• Archives of Plastic Surgery
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• v.49 no.1
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• pp.12-18
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• 2022

Botulinum toxin treatment is the most common non-surgical cosmetic treatment. Although there are many available treatments using botulinum toxin, their effects are temporary and repeated injections are required. These frequent injections can trigger an immunological response. In addition, botulinum toxin acts as an antigen in the body; thus, its effect disappears progressively due to this immunological reaction, which may cause treatment failure. Active botulinum toxin consists of a core neurotoxin and complexing proteins, the exact effects of which remain unclear. However, the complexing proteins are closely related to the immune response and the formation of neutralizing antibodies. Since neutralizing antibodies can lead to treatment failure, their formation should be prevented. Furthermore, various methods of detecting neutralizing antibodies have been used to predict treatment failure.

• Knowledge Management Research
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• v.9 no.1
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• pp.61-76
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• 2008

The purpose of this study is to examine the effects of lifelong learners' learned helplessness and failure tolerance on academic achievement and job performance. The result of this empirical study exhibits that learned helplessness has negative effects on their academic achievement and job performance. Failure tolerance, however, has positive effects on their academic achievement and job performance. In addition, their academic achievement has mediated between learned helplessness and/or failure tolerance, and job performance. This study suggests that lifelong learners' positive response to failures is helpful for both learning and working performances.

• Ocean Systems Engineering
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• v.9 no.3
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• pp.219-240
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• 2019

This paper presents the comparison between SFT response with linear and nonlinear cables. The dynamic response analysis of submerged floating tunnel (SFT) is presented computationally with linear and nonlinear tension legs cables. The analysis is performed computationally for two wave directions one at 90 degrees (perpendicular) to tunnel and other at 45 degrees to the tunnel. The tension legs or cables are assumed as linear and non- linear and the analysis is also performed by assuming one tension leg or cable is failed. The Response Amplitude Operators (RAO's) are computed for first order waves, second order waves for both failure and non-failure case of cables. For first order waves- the SFT response is higher for sway and heave degree of freedom with nonlinear cables as compared with linear cables. For second order waves the SFT response in sway degree of freedom is bit higher response with linear cables as compared with nonlinear cables and the SFT in heave degree of freedom has higher response at low time periods with nonlinear cables as compared with linear cables. For irregular waves the power spectral densities (PSD's) has been computed for sway and heave degrees of freedom, at $45^0$ wave direction PSD's are higher with linear cables as compared with nonlinear cables and at $90^0$ wave direction the PSD's are higher with non-linear cables. The mooring force responses are also computed in y and z directions for linear and nonlinear cables.

• Advances in Computational Design
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• v.1 no.1
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• pp.105-117
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• 2016

The objective of this work is to study the restraining effect in fire resistance of framed structures and to evaluate the global response of reinforced concrete frames when exposed to fire based on advanced finite element method. To study the response a single portal frame is analyzed. The effect of floor slab on this frame is studied by modeling a beam-column-slab assembly. The evolution of temperature distribution, internal stresses and deformations of the frame subjected to ISO 834 standard fire curve for both the frames are studied. The thermal and structural responses are evaluated and a comparison of results of individual members and entire structure is done. From the study it can be seen that restraining forces has significant influence on both stresses and deflection and overall response of the structure when compared to individual structural member. Among the various structural elements, columns are the critical members in fire and failure of column causes the failure of entire structure. The fire rating of various structural elements of the frame is determined by various failure criteria and is compared with IS456 2000 tabulated fire rating.

• Structural Engineering and Mechanics
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• v.35 no.3
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• pp.335-348
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• 2010

Cutouts are often provided in structural and aircraft components for ventilation, for access, inspection, electric lines and fuel lines or sometimes to lighten the structure. This paper addresses the effects of cutout shape (i.e., circular, square, diamond, elliptical-vertical and elliptical-horizontal) and size on buckling and postbuckling response of quasi-isotropic (i.e., $(+45/-45/0/90)_{2s}$) composite laminate under uni-axial compression. The finite element method is used to carry out the investigation. The formulation is based on first order shear deformation theory and von Karman's assumptions are used to incorporate geometric nonlinearity. The 3-D Tsai-Hill criterion is used to predict the failure of a lamina while the onset of delamination is predicted by the interlaminar failure criterion. It is observed that for the smaller size cutout area there is no significant effect of cutout shape on load-deflection response of the laminate. It is also concluded that the cutout size has substantial influence on the buckling and postbuckling response of the laminate with elliptical-horizontal cutout, while this effect is observed to be the least in case of laminate with elliptical-vertical cutout.

• Structural Engineering and Mechanics
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• v.47 no.1
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• pp.45-58
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• 2013

In structural reliability analysis, the response surface method is a powerful method to evaluate the probability of failure. However, the location of experimental points used to form a response surface function must be selected in a judicious way. It is necessary for the highly nonlinear limit state functions to consider the design point and the nonlinear trend of the limit state, because both of them influence the probability of failure. In this paper, in order to approximate the actual limit state more accurately, experimental points are selected close to the design point and the actual limit state, and consider the nonlinear trend of the limit state. Linear, quadratic and cubic polynomials without mixed terms are utilized to approximate the actual limit state. The direct Monte Carlo simulation on the approximated limit state is carried out to determine the probability of failure. Four examples are given to demonstrate the efficiency and the accuracy of the proposed method for both numerical and implicit limit states.

• Structural Engineering and Mechanics
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• v.42 no.2
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• pp.175-189
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• 2012

This paper presents an algorithm for structural reliability with the response surface method. For this aim, an approach with three stages is proposed named as improved response surface method. In the algorithm, firstly, a quadratic approximate function is formed and design point is determined with First Order Reliability Method. Secondly, a point close to the exact limit state function is searched using the design point. Lastly, vector projected method is used to generate the sample points and Second Order Reliability Method is performed to obtain reliability index and probability of failure. Five numerical examples are selected to illustrate the proposed algorithm. The limit state functions of three examples (cantilever beam, highly nonlinear limit state function and dynamic response of an oscillator) are defined explicitly and the others (frame and truss structures) are defined implicitly. ANSYS finite element program is utilized to obtain the response of the structures which are needed in the reliability analysis of implicit limit state functions. The results (reliability index, probability of failure and limit state function evaluations) obtained from the improved response surface are compared with those of Monte Carlo Simulation, First Order Reliability Method, Second Order Reliability Method and Classical Response Surface Method. According to the results, proposed algorithm gives better results for both reliability index and limit state function evaluations.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.187-190
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• 2001

Response surface method is applied to evaluate the reliability of laminated composite panels. Since the linear and nonlinear first-ply failure load are computed using deterministic finite element analysis, new probabilistic finite element analysis is not necessary. Tsai-Wu criterion is used to construct the limit state suface. Material properties, layer thickness and lamina strengths of laminated composite panel are treated as random design variables. feasibility and accuracy of current method is validated using Monte-Carlo method Which perform thousand times of finite element analysis directly.

• Journal of Mechanical Science and Technology
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• v.20 no.2
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• pp.205-211
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• 2006

Among other critical conditions in rotor systems the large non-linear vibration excited by bearing non-linearity causes the rotor failure. For reducing this catastrophic failure and predictive detection of this phenomenon the analysis of orthotropic bearing non-linearity in rotor system using higher order frequency response functions (HFRFs) is conducted and is shown to be theoretically feasible as that of non-rotating structures. The complex HFRFs based on the Volterra series are newly developed for the process and investigated their features by using the simple forms of the FRFs associated with the forward and the backward modes.

• Journal of the Korea Society of Computer and Information
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• v.24 no.4
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• pp.107-112
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• 2019

Failure testing is a test that verifies that the system is operating in accordance with failure response requirements. A typical failure test approaches the operating system by identifying and testing system problems caused by unexpected errors during the operational phase. In this paper, we study how to evaluate these Failure at the software development stage. Evaluate the probability of failure due to code changes through the complexity and duplication of the code, and evaluate the probability of failure due to exceptional situations with bugs and test coverage extracted from static analysis. This paper studies the possibility of failure based on the code quality of software development stage.