• 대한한방내과학회지
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• 제42권2호
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• pp.175-183
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• 2021

Diabetes mellitus, commonly known as diabetes, comprises a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Diabetes is classified into type 1 diabetes and type 2 diabetes, and the incidence and prevalence of diabetes, mostly type 2, have increased remarkably in recent decades. A diagnosis of type 2 diabetes is greatly influenced by heredity, and it is important to prevent diabetes in people with a family history by improving lifestyle and environmental factors. Controlling overeating, obesity, lack of exercise, and stress is effective to prevent diabetes. The patient in this case report had impaired fasting glucose and mild hyperlipidemia. The patient experienced improvements in these sequelae after the administration of herbal medicine (Yangkyuksanwha-tang) for 12 weeks and the implementation of a plant-based diet. The complete blood count, XXXX, fasting blood sugar, HbA1c, insulin, and C-peptide levels were measured, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and HOMA-β were calculated according to the FBS and fasting insulin levels. Total cholesterol, triglyceride, FBS, and HbA1c levels all decreased after 12 weeks compared with baseline measures. There was no change in the insulin secretory ability; the C-peptide level did not change as a result of β-cell function; and the HOMA-β level reflected an improved insulin secretory ability.

• Archives of Pharmacal Research
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• 제12권2호
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• pp.125-127
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• 1989

Effects of three types of dietary fibres on blood glucose and liver glycogen were studied in male rats. The fibres were used as 10% of the diet supplemented from dietary sources, white beans, peas and carrots. The experiment continued for 5 weeks. At the end of the experiment, fasting blood glucose and liver glycogen were determined. The results showed that replacing carrot fibres and pea fibres by white bean fibres produced significant reduction of blood glucose by 28% and 43%, respectively, while exchanging pea fibres by carrot fibres produced no significant reduction of blood glucose gy 20%. Liver glycogen level (mg/100 g liver) was not affected by altering the fibre type in the diet.

• Journal of Nutrition and Health
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• 제27권8호
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• pp.819-827
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• 1994

The present study was undertaken to evaluate the effects of 50% buckwheat diet on the body weight, organ weight, urine albumin, urine glucose, plasma glucose and plasma lipid in normal rats and diabetic rats treated with streptozotocin(STZ). The food intake, body weight, the level of urine glucose in diabetic buckwheat groups were not significantly different with diabetic control group. The level of urine albumin was lower in raw and steam buckwheat group than in the diabetic control group. Compared to the normal control group, liver and kidney weights were heavier in the diabetic groups. Pancreas weight was heavier diabetic buckwheat groups than in normal and diabetic control groups. Fasting plasma glucose level of diabetic buckwheat groups significantly decreased by 18-37% compared with the diabetic control group. Plasma triglyceride level of diabetic buckwheat groups significantly decreased by 34-50% compared with the diabetic control group. Plasma total cholesterol level of diabetic buckwheat groups decreased by 15-27% compared with the diabetic control group. The level of HDL-cholesterol was not affected by buckwheat diet. These results indicate that buckwheat is an effective therapeutic regimen for the control of metabolic derangements in diabetics.

• 생명과학회지
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• 제19권4호
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• pp.492-501
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• 2009

일반계 비만고교생 60명을 4그룹으로 구분, 웨이트트레이닝을 1일 60${\sim}$70분, 주 3회, 8주간 강도별(A group: control group, B group: $40{\sim}55%RM$, C group: $60{\sim}75%RM$, D group: $80{\sim}90%RM$)로 실시하여 대사증후군 5가지 인자(waist size, fasting glucose, TG, HDL-C, blood pressure) 개선을 위한 가장 효과적인 WT 강도를 알아보았다. Waist size의 감소는 운동군 모두 효과적이었으나 $40{\sim}55%RM$과 $60{\sim}75%RM$ 실시 그룹이 더욱 효과적이었고, TG의 감소도 운동군 모두 효과적이었으나 $40{\sim}55%RM$ RM 실시 그룹이 더욱 효과적이었다. Fasting glucose는 차이가 없었으며, HDL-C는 대조군보다 $80{\sim}90%RM$ 실시 그룹이 유의하게 증가하였고, blood pressure는 diastolic blood pressure는 차이가 없었고, systolic blood pressure는 다른 그룹보다 $40{\sim}55%RM$ 실시 그룹이 유의하게 감소하였다. 이러한 결과는 중 고강도보다는 오히려 저강도가 대사증후군 인자 개선에 효과적이라는 것을 시사하며, 웨이트트레이닝이 비만고교생의 대사증후군 위험 인자를 개선해준다는 사실을 확인하였다. 따라서, 비만고교생은 대사증후군 인자의 개선을 위해 $40{\sim}55%\;RM$의 웨이트트레이닝을 실시하는 것이 효과적이라 생각된다.

• 한국식품영양과학회지
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• 제45권7호
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• pp.1049-1056
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• 2016

본 연구는 2015년 7월부터 2016년 3월까지 내원한 대상자들을 공복혈당에 따라 정상군과 전당뇨병군으로 구분하고 각 대상자의 유제품 섭취량과 당뇨병 위험인자 및 전당뇨병 발병 유무와의 연관성을 분석하고자 하였다. 분석한 당뇨병 위험인자 중 특히 수축기 혈압과 이완기 혈압이 전당뇨병 발병 위험과 유제품 섭취량과 유의적인 연관성을 보였다. 또한, 유제품 섭취 수준에 따른 당뇨병 위험 인자의 특성에 있어 유의적인 차이는 없었지만 유제품 섭취량과 전당뇨병 발병 위험과 유의적인 음의 연관성을 보여주어 대규모 연구 수행의 필요성을 제안하였다. 그리고 당뇨병 관리의 대상을 전당뇨병 대상자까지 확대시켜 지속적인 공복혈당 모니터링을 실시하고, 당뇨병 예방 영양중재와 유제품 식사 가이드 라인을 개발하는 것이 중요하다.

• Journal of Preventive Medicine and Public Health
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• 제38권1호
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• pp.101-106
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• 2005

Objectives : We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases Methods : We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDLcholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. All the patients' GGT levels were within the normal range. Results : After adjustment were made for age, body mass index (BMI), smoking status, drinking frequency, exercise frequency and coffee intake, the serum GGT level was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.01), and triglyceride (p<0.01) in men, and it was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.05), triglyceride (p<0.01), and uric acid (p<0.01) in women. The associations were not significantly different depending on the status of alcohol drinking or obesity, except for the associations of serum GGT with diastolic blood pressure (P for interaction=0.04) and uric acid (P for interaction=0.04) between the lean and obese subjects. Conclusions : Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. These results suggest that GGT has important clinical implications as being more than just a marker of alcohol consumption and hepatobiliary disease.

• Journal of Preventive Medicine and Public Health
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• 제39권4호
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• pp.353-358
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• 2006

Objectives: An increase in the serum gamma-glutamyltransferase (GGT) concentration has been regarded as a marker of alcohol drinking or liver disease. Some reports, however, have suggested that the serum GGT may be a sensitive and early biomarker for the development of prediabetes and diabetes. In this study we investigated whether serum GGT is a reliable predictor of the incident impaired fasting glucose (IFG), including diabetes. Methods: We performed a prospective study for two years (2002-2004). We analyzed the periodic health examination data from a total of 4,711 men. The examinations were done in the years 2002 and 2004. The analyzed data included a self-questionnaire, a physical examination and the laboratory results. Both IFG and diabetes were defined as a serum fasting glucose concentration of more than 100 mg/dL and 126 mg/dL, respectively. Results: A total of 738 cases (15.7%) of incident IFG and 13 cases (0.3%) of diabetes occurred. The mean serum GGT concentrations were quite different between the normal (38.0 IU) and incident IFG groups (50.3 IU), and the incident diabetes group (66.0 IU) (p<0.001). After multivariable adjustment, the relative risks for incident IFG or diabetes across the baseline GGT categories (<10th, 10th-20th, 30th-40th, 50th-60th, 70th-80th and >90th percentile) were 1.0, 1.172 (0.769-1.785), 1.107 (0.725-1.689), 1.444 (0.934-2.232), 2.061 (1.401-3.031) and 2.545 (1.784-3.631) (p-value for trend: <0.001). The risks significantly increased with increasing levels of GGT for 2 years; when comparing the increased groups (<10%, 10-20%, >20%) versus the decreased over 20% group of GGT, the risks for IFG or diabetes were 1.334 (1.002-1.776), 1.613 (1.183-2.199) and 1.399 (1.092-1.794). Conclusions: Our findings suggest that serum GGT concentrations within its normal range may be an early predictor of the development of IFG and diabetes. As serum GGT is a relatively inexpensive test and a reliable marker, it might have important implications in public health promotion.

• Clinical and Experimental Reproductive Medicine
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• 제32권2호
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• pp.155-164
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• 2005

Objective: This study was performed to investigate the effects of pioglitazone, an insulin sensitizing agent, on insulin resistance, ovarian function and intraovarian stromal blood flow in patients with polycystic ovarian syndrome (PCOS). Material and Methods: Thirty patients with PCOS, aged 18~34 years, were recruited. Criteria for diagnosis of PCOS were as defined in 2003 Rotterdam consensus. They were treated for 6 months with pioglitazone at a dose of 30 mg/day orally. The hormonal blood profile, fasting serum glucose levels, a glycemic response to 75 g oral glucose tolerance test (OGTT), and an ovarian stromal artery (OSA) blood flow were assessed at baseline and after 6 months of treatment. Results: Eighteen (60.0%) of 30 patients treated with pioglitazone demonstrated a spontaneous ovulation After pioglitazone treatment, fasting insulin concentrations, serum glucose levels after 75 g OGTT significantly decreased (p=0.001, p=0.04, respectively), and fasting glucose to insulin (G/I) ratio significantly increased (p<0.001). The pioglitazone treatment induced a significant reduction in serum LH, testosterone (T) and free T levels (p<0.001, p=0.02, p=0.002, respectively). The resistance index (RI) values of OSA significantly increased after treatment (p<0.001). In analyzing pioglitazone-treated patients according to their body mass index (BMI), nonobese group as well as obese group showed a significant improvement in fasting G/I ratio (p<0.01). The pioglitazone treatment induced a significant reduction in serum LH and free T levels in nonobese group (p<0.001, p<0.05, respectively) as well as obese group (p=0.001, p<0.05, respectively). The RI values of OSA significantly increased in both nonobese and obese groups after pioglitazone treatment (p<0.001, p=0.003, respectively). Conclusions: Pioglitazone could ameliorate the glycoinsulinemic metabolism, and this beneficial effects of this drug could improve the endocrine-reproductive condition associated with the decrease of ovarian stromal artery blood flow, in both nonobese and obese patients with PCOS.

• Preventive Nutrition and Food Science
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• 제10권1호
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• pp.34-39
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• 2005

This study examined the anti-diabetic effect of a silkworm extract in C57BL/6J mice, an ob/㏈ model, fed a high fat diet for 8 weeks. The body weight was not significantly different with the silkworm-extract supplement, nor did food intake and body weight gains also did not differ significantly among the high-fat diet groups. However, the water intake by the silkworm-extract supplemented groups increased significantly compared with that by the distilled-water supplement group, nonetheless, the FER did not differ significantly. For all groups, the blood glucose increased the most after 30 minutes and yet returned to a fasting level within 90 minutes. The fasting time and resulting glucose tolerance for the silkworm-extract supplemented groups were significantly decreased compared to that for the high fat diet with distilled water supplement group, while the level of blood glucose in silkworm-extract supplemented groups was significantly decreased compared with than in the diabetic control group. The HbA1c and insulin levels were no different among the groups. The sucrase and lactase activities in the proximal small intestine were significantly decreased in the silkworm-extract supplement groups compared to that in the diabetic control group. There was no significant difference in the glycogen contents in the liver and muscle among the groups. In conclusion, it was found that the silkworm-extract supplement repressed the disaccharidase activity in the small intestines mucosa of the C57BL/6J mice.

• 한국식품영양학회지
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• 제22권2호
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• pp.302-307
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• 2009

The present study was designed to clarify the antidiabetic activity and mechanism of Dioscorea rhizome in diabetic db/db mice. Mice were administered Dioscorea rhizome and rosiglitazone orally for 7 weeks and the effects of these compounds on fasting blood glucose, glucose tolerance and intestinal disaccharidase activity in db/db mice were evaluated. The fasting serum glucose of the D. rhizome treated group was reduced when compared with that of the db/db control group. In addition, the disaccharidase activities in homogenates of the proximal, middle and distal segment of the small intestine were significantly decreased response to D. rhizome treatment, especially in the middle segment. These results suggest that D. rhizome decreases blood glucose via a decrease in the activity of disaccharidase in the mucosa of the middle region of the small intestine in db/db mice.