• The Journal of the Korea Contents Association
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• v.17 no.6
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• pp.527-539
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• 2017

This case study examines the experiences of an African American student's successful second language acquisition in Korea. There is an increasing number of multicultural families in Korea; but few research on African American students' second language learning. In the past, some American researchers have analyzed African American students as academic underachievers for learning and there is a scarcity of research on African American students' successfully acquiring a second language. With this qualitative research design, the researchers interviewed, and observed an African American girl named Mary. The researchers also interviewed Mary's mother, teacher, and peers about Mary's Korean language development. The results of this study revealed Mary's determined efforts to become a fluent Korean speaker with support from family, community and friends. Mary underwent unique social and systematic supports for her language development. This paper concludes with the educational implication for multicultural language learners in Korea and the possibility to diminish the common stereotypes of African Americans as underachievers.

• Journal of Microbiology and Biotechnology
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• v.19 no.8
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• pp.765-773
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• 2009

Edwardsiella tarda is a pathogen with a broad host range that includes human and animals. The E. tarda hemolysin (Eth) system, which comprises EthA and EthB, is a noted virulence element that is widely distributed in pathogenic isolates of E. tarda. Previous study has shown that the expression of ethB is regulated by iron, which suggests the possibility that the ferric uptake regulator (Fur) is involved in the regulation of ethB. The work presented in this report supports the previous findings and demonstrates that ethB expression was decreased under conditions when the E. tarda Fur ($Fur_{Et}$) was overproduced, and enhanced when $Fur_{Et}$ was inactivated. We also identified a second ethB regulator, EthR, which is a transcription regulator of the GntR family. EthR represses ethB expression by direct interaction with the ethB promoter region. In addition to ethB, EthR also modulates, but positively, luxS expression and AI-2 production by binding to the luxS promoter region. The expression of ethR itself is subject to negative autoregulation; interference with this regulation by overexpressing ethR during the process of infection caused (i) drastic changes in ethB and luxS expressions, (ii) vitiation in the tissue dissemination and survival ability of the bacterium, and (iii) significant attenuation of the overall bacterial virulence. These results not only provide new insights into the regulation mechanisms of the Eth hemolysin and LuxS/AI-2 quorum sensing systems but also highlight the importance of these systems in bacterial virulence.

• The Journal of the Korea Contents Association
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• v.17 no.8
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• pp.570-578
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• 2017

This study aims to develop suitable and appropriate support models for ADHD children to provide effective and efficient support for the target children. The diverse characteristics of target area, educational, social conditions, and supporting organization and delivery systems have been comprehensively considered. Domestic and overseas literature review has been performed to analyze the status of support services for ADHD children to develop the model. The FGI was adapted to identify eligibility and expectations for the qualification of ADHD children and the awareness and expectations of relevant professionals. Based on the theoretical rationale and empirical analysis results derived from these systematic procedures, suitable and appropriate support models were developed for ADHD children as a special educational subjects. The support model includes the development of individualized support programs for the needs of the entire ADHD student population, which require screening and assessment of the entire student population and requiring support for special needs. Support methods were developed in a system that supports family support, educational support, medical assistance, and medical support.

• Korea journal of population studies
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• v.35 no.1
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• pp.1-30
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• 2012

This study explores the effects of spousal dissimilarity on marital stability among transnational couples in Korea. Utilizing micro-data from the 2009 Korean National Multi-culture Family Survey, this paper examines whether formation of transnational marriage generally involves positive assortative matching on age and education. Indices of age dissimilarity and educational dissimilarity are calculated for each country of origin of the foreign wife, and their relationships to the average duration of marriage are analyzed. This study also conducts a micro-level analysis of whether age and educational dissimilarity between spouses helps explain variations in marital duration and probability of getting divorced. Results show greater incidences of spousal dissimilarity in age and educational attainment among transnational couples, which supports the transnational openness hypothesis proposed in this paper. The extant hypothesis that spousal dissimilarity increases the risk of marital dissolution and shortens the duration of marriage is not found to fit transnational couples in Korea.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7947-7950
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• 2014

Background: Pancreatic cancer is the sixth leading cause of cancer death with an increasing trend in China. Dietary intake is believed to play an important role in pancreatic cancer carcinogenesis. The aim of this paper was to evaluate associations between some dietary factors and risk of pancreatic cancer in a multi-centre case-control study conducted in China. Materials and Methods: Cases (n=323) were ascertained from four provincial cancer hospitals. Controls (n=323) were randomly selected from the family members of patients without pancreatic cancer in the same hospitals, 1:1 matched to cases by gender, age and study center. Data were collected with a questionnaire by personal interview. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using conditional logistic regression. Results: Tea intake (OR =0.49; 95%CI: 0.30-0.80) was associated with a half reduction in risk of pancreatic cancer. Reduced vegetable consumption (P trend: 0.04) was significant related to pancreatic cancer. Although no significant association was found for meat and fruit, ORs were all above or below the reference group. A protective effect was found for fruit (OR=1.73 for consumption of 1-2 times/week vs more than 3 times/week; 95%CI: 1.05-2.86). A high intake of meat was associated to a higher risk of pancreatic cancer (OR=0.59 for consumption of 1-2 times/week vs. more than 3 times/week; 95%CI: 0.35-0.97). Conclusions: The present study supports fruit consumption to reduce pancreatic cancer risk and indicates that high consumption of meat is related to an elevated risk. Direct inverse relations with tea and vegetable intake were also confirmed.

• Korean Journal of Social Welfare
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• v.37
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• pp.241-269
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• 1999

This study investigated the relationship between social support and the well-being among the unemployed. Special attention was given to the empirical tests of the main effect and the stress buffering effect of social support on the psychosocial well-being and the practical implications in developing service strategies for the unemployed. Three-hundred-Sixty-nine(369) unemployed people in Choong-ju City and surrounding areas participated to the study. The results showed that both main and direct effects were partially supported by the data. In exploring the direct effect, social support from the family showed the strongest positive effect on the well-being of the unemployed. In the test of the stress buffering effect, the results showed a marginal buffering role of social support against the negative impacts of stress. Drawn from the results, the needs for further research in investigating the social support theory were suggested and possible implications for developing social work intervention strategies for the unemployed were identified.

• Human Ecology Research
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• v.58 no.1
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• pp.105-120
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• 2020

This study helps infant teachers practice a constructivism-based teacher education program that supports infant mathematical inquiry activities and examines improvements in mathematical teaching knowledge, mathematical teaching initiatives, mathematical interaction, constructivism belief and mathematical teaching efficacy. Twenty two experiment group infant teachers and twenty two comparison group infant teachers were chosen at two workforce educare centers. The experiment group infant teachers participated in 18 sessions of a constructivism teacher training program for 8 weeks, but the comparison group infant teachers did not take part in the program. Pretest and post-tests were implemented for the mathematical teaching knowledge, mathematical teaching initiatives, mathematical interactions, constructivism belief and mathematical teaching efficacy in the experiment group. Independent sample t-test and ANCOVA were tested using Windows SPSS statistics 21.0. The homogeneity test for the experiment and comparison group revealed significant differences. ANCOVA was carried out after the pretest score was controlled as a co-variance. Significant differences were indicated in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. The results indicated that a constructivism-based teacher education program to support infant mathematical inquiry activities influenced improvements in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. This study proved the effects of the program based on constructivism theory content for the knowledge, skills and attitude about infant teaching of mathematical initiatives and practiced a program of exploration, investigation, application and assessment for infant teachers. The results can help infant teachers teach mathematical exploration activities and help activate infant mathematical exploration activities.

• The Korean Nurse
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• v.28 no.3
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• pp.83-93
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• 1989

This study analysed marital comflicts, related factors, and adjustments to those conflicts described by urban Korean women. The purpose was to discover directions for resolution that would enhance the helpfulness of volunteers or prfessionals working with women in counselling settings. The investigator interviewed 20 married women, all mothers and housewives living in Seoul, attending marriage encounter programs and the Lifeline telephone counselling service. An interview schedule using six open-ended questiona guided the data colleciton which took place between May 31 and December 29, 1988. Content analysis of the data revealed, in order of reported frequency, the following areas of conflict: relationships between husband wife, relationships with children, relationships between the wife and her mother-in-Law, unsatisfied sexual needs, the husband's extra marital relationships, lack of self actualization and finacial matters. Analysis of the data suggested the following factors were related to the conflicts: reasons for marriage, traditional views about marriage and divorce including to accept a marriage arranged by the parents, the husband's traditonal attitude toward the sex role of the wife, the husband's patriarchical authoritarianism, and his attitude toward the wife;s empolyment outside the home. The women thought these conflicts severely affected their relationships within the famaily, particularly with their children. Literature suggests links with such poor parent-child-family relationships and adolescent or young people's social problems. Volunteers or professionals working with married women in counselling situation need to be conscious of the possibility of these conflict during assessment, and direct their guidance toward such conflict resolution. The researcher makes several suggestions which include the need for the husband to give emotional supports to his wife, to recognize the worth of housework, to share the work of the home, to fine ways to enhance the wife's self-actualization and to ease dreary housework routines by prviding modern appliances.

• Journal of Microbiology and Biotechnology
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• v.26 no.12
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• pp.2019-2029
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• 2016

Zinc finger proteins are among the most extensively applied metalloproteins in the field of biotechnology owing to their unique structural and functional aspects as transcriptional and translational regulators. The classical zinc fingers are the largest family of zinc proteins and they provide critical roles in physiological systems from prokaryotes to eukaryotes. Two cysteine and two histidine residues ($Cys_2His_2$) coordinate to the zinc ion for the structural functions to generate a ${\beta}{\beta}{\alpha}$ fold, and this secondary structure supports specific interactions with their binding partners, including DNA, RNA, lipids, proteins, and small molecules. In this account, the structural similarity and differences of well-known $Cys_2His_2$-type zinc fingers such as zinc interaction factor 268 (ZIF268), transcription factor IIIA (TFIIIA), GAGA, and Ros will be explained. These proteins perform their specific roles in species from archaea to eukaryotes and they show significant structural similarity; however, their aligned amino acids present low sequence homology. These zinc finger proteins have different numbers of domains for their structural roles to maintain biological progress through transcriptional regulations from exogenous stresses. The superimposed structures of these finger domains provide interesting details when these fingers are applied to specific gene binding and editing. The structural information in this study will aid in the selection of unique types of zinc finger applications in vivo and in vitro approaches, because biophysical backgrounds including complex structures and binding affinities aid in the protein design area.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.04a
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• pp.147-153
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• 2007

Central to developing new treatment strategies for late onset sporadic Parkinson's disease (PD) and early onset familial PD is resolving the enigma of the specific vulnerability exhibited by substantia nigra dopamine (DA) neurons despite multiple risk factors. Neuropathological evidence from both human and experimental models of PD firmly supports a significant role for oxidative stress (OS) and mitochondrial dysfunction in the death of nigral DA neurons. Largely unknown are the genes underlying selective susceptibility of nigral DA neuron to OS and mitochondrial dysfunction and how they effect nigral DA cell death. To overcome the paucity of nigral DA neurons as well as the dilution effect of non-DA cells in brain tissues, we have developed wild type DA cell line model, SN4741 and mutant DJ-1 (-/-) DA cells, appropriate for microarray analysis and differential mitochondrial proteomics. Mutations in the DJ-1 gene (PARK7), localized in cytoplasm and mitochondria, cause autosomal recessive early onset PD. Through microarray analysis using SN4741 cells followed by validation tests, we have identified a novel phylogenically conserved neuroprotective gene, Oxi-a, which is specifically expressed in DA neurons. The knockdown of the gene dramatically increased vulnerability to as. Importantly as down-regulated the expression level of the gene and recovery of its expression via transient transfection exerted significant neuroprotection against as insult. We also have identified altered expression of mitochondrial proteins and other familial PD genes in DJ-1 (-/-) mutant cells by differential mitochondrial proteomics. In DJ-1 (-/-) cells the knockdown of the other familial PD genes (Parkin and PINK1) dramatically increased susceptibility to as. Thus, further functional characterization of the Oxi-$\alpha$ gene family and the mitochondrial alteration in the DJ-1 (-/-) cell model will provide the rationale for the neuroprotective therapy against both sporadic and familial PD.