• 한국콘텐츠학회논문지
• /
• 제17권6호
• /
• pp.527-539
• /
• 2017

본 연구는 아프리카계 미국인 학생의 한국에서의 성공적인 제 2 언어 학습 경험을 조사하였다. 한국에 많은 다문화 가정들이 있지만, 아프리카계 미국인 학생들의 제 2 언어 학습에 관한 연구는 부족하다. 과거에, 몇 몇 미국 연구자들은 아프리카계 미국 학생들을 학습부진아들로 분석하였지만, 그들의 제 2 언어 학습의 성공적인 사례에 대한 보고는 거의 없다. 질적 연구 방법론을 사용하여, 본 연구자들은 메리라는 한 아프리카계 미국인 여학생을 인터뷰하고 관찰조사 하였다. 또한, 메리의 어머니, 선생님, 그리고 친구들을 인터뷰하여, 메리의 한국어 발달에 대하여 조사하였다. 연구 결과로 메리의 한국어 화자로서의 노력은 가족, 한국사회, 그리고 친구들의 도움으로 이루어졌다. 메리는 언어 발달에 있어서 특별한 사회적 조직적 지원들을 경험했음을 또 한 묘사하였다. 본 연구는 한국에 있는 다문화 학습자들 교육에 대한 교육적 시사점을 논의하고, 아프리카계 미국인 학습자에 대한 부정적인 편견을 극복할 수 있는 가능성에 대하여 토론하였다.

• Journal of Microbiology and Biotechnology
• /
• 제19권8호
• /
• pp.765-773
• /
• 2009

Edwardsiella tarda is a pathogen with a broad host range that includes human and animals. The E. tarda hemolysin (Eth) system, which comprises EthA and EthB, is a noted virulence element that is widely distributed in pathogenic isolates of E. tarda. Previous study has shown that the expression of ethB is regulated by iron, which suggests the possibility that the ferric uptake regulator (Fur) is involved in the regulation of ethB. The work presented in this report supports the previous findings and demonstrates that ethB expression was decreased under conditions when the E. tarda Fur ($Fur_{Et}$) was overproduced, and enhanced when $Fur_{Et}$ was inactivated. We also identified a second ethB regulator, EthR, which is a transcription regulator of the GntR family. EthR represses ethB expression by direct interaction with the ethB promoter region. In addition to ethB, EthR also modulates, but positively, luxS expression and AI-2 production by binding to the luxS promoter region. The expression of ethR itself is subject to negative autoregulation; interference with this regulation by overexpressing ethR during the process of infection caused (i) drastic changes in ethB and luxS expressions, (ii) vitiation in the tissue dissemination and survival ability of the bacterium, and (iii) significant attenuation of the overall bacterial virulence. These results not only provide new insights into the regulation mechanisms of the Eth hemolysin and LuxS/AI-2 quorum sensing systems but also highlight the importance of these systems in bacterial virulence.

• 한국콘텐츠학회논문지
• /
• 제17권8호
• /
• pp.570-578
• /
• 2017

본 연구는 특수교육 대상자로서 ADHD 아동에게 효과적이고 효율적인 지원을 제공하기 위해 ADHD 아동에게 타당하고 적합한 지원 모형을 개발하는데 목적이 있다. 이를 위해 다양한 특성과 교육적, 사회적 여건, 그리고 지원 주체와 전달 체계 등을 포괄적으로 고려하였다. 지원 모형을 개발하기 위해 ADHD 아동의 적격성과 지원 요구 그리고 이에 대한 관련 전문가들의 인식과 기대를 확인하기 위해 FGI를 실시하였다. 이러한 체계적인 절차와 방법을 통해 도출한 이론적 근거와 실증적 분석결과에 근거하여 특수교육 대상으로서 ADHD 아동에게 타당하고 적합한 지원 모형을 개발하였다. 지원 모형은 전체 학생을 대상으로 선별과정을 거쳐서 진단 및 평가를 하고 특수교육 대상으로 지원이 필요한 경우 ADHD 아동의 요구에 맞는 개별화 지원 프로그램의 개발을 포함하고 있다. 지원 방법에는 가족지원, 교육지원, 의료지원, 치료지원을 받을 수 있는 체계로 모형을 개발하였다.

• 한국인구학
• /
• 제35권1호
• /
• pp.1-30
• /
• 2012

이 연구의 주된 목적은 한국에 거주하는 국제결혼 부부의 사회인구학적 상이성이 결혼안정성에 미치는 영향을 파악하는 것이다. 이 연구는 "2009년 전국 다문화가족 실태조사" 자료를 활용하여 국제결혼이 연령과 교육수준이 동질적인 선택혼(positive assortative matching)의 형태로 이루어지는가의 여부를 확인하고자 시도하였다. 그리고 외국인 아내의 출신국가별로 부부의 연령상이성과 교육상이성 지수를 계산하고, 이 지수들과 평균 결혼지속기간과의 관계를 분석하였다. 이 연구는 또한 미시수준에서 부부의 연령 및 교육수준 격차가 결혼만족도, 결혼지속기간과 이혼확률의 편차를 설명하는데 얼마나 도움이 되는가를 검증하였다. 이 연구의 분석결과, 국제결혼 부부의 연령과 교육수준 격차가 내국인 부부들의 경우보다 현저하게 크게 나타나는 것으로 확인되었다. 또한, 외국인 아내를 구하는 한국 남자들이 배우자와의 사회인구학적 격차에 대해 보다 개방적이고 융통적일 것이라고 가정한 국제결혼개방성 가설(the transnational openness hypothesis)이 지지되었다. 부부의 사회인구학적 격차가 커질수록 결혼의 해체가능성이 높아지고 결혼지속기간이 짧아질 것이라는 기존 연구의 가설은 한국에 거주하는 국제결혼 부부들에는 적용되지 않는 것으로 밝혀졌다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권18호
• /
• pp.7947-7950
• /
• 2014

Background: Pancreatic cancer is the sixth leading cause of cancer death with an increasing trend in China. Dietary intake is believed to play an important role in pancreatic cancer carcinogenesis. The aim of this paper was to evaluate associations between some dietary factors and risk of pancreatic cancer in a multi-centre case-control study conducted in China. Materials and Methods: Cases (n=323) were ascertained from four provincial cancer hospitals. Controls (n=323) were randomly selected from the family members of patients without pancreatic cancer in the same hospitals, 1:1 matched to cases by gender, age and study center. Data were collected with a questionnaire by personal interview. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using conditional logistic regression. Results: Tea intake (OR =0.49; 95%CI: 0.30-0.80) was associated with a half reduction in risk of pancreatic cancer. Reduced vegetable consumption (P trend: 0.04) was significant related to pancreatic cancer. Although no significant association was found for meat and fruit, ORs were all above or below the reference group. A protective effect was found for fruit (OR=1.73 for consumption of 1-2 times/week vs more than 3 times/week; 95%CI: 1.05-2.86). A high intake of meat was associated to a higher risk of pancreatic cancer (OR=0.59 for consumption of 1-2 times/week vs. more than 3 times/week; 95%CI: 0.35-0.97). Conclusions: The present study supports fruit consumption to reduce pancreatic cancer risk and indicates that high consumption of meat is related to an elevated risk. Direct inverse relations with tea and vegetable intake were also confirmed.

• 한국사회복지학
• /
• 제37권
• /
• pp.241-269
• /
• 1999

본 연구는 사회적 지지가 실직자의 심리사회적 안녕감에 갖는 영향을 탐구함으로서 사회적 지지이론에 대한 경험적 분석과 실직자를 위한 사회복지서비스 전략개발을 목적으로 수행되었다. 충청북도, 충주시 및 인근지역에 거주하는 369명의 실직자를 대상으로 설문조사를 실시, 사회적 지지가 실직자의 심리사회적 상태에 미치는 주효과(main effect)가설과 스트레스 완충효과(stress buffering effect)가설을 탐구하였다. 연구결과는 사회적 지지의 주효과가설과 스트레스 완충효과가설의 부분적인 검증을 시사하였다. 사회적 지지의 주효과에 대한 검증에서는 가족으로부터의 지지가 표본 실직자들에게 가장 유용한 사회적 지지의 출처였고 실직자의 심리사회적 안녕감에 가장 긍정적인 영향을 주는 요인으로 밝혀졌다. 또 사회적 지지의 스트레스완충효과가설이 검증이 된 경우에도 완충효과는 그다지 크지 않았던 것으로 분석되었다. 본 연구결과를 바탕으로 사회적 지지의 이론 검증을 위한 추후연구방향이 제시되었고 실직자를 위한 사회복지서비스 개발전략에 대한 시사점이 제기되었다.

• Human Ecology Research
• /
• 제58권1호
• /
• pp.105-120
• /
• 2020

This study helps infant teachers practice a constructivism-based teacher education program that supports infant mathematical inquiry activities and examines improvements in mathematical teaching knowledge, mathematical teaching initiatives, mathematical interaction, constructivism belief and mathematical teaching efficacy. Twenty two experiment group infant teachers and twenty two comparison group infant teachers were chosen at two workforce educare centers. The experiment group infant teachers participated in 18 sessions of a constructivism teacher training program for 8 weeks, but the comparison group infant teachers did not take part in the program. Pretest and post-tests were implemented for the mathematical teaching knowledge, mathematical teaching initiatives, mathematical interactions, constructivism belief and mathematical teaching efficacy in the experiment group. Independent sample t-test and ANCOVA were tested using Windows SPSS statistics 21.0. The homogeneity test for the experiment and comparison group revealed significant differences. ANCOVA was carried out after the pretest score was controlled as a co-variance. Significant differences were indicated in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. The results indicated that a constructivism-based teacher education program to support infant mathematical inquiry activities influenced improvements in mathematical teaching knowledge, mathematical teaching initiative, mathematical interaction, constructivism belief and mathematical teaching efficacy. This study proved the effects of the program based on constructivism theory content for the knowledge, skills and attitude about infant teaching of mathematical initiatives and practiced a program of exploration, investigation, application and assessment for infant teachers. The results can help infant teachers teach mathematical exploration activities and help activate infant mathematical exploration activities.

• 대한간호
• /
• 제28권3호
• /
• pp.83-93
• /
• 1989

This study analysed marital comflicts, related factors, and adjustments to those conflicts described by urban Korean women. The purpose was to discover directions for resolution that would enhance the helpfulness of volunteers or prfessionals working with women in counselling settings. The investigator interviewed 20 married women, all mothers and housewives living in Seoul, attending marriage encounter programs and the Lifeline telephone counselling service. An interview schedule using six open-ended questiona guided the data colleciton which took place between May 31 and December 29, 1988. Content analysis of the data revealed, in order of reported frequency, the following areas of conflict: relationships between husband wife, relationships with children, relationships between the wife and her mother-in-Law, unsatisfied sexual needs, the husband's extra marital relationships, lack of self actualization and finacial matters. Analysis of the data suggested the following factors were related to the conflicts: reasons for marriage, traditional views about marriage and divorce including to accept a marriage arranged by the parents, the husband's traditonal attitude toward the sex role of the wife, the husband's patriarchical authoritarianism, and his attitude toward the wife;s empolyment outside the home. The women thought these conflicts severely affected their relationships within the famaily, particularly with their children. Literature suggests links with such poor parent-child-family relationships and adolescent or young people's social problems. Volunteers or professionals working with married women in counselling situation need to be conscious of the possibility of these conflict during assessment, and direct their guidance toward such conflict resolution. The researcher makes several suggestions which include the need for the husband to give emotional supports to his wife, to recognize the worth of housework, to share the work of the home, to fine ways to enhance the wife's self-actualization and to ease dreary housework routines by prviding modern appliances.

• Journal of Microbiology and Biotechnology
• /
• 제26권12호
• /
• pp.2019-2029
• /
• 2016

Zinc finger proteins are among the most extensively applied metalloproteins in the field of biotechnology owing to their unique structural and functional aspects as transcriptional and translational regulators. The classical zinc fingers are the largest family of zinc proteins and they provide critical roles in physiological systems from prokaryotes to eukaryotes. Two cysteine and two histidine residues ($Cys_2His_2$) coordinate to the zinc ion for the structural functions to generate a ${\beta}{\beta}{\alpha}$ fold, and this secondary structure supports specific interactions with their binding partners, including DNA, RNA, lipids, proteins, and small molecules. In this account, the structural similarity and differences of well-known $Cys_2His_2$-type zinc fingers such as zinc interaction factor 268 (ZIF268), transcription factor IIIA (TFIIIA), GAGA, and Ros will be explained. These proteins perform their specific roles in species from archaea to eukaryotes and they show significant structural similarity; however, their aligned amino acids present low sequence homology. These zinc finger proteins have different numbers of domains for their structural roles to maintain biological progress through transcriptional regulations from exogenous stresses. The superimposed structures of these finger domains provide interesting details when these fingers are applied to specific gene binding and editing. The structural information in this study will aid in the selection of unique types of zinc finger applications in vivo and in vitro approaches, because biophysical backgrounds including complex structures and binding affinities aid in the protein design area.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
• /
• pp.147-153
• /
• 2007

Central to developing new treatment strategies for late onset sporadic Parkinson's disease (PD) and early onset familial PD is resolving the enigma of the specific vulnerability exhibited by substantia nigra dopamine (DA) neurons despite multiple risk factors. Neuropathological evidence from both human and experimental models of PD firmly supports a significant role for oxidative stress (OS) and mitochondrial dysfunction in the death of nigral DA neurons. Largely unknown are the genes underlying selective susceptibility of nigral DA neuron to OS and mitochondrial dysfunction and how they effect nigral DA cell death. To overcome the paucity of nigral DA neurons as well as the dilution effect of non-DA cells in brain tissues, we have developed wild type DA cell line model, SN4741 and mutant DJ-1 (-/-) DA cells, appropriate for microarray analysis and differential mitochondrial proteomics. Mutations in the DJ-1 gene (PARK7), localized in cytoplasm and mitochondria, cause autosomal recessive early onset PD. Through microarray analysis using SN4741 cells followed by validation tests, we have identified a novel phylogenically conserved neuroprotective gene, Oxi-a, which is specifically expressed in DA neurons. The knockdown of the gene dramatically increased vulnerability to as. Importantly as down-regulated the expression level of the gene and recovery of its expression via transient transfection exerted significant neuroprotection against as insult. We also have identified altered expression of mitochondrial proteins and other familial PD genes in DJ-1 (-/-) mutant cells by differential mitochondrial proteomics. In DJ-1 (-/-) cells the knockdown of the other familial PD genes (Parkin and PINK1) dramatically increased susceptibility to as. Thus, further functional characterization of the Oxi-$\alpha$ gene family and the mitochondrial alteration in the DJ-1 (-/-) cell model will provide the rationale for the neuroprotective therapy against both sporadic and familial PD.