• BMB Reports
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• 제53권3호
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• pp.125-132
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• 2020

Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca²⁺ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca²⁺ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer.

• 가족자원경영과 정책
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• 제26권1호
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• pp.59-73
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• 2022

이 연구는 질적 연구 방법론에 의한 현장사례연구로서, 공동육아나눔터의 주요 기능과 운영상의 문제 및 활성화 조건을 탐구한 것이다. 지역(대도시·중소도시·군단위), 개소 시기, 운영기관, 위치, 맞벌이자녀초등전담돌봄 여부, 2020년 돌봄공동체시범사업 참여 여부 등을 고려하여 전국 8지역을 사례로 선정하였다. 공동연구자가 각 센터 현장을 함께 방문하여 센터장 혹은 전담직원을 대상으로 반구조화된 질문지를 활용하여 심층면접을 진행하였다. 면접자료를 전사하여 34개의 하위범주와 12개의 범주를 구성하고, 공동육아나눔터의 주요기능과 운영상의 어려움 그리고 활성화 조건이라는 세 가지 주제를 도출하였다. 이러한 주제를 토대로 공동육아나눔터 활성화방안을 제안하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제14권3호
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• pp.157-161
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• 2010

Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB) locomotor rating scale, before and after spinal hemisection at T13 level. We also examined lesion size in the spinal cord using Luxol fast blue/cresyl violet staining. One day after injury, KO and WT mice showed no significant difference in the motor function due to complete paralysis following spinal hemisection. However, when it compared to WT mice, KO mice had significantly delayed and decreased functional outcomes from 4 days up to 21 days after SCI. KO mice also showed significantly greater lesion size in the spinal cord than WT mice showed at 21 days after spinal hemisection. These results suggest that Hsp70 has a protective effect against traumatic SCI and the manipulation of the hsp70.1 gene may help improve the recovery of motor function, thereby enhancing neuroprotection after SCI.

• 한국콘텐츠학회논문지
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• 제17권8호
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• pp.597-609
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• 2017

본 연구는 학교 밖 청소년의 가정폭력피해경험이 또래폭력가해에 미치는 영향과 이 과정에서 불안과 공격성의 매개효과를 검증하는 것을 목적으로 하였다. 연구대상은 충북의 학교 밖 청소년 169명이다. 자료는 SPSS를 활용하여 분석하였으며 매개효과를 검증하기 위해 Sobel test를 실시하였다. 연구결과를 보면 먼저, 가정폭력피해는 또래폭력가해에 정적인 영향을 미쳐 직접효과가 있었다. 다음으로 가정폭력피해와 또래폭력가해와의 관계에서 불안과 공격성의 매개역할을 검증한 결과, 공격성의 간접효과는 유의하게 나타났으나 불안은 유의하지 않았다. 이러한 결과는 가정폭력피해가 학교 밖 청소년의 또래폭력가해를 높이는 중요한 요인으로 가정폭력피해를 줄이기 위한 개입 및 또래폭력 예방을 위한 공격성 감소 노력이 필요함을 시사한다. 이를 통해 본 연구는 학업중단 후 학교 밖 청소년과 그 가족에 대한 신속한 개입, 가족관계 및 기능 강화, 학교 밖 청소년의 임파워먼트 강화, 학교 밖 청소년에 대한 사회의 인식 전환을 제안하였다.

• 한국잠사곤충학회지
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• 제54권1_2호
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• pp.1-5
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• 2016

The dpp gene originated from the silkworms is an important gene that is well conserved in the genome of humans, cattle, rodents, poultry and Drosophila. The dpp gene belonging to the TGF-beta (Transforming Growth Factor-beta) superfamily is known to play an important role in several developmental stages. The $TGF-{\beta}$ gene family is a genetically well-conserved and playing an important role gene family in various species such as determining cell proliferation and differentiation, apoptosis and cell fate. In this review, we have confirmed the following studies data. The recent studies on the silkworm dpp gene have confirmed for the first time the biological functions such as promoting osteogenesis activity. In addition, previous data shows that dpp have developmental functions such as morphogenetic materials at the blastophyllum stage, induction of the mesoblast at the late embryonic stage and involved in the proliferation and morphogenesis of imaginal disc in adult development. We found the splice variant of the dpp gene originated from the wildtype silkworm by using comparative genomics. It has provided important data for basic research based on genetics studies of these processes may promote a better understanding of evolution. Silkworm is a medicinal insect and is approved for its safety. It is used as a natural antibiotic for promoting growth as a medical material, a health functional food, and a feed additive. Therefore, it is necessary to present various data to obtain more value of functional insect.

• BMB Reports
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• 제56권3호
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• pp.172-177
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• 2023

BEST family is a class of Ca²⁺-activated Cl- channels evolutionary well conserved from bacteria to human. The human BEST paralogs (BEST1-BEST4) share significant amino acid sequence homology in the N-terminal region, which forms the transmembrane helicases and contains the direct calcium-binding site, Ca²⁺-clasp. But the cytosolic C-terminal region is less conserved in the paralogs. Interestingly, this domain-specific sequence conservation is also found in the BEST1 orthologs. However, the functional role of the C-terminal region in the BEST channels is still poorly understood. Thus, we aimed to understand the functional role of the C-terminal region in the human and mouse BEST1 channels by using electrophysiological recordings. We found that the calcium-dependent activation of BEST1 channels can be modulated by the C-terminal region. The C-terminal deletion hBEST1 reduced the Ca²⁺-dependent current activation and the hBEST1-mBEST1 chimera showed a significantly reduced calcium sensitivity to hBEST1 in the HEK293 cells. And the C-terminal domain could regulate cellular expression and plasma membrane targeting of BEST1 channels. Our results can provide a basis for understanding the C-terminal roles in the structure-function of BEST family proteins.

• 가정과삶의질연구
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• 제2권1호
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• pp.131-150
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• 1984

The purpose of this study is to explore the family as an interaction system, concentrating on the mutual influences between communication and family development; (1) how Communication patterns affect family relationships, and (2) how relationships among family members affect communication. In order to do this Galvin, Brommel used the following frame work; family is a system in which communication regulates cohesion and adaptability by a flow of message patterns through a defined network of evolving interdependent relationships. A family system consists of members, the relationships among them, the family attributes, the members attributes and an environment in which family functions. Within the framework of common cultural communication patterns, each family has the capacity to develop its own communication code based on the experiences of individual members and the collective family experience. Most of us develop our communication skills within the family context learning both the general cultural language and the specific familial communication code. Communication may be viewed as a symbolic, transactional process as the process of creating and sharing meanings. To say that communication is a process implies a continuous interaction of an indefinite large numbers of variables with a concomitant,. continuous change in the values taken by these variables. Finally the process implies change, Family functions include the primary functions of cohesion and adaptability, and supporting functions of family images, themes, boundaries, and biosocial issues. The primary functions reveal concepts integrated family interaction and supporting function, along with those of cohesion and adaptability, give shape to family life. the characteristics of developed relationships of richness, uniqueness efficiency, substitutability, pacing , openness spontaneity, and evaluation are reflected in the verbal and nonverbal behaviors with which family members negotiated a set of common meanings and develop thier own unique message system. The message system is the major element of communication process and influences both the form and the content of thier relationship and in create and share meanings. Family systems need to provide order and predictability for thier members, specifically focusing on communication rules and the networks by which messages are transmitted. Most rules emerge as a result of multiful interactions. There are basic rules and rules about rules, or metarules. Perceiving the rules of family system is very difficult because often family members don't think about the basic rules, much less the metarules. Breaking the rule may result in the creation of a new set because the system may recalibrate itself to accept more variety of behavior. Families develop communication networks to deal with the general issue. Family adaptability may be seen through the degree of flexibility in forming and reforming networks and networks become a vital part of the decision- making process and relate to the power dynamics operating within the family. Networks also play an integral part in maintaining the roles and rules operating with the family system. Thus networks and rules have mutual influence. The family -of -origin issues influence all aspects of family communication and account for many of the communication patterns, rules and networks and the role of the family -of-origin influences as a primary force for communication on behavior of newly forming systems. Each family system develops its own communication meanings. There is not one right way to communicate within a family but may be indefinitly large change of family life and communication behavior. Study on functional family communication helps to gain a better understanding of dynamics of family communication and ability of a new insight into the family.

• International Journal of Human Ecology
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• 제4권2호
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• pp.89-100
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• 2003

This paper identifies trends in research methodology due to globalization. Context in both research and in practice and forms the key perspective for modern methodology and theory. Ecological perspectives are a necessary condition for quality global research. Human ecology researchers must advance the role of interdisciplinary and inter-functional perspectives and be open to collaborative relationships. These researchers must work in teams across disciplinary and functional boundaries. The paper discusses directions for research within the context of trends at U.S. federal agencies with applications to globalization and family life. Trends include： (a) use of diverse but rigorous methodologies； (b) recognition of the research-practice-research feedback loop；(c) primacy of context and diverse sampling; and (d) connections of research to problem solving. The terms promoted recently such as ″relationships″, ″diversity″ or ″problem-based″ are ingrained in human ecology. Key aspects for research in the next decade will be： (a) seeking diversity in sampling； (b) seeking colleagues with different perspectives； (c) incorporating meta-analysis into our work； (d) seeking meaningful results； (e) utilizing varieties of research methodologies to address our problems； and (0 understanding that practice must continually change as a function of research.

• 대한가정학회지
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• 제43권3호
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• pp.75-89
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• 2005

The purpose of this study was to examine the effects of the mentoring function and its levels as perceived by the fashion merchandisers and designers in the fashion industry who are playing major roles in providing organizational socialization for mentees. A survey questionnaire was developed and conducted among 200 fashion merchandisers and designers in Seoul. For data analysis, the SPSS 10.0 program was employed and frequency analysis, factor analysis, reliability analysis, correlation analysis, recurrence analysis, T-test, and ANOVA were used to test the research questions. The results were as follows: (1) Although the overall level of the mentoring function recognized by the fashion merchandisers and designers in the study appeared to be high, there were no significant differences by their demographic attributes. (2) The level of the mentoring function acknowledged by the respondents demonstrated substantial differences according to their perception by the personal attributes and the degree of openness. (3) The level of the mentoring function and organizational socialization perceived by the respondents had a significant correlation. As the level of perceived mentoring function of the respondents increased, it appeared that the degree of their job satisfaction and organizational commitment increased. On the other hand, their role ambiguity and turnover intention decreased.

• Architectural research
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• 제19권1호
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• pp.13-19
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• 2017

In banquets of royal courts held in the late Joseon Dynasty, a procedure that follows the customs as well as physical components to follow that procedure were necessary. A noticeable trait of the red blinds(朱簾) is that they are seen in the naeyon(內宴) types of banquets, which is mostly centered on the queen dowager and relatives, and they function as a makeshift facility that divide the different banquet spaces according to the hierarchy of the royal family. Furthermore, the red blinds within the court played an important role in the procedure of the banquet along with the incense, as it was drawn upon the queen dowager's appearance to signal the beginning, and folded out again to signal the end. This indicates that they were of higher importance within the banquet space. The red blinds used in the playacting stage of the royal court not only segmented the space, but also upon being taken down, expanded and integrated the banquet hall, thereby maximizing the playacting stage. Once the banquet was finished, the red blinds within the court were once again folded out so as to restore dignity to the space. The red blind is a symbolic item that could open the private space of the court so as to enable communication with the public space, and also close it off to restore privacy. Also, the layout of the banquet space was divided by the red blinds into primary, secondary, and tertiary hierarchal space, according to the status of the royal family and the banquet attendants. In other words, the red blinds played an important role in its the symbolic meaning in the national precedent as well as distinguishing the hierarchy of space within the naeyon banquet in the royal court.