• KSBB Journal
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• 제28권6호
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• pp.387-393
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• 2013

In this study, the domestic onion skin has been used to investigate the anti-wrinkle effect of the ethanolic extract. The onion skin has been known to contain a large amount of antioxidant including quercetin. Solvent extraction by 80% ethanol was carried out of the onion skin. The high amount of quercetin have been identified using HPLC as a bioactive compound. The extraction yield of the quercetin increased according to temperature up to $80^{\circ}C$. Two different antioxidant assays (DPPH and ABTS) were performed to determine the free-radical scavenging activity of onion skin extracts. The antioxidant activities ($EC_{50}$ of DPPH) of the vitamin C and the onion extracts were 2.2 and $5.09{\mu}g/mL$, respectively. The results of ABTS tests were 2.33 (of vitamin C) and $2.40{\mu}g/mL$ (of the onion extracts), respectively. In a clinical study, a panel of 10 female volunteers between the ages of 30 and 40 (mean age: 42 years) was given a mask pack containing 1% of this extracts for 4 weeks. It was shown that a highly significant reduction in the deep and moderate wrinkled was obtained with those treated with this onion extracts as compared to the control group. The reduction in deep wrinkles increased with time. Eye wrinkle were reduced statistically significant (p<0.05). The application of the proper topical cream and mask pack containing onion skin extracts has therefore shown to be effective enhancing anti-wrinkle activities.

• 대한화장품학회지
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• 제44권3호
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• pp.259-266
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• 2018

오늘날의 사회에서는 삶의 질 향상으로 실제 나이보다 젊어 보이며 이에 따라 노화방지에 대한 관심이 증가하고 있다. 또한 같은 나이의 사람들과 비교했을 때 본인이 젊어 보이는지에 대한 관심이 높아지고 있다. 이 연구에서 우리는 외적 노화에 가장 주요한 영향을 주는 주름 지수를 구하고자 하였다. 전체 얼굴의 주름은 8개로 분할된 영역에 의해 점수화되었고, 실제 연령과 피부 파라미터 사이의 상관 관계를 분석하였다. 연구 대상자 206명(한국인 여성 105명, 몽골 여성 101명)을 대상으로 하였다. 대상자는 연령대별로 20대, 30대, 40대, 50대를 네 군으로 나누었다. 주름 패턴은 주름, 미간, 코뿌리, 눈꺼풀, 눈밑주름, 눈꼬리, 팔자주름, 입가 8개 부위의 주름을 평가하고 주름 점수에 따른 계산식을 개발 하였다. 또한 계산식에 의해 얻어진 주름지수와 연관성 있는 피부 특성 파라미터를 알아보고자 피부 탄력, 모공, 주름, 피지 분비를 측정하였다. 방정식을 적용하여 계산한 한국인의 경우 주름연령과 실제연령과의 차이는 없었다. 반면, 몽골인에서는 실제연령과 비교하여 9세가 더 나이 들어 보인다고 밝혀졌다. 얼굴 주름 나이와 피부 특성 파라미터 사이의 상관 관계는 양국에서 피부 탄력 > 모공 또는 눈꼬리 주름 > 피부 색 > 피지 분비 순으로 나타났다. 피부 탄력은 얼굴 주름 나이와 가장 관련이 있는 변수로 나타났다. 본 연구를 통해 한국과 몽골 여성의 연령별 피부 주름 패턴을 규명하였으며, 이 연구로부터 개발된 주름살 계산식을 향후 화장품의 효능 연구에서 얼굴 주름의 나이를 계산하는 도구로 사용할 수 있을 것으로 생각된다.

• 동의생리병리학회지
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• 제23권6호
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• pp.1261-1266
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• 2009

The wrinkle is a typical sign showing aging. These days lots of people want to have a young and healthy appearance and many medical doctors are studying about wrinkle cure. In fact a young face without wrinkle looks more healthy and energetic. Therefore the wrinkle cure is important at the point of medical view. This research is an investigation of several studies about wrinkle cure using acupuncture needle. We have to consider the problem of the whole body which is related 12 meridians and meridian muscles as well as topical skin and tissues. There are three parts affecting wrinkle formation and cure. The first is a meridian and meridian muscle, the second is a local muscle and fascia on the head and neck, the third is a local skin structure. There are three kinds of method to cure the wrinkle locally. The first one is the perpendicular treatment of acupuncture, called the microneedle therapy, the process of this method is that lots of microneedles stab in the skin to dermis. The second one is the transverse treatment of acupuncture. The process of this method is that an acupuncture needle inserts just under the wrinkle skin. The third one is the incision treatment of acupuncture, called subcision, the process of this method is to cut the fibrous band which connect from the facial muscle to SMS(superficial musculoaponeurotic system) using cuttable needle. The hematoma after treatment let a collagen increase.

• 사상체질의학회지
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• 제34권4호
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• pp.49-56
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• 2022

Objectives The purpose of this study is to compare the changes before and after constitutional acupuncture treatment in soyangin who received embedding therapy for wrinkle improvement. Methods A retrospective study reviewing medical records was conducted. The patient was classified as a Soyangin by a specialist based on K-PRISM, personality, appearance, voice and usual symptoms. Records on the degree of wrinkles, postoperative symptoms, and patient satisfaction were reviewed. Results The patient's wrinkles were improved after the embedding therapy. After therapy symptoms were fever, flushing, and burning sensation. After acupuncture, these symptoms were reduced. Patient satisfaction increased after constitutional acupuncture treatment. Conclusion As a result of embedding treatment in Soyangin patients, there was an effect of wrinkle improvement. As a result of constitutional acupuncture treatment, anxiety and stress were reduced before the procedure, and symptoms of heat, burning, and flushing were reduced after the procedure.

• 한방안이비인후피부과학회지
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• 제27권2호
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• pp.1-13
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• 2014

Objective : The purpose of this study is to understand conspicuous features of geroderma with visceral manifestation theory(臟象論). Methods : We categorized skin aging into wrinkles, hyperpigmentation, dry skin and face flush. After investigating the reason, histological changes and mechanism of each classification in western medicine, we interpreted them according to the malfunction of five viscera(五臟) in Korean medicine. Result : The results are as follows. 1. Pathologic change of dermis and subcutaneous fat makes wrinkles. We consider wrinkles as the malfunction of the spleen(脾). 2. Irregular synthesis and disproportion of melanin makes hyperpigmentation. We consider hyperpigmentation as the malfunction of the liver(肝). 3. Dry skin is attributed to a subtle disorder of epidermal maturation. We consider dry skin as the malfunction of the lung(肺). 4. Facial flush is detected in rosacea and menopausal hot flush, which are both related with blood vessel abnormality. We consider facial flush as the malfunction of the heart(心) Conclusion : We interpreted the pathologic changes and mechanism of skin aging in western medicine as the decrease of five viscera(五臟) in visceral manifestation theory(臟象論) of Korean medicine. Further studies are needed to apply these hypothesis to clinical diagnosis and treatment.

• 대한한방부인과학회지
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• 제31권1호
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• pp.147-154
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• 2018

Objectives: This study aims to examine the improvement against facial wrinkles after needle-embedding therapy. Methods: The study participants were 10 women treated with needle-embedding therapy in the Korean Medical Clinic from September, 2011 to August, 2014. The subjects were treated every ten days for twenty days, totally three times, and the result of treatment was evaluated five times, such as pre-treatment, after each treatments, one month and two months later of the last treatment with ARAMO-SG. Results: 1. Depth and range of facial wrinkles, facial skin pore test, and sensitivity test were visibly improved after needle-embedding therapy and follow-up compared pre-treatment (p<0.05). 2. The significant improvements in facial skin texture test was not observed and sustained until the follow-up measurement at 2 months. 3. Any adverse reaction related to needle-embedding therapy did not happen. Conclusions: This study suggests that needle-embedding therapy can improve facial wrinkles. The positive results of this study support the requirement for additional research investigating the efficacy of needle-embedding therapy in women.

• 대한한의학방제학회지
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• 제17권2호
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• pp.111-121
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• 2009

Objectives : This study was performed to evaluate the efficacy of ampule containing herbal extract(Ulmus davidiana, Ginkgo biloba, Perilla ocymoides, Morus alba, Glycyrrhiza uralensis (licorice), and Angelica gigas) on skin wrinkles in adult women with facial wrinkles. Methods : A total of 12 women, 30 to 46 years of age, with wrinkles in the corner of eyes, applied ampule containing herbal extract twice daily for up to 12 weeks. Silicon replicas of right crow's feet area and antecubital fossa were taken before use of test product and at 4, 8 and 12 weeks. The replicas were analyzed by optical profilometry with Skin Visiometer SV600. The wrinkle and roughness parameters, R1, R2, R3, R4 and R5 were calculated and statistically analyzed. In addition, a subjective evaluation of product efficacy was conducted by patient's assessment. Results : The mean values of all the skin roughness parameters were decreased at 4-week, and decreased significantly at 8 and 12-week except R4 at 12-week after test product use. The subjective evaluation of wrinkle by patient's assessment was also improved. However, one patient noted stiffness of face after use of test product. Conclusions : These study suggested that the application of ampule containing herbal extract twice daily for 12 weeks may effectively improve the facial wrinkles without severe side effect.

• 대한화장품학회지
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• 제44권2호
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• pp.191-200
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• 2018

본 연구에서는 제1형 프로콜라겐 분비량 측정을 통해 피부 주름개선 효과가 있는 천연물을 검색하던 중, 연꽃잎추출물(Nelumbo nucifera leaves extract, NLE)이 가장 우수한 효능을 나타냄을 확인하였다. 고압액체크로마토그래피로 NLE를 분석한 결과 isoquercitrin이 함유되어 있었으며, isoquercitrin도 normal human dermal fibroblast (NHDF)에서 제1형 프로콜라겐의 분비를 촉진한다는 것을 확인할 수 있었다. 또한 NLE와 isoquercitrin은 자유 라디컬 소거 활성을 가지고 있었으며, 특히 isoquercitrin은 인간 피부유래 세포주인 HaCaT 및 NHDF에서 활성산소종의 생성을 억제하고 총항산화능을 증가시켰다. 최종적으로 본 연구팀은 isoquercitrin의 함유량을 높이기 위해 정제한 NLE를 1.7% 함유한 크림(isoquercitrin 51 ppm 함유)을 제조하여 눈가의 주름개선 효과를 평가하였다. 30 ~ 65세의 한국인 여성 22명을 대상으로 얼굴의 한쪽 면엔 NLE 함유 크림을, 그리고 다른 한쪽 면엔 대조제품을 매일 2회씩, 8주간 연속 사용하도록 하였다. 그 결과 NLE 함유크림을 사용하였을 때 피부자극이 발견되지 않았으며, 대조제품과 비교하여 통계적 유의성 있게 눈가의 주름을 감소시키는 것을 확인할 수 있었다. 본 연구결과는 NLE 및 isoquercitrin이 우수한 콜라겐 생성 촉진 및 항산화 효능을 가지며, isoquercitrin 함유 NLE는 안전한 천연 주름개선 화장품 소재로 적용 가능하다는 것을 시사한다.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.165-171
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• 2014

Objectives : The purpose of this study was to examine and report improvements of facial wrinkles with the use of subcision. Methods : Subcision acupuncture was performed on outpatients with facial wrinkles for one to two times. Evaluation of improvement was conducted with patient-report questionnaires and comparison of before and after pictures. Items for satisfaction and adverse events were included in the questionnaire, and it was filled out after treatment. The photographs were taken three times; before the first and the second subcision acupuncture, and two to four weeks after the second subcision acupuncture. Results : The results from questionnaire and photo comparison were reported positive and satisfactory. There were minor adverse events such as bruise or conspicuousness of other wrinkles that were not treated. Conclusions : Our study results suggests that the use of subcision acupuncture is effective for facial wrinkles.

• Journal of Nutrition and Health
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• 제43권5호
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• pp.453-462
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• 2010

The effects of unripe apple mask pack made from unripe apple extracts on the skin status of middle-aged women for 4 weeks were investigated. The subjects were divided into three groups: placebo mask pack as the control (PM, n = 8), apple mask pack (AM, n = 16), and apple mask pack + apple intake (AAM, n = 12). The study included a survey questionnaire, and evaluations of nutrients intakes and of skin status. Skin status was measured by Aramo-TS. After 4 weeks, facial moisture, elasticity, evenness, and wrinkle level were improved in AM and AAM. The facial moisture level (AM: $+3.13\;{\pm}\;2.73$, AAM: $+2.25\;{\pm}\;2.93$) and elasticity level (AM: $+5.81\;{\pm}\;8.27$, AAM: $+5.50\;{\pm}\;6.13$) of AM (p < 0.001) and AAM (p < 0.05) were increased. The facial evenness level (AM: $-5.25\;{\pm}\;8.13$, AAM: $-9.17\;{\pm}\;4.26$) and wrinkle level (AM: $-10.88\;{\pm}\;11.74$, AAM: $-17.83\;{\pm}\;12.22$) were significantly decreased. AAM was more effective in improving skin elasticity, evenness, and wrinkle. The skin status of PM was not changed. While the macronutrient intakes of all the subjects were not different before and after the study, the daily intakes of some vitamins (vitamins $B_6$, C, and E and folic acid) during the study were significantly increased in AAM. These findings suggested that regular use of apple mask pack was effective in improving overall skin status. Furthermore, the consumption of apples with mask pack application was much better in improving skin status.