• Title/Summary/Keyword: Factor of Rupture

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Transforming Growth Factor β Receptor Type I Inhibitor, Galunisertib, Has No Beneficial Effects on Aneurysmal Pathological Changes in Marfan Mice

  • Park, Jeong-Ho;Kim, Min-Seob;Ham, Seokran;Park, Eon Sub;Kim, Koung Li;Suh, Wonhee
    • Biomolecules & Therapeutics
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    • v.28 no.1
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    • pp.98-103
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    • 2020
  • Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 (Fbn1) gene, has vascular manifestations including aortic aneurysm, dissection, and rupture. Its vascular pathogenesis is assumed to be attributed to increased transforming growth factor β (TGFβ) signaling and blockade of excessive TGFβ signaling has been thought to prevent dissection and aneurysm formation. Here, we investigated whether galunisertib, a potent small-molecule inhibitor of TGFβ receptor I (TβRI), attenuates aneurysmal disease in a murine model of MFS (Fbn1C1039G/+) and compared the impact of galuninsertib on the MFS-related vascular pathogenesis with that of losartan, a prophylactic agent routinely used for patients with MFS. Fbn1C1039G/+ mice were administered galunisertib or losartan for 8 weeks, and their ascending aortas were assessed for histopathological changes and phosphorylation of Smad2 and extracellular signal-regulated kinase 1/2 (Erk1/2). Mice treated with galunisertib or losartan barely exhibited phosphorylated Smad2, suggesting that both drugs effectively blocked overactivated canonical TGFβ signaling in Fbn1C1039G/+ mice. However, galunisertib treatment did not attenuate disrupted medial wall architecture and only partially decreased Erk1/2 phosphorylation, whereas losartan significantly inhibited MFS-associated aortopathy and markedly decreased Erk1/2 phosphorylation in Fbn1C1039G/+ mice. These data unexpectedly revealed that galunisertib, a TβRI inhibitor, showed no benefits in aneurysmal disease in MFS mice although it completely blocked Smad2 phosphorylation. The significant losartan-induced inhibition of both aortic vascular pathogenesis and Smad2 phosphorylation implied that canonical TGFβ signaling might not prominently drive aneurysmal diseases in MFS mice.

Dynamic response of coal and rocks under high strain rate

  • Zhou, Jingxuan;Zhu, Chuanjie;Ren, Jie;Lu, Ximiao;Ma, Cong;Li, Ziye
    • Geomechanics and Engineering
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    • v.29 no.4
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    • pp.451-461
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    • 2022
  • The roadways surrounded by rock and coal will lose their stability or even collapse under rock burst. Rock burst mainly involves an evolution of dynamic loading which behaves quite differently from static or quasi-static loading. To compare the dynamic response of coal and rocks with different static strengths, three different rocks and bituminous coal were selected for testing at three different dynamic loadings. It's found that the dynamic compression strength of rocks and bituminous coal is much greater than the static compression strength. The dynamic compression strength and dynamic increase factor of the rocks both increase linearly with the increase of the strain rate, while those of the bituminous coal are irregular due to the characteristics of multi-fracture and heterogeneity. Moreover, the absorbed energy of the rocks and bituminous coal both increase linearly with an increase in the strain rate. And the ratio of absorbed energy to the total energy of bituminous coal is greater than that of rocks. With the increase of dynamic loading, the failure degree of the sample increases, with the increase of the static compressive strength, the damage degree also increases. The static compassion strength of the bituminous coal is lower than that of rocks, so the number of small-scale fragments was the largest after bituminous coal rupture.

Helium-Air Exchange Flow with Fluids Interaction (유체간섭을 동반하는 헬륨과 공기의 치환류)

  • T.I. Kang
    • Journal of Advanced Marine Engineering and Technology
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    • v.21 no.4
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    • pp.372-380
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    • 1997
  • This paper describes experimental investigations of helium-air exchange flows through parti¬tioned opening and two-opening. Such exchange flows may occur following rupture accident of stand pipe in high temperature gas cooled reactor. A test vessel with the two types of small open¬ing on top of test cylinder is used for experiments. An estimation method of mass increment is developed and applied to measure the exchange flow rate. A technique of flow visualization by Mach-Zehnder interferometer is provided to recognize the exchange flows. In the case of exchange flow through the partitioned opening, flow passages of upward flow of the helium and downward flow of the air within the opening are separated by vertical partition, and the two flows interact out of entrance and exit of the opening. Therefore, an experiment of the exchange flow through two-opening is made to investigate effect of the fluids interaction of the partitioned opening sys¬tem. As a result of comparison of the exchange flow rates between the two types of the opening system, it is found that the exchange flow rate of the two-opening system is larger than that of the partitioned opening system due to absence of the effect of fluids interaction. Finally, the fluids interaction between the upward and downward flows through the partitioned opening is found to be an important factor on the helium-air exchange flow.

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Reliability Analysis for Stress Corrosion Cracking of Suspension Bridge Wires (현수교케이블의 응력부식에 관한 신뢰성해석)

  • Taejun;Andrzej S. Nowak
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2003.04a
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    • pp.537-544
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    • 2003
  • This paper deals with stress corrosion cracking behavior of high strength steel exposed to marine environments. The objective is to determine the time to failure as a function of hydrogen concentration and tensile stress in the wires. A crack growth curve is modeled using finite element method (FEM) program. The coupled hydrogen diffusion-stress analyses of SCC were programmed separately. The first part is calculating stress and stress intensity /sup 1)/factor of a cylindrical shell, prestressing tendon or suspension bridge wires, from the initiation of cracks to rupture. Virtual crack extension method, contour integral method, and crack tip elements are used for the calculation of stresses in front of the crack tip. Comparisons of the result show a good agreement with the analytical equations and wire tests. The second part of the study deals with the programming of hydrogen diffusion, affected by hydrostatic stress, calculated at the location of boundary of plastic area around the crack tip. The results of paper can be used in the design and management of prestressed structures, cable stayed and suspension bridges. Time dependent correlated parallel reliabilities of a cable, composed of 36 wires, were evaluated by the consideration of the deterioration of stress corrosion cracking.

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A Study on the Safety of Small LPG Storage Tanks at External Fires (외부화재시 LPG 소형저장탱크의 안전성에 관한 연구)

  • Yim, Ji-Pyo;Ma, Byung-Chol;Chung, Chang-Bock
    • Journal of the Korean Society of Safety
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    • v.30 no.4
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    • pp.64-72
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    • 2015
  • The purpose of this study is to study the safety of a small LPG storage tank with a capacity less than 3 ton when it is exposed to an external fire. First, simulation studies were carried out using ASPEN Plus and PHAST to demonstrate that overpressurization in the tank can be relieved by discharging the LPG through an adequately sized safety valve, but the release may lead to the secondary risk of fire and explosion around the tank. Next, the temporal variations of the temperatures of the lading and tank wall were obtained using AFFTAC, which showed that the tank wall adjacent to the vapor space could be overheated in about 11 min to such a point that the weakened strength might cause a rupture of the tank and subsequent BLEVE. The consequences of the BLEVE were estimated using PHAST. Finally, several practical measures for preventing the hazards of overheating were suggested, including an anti-explosion device, sprinkling system, insulation, heat-proof coating, and enhanced safety factor for tank fabrication. The effectiveness of these measures were examined by simulations using AFFTAC and ASPEN Plus.

Ovarian stimulation and liver dysfunction: Is a clinical relationship possible? A case of hepatic failure after repeated cycles of ovarian stimulation

  • Giugliano, Emilio;Cagnazzo, Elisa;Pansini, Giancarlo;Vesce, Fortunato;Marci, Roberto
    • Clinical and Experimental Reproductive Medicine
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    • v.40 no.1
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    • pp.38-41
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    • 2013
  • Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.

Estradiol Valerate Exerts Neuroprotective Effects in Ischemic Rat Brain when Administered after Middle Cerebral Artery Occlusion

  • Yoo, Seong-Jin;Yu, Jeong-Min;Youm, Mi-Young;Kim, Do-Rim;Kim, Jee-Yun;Kang, Sung-Goo
    • Proceedings of the Korean Society of Embryo Transfer Conference
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    • 2002.11a
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    • pp.111-111
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    • 2002
  • Stroke occurs when local thrombosis, embolic particle or the rupture of blood vessele interrupts the blood floe to the brain. $\beta$-estradiol 17-valerate has been reported to exert neuroprotective effects when administered before an ischemic insult. Recently, the pathophysiology of cerebral ischemia has been studied extensively in rat with various methods. In the present study, we investigates whether $\beta$-estrodiol 17-valerate can protect against brain injury. RNA sample were extracted from the hippocampus of female rat, reverse-transcription in the presence of [$\alpha$32p] dATP. Differential gene express-ion profiles were revealed (Bone morphogenetic protein type 1A receptor, Protein disulphide isomerase, Leukemia inhibitor factor receptor, cytochrome bc- 1 complex-x core P, thiol-specific antioxidant protein). RT-PCR was used to validate the relative expression pattern obtained by the cDNA array. The precise relationship between the early expression of recovery genes and stroke is a matter of luther investigation. This Study was supported by the Korea Science and Engineering Foundation(KOSEF) through the Biohealth Products Research Center(BPRC), Inje University, Korea.

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Stress Corrosion Cracking Behavior under Cavitation Erosion-Corrosion in Sea Water-Part (II) (해수환경중 캐비테이션 침식-부식 하에서의 응력부식균열 거동 (II))

  • 안석환;임우조
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.2
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    • pp.139-146
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    • 2000
  • Cavitation can occur in pipes when liquid is moving at high velocity, especially at pittings where the smooth bore of the pipe is interrupted. The effect is usually to produce pitting on the downstream side of the turbulence. However, stress corrosion cracking behavior under cavitation erosion-corrosion was neatly unknown. In this study, therefore, some were investigated of stress corrosion cracking behavior, others were stress corrosion cracking behavior under cavitation erosion-corrosion of water injection. And datas obtained as the results of experiment were compared between the two. Mainresult obtained are as follows: 1) Stress corrosion cracking growth rate of heat affected zone under cavitation erosion-corrosion becomes most rapid, and stress intensity factor $K_1$becomes most high. 2) Stress corrosion cracking growth mechanism by cavitation erosion-corrosion is judgement on the strength of the film rupture model and the tunnel model. 3) The range of potential as passivation of heat affected zone is less noble than that of base metal, and that value is smaller. 4) Corrosion potential under cavitation erosion-corrosion in loaded stress is less noble than that of stress corrosion, and corrosion current density is higher.

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Effect of Multi-Layer Carbon Fiber Sheet Used for Strengthening Reinforced Concrete Beams

  • You Young-Chan;Choi Ki-Sun;Kim Keung-Hwan
    • Journal of the Korea Concrete Institute
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    • v.17 no.1 s.85
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    • pp.149-155
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    • 2005
  • The purpose of this study is to investigate the flexural strengthening effects of CF(Carbon Fiber) sheet for the full-scale RC beams with multi-layer CF sheets. The partial strength reduction factors of CF sheets are suggested from the full-scale RC beams tests strengthened with multi-layer CF sheets up to six layers as well as material tests. From the material tensile tests, it was observed that the average tensile strengths of CF sheets per layer are decreased as the number of CF sheets is increased. Also the steep strength reductions of CF sheets in material test results at rupture are observed compared with the structural tests results for the full-scale RC beams strengthened with multi-layer CF sheets. Finally, the partial strength reduction factors far CF sheets up to six layers are suggested considering the effects of multi-layer and unit weight of CF sheets.

A Study on Properties Cu-Sn Matrix Used in Diamond Wheel for Grinding Glass (Diamond Wheel용 Cu-Sn 기지의 유리연삭에 미치는 특성에 관한 연구)

  • Choi, Sung-Kook;Suh, Hyung-Suck;Choe, Jeong-Cheol
    • Journal of Korea Foundry Society
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    • v.12 no.4
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    • pp.317-325
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    • 1992
  • Diamond is the hardest material known to humans, also possesses the highest thermal conductivity and a very low thermal expansion coefficient. Therefore, these properties of diamond make them logical choices for many difficult grinding application. Bonding material is a very important factor to performance of a grinding wheel. Grinding glass constitutes one of the major application areas of diamond grinding wheels, and Cu-Sn tin bronze matrix is widely used as a metal bond of diamond wheel in grinding glass but these studies are rarely reported. The bronze test pieces excluding diamond are sintered by the method of hot sizing respectively at $600^{\circ}C$, $650^{\circ}C$, $700^{\circ}C$, with a composition(Cu-10wt%Sn) on ${\alpha}$ phase and two compositions(Cu-20wt%Sn and Cu-23wt%Sn) on ${\alpha}+{\beta}$ phase. The rupture strength of Cu-10wt%Sn is highest. The bronze bonded diamond wheels are manufactured by same conditions as the bronze test pieces. The results of grinding ratio of wheels are highest in case of Cu-10wt%Sn bonded wheel sintered at $650^{\circ}C$ and grinding power is highest in same composition sintered at $700^{\circ}C$.

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