• The KIPS Transactions:PartD
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• v.16D no.6
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• pp.945-960
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• 2009

The purpose of this study is to define determinants of VoIP user acceptance and to verify significant causality among latent variables - performance expectancy, effort expectancy, cost expectancy, social influence, facilitating conditions, behavioral intend, use behavior - based on UTAUT model. We presented the expanded hypotheses including the new factor, cost expectancy and analyzed the moderating effect of user age, gender and usage experience variables. For a accuracy of predicted results, we focused on survey analysis with 641 real user samples. Compared to previous studies, it is meaningful that this research verified the conceptual difference between behavioral intention and usage behavior. As a result, all proposed hypotheses accepted and moderating effects are supported significantly in age and use experience moderating variables.

• Korean Journal of Plant Resources
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• v.27 no.6
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• pp.707-713
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• 2014

This study examined the inflammatory reaction effects of Allium victorialis var. platyphyllum in vivo at the time of a lipopolysaccharide (LPS) shock in rats, and in vitro in cultured Raw 264.7 cells, with the aim of facilitating the development of a new anti-inflammatory medicine. Plasma concentrations of interleukin (IL)-$1{\beta}$, IL-6, tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$), and IL-10 in rats peaked 5 h after LPS treatment in all experimental groups, with those of IL-$1{\beta}$, IL-6, and TNF-${\alpha}$ being significantly lower in all animals treated with A. victorialis than in the control group at that time point. Conversely, the plasma concentration of IL-10 was higher in the rats treated with 300 mg/kg A. victorialis extract than in the control group at both 2 and 5 h after LPS treatment. Concentrations of IL-$1{\beta}$ and IL-6 in the liver of rats treated with A. victorialis extract were significantly lower than those of the saline-treated control group. However, the liver concentrations of TNF-${\alpha}$ and IL-10 did not vary significantly between the four animal groups. Similarly, concentrations of IL-$1{\beta}$, IL-6, and TNF-${\alpha}$ obtained from cultured Raw 264.7 macrophages were lower in all of the A.-victorialis-extract-treated groups than in the control group. Although the concentration of IL-10 in the A.-victorialis-extract-treated groups tended to be greater than in the control group, the differences between groups were not statistically significant. Together the findings of this study suggest that A. victorialis var. platyphyllum contains functional substances that are involved in inflammatory reactions.

• Journal of Fashion Business
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• v.19 no.2
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• pp.69-84
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• 2015

The objective of this study is to investigate the intention to adopt smart wear, based on extended UTAUT model. We examined the effects of performance expectancy (PE), effort expectancy (EE), hedonic motivation (HE), social influence (SI), facilitating conditions (FC), and price value (PV) on the intended adoption of smart watch and smart shoes, respectively. In addition, moderating effects of gender, age, and innovation resistance were examined. An online survey was conducted, comprised of 2030 consumers who were aware of smart watch or smart shoes. In total, 393 responses were analyzed. About 50.4% were male, and 44.8% were in their 20's. An exploratory factor analysis generated five factors - PE & HM, EE, SI, FC, and PV- which were employed as independent variables in the multiple regression models. PE & HM, PV, and SI influenced on the intention to use both smart devices. FC showed the significant effect only on the intention to adopt the smart watch. In terms of gender differences, SI and PV were the important predictors of the intention to adopt the smart watch in the female group only. With respect to age difference, SI was very effective in explaining the intention of individuals in their 30's to adopt smart wear. Among the low innovation resistance group, SI was significant predictor, while PE & HE and PV were significant among the high resistance group. The findings provide useful information about the possibility of the adoption of smart wear, and new insight into market segmentation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.5
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• pp.951-958
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• 2021

With the growing cyber threat to information assets, it has become important to share threat information quickly. This paper examines the sharing of cyber threat information and presents a method to determine the importance of threat indicators in the information sharing market by calculating weights. The analysis was conducted using AHP techniques, with a pairwise comparison of the four factors(attacker & infected system indicators, role indicators, malicious file indicators, technique & spread indicators) and the details of each factor. Analysis shows that malicious file indicators are the most important among the higher evaluation factors and infected system IP, C&C and Smishing are the most important factors in comparison between detailed items. These findings could be used to measure the preference of consumers and the contribution of information provider for facilitating information sharing.

• Molecules and Cells
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• v.44 no.9
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• pp.647-657
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• 2021

As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.

• Plant Breeding and Biotechnology
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• v.5 no.2
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• pp.123-133
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• 2017

AP2/EREBP gene family consists of transcription factor genes with a conserved AP2 DNA-binding domain and is involved in various biological processes. AP2/EREBP gene families were identified through genome-wide searches in five Cucurbitaceae species including cucumber, wild cucumber, melon, watermelon, and bitter gourd, which consisted of more than 100 genes in each of the five species. The gene families were further divided into five groups including four subfamilies (ERF, DREB, AP2 and RAV) and a soloist group. Among the subfamilies, DREB subfamily which is known to be related to abiotic stress response was more analyzed and a total of 25 genes were identified as Cucurbitaceae homologues of Arabidopsis CBF/DREB1 genes which are important for abiotic stress-response and tolerance. In silico expression profiling using RNA-Seq data revealed diverse expression patterns of cucumber AP2/EREBP genes. AP2/EREBP gene families identified in this study will be valuable for understanding the stress response mechanism as well as facilitating molecular breeding in Cucurbitaceae crops.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.191-197
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• 2019

This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than $50{\mu}g/ml$ in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.1
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• pp.40-53
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• 2021

Recently, shared dockless e-scooter usage has rapidly increased, rather than the station-based shared mobility service, because of convenience. This transition leads to new social problems in urban areas such as increased traffic accidents and hindrance of pedestrian environments. In this study, we analyze the usage characteristics of shared e-scooters in Seoul, and identify factors influencing demand for shared e-scooters by developing a negative binomial regression model. As a result, the usage characteristics show that the average trip distance, the average trip duration, and the average trip speed were 1.5km, 9.4min, and 10.3km/h, respectively. Demographic factor, transport facility factors, land use factors, and weather factors have statistically significant impacts on demand for shared e-scooters. The results of this study will be used as basic data for suggesting effective operation strategies for areas with higher shared e-scooter demand and for establishing transport policies for facilitating shared e-scooter usage.

• Korean Medical Education Review
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• v.23 no.1
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• pp.46-55
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• 2021

Since the emergence of coronavirus disease 2019 (COVID-19), medical schools have experienced a sudden, full-scale transition to online classes. As the COVID-19 pandemic continues, it is important to evaluate current educational programs and to assess their implications. This study explored perceptions of online classes and learning behavior among medical students. Twenty preclinical medical students were interviewed in focus groups for 2 months. They generally expressed positive perceptions about online classes, and in particular, positively assessed the ability to lead their individual lifestyles and study in comfortable environments with fewer time and space constraints. Students thought that the online environment provided a fair chance of facilitating positive interactions with the professor and considered communication with the professor to be an important factor only when it was related to the class content or directly helped with their grades and careers. Students also had negative views, such as feeling uncertain when they could not see their peers' learning progress and assess themselves in comparison and feeling social isolation. Learning behaviors have also changed, as students explored their learning styles and adapted to the changed learning environment. Students expanded their learning by using online functions. However, students sometimes abused the online class format by "just playing" the lecture while not paying attention and relying on other students' lecture transcripts to study. The results of this study are hoped to provide a useful foundation for future research on online class-based teaching and learning.

• Steel and Composite Structures
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• v.49 no.2
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• pp.143-159
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• 2023

Recently, the design of scaffolding systems has garnered considerable attention due to the increasing number of scaffold collapses. These incidents arise from the underestimation of imposed loads and the site-specific conditions that restrict the application of lateral restraints in scaffold assemblies. The present study is committed to augmenting the buckling resistance of vertical support members, obviating the need for supplementary lateral restraints. To achieve this objective, experimental and computational analyses were performed to assess the axial load buckling capacity of steel props, composed of two hollow steel pipes that slide into each other for a certain length. Three full-scale steel props with various geometric properties were tested to construct and validate the analytical models. The total unsupported length of the steel props is 6 m, while three pins were installed to tighten the outer and inner pipes in the distance they overlapped. Finite Element (FE) modeling is carried out for the three steel props, and the developed models were verified using the experimental results. Also, theoretical analysis is utilized to verify the FE analysis. Using the FE-verified models, a parametric study is conducted to evaluate the effect of different inserted pipe lengths on the steel props' axial load capacity and lateral displacement. Based on the results, the typical failure mode for the studied steel props is global elastic buckling. Also, the prop's elastic buckling strength is sensitive to the inserted length of the smaller pipe. A threshold of minimum inserted length is one-third of the total length, after which the buckling strength increases. The present study offers a prop with enhanced buckling resistance and introduces an equation for calculating an equivalent effective length factor (k), which can be seamlessly incorporated into Euler's buckling equation, thereby facilitating the determination of the buckling capacity of the enhanced props and providing a pragmatic engineering solution.