823-833
• /
• 2012

Now a days, number of non alcoholic fatty liver patients are increasing more rapidly compare to past rate, and the average age of patients is getting younger, but there are no appropriate therapeutics in non alcoholic fatty liver disease. This study was aimed to analyze relationship between non alcoholic fatty liver disease and Injinho-tang. The papers were collected and analysed from domestic and international journals. The effects of Injinho-tang and constituent-herb were researched. Non-alcoholic fatty liver disease was induced complex causes of the metabolic syndrome. Medications that can be used in non-alcoholic fatty liver disease, it should be have many effects such as anti-hepatic fibrosis, hepatocyte protection, liver cancer inhibitory effect, inflammatory cytokine regulation, improving hyperlipidemia, weight control, decrease the toxicity of the drug, antioxidant. Injinho-tang (Artemisia capillaris Thunb, Gardenia fructus, Rhei rhizome) has been widely used in disease that causes jaundice and liver biliary disease. Drugs for standardization of Injinho-tang index components(6,7-Dimethylesculetin, geniposide, rhein) have been presented. And Injinho-tang has been proven reliability in the administration of single dose toxicity. Also clinical stability in the administration of four years was reported. Injinho-tang has been reported some effects which anti-hepatic fibrosis, hepatocyte protection, liver cancer inhibitor, inflammatory cytokine regulation, improving hyperlipidemia, weight control, decrease the toxicity of the drug, and antioxidant. Therefore, Injinho-tang can be used in Non alcoholic fatty liver disease without Syndrome Differentiation.

• 사상체질의학회지
• /
• 제31권2호
• /
• pp.22-30
• /
• 2019

Objectives The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD). Methods The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed. Results Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control. Conclusions The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.

• Journal of Ginseng Research
• /
• 제41권4호
• /
• pp.450-455
• /
• 2017

Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of Korean Red Ginseng on chronic liver disease, a condition encompassing nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, and hepatocellular carcinoma, as supported by experimental evaluation and clinical investigation.

• BMB Reports
• /
• 제54권6호
• /
• pp.323-328
• /
• 2021

Periodontal diseases have been reported to have a multidirectional association with metabolic disorders. We sought to investigate the correlation between periodontitis and diabetes or fatty liver disease using HFD-fed obese mice inoculated with P. gingivalis. Body weight, alveolar bone loss, serological biochemistry, and glucose level were determined to evaluate the pathophysiology of periodontitis and diabetes. For the evaluation of fatty liver disease, hepatic nonalcoholic steatohepatitis (NASH) was assessed by scoring steatosis, inflammation, hepatocyte ballooning and the crucial signaling pathways involved in liver metabolism were analyzed. The C-reactive protein (CRP) level and NASH score in P. gingivalis-infected obese mice were significantly elevated. Particularly, the extensive lobular inflammation was observed in the liver of obese mice infected with P. gingivalis. Moreover, the expression of metabolic regulatory factors, including peroxisome proliferator-activated receptor γ (Pparγ) and the fatty acid transporter Cd36, was up-regulated in the liver of P. gingivalis-infected obese mice. However, inoculation of P. gingivalis had no significant influence on glucose homeostasis, insulin resistance, and hepatic mTOR/AMPK signaling. In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.

• Genomics & Informatics
• /
• 제21권4호
• /
• pp.45.1-45.11
• /
• 2023

Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.

• 대한한방내과학회지
• /
• 제41권5호
• /
• pp.740-744
• /
• 2020

Objective: The aim of this study was to report on the effectiveness of Chunggan-tang in a patient with non-alcoholic fatty liver disease. Methods: A 57-year-old woman diagnosed with non-alcoholic fatty liver disease took Chunggan-tang from March 27. 2019 to April 3. 2019. We observed her laboratory findings. Results: After treatment, her laboratory findings showed a reduction in liver enzyme levels. Conclusion: This study shows that Chunggan-tang may be an effective treatment for non-alcoholic fatty liver disease.

• Archives of Pharmacal Research
• /
• 제29권9호
• /
• pp.768-776
• /
• 2006

Non-alcoholic fatty liver disease (NAFLD) is common in obesity. However, weight reduction alone does not prevent the progression of NAFLD to end-stage disease associated with the development of cirrhosis and liver disease. In a previous experiment, 50% ethanol extract of Acanthopanax senticosus stem bark (ASSB) was found to reduce body weight and insulin resistance in high fat diet-induced hyperglycemic and hyperlipidemic ICR mice. To evaluate the anti-steatosis action of ASSB, insulin-resistant ob/ob mice with fatty livers were treated with ASSB ethanol extract for an 8 week-period. ASSB ethanol extract reversed the hepatomegaly, as evident in reduction of % liver weight/body weight ratio. ASSB ethanol extract also specifically lowered circulating glucose and lipids, and enhanced insulin action in the liver. These changes culminated in inhibition of triglyceride synthesis in non-adipose tissues including liver and skeletal muscle. Gene expression studies confirmed reductions in glucose 6-phosphatase and lipogenic enzymes in the liver. These results demonstrate that ASSB ethanol extract is an effective treatment for insulin resistance and hepatic steatosis in ob/ob mice by decreasing hepatic lipid synthesis.

• East Asian mathematical journal
• /
• 제36권3호
• /
• pp.365-376
• /
• 2020

Nonalcoholic fatty liver is a type of fatty liver in which fat accumulates in the liver without alcohol. In the accumulation, Nrf1 and miR-378 genes play very important role, so called negative feedback loop, in which the two genes suppress the other's production. In other words, Nrf1 activates fatty acid oxidation which promotes fat consumption in the liver, while miR-378 deactivates fatty acid oxidation. Thus, both genes regulate nonalcoholic fatty liver. In this paper, the negative feedback loop of Nrf1 and miR-378 are expressed by a system of ordinary differential equations. And, bifurcation simulation shows the change in the amount of each gene with significant parameter range changes. Bifurcation simulation has also used to determine the thresholds for transit between disease and steady state.