대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

양격산화탕 투여와 식이요법을 병행하여 호전된 공복혈당장애 증례 보고

Case Report of Impaired Fasting Glucose Improved with Korean Medicine Treatment and Dietetic Therapy

  • 김은미 (세명대학교 부속 제천한방병원 내과학교실) ;
  • 김기태 (세명대학교 부속 제천한방병원 내과학교실)
  • Kim, Eun-mi (Dept. of Internal Medicine of Clinical Korean Medicine, Se-Myung University Jecheon Hospital) ;
  • Kim, Ki-tae (Dept. of Internal Medicine of Clinical Korean Medicine, Se-Myung University Jecheon Hospital)
  • 투고 : 2021.03.26
  • 심사 : 2021.05.25
  • 발행 : 2021.05.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Diabetes mellitus, commonly known as diabetes, comprises a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Diabetes is classified into type 1 diabetes and type 2 diabetes, and the incidence and prevalence of diabetes, mostly type 2, have increased remarkably in recent decades. A diagnosis of type 2 diabetes is greatly influenced by heredity, and it is important to prevent diabetes in people with a family history by improving lifestyle and environmental factors. Controlling overeating, obesity, lack of exercise, and stress is effective to prevent diabetes. The patient in this case report had impaired fasting glucose and mild hyperlipidemia. The patient experienced improvements in these sequelae after the administration of herbal medicine (Yangkyuksanwha-tang) for 12 weeks and the implementation of a plant-based diet. The complete blood count, XXXX, fasting blood sugar, HbA1c, insulin, and C-peptide levels were measured, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and HOMA-β were calculated according to the FBS and fasting insulin levels. Total cholesterol, triglyceride, FBS, and HbA1c levels all decreased after 12 weeks compared with baseline measures. There was no change in the insulin secretory ability; the C-peptide level did not change as a result of β-cell function; and the HOMA-β level reflected an improved insulin secretory ability.

키워드

참고문헌

  1. Kim DH, Park SC, Lee JH, Lee HY, Cho MK, Choi JY, et al, Park SH. Recent Research Trends in Korean Medicine Treatment of Diabetes Mellitus(Focusing on Domestic Articles from 2008 to 2013). Korean J Orient Int Med 2013;34(3):240-55.
  2. World Health Organization. 10 facts about diabetes: diabetic programme[Internet] Geneva: World Health Organization; 2014.
  3. Kitada M, Koya D. SIRT in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes Metab J 2013;37(5):315-25. https://doi.org/10.4093/dmj.2013.37.5.315
  4. Yoo JM. Fasting Blood Glucose Disorder and Impaired Glucose Tolerance. A Monthly Diabetes Magazine 2006;11:32-3.
  5. Type 2 diabetes clinical research center designated by the Ministry of Health and Welfare. Instructional guidelines for diabetes treatment. Seoul: Gold Planning; 2008, p. 1-6.
  6. Association of Korean Medicine Professors for Nephro-Endocrine system. Nephro-Endocrine system. Seoul: Gunja; 2011, p. 89.
  7. Lee JM. Dongeuisusebowon. Seoul: Shinil Publishing Co: 1964, p. 70.
  8. McMacken M, Shah S. A plant-based diet for the prevention and treatment of type 2 diabetes. Journal of Geriatric Cardiology 2017;14(5):342-54. https://doi.org/10.11909/j.issn.1671-5411.2017.05.009
  9. Hong YH, Kim MA. Analysis of domestic nursing research on diabetes. Journal of Basic Nursing 2001;8(3):416-29.
  10. Statistical Office. Cause of death statistics in 2019. Daejeon: Statistics Korea; 2020.
  11. Choi CS, Park SW. Review : The mechanism of development of insulin resistance in type 2 diabetes mellitus. The Korean Journal of Medicine 2002;63(6):613-25.
  12. Chun KH. Evidence-based management and treatment of highrisk individuals with pre-diabetes. J Korean Med Assoc 2011;54(10):1020-7. https://doi.org/10.5124/jkma.2011.54.10.1020
  13. Kim IS, Kim MS, Lee YS. Case Report:The Hypoglycemic Effect of Gamiyookmigihwang-tang on A Mild Diabetes Mellitus patient with Impaired Glucose Tolerance & Impaired Fasting Glucose. Korean J Oriental Physiology & Pathology 2013;27(5):677-82.
  14. Ko Jade HJ, Kim DJ, Kim SN. Effects of Acupuncture Treatment on Weight Loss and Glucose Intolerance Induced by a Ketogenic Diet. Korean Journal of Acupuncture 2019;36(4):274-80. https://doi.org/10.14406/acu.2019.033a
  15. Campbell MK, Farrell SO. Biochemistry 8th Ed. Stamford(CT): Cengage Learning; 2015.
  16. Boren J, Williams KJ. The central role of arterial retention of cho-lesterol-rich apolipoprotein-Bcontaining lipoproteins in thepathogenesis of atherosclerosis: a triumph of simplicity. Curr OpinLipidol 2016;27(5):473-83. https://doi.org/10.1097/MOL.0000000000000330
  17. Turley SD, Dietschy JM. Sterol absorption by the small intestine. Curr Opin Lipidol 2003;14(3):233-40. https://doi.org/10.1097/00041433-200306000-00002
  18. Lally S, Tan CY, Owens D, Tomkin GH. Messenger RNA levels ofgenes involved in dysregulation of postprandial lipoproteins intype 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-bindingcassette, transporters G5 and G8, and of microsomal triglyceridetransfer protein. Diabetologia 2006;49(5):1008-16. https://doi.org/10.1007/s00125-006-0177-8
  19. Sim YJ. A Low-carbohydrate and High-fat Diet. Korean J Obes 2016 December;25(4):188-9. https://doi.org/10.7570/kjo.2016.25.4.188
  20. Lee HJ, Shin GJ, Park SH, Cho HK. Insulin Resistance and Visceral Fat Obesity in Hyperlipidemia. Korean Circulation J 1999;29(7):673-9. https://doi.org/10.4070/kcj.1999.29.7.673
  21. Choi CS. Pathogenesis of insulin resistance. The Korean Journal of Medicine 2009;77(2):171-7.
  22. Kim CH. Nutritional Management of the Patients with Diabetes. Hanyang Medical Reviews 2011;31(4):220-7. https://doi.org/10.7599/hmr.2011.31.4.220
  23. Jung SI, Kim JW. Clinical Study about the Diabetes Mellitus Patients Administration of Yangkyuksanwha-tang. Korean J Orental Physiology & Pathology 2002;16(6):1308-13.
  24. Kim EJ, Kim YS. Effects of Yanggyuksanhwa-tnag on Diabetic Rats Induced by Streptozotocin. Korean J Oriental Physiology & Pathology 2007;21(2):474-8.
  25. Yates AP, Laing I. Age-related increase in haemoglobin A1c and fasting plasma glucose is accompanied by a decrease in beta cell function without change in insulin sensitivity: evidence from a cross-sectional study of hospital personnel. Diabet Med 2002;19(3):254-8. https://doi.org/10.1046/j.1464-5491.2002.00644.x
  26. Nah EH, Cho HI. Relationship between Hemoglobin A1c Levels and Metabolic Syndrome using Data Collected during a Medical Check-ups Program. Lab Med Online 2011;1(1):3-9. https://doi.org/10.3343/lmo.2011.1.1.2
  27. Shim WS, Kim SK, Kim HJ, Park SE, Kang ES, Rhee YM, et al. Clinical Meaning of Postprandial Insulin Secretory Function in Korean Type 2 Diabetes Mellitus. J Kor Diabetes Assoc 2005;29(4):367-77.
  28. Kim JH, Lee LY, Lee SH. Assessment of Insulin Resistance and Its Clinical Application. J Korean Soc Endocrinol 2009;24(2):75-83. https://doi.org/10.3803/jkes.2009.24.2.75
  29. Choi ES, Rhee EJ, Kim JH, Won JC, Park CY, Lee WY, et al. InsulinSensitivity and Insulin Secretion Determined by HomeostasisModel Assessment and Future Risk of Diabetes Mellitus in KoreanMen. Korean Diabetes J 2008;32(6):498-505 https://doi.org/10.4093/kdj.2008.32.6.498