• 한국병원경영학회지
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• 제6권1호
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• pp.18-40
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• 2001

This study purports to investigate the readiness of the university hospital employees in the knowledge-based management. Data were collected from 550 employees including administrative, nursing, and technical staff of 9 university hospitals located in Seoul and Kyunggi Province through the self-administered questionnaires. The response rate was 79% and 425 questionnaires were used as final data and analyzed using 2 test, t-test, and ANOVA. The main findings of the study are as follows. 1) It seems that most employees of the study hospitals have basic knowledge on the concept of knowledge-based management. This finding implies that the implementation of the knowledge-based management in Korean university hospitals will not likely to face strong resistance from their employees. 2) The results show that Korean hospital employees are still not so accustomed to using e-mail as the main communication tool. This finding suggests that it is necessary to use various communication tools which include electronic data interchange, teleconference, and cyber chatting for facilitating the knowledge-based management in Korean university hospitals. 3) It is desirable to appoint a chief knowledge officer(CKO) for operating knowledge-based management system effectively. 4) A reward system for employees who show a distinguished performance in the creation and sharing of new knowledge should be established. Knowledge mileage system, selection of the best knowledge employee and team will be a good example of the effective reward system. 5) The participation and support from the chief executive officers (CEO) of the hospitals is an important factor for successful knowledge-based management. Furthermore, to make physicians actively participate in the knowledge-based management is another important factor for obtaining valuable outputs from the system. 6) It is found that the knowledge and skills of the hospitals employees on the information technology (IT) are not sufficient for making knowledge-based management more popular. This implies that it is very important to select IT-oriented employees and educate them continuously on the knowledge-based management.

• 경영과학
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• 제31권2호
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• pp.15-32
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• 2014

This research empirically investigated the influence factors on the adoption of environmental management systems (EMS) in Korean manufacturing firms. In this study, the external factors (cause factors), the internal factors (facilitating factors) and the firm specific characteristics were integrally considered. In the factor analysis, the third item (regional society) of the external factors and the first item (environmental law) of government regulation were confounded with the items of the other factors. Thus, the confounded items were removed. In the second factor analysis, no items were replicated. The results of a multiple regression analysis showed that the influence factors such as government regulation, normative pressure, top management support, environmental strategy and employees' recognition, and ratio of large shareholders have a significant impact on the construction of EMS. However, the effects of the other firm specific characteristics were not statistically significant. We also examined whether both the number of environmental personnel and the allocation of environmental resources, which are directly related with the adoption of EMS, have a moderating impact on the relationships between other internal factors and the construction of EMS. With a subgroup analysis, the moderating roles of the number of environmental personnel were empirically confirmed. Through a multiple regression analysis, the direct effects of the external factors on the adoption or construction of the internal factors were demonstrated. The effects of government regulation, normative pressure and imitative pressure on the internal factors were significant and positive. Finally, in this study, the fact that the adoption of EMS can improve the environmental performance of a firm was also empirically found.

• 한국수산과학회지
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• 제45권2호
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• pp.167-172
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• 2012

Minerals from marine materials such as deep ocean water and Dead Sea water have been used since ancient times. We made a mask pack sheet including deep ocean water and salt from the Dead Sea and evaluated the function of the mask pack sheet through animal study. Three full-thickness skin defects were made on the backs of Sprague-Dawley rats. The wounds were left untreated in group Con, and mask pack sheets including deep ocean water or deep ocean water and Dead Sea water were used as treatment for 20 min on the skin of animals in groups DP and DDP, respectively. We analyzed the gross, histological and biochemical findings. Groups DDP and DP showed decreases in wound size, as compared to group Con at 7 days after wound infliction. The histological findings revealed that wound healing had progressed further in groups DP and DDP than in group Con, with more rapid collagen deposition and regression of neutrophils. Also, the expression of vascular endothelial growth factor and transforming growth factor ${\beta}1$ were increased in groups DDP and DP compared with those in group Con at 3 days after wound infliction. Mask sheet packs including deep ocean water and Dead Sea salt affected wound healing by reducing the inflammatory phase and stimulated wound contracture by facilitating the deposition of collagen.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4339-4347
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• 2014

Purpose: This study aimed at exploring treatment delay (TD) among cancer patients in China with an attempt to develop a practical methodology facilitating frontline Chinese clinicians in promoting earlier cancer diagnosis and treatment. Materials and Methods: The study comprised framework development, qualitative interviews and paired factor rating. Framework development utilized systematic literature review, soft systems thinking and consensus groups. Qualitative interviews employed a checklist of open questions soliciting information about all the domains included the framework from cancer patients drawn via stratified randomized sampling of inpatients at 10 hospitals in Hefei, China. Paired factor rating used a self-developed computer aid and the interviewed patients as referring cases to weigh the relative importance of the factors listed in the framework in terms of their contributions to specific components of total delay (TD). Results: a) A conceptual framework was proposed consisting of a 6-step path to TD and 36 category determinants. b) A total of 227 patients were interviewed; their TD was 267.3 mean or 108 median days ranging from 0 to 2475 days; average appraisal, illness, behavioral, preparation and treatment delay accounted for 52.1%, 9.4%, 0.30%, 8.8% and 29.4% of the TD respectively. Individual side factors were rated substantially more important than environmental side factors (60% vs. 40%); most influential TD factors included cancer symptoms, overall health, family relations and knowledge about cancer and health. Conclusions: The framework proposed together with the interviewing and rating approaches used provide a potential new methodology for understanding cancer patients' TD and promoting earlier cancer treatment.

• 디지털융복합연구
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• 제14권4호
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• pp.209-220
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• 2016

조직은 정보보안정책을 제공하고 이를 준수하기 위한 교육 및 지원 등 지속적인 노력을 하고 있으나, 조직 구성원의 보안 미준수에 따른 사고는 끊이지 않고 있다. 본 연구는 조직 구성원의 정보보안정책 준수행동에 영향을 주는 요인들을 Triandis 모델을 적용하여 규명하였으며, 요인들간의 영향 관계를 구조방정식모델링 기법인 PLS(Partial Least Squares)를 통해 살펴보았다. 가설검증 결과 조직은 정보보안정책과 이를 지원하는 촉진조건을 통해 구성원의 정보보안정책 준수의도 및 행동을 유도할 수 있으며, 조직의 정보보안정책에 대한 구성원의 기대가치, 습관 및 감정이 중요함을 증명하였다. 본 연구는 Triandis 모델을 정보보안 분야에 적용하여 분석하고, 구성원의 정보보안 행동에 대한 방향성을 제시하였다는 점에 의의가 있다. 그리고 본 연구 결과를 통해 조직의 정보보안정책 수립 및 구성원의 준수행동을 높이기 위한 방안을 제공할 수 있을 것이다.

• 한방재활의학과학회지
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• 제30권1호
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• pp.13-29
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• 2020

Objectives This study was performed to decide the bone union effect of Hwaweo-jeon on tibia fractured mice. Methods In this study, laboratory experiments were implemented by the stage of in vitro and in vivo. In in vitro, MC3T3-E1 cells were treated with various concentration of Hwaweo-jeon extract (HWJ). To investigate effect of HWJ for osteoblast, relative mRNA expression of 5 substances (alkaline phosphatase [ALP], runt-related transcription factor 2 [Runx2], osteocalcin [OCN], osterix [OSX] and collagen type II alpha 1 chain [Col2a1]) was used as a marker of osteogenesis. In order to determine HWJ's effect for fracture healing, relative gene expression level of ALP, Runx2, OCN, OSX and Col2a1 were used to find out the influence to osteoblast. Furthermore, receptor activator of nuclear factor kappa-B ligand and osteoprotegerin relative mRNA expression were used to estimate the impact to osteoclast. Also, X-ray was used for the purpose of identifying bone union in tibia-fracture mouse model. Results In in vitro experiment, most part of relative mRNA expression were increased compared to control group. In in vivo and in vitro experiment, HWJ induced osteoblast activitation by verifying relative mRNA expression of 5 substances. And in vivo experiment, we can also identify that HWJ triggered osteoclast activation during early stage of tibia fracture. Furthermore, X-ray pictures show noticeable recovery of tibia fracture. Conclusions HWJ extract promotes bone union by facilitating the osteoblast. But, HWJ may occur liver & kidney toxicity over specific concentration. Therefore, when HWJ is applied to human body, doctors have to follow up the liver function test & renal function test of patient.

• 한국전자거래학회지
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• 제13권2호
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• pp.117-147
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• 2008

유비쿼터스 컴퓨팅을 활용한 다양한 서비스의 개발이 정부는 물론 업계 전반에 걸쳐 추진되고 있다. 이와 같이 유비쿼터스 서비스가 실제 생활에 적용됨에 따라 사용자들이 이러한 서비스를 수용하는데 영향을 미치는 요인에 대한 연구의 필요성이 대두되었다. 이를 위해 정보기술수용에 관한 기존 연구를 고찰한 후, 기존 8개 모형을 통합한 UTAUT모형을 유비쿼터스 컴퓨팅 상황에 확장 적용하였으며, 특히 유비쿼터스 컴퓨팅 서비스의 특성요인인 '상황기반 개인화' 요인을 추가하였다. 연구결과는 기존 UTAUT모형에서 유의하게 보고된 4개 요인(성과기대, 노력기대, 사회적 영향, 촉진조건)과 더불어 본 연구에서 새롭게 제안한 '상황기반 개인화' 요인이 이용의도에 유의한 영향을 미치는 것으로 나타났으며, 이용의도의 63.4%를 설명하는 것으로 나타났다.

• 통상정보연구
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• 제16권2호
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• pp.221-249
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• 2014

본 연구는 글로벌기업의 해외자회사가 새로운 지식을 창출하고 이를 확산하는데 있어서 선도적 역할을 수행하는 초우량센터(center of excellence)로 발전하는데 영향을 주는 결정요인을 파악하고, 이를 한국기업을 대상으로 실증분석하고자 한다. 이를 위해, 기존 연구의 결과를 통합함으로써 연구모형을 개발하였다. 구체적으로 해외자회사의 지식창출에 영향을 미치는 7개 요인을 제시하였는데, 이들은 일반적 결정요인(general factors) 2개, 전략적 중요요인(strategic important factors) 2개, 초우량요인(excellent factors) 3개로 나눌 수 있다. 각 요인들은 연구목적에 따라 필요조건이 되거나 충분조건이 된다. 예컨대, 일반적 결정요인에 속하는 분권적 조직구조는 해외자회사의 지식창출을 촉진시키는 요인이 된다(충분조건). 그러나 분권적 조직구조를 가진 모든 해외자회사가 전략적 중요도가 높은 해외자회사가 되지는 않는다(결과적으로 필요조건)는 것을 알 수 있다. 이상 7개 결정요인이 해외자회사의 지식창출에 미치는 영향에 대해 논의하고, 이를 바탕으로 가설을 개발한 후 실증자료를 통해 검증하였다.

• 대한두경부종양학회지
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• 제20권1호
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• pp.13-18
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• 2004

Objectives: Cancer lethality is usually the result of local invasion and metastasis of neoplastic cell from the primary tumor. Because of their ability to degrade extracellular matrix components, matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) have been implicated in the breakdown of basement membrane and underlying stroma, thereby facilitating tumor growth and invasion. It has been well established that MMPs and bFGF expression correlate with cervical lymph node metastasis, but studies on expression in the metastatic cervical lymph node itself are not enough. We have analyzed matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) in squamous cell carcinoma of the head and neck and metastatic cervical lymph node, and evaluated their relationship and clinicophathologic significance. Material and Methods: 20 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for MMP-9 and bFGF in the obtained tissue from primary tumor and metastatic cervical lymph node. We analyzed the relationship between MMP-9, bFGF expression of the primary tumor and metastatic node with age, sex, T-stage, N-stage, histologic grade, pathologic stage and disease free survival. Results: Expression of MMP-9 and bFGF in cancer cell and metastatic lymph node was higher than that in normal cell and lymph node. According to histologic differentiation, expression of MMP-9 of the metastatic cervical lymph node was higher than primary tumor. Considering to other clinicopathologic factor, no statistical significance was seen in MMP-9 and bFGF. Conclusion: We found that expression of MMP-9 is higher in the metastatic lymph node than primary tumor in the poorly differentiated squamous cell carcinoma. But we don't find out the statistical significance in relation between bFGF and clinical factors. So we guess that some different mechanism of MMP-9 and bFGF in Head & Neck squamous cell carcinoma exist. Further studies will be necessary to establish their pathogenesis in the Head and Neck cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1657-1663
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• 2015

Background: Early diagnosis of hepatocellular carcinoma (HCC) is the most important step in successful treatment. However, it is usually rare due to the lack of a highly sensitive specific biomarker so that the HCC is usually fatal within few months after diagnosis. The aim of this work was to study the role of plasma nuclear factor kappa B (NF-${\kappa}B$) and serum peroxiredoxin 3 (PRDX3) as diagnostic biomarkers for early detection of HCC in a high-risk population. Materials and Methods: Plasma nuclear factor kappa B level (NF-${\kappa}B$) and serum peroxiredoxin 3 (PRDX3) levels were measured using enzyme linked immunosorbent assay (ELISA), in addition to alpha-fetoprotein (AFP) in 72 cirrhotic patients, 64 patients with HCC and 29 healthy controls. Results: NF-${\kappa}B$ and PRDX3 were significantly elevated in the HCC group in relation to the others. Higher area under curve (AUC) of 0.854 (for PRDX3) and 0.825 (for NF-${\kappa}B$) with sensitivity of 86.3% and 84.4% and specificity of 75.8% and 75.4% respectively, were found compared to AUC of alpha-fetoprotein (AFP) (0.65) with sensitivity of 72.4% and specificity of 64.3%. Conclusions: NF-${\kappa}B$ and PRDX3 may serve as early and sensitive biomarkers for early detection of HCC facilitating improved management. The role of nuclear factor kappa B (NF-${\kappa}B$) as a target for treatment of liver fibrosis and HCC must be widely evaluated.