Browse > Article
http://dx.doi.org/10.15429/jkomor.2018.18.1.19

The Effects of Scutellaria Radix Extract on the Alcohol-Induced Fatty Acid Synthesis of Liver in Rats  

Kim, Bum Hoi (Department of Anatomy, College of Korean Medicine and Research Institute of Oriental Medicine, Dong-Eui University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.18, no.1, 2018 , pp. 19-26 More about this Journal
Abstract
Objectives: Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis. The objective of this study is to investigate the effects of Scutellaria Radix (SR) extract on the alcoholic fatty liver induced by long-term EtOH administration. Results: Male Sprague Dawley rats were used in this study. All animals were randomly divided into Normal group, treated with saline (n=10); EtOH group, treated with ethanol (n=10); EtOH+SR group, treated with ethanol+Scutellaria Radix extract (n=10). For oral administration of ethanol in EtOH and EtOH+SR group, the ethanol was dissolved in distilled water in concentrations of 25% (v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Scutellaria Radix extract daily for 8 weeks. Results: The levels of hepatic marker such as aspartate aminotransferase and alanine aminotransferase were altered. Histopathological changes such as ballooning, fatty and hydropic degeneration were reduced and the expression of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) was significantly attenuated by Scutellaria Radix extract. Conclusions: These data suggest that Scutellaria Radix extract attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of $TNF-{\alpha}$ protein. Scutellaria Radix could be effective in protecting the liver from alcoholic fatty liver.
Keywords
Alcoholic fatty liver; Scutellaria Radix; $TNF-{\alpha}$; AST; ALT;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bai T, Yang Y, Yao YL, Sun P, Lian LH, Wu YL, et al. Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacol Res. 2016 ; 105 : 1-12.   DOI
2 Macieira MS, Almeida WG, Silva EA, Schenberg LC, Nakamura-Palacios EM. Alcohol dependence induced in rats by semivoluntary intermittent intake. Braz J Med Biol Res. 1997 ; 30(9) : 1107-11.   DOI
3 Larue-Achagiotis C, Poussard AM, Louis-Sylvestre J. Alcohol drinking, food and fluid intakes and body weight gain in rats. Physiol Behav. 1990 ; 47(3) : 545-8.   DOI
4 Herlong HF. Approach to the patient with abnormal liver enzymes. Hosp Pract (Off Ed). 1994 ; 29(11) : 32-8.   DOI
5 McGill MR. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J. 2016 ; 15 : 817-28.
6 Altavilla D, Marini H, Seminara P, Squadrito G, Minutoli L, Passaniti M, et al. Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice. Pharmacology. 2005 ; 74(1) : 6-14.   DOI
7 Augustyniak A, Waszkiewicz E, Skrzydlewska E. Preventive action of green tea from changes in the liver antioxidant abilities of different aged rats intoxicated with ethanol. Nutrition. 2005 ; 21(9) : 925-32.   DOI
8 Altamirano-Barrera A, Uribe M, Chavez-Tapia NC, Nuno-Lambarri N. The role of the gut microbiota in the pathology and prevention of liver disease. J Nutr Biochem. 2018 ; 60 : 1-8.   DOI
9 Lieber CS. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol. 2004 ; 34(1) : 9-19.   DOI
10 Willner IR, Reuben A. Alcohol and the liver. Curr Opin Gastroenterol. 2005 ; 21(3) : 323-30.
11 Nagata K, Suzuki H, Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci. 2007 ; 32(5) : 453-68.   DOI
12 Mezey E. Alcoholic liver disease: roles of alcohol and malnutrition. Am J Clin Nutr. 1980 ; 33(12) :2709-18.   DOI
13 Purohit V, Gao B, Song BJ. Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res. 2009 ; 33(2) : 191-205.   DOI
14 Nagy LE. The role of innate immunity in alcoholic liver disease. Alcohol Res. 2015 ; 37(2) : 237-50.
15 Lin HZ, Yang SQ, Zeldin G, Diehl AM. Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. Alcohol Clin Exp Res. 1998 ; 22(5 Suppl) : 231S-7S.   DOI
16 Ji C, Deng Q, Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology. 2004 ; 40(2) : 442-51.   DOI
17 French JB, Bonacini M, Ghabril M, Foureau D, Bonkovsky HL. Hepatotoxicity associated with the use of anti-TNF-${\alpha}$ agents. Drug Saf. 2016 ; 39(3) : 199-208.   DOI
18 Kim EH, Shim B, Kang S, Jeong G, Lee JS, Yu YB, et al. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. J Ethnopharmacol. 2009 ; 126(2) : 320-31.   DOI
19 The textbook compilation committee of Korean herbology. Bonchohak. 2nd ed. Seoul : Younglimsa. 1994 : 178-9.
20 Kim KS, Kim LH, Rhee YJ, Lee SH, Choi JH, Ko HN. Analysis on research trend of studies related with Scutellariae Radix in Korea. Korean J Orient Physiol Pathol. 2011 ; 25(6) : 1095-101.
21 Song KH, Lee SH, Kim BY, Park AY, Kim JY. Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db mice. Phytother Res. 2013 ; 27(2) : 244-50.   DOI
22 Lieber CS. Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases. Mt Sinai J Med. 2000 ; 67(1) :84-94.
23 Yoon HJ, Park YS. Effects of Scutellaria baicalensis water extract on lipid metabolism and antioxidant defense system in rats fed high fat diet. J Korean Soc Food Sci Nutr. 2010 ; 39(2) : 219-26.   DOI
24 Kim JJ, Seo BI, Choi HS, Kim SM, Woo CH, Koo JS, et al. Preventive effects of Daekumeumja on fatty degeneration of liver and immunosuppression induced by alcohol. Korean J Oriental Medicine. 2010 ; 16(2) : 167-79.
25 Yoon SK. Diagnosis and treatment of fatty liver. Korean J Med. 2009 ; 76(6) : 677-79. S
26 Ma Z, Zhang Y, Li Q, Xu M, Bai J, Wu S. Resveratrol improves alcoholic fatty liver disease by downregulating HIF-$1{\alpha}$ expression and mitochondrial ROS production. PLoS One. 2017 ; 12(8) : e0183426..   DOI