• Title/Summary/Keyword: Fatty degeneration

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PATHOLOGIC STUDIES ON SODIUM MONOFLUOROACETATE (COMPOUND 1080) POISONING IN RABBITS (Sodium monofluoroacetate (Compound 1080) 중독(中毒)에 관(關)한 가토(家兎)의 병리해부학적(病理解剖學的) 연구(硏究))

  • Kim, Hwa Sik
    • Korean Journal of Veterinary Research
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    • v.1 no.1
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    • pp.65-70
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    • 1961
  • Many losses in domestic animals have bern reported in this country, since sodium monofluoroacetate (Compound 1080) was used as a rodenticide. Lesions described inclubed multiple petechiae in epi- and endocardium, lung and intestinal mucosa, or superficial necrosis of the gastric mucosa. In this studies as to the poisoning 7 rabbits were administered 0.6mg (Group I), 0.4mg (Group II), and 0.3mg (Group III) of sodium monofluoroacetate per kilogram of body weight. and the results obtained were as follows: In addition to the changes mentioned above fatty degeneration in central parts of hepatic lobule or nut meg liver, haemorrhagic feci in cerebral cortex and leptomeninges and fatty degeneration in kidney and cardiac muscles were found.

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Severe Paraspinal Muscle Atrophy with Fatty Degeneration in a Young Adult: A Case Report (젊은 성인의 척추주위근에 발생한 지방 변성을 동반한 심한 근위축: 증례보고)

  • Huh, Jae-Won;Yang, Won-Jong;Park, Eunhee;Lee, Jae Eun;Kim, Chul-Hyun
    • Journal of Electrodiagnosis and Neuromuscular Diseases
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    • v.20 no.2
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    • pp.130-134
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    • 2018
  • A 36-year-old male patient developed diffuse low back pain. His past medical history was unremarkable and had no family history of neuromuscular disease. He had no bladder and bowel problems. Creatine kinase was 172 U/L (normal < 170). Other fluid and blood chemistry tests were normal. Manual muscle test grades of extremities and sensory examination were normal. Muscle stretch reflexes were normal. Fasciculations and myotonia were not detected. Straight leg raising test was negative. There was no spinal root compression, spinal stenosis, or signal intensity change of spinal cord on magnetic resonance imaging (MRI). Fatty change and atrophy of the cervical, thoracic and lumbar paraspinal muscles were noted on MRI. Nerve conduction studies were normal. Electromyography showed 1+ positive sharp waves in the lumbar paraspinal muscles. Electromyography of upper and lower extremity muscles revealed no abnormal spontaneous activity. We report a rare case of severe paraspinal muscle atrophy with fatty degeneration in a Young Adult.

Pathological Studies on Urea Poisoning in Milk Goats (산양(山羊)의 요소중독(尿素中毒)에 관한 병리학적(病理學的) 연구(硏究))

  • Kim, Soon-Bok;Chung, Un-Ik
    • Korean Journal of Veterinary Research
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    • v.22 no.2
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    • pp.233-237
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    • 1982
  • Pathological studies on 6 milk goats administrated with urea were carried out to determine the effects of acute and chronic poisonings on the animal. Clinical signs appeared about 10 minutes after ingestion of the urea and they consisted chiefly in dullness, staggering, uncontrolled urination, dyspnea, frothy salivation, bloating, muscular tremor, humping of back and tetanic spasms. Macroscopic lesions were failure of blood clot, frothy and bloody contents in the highly congested respiratory tract, pulmonary edema, rumenitis and abomatitis accompanying with petechiation of the upper small intestine. Microscopically, the liver showed vacuolar degeneration, fatty change and areas of necrosis and partial proliferation of the interlobular connective tissues in chronic crises. The renal epithelium displaced vacuolar degeneration, necrosis and hyaline casts in their lumens. In the lungs, there were hyperemia, edema, hemorrhages, and acute catarrhal bronchitis. Neuronal degeneration and necrosis in the central nervous system, catarrhal rumenitis, abomatitis, doudenitis and myocardial hemorrhage were also demonstrated.

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Fatty Acid Concentration of Serum Phospholipids in Normal and Glaucoma Patients (정상인과 녹내장 환자의 혈청 인지질 지방산 농도)

  • Chung, Hae-Yun
    • Journal of the Korean Society of Food Culture
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    • v.35 no.2
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    • pp.224-232
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    • 2020
  • Glaucoma is one of the leading causes of blindness worldwide and is characterized by degeneration of the optic nerve. Elevated intraocular pressure (IOP) is the major contributing factor to optic nerve damage. However, some patients develop glaucoma even with normal IOP. Other factors, including age, race, myopia, and nutrition, can affect glaucoma risk. Dietary fat intake and serum fatty acid composition are closely related with the fatty acid profile of the retina and thus can modulate glaucoma risk. In this study, we collected serum samples from 34 glaucoma patients (26 primary open angle glaucoma (POAG) and 8 normal tension glaucoma (NTG)) and 45 healthy controls and analyzed their serum phospholipid fatty acid concentrations. The results show that the ratio of oleic acid to stearic acid (OA/SA), which is an indicator of stearoyl-CoA desaturase activity, was higher in POAG patients when compared to normal controls. The ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA), which is an indirect marker of eicosanoid biosynthesis, was also higher in glaucoma patients (p=0.048). These results imply that dietary fatty acid intake and serum fatty acid profile can influence glaucoma risk. Additional study is necessary to identify the relationship between fatty acids and glaucoma.

The Effects of Scutellaria Radix Extract on the Alcohol-Induced Fatty Acid Synthesis of Liver in Rats (알코올로 유도된 흰쥐의 간 지방 형성에 황금 추출물이 미치는 효과)

  • Kim, Bum Hoi
    • Journal of Korean Medicine for Obesity Research
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    • v.18 no.1
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    • pp.19-26
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    • 2018
  • Objectives: Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis. The objective of this study is to investigate the effects of Scutellaria Radix (SR) extract on the alcoholic fatty liver induced by long-term EtOH administration. Results: Male Sprague Dawley rats were used in this study. All animals were randomly divided into Normal group, treated with saline (n=10); EtOH group, treated with ethanol (n=10); EtOH+SR group, treated with ethanol+Scutellaria Radix extract (n=10). For oral administration of ethanol in EtOH and EtOH+SR group, the ethanol was dissolved in distilled water in concentrations of 25% (v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Scutellaria Radix extract daily for 8 weeks. Results: The levels of hepatic marker such as aspartate aminotransferase and alanine aminotransferase were altered. Histopathological changes such as ballooning, fatty and hydropic degeneration were reduced and the expression of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) was significantly attenuated by Scutellaria Radix extract. Conclusions: These data suggest that Scutellaria Radix extract attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of $TNF-{\alpha}$ protein. Scutellaria Radix could be effective in protecting the liver from alcoholic fatty liver.

Early Complications after Repair of Massive Rotator Cuff Tear (광범위 회전근개 파열의 수술적 치료 후 발생한 단기 합병증)

  • Seo, Joong-Bae;Bahng, Seung-Chul
    • Clinics in Shoulder and Elbow
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    • v.9 no.1
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    • pp.27-33
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    • 2006
  • Purpose: To investigate early complications after repair of massive rotator cuff tears and to find out factors that compromise the results. Materials and Methods: Fourteen patients who had two or more cuff tendons involved were included. All patients were operated by open acromioplasty and rotator cuff repair. At 3 months after operation, we investigated whether there were any early complications or not. We used ASES scoring system for preoperative and follow up evaluation. In addition, various preoperative factors, such as duration of symptom, degree of tendon retraction, degree of fatty degeneration, and acromio-humeral distance, were compared between the complicated patients and non-complicated patients. Results: At 3 months after operation, the ASES score and pain were improved in any degree in all patients. But 5 patients complained persisting pain, and three of them showed major complications such as re-rupture of rotator cuff or deltoid rupture. But no preoperative factors in complicated patients were significantly different from those in non-complicated patients. Conclusion: None of the preoperative factors were related to the complications. There was a tendency of overestimation of fatty degeneration in MRI. Some factors in surgical technique and rehabilitation were highly suspected to be related to the complications.