• Journal of Korean Medicine Rehabilitation
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• v.30 no.1
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• pp.13-29
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• 2020

Objectives This study was performed to decide the bone union effect of Hwaweo-jeon on tibia fractured mice. Methods In this study, laboratory experiments were implemented by the stage of in vitro and in vivo. In in vitro, MC3T3-E1 cells were treated with various concentration of Hwaweo-jeon extract (HWJ). To investigate effect of HWJ for osteoblast, relative mRNA expression of 5 substances (alkaline phosphatase [ALP], runt-related transcription factor 2 [Runx2], osteocalcin [OCN], osterix [OSX] and collagen type II alpha 1 chain [Col2a1]) was used as a marker of osteogenesis. In order to determine HWJ's effect for fracture healing, relative gene expression level of ALP, Runx2, OCN, OSX and Col2a1 were used to find out the influence to osteoblast. Furthermore, receptor activator of nuclear factor kappa-B ligand and osteoprotegerin relative mRNA expression were used to estimate the impact to osteoclast. Also, X-ray was used for the purpose of identifying bone union in tibia-fracture mouse model. Results In in vitro experiment, most part of relative mRNA expression were increased compared to control group. In in vivo and in vitro experiment, HWJ induced osteoblast activitation by verifying relative mRNA expression of 5 substances. And in vivo experiment, we can also identify that HWJ triggered osteoclast activation during early stage of tibia fracture. Furthermore, X-ray pictures show noticeable recovery of tibia fracture. Conclusions HWJ extract promotes bone union by facilitating the osteoblast. But, HWJ may occur liver & kidney toxicity over specific concentration. Therefore, when HWJ is applied to human body, doctors have to follow up the liver function test & renal function test of patient.

• The Journal of Society for e-Business Studies
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• v.13 no.2
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• pp.117-147
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• 2008

Developing various ubiquitous computing services (U-services) is being propelled throughout the industry. As U-services are being penetrated into our daily life, research on the factors influencing the acceptance of U-services is highly needed. In this line of study, we examined previous literatures about information technology acceptance and UTAUT model, and applied UTAUT model to U-service acceptance. To characterize the U-services into our research model, we newly introduced 'context based personalization' factor. Since the respondents could not directly experience the U-services yet, we adopted scenario-based questionnaire. For this, we deliberately developed U-service scenario. And then this U-service scenario is verified using capability-based assessment method. Using data collected from 251 respondents, this study found that 'context based personalization' factor was positively and significantly related to the acceptance of U-service as well as UTAUT model's 4 factors such as performance expectancy, effort expectancy, social influence and facilitating conditions.

• International Commerce and Information Review
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• v.16 no.2
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• pp.221-249
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• 2014

This study analyzed the sufficient conditions for Korean firm's foreign subsidiaries in order to evolve into a center of excellence for knowledge creation and diffusion. In this respect, the purpose of this study is to develop a new framework based on literatures related to subsidiary knowledge creation and a center of excellence. Specifically, we created seven decisive factors for subsidiary knowledge creation: two general factors, two strategic important factors, and three excellent factors. Each factor can be a necessary condition or sufficient condition according to research purpose. For example, the decentralized organizational structure belonging to general factors become a sufficient factor for facilitating subsidiary's knowledge creation but it become a necessary condition for a center of excellence because all subsidiaries with decentralized organizational structure cannot be strategically important subsidiaries. By using seven decisive factors, this study examines the determinants' validity theoretically and practically.

• Korean Journal of Head & Neck Oncology
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• v.20 no.1
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• pp.13-18
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• 2004

Objectives: Cancer lethality is usually the result of local invasion and metastasis of neoplastic cell from the primary tumor. Because of their ability to degrade extracellular matrix components, matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) have been implicated in the breakdown of basement membrane and underlying stroma, thereby facilitating tumor growth and invasion. It has been well established that MMPs and bFGF expression correlate with cervical lymph node metastasis, but studies on expression in the metastatic cervical lymph node itself are not enough. We have analyzed matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) in squamous cell carcinoma of the head and neck and metastatic cervical lymph node, and evaluated their relationship and clinicophathologic significance. Material and Methods: 20 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for MMP-9 and bFGF in the obtained tissue from primary tumor and metastatic cervical lymph node. We analyzed the relationship between MMP-9, bFGF expression of the primary tumor and metastatic node with age, sex, T-stage, N-stage, histologic grade, pathologic stage and disease free survival. Results: Expression of MMP-9 and bFGF in cancer cell and metastatic lymph node was higher than that in normal cell and lymph node. According to histologic differentiation, expression of MMP-9 of the metastatic cervical lymph node was higher than primary tumor. Considering to other clinicopathologic factor, no statistical significance was seen in MMP-9 and bFGF. Conclusion: We found that expression of MMP-9 is higher in the metastatic lymph node than primary tumor in the poorly differentiated squamous cell carcinoma. But we don't find out the statistical significance in relation between bFGF and clinical factors. So we guess that some different mechanism of MMP-9 and bFGF in Head & Neck squamous cell carcinoma exist. Further studies will be necessary to establish their pathogenesis in the Head and Neck cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1657-1663
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• 2015

Background: Early diagnosis of hepatocellular carcinoma (HCC) is the most important step in successful treatment. However, it is usually rare due to the lack of a highly sensitive specific biomarker so that the HCC is usually fatal within few months after diagnosis. The aim of this work was to study the role of plasma nuclear factor kappa B (NF-${\kappa}B$) and serum peroxiredoxin 3 (PRDX3) as diagnostic biomarkers for early detection of HCC in a high-risk population. Materials and Methods: Plasma nuclear factor kappa B level (NF-${\kappa}B$) and serum peroxiredoxin 3 (PRDX3) levels were measured using enzyme linked immunosorbent assay (ELISA), in addition to alpha-fetoprotein (AFP) in 72 cirrhotic patients, 64 patients with HCC and 29 healthy controls. Results: NF-${\kappa}B$ and PRDX3 were significantly elevated in the HCC group in relation to the others. Higher area under curve (AUC) of 0.854 (for PRDX3) and 0.825 (for NF-${\kappa}B$) with sensitivity of 86.3% and 84.4% and specificity of 75.8% and 75.4% respectively, were found compared to AUC of alpha-fetoprotein (AFP) (0.65) with sensitivity of 72.4% and specificity of 64.3%. Conclusions: NF-${\kappa}B$ and PRDX3 may serve as early and sensitive biomarkers for early detection of HCC facilitating improved management. The role of nuclear factor kappa B (NF-${\kappa}B$) as a target for treatment of liver fibrosis and HCC must be widely evaluated.

• Informatization Policy
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• v.24 no.3
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• pp.27-41
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• 2017

With the growing interest in the 4th industrial revolution and big data, various policies are being developed for facilitating the use of public open big data, which are leading to a wide range of added values created from use of such data. Despite the expanded requirements for public data disclosure and the legal system improvement, however, the use of public open big data is still limited. According to the literature review, there are studies on policy proposals for the government guiding directions for public open big data, but there is a lack of studies that handle the issue from the users' viewpoint. Therefore, this study aims to analyze the public open data ecosystem in Korea and to analyze public open big data through interviews with the providers (the government and public institutions) and users (private sector companies and citizens). This way, the study finds inhibition factors and facilitation factors, draws out issues and suggests solutions through a causal relationship analysis between each factor. Being a research on finding measures for facilitating both public big data release and use, this study has theoretical implications. In the meanwhile, the derived issues and alternatives provide practical implications also for stakeholders who are planning to facilitate release and use of public open big data.

• Land and Housing Review
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• v.15 no.2
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• pp.107-124
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• 2024

Based on Muan-gun, Jeollanam-do, this study explores how to mitigate the disappearance of rual areas. The study surveyed 95 young farmers in Muan-gun to assess their farming practices and the challenges they face. We further employ factor analysis and cluster analysis classify young farmers in Muan-gun, facilitating the identification of tailored policies or initiatives aimed at fostering and supporting young farmers. The results are summarized as follows. First, Muan County does not have any ordinances or original projects specifically designed to support young farmers. Second, the succession rate of farmland among young farmers in Muan County is 41.1%, which is comparable to the national rate of 43.7%. This indicates that approximately 40% of young farmers in Korea have inherited farmland, a critical foundation for agricultural activities. Third, despite accumulating farming experience, young farmers have not seen any improvement in local living conditions, and rather their difficulties have intensified. Fourth, this study conducted a factor analysis using 21 variables, resulting in the selection of seven common factors for cluster analysis. Consequently, young farmers in Muan County were categorized into three groups. The multinomial logit analysis revealed that the typology of young farmers is influenced by indicators such as cultivated area, farming experience, demand for smart farms, farm income, and farming type (rice cultivation or other). Therefore, to attract young farmers and prevent the decline of rural areas, policy efforts should focus on minimizing entry barriers to farming infrastructure, such as access to farmland, and improving local settlement conditions.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.3
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• pp.287-292
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• 2017

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, $10^2$nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, $10^2$ and $10^3nM$ significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to $10^2$nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at $10^2nM$. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

• Clinical and Experimental Reproductive Medicine
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• v.42 no.3
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• pp.106-110
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• 2015

Objective: This study aimed to investigate the effect of a new clomiphene citrate (CC) regimen on preventing thin endometrial lining in polycystic ovary syndrome (PCOS) patients receiving CC plus gonadotropin treatment with a timed intercourse cycle. Methods: A total of 114 women with PCOS were included in this trial. Patients were divided into two groups and treated in accordance with the controlled ovarian stimulation (COS) protocol. In group A, 104 COS cycles in 67 patients were included, and in each cycle 150 mg CC was given for three days, starting from day 3. In group B, 69 COS cycles in 47 patients were included, in which 100 mg CC was given for five days, starting from day 3. The thickness of the endometrium was measured on the day of human chorionic gonadotropin (hCG) injection. Timed intercourse was recommended at 24 and 48 hours after the hCG injection. Results: Additional doses of human menopausal gonadotropin and the number of days of hCG administration were not significantly different between the two groups. Endometrial thickness on the day of hCG administration was significantly larger in group A than group B (4$9.4{\pm}2.1mm$ vs. $8.5{\pm}1.7mm$, p=0.004). The pregnancy rate was significantly higher in group A than in group B (38.4% vs. 21.7%, p=0.030). Conclusion: Three-day CC treatment resulted in a significantly higher pregnancy rate than the standard five-day CC treatment in a timed intercourse cycle in PCOS patients. Facilitating adequate endometrial growth via the early discontinuation of CC might be a crucial factor in achieving a higher pregnancy rate.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.1
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• pp.92-102
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• 2000

Social trends influence the need for inclusion of basic concepts of occupational health into generic nursing education. Several techniques have been used to incorporate occupational health into baccalaureate programme. These include clinical preceptorships in employee health services, lectures on occupational health issues into community health nursing courses and the integration of occupational health concepts throughout the nursing curriculum and organize an independent course of occupational health nursing for two semester hours. The purpose of this study was to examine the impact of this course to the role orientation of nursing students. In March 1998, pre-test was conducted with all 39 students. Post- test for the subjects and the survey for the other comparison group were conducted after the course in May. Structured questionnaires were distributed which were composed of 42 items related to the role of occupational health nurse and each item was measured on a scale of 1 to 5. Results are as follows: 1) The paired t-test supported the hypothesis that role orientation of students was improved through the occupational health nursing course (t=-3.93, p=.000), 2) As the result of t-test between the subject and the comparison group, the mean score of the role orientation in the case of subject was significantly higher than that of the comparison group(t=13.3449, p=.0005). The enlargement of occupational health nursing course must be a facilitating factor to the improvement of the role orientation of baccalaureate students. It is needed to measure occupational health nursing competence of them in the future.