• Human Ecology Research
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• v.57 no.1
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• pp.15-26
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• 2019

This study showed that the association between solidarity and conflict is mediated by the communication of grandmothers and an adult child at the dyadic level. The common fate model (CFM) was designed to model mediation effects at the level of dyads. Participants consisted of 297 grandmother dyads and their adult child who were rearing preschool-aged grandchildren in Seoul and Gyeonggi-do. For analysis at the dyadic level, grandmothers and adults responded to the same questionnaire on the same variables. SPSS 23.0 performed descriptive statistical analysis and correlation analysis. The structural equation model (SEM) was estimated with AMOS 23.0. We tested the mediation model using the maximum likelihood method. Model fit index used the chi-square statistic, the incremental fit index (IFI), the comparative fit index (CFI), the root mean square error of approximation (RMSEA). The statistical significance of the indirect effect was examined using a bootstrapping procedure. The results are as follows. First, in the CFM, the direct effect between solidarity and conflict was significant. Therefore, the higher the solidarity, the lower conflict of grandmothers and an adult child. Second, the association between solidarity and conflict is mediated by communication at the dyadic level. Based on the results of this study, we discussed ways to strengthen the capacity of co-parenting between grandmothers and an adult child.

• Biomolecules & Therapeutics
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• v.23 no.1
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• pp.26-30
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• 2015

Wnt/${\beta}$-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated ${\beta}$-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes. In this study, we identified an inhibitor of ${\beta}$-catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (atractylochromene, AC). AC suppressed b-catenin/Tcell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-$3{\beta}$. AC down-regulated the nuclear level of ${\beta}$-catenin through the suppression of galectin-3 mediated nuclear translocation of ${\beta}$-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell. Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.6
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• pp.936-942
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• 2012

This review was to elucidate the fate of Bentazon(3-isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide) and its metabolites in soil. Bentazon is rapidly degraded to form polar metabolites which are mostly adsorbed to soil components, such as humin or fulvic acid, as non extractable forms and mineralized into $CO_2$ by light or micro-organisms in both aerobic or nonaerobic condition. The degradation of Bentazon is dependent on the rate of organic matters in soil and the use of land for the tillage. The degradation rate is decreased as the amount of organic matters in soil increases and if the land is under use for tillage. Sorption and mobility of Bentazon depends on soil pH and the content of organic matters in soil. Usually, the sorption of the metabolites of Bentazon is decreased with increase in the mobility and pH. Almost all of Bentazon is degraded within rhizosphere or forms conjugate bonds with soil organic matters before it reaches to the ground water.

• Environmental Engineering Research
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• v.14 no.1
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• pp.53-60
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• 2009

The main objective was to develop and assess a dynamic fate and transport model for lead in air, soil, sediment, water and vegetation. Daejeon was chosen as the study area for its relatively high contamination and emission levels. The model was assessed by comparing model predictions with measured concentrations in multi-media and atmospheric deposition flux. Given a lead concentration in air, the model could predict the concentrations in water and soil within a factor of five. Sensitivity analysis indicated that effective compartment volumes, rain intensity, scavenging ratio, run off, and foliar uptake were critical to accurate model prediction. Important implications include that restriction of air emission may be necessary in the future to protect the soil quality objective as the contamination level in soil is predicted to steadily increase at the present emission level and that direct discharge of lead into the water body was insignificant as compared to atmospheric deposition fluxes. The results strongly indicated that atmospheric emission governs the quality of the whole environment. Use of the model developed in this study would provide quantitative and integrated understanding of the cross-media characteristics and assessment of the relationships of the contamination levels among the multi-media environment.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2711-2715
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• 2012

Background: Bisphenol A (BPA), an endocrine disrupting chemical, has been suspected to pose carcinogenic risks. However, likely mechanisms are obscure and there are difficulties to estimating its real significance for cancer development. Methods: We therefore studied BPA-induced proteomic alterations in immune organs of ICR mice offspring that were prenatally exposed to BPA (15 and 300 mg/L of drinking water). We performed 2D-gel analyses of samples, considering differences in spleen, exposure levels, sex, and ages. Results: From proteomic analyses, we found various proteins were up- or down-regulated by BPA. Among them, SET, a putative oncogene and inhibitor of phosphatase 2A, was significantly down-regulated in a BPA dose-dependent manner. We also confirmed down-regulation of SET in western blot and real time PCR analyses. From gene network analysis, SET is predicted to communicate with other genes including CYP17, which is involved in biosynthesis and metabolism of sex-hormones. Conclusions: This study provided evidence that SET can be applied as a new biomarker for prenatal BPA exposure and suggests a potential new mechanism of action in that BPA may disrupt CYP17 via SET.

• Journal of Ecology and Environment
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• v.34 no.3
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• pp.295-305
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• 2011

Many studies have suggested the positive effects of grazing by large herbivorous mammals on seed dispersal, but little is known about how herbivores could affect the fate of ingested seeds. This study examined the effects of seed ingestion by sika deer (Cervus nippon) on seed fate in a temperate grassland established in an urban park long resided by high densities of sika deer. I compared species composition and seasonal traits of seed abundance and maturity in the grassland community with those in deer fecal pellets. In total, 27 herbaceous species were observed, including the predominant Zoysia japonica. Seed phenology and production differed among the three dominant species (Z. japonica, Digitaria violascens, and Hydrocotyle maritima). Pellets contained at least 26 species of herbaceous seeds, and their abundance differed among species. Of the 26 species, 15 were observed in the vegetation at the study site. The peak of seed abundance in pellets for the dominant species appeared 1 month after the peak of inflorescence production (but most of the inflorescences were immature and susceptible to digestion) and consequently corresponded to the peak of mature inflorescence. Because sika deer are likely to ingest seeds at any maturity stage in the grassland and immature seeds are less hardened, ingested immature seeds can suffer great losses. The results suggested that the survival of germable seeds with great losses of immature seeds may be a factor determining which plant species can be successfully dispersed by herbivores.

• Journal of Family Resource Management and Policy Review
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• v.2 no.1
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• pp.15-31
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• 1998

The purpose of study is to understand the home management strategy to cope with rapid changing environments and to verify that how personal value orientation affect home management strategy. The research results are summarized below. First, variables that affect the value orientation of Korean urbanite are sex, area of dwelling, degree of information using and degree of stress recognition in case of material orientation, degree of information using in case of environmental orientation, academic career, sex, degree of information using, degree of stress recognition in cases of fate control orientation, number of children, sex, degree of information using in case of equilibrium orientation, sex, degree of stress recognition in case of present orientation and academic career, degree of stress recognition in case of individualistic orientation. Second, value orientation variables that affect overall home management strategy of Korean urbanite are material orientation, environmental orientation, fate control orientation and individualistic orientation. Third, variables that affect overall home management strategy of Korean urbanite are age, academic career, degree of information using, degree of stress recognition, perception level of living relative to others, environmental orientation and fate control orientation and it is shown that degree of information using is domineering variable.

• Journal of Family Resource Management and Policy Review
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• v.2 no.2
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• pp.1-19
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• 1998

The purpose of study is to understand the home management strategy to cope with rapid changing environments and to verify that how personal value orientation affect home management strategy. The research results are summarized below. First, variables that affect the value orientation of Korean urbanite are sex, area of dwelling, degree of information using and degree of stress recognition in case of material orientation, degree of information using in case of environmental orientation, academic career, sex, degree of information using, degree of stress recognition in cases of fate control orientation, number of children, sex, degree of information using in case of equilibrium orientation, sex, degree of stress recognition in case of present orientation and academic career, degree of stress recognition in case of individualistic orientation. Second, value orientation variables that affect overall home management strategy of Korean urbanite are material orientation, environmental orientation, fate control orientation and individualistic orientation. Third, variables that affect overall home management strategy of Korean urbanite are age, academic career, degree of information using, degree of stress recognition, perception level of living relative to others, environmental orientation and fate control orientation and it is shown that degree of information using is domineering variable.

• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.68-72
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• 2014

When chemotherapy is administered during pregnancy, it is important to consider the fetus chemotherapy exposure, because it may lead to fetal consequences. Paclitaxel has become widely used in the metastatic and adjuvant settings for woman with cancer including breast and ovarian cancer. Therefore, we attempted to clarify the transport mechanisms of paclitaxel through blood-placenta barrier using rat conditionally immortalized syncytiotrophoblast cell lines (TR-TBTs). The uptake of paclitaxel was time- and temperature-dependent. Paclitaxel was eliminated about 50% from the cells within 30 min. The uptake of paclitaxel was saturable with $K_m$ of $168{\mu}M$ and $371{\mu}M$ in TR-TBT 18d-1 and TR-TBT 18d-2, respectively. [$^3H$]Paclitaxel uptake was markedly inhibited by cyclosporine and verapamil, well-known substrates of P-glycoprotein (P-gp) transporter. However, several MRP substrates and organic anions had no effect on [$^3H$]paclitaxel uptake in TR-TBT cells. These results suggest that P-gp may be involved in paclitaxel transport at the placenta. TR-TBT cells expressed mRNA of P-gp. These findings are important for therapy of breast and ovarian cancer of pregnant women, and should be useful data in elucidating teratogenicity of paclitaxel during pregnancy.

• Journal of Preventive Medicine and Public Health
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• v.45 no.6
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• pp.335-343
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• 2012

Mercury is emitted to the atmosphere from various natural and anthropogenic sources, and degrades with difficulty in the environment. Mercury exists as various species, mainly elemental ($Hg^0$) and divalent ($Hg^{2+}$) mercury depending on its oxidation states in air and water. Mercury emitted to the atmosphere can be deposited into aqueous environments by wet and dry depositions, and some can be re-emitted into the atmosphere. The deposited mercury species, mainly $Hg^{2+}$, can react with various organic compounds in water and sediment by biotic reactions mediated by sulfur-reducing bacteria, and abiotic reactions mediated by sunlight photolysis, resulting in conversion into organic mercury such as methylmercury (MeHg). MeHg can be bioaccumulated through the food web in the ecosystem, finally exposing humans who consume fish. For a better understanding of how humans are exposed to mercury in the environment, this review paper summarizes the mechanisms of emission, fate and transport, speciation chemistry, bioaccumulation, levels of contamination in environmental media, and finally exposure assessment of humans.