• Title/Summary/Keyword: FLAIR

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Wallerian Degeneration of Insufficiently Affected White Matters in Old Infarction: Tract of Interest Analysis of Diffusion Tensor Imaging

  • Choi, Chi-Hoon;Lee, Jong-Min;Koo, Bang-Bon;Park, Jun-Sung;Kwon, Jun-Soo;Kim, Sun-I.
    • Journal of Biomedical Engineering Research
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    • v.28 no.3
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    • pp.317-324
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    • 2007
  • The application of diffusion tensor imaging (DTI) and fiber tractography to Wallerian degeneration (WD) is important because this technique is a very potent tools for quantitatively evaluating fiber tracts in vivo brain. We analyzed a case and control using tracts of interest (TOI) analysis to quantify WD. We scanned a case of old infarction and an age-matched healthy volunteer. T1 magnetization prepared rapid acquisition gradient echo (MPRAGE), fluid attenuated inversion recovery (FLAIR) and 12-direction diffusion tensor imaging (DTI) were obtained and analyzed using TOI analysis. The value of mean diffusity ($D_{av}$) and fracional anisotrophy (FA) were analyzed statistically by MWU test. A p-value of less than 0.05 was considered to indicate statistical significance. A comparison of the global fiber diffusion characteristics shows WD of both the corpus callosum and the ipsilateral superior longitudinal fasciculus. The corpus callosum in particular showed trans-hemispherical degeneration. Local fiber characteristics along the geodesic paths show WD in the corpus callosum, ipsilateral superior longitudinal fasciculus, ipsilateral corticospinal tract, and ipsilateral corticothalamic tract. We have demonstrated changes in $D_{av}$ and FA values and a clear correspondence with the WD in various tracts. TOI analysis successfully revealed radial WD in white matter tracts from a region of encephalomalacia and primary gliosis, although they were only slightly affected.

Acute Intervertebral Disc Protrusion in a Korean Domestic Shorthaired Cat: Clinical and MRI Findings

  • Lee, Narae;Lee, Young-jae;Song, Jin-young;An, Dae-gi;Kang, Byeung-taek;Chang, Jin-hwa;Chang, Dong-woo
    • Journal of Veterinary Clinics
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    • v.34 no.6
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    • pp.467-469
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    • 2017
  • Signalment: A 7-month-old, female domestic shorthaired cat was presented for acute pelvic limb paraparesis. Results: There was no abnormality on survey radiographs and blood analysis, however neurological examination revealed proprioception positioning and hopping was absent in the pelvic limbs. Also, anal tone and perineal sensation were reduced. Magnetic resonance (MR) imaging showed nucleus pulposus dehydration and disc protrusion at T12-T13. Ill-defined diffuse lesion was found at T10-L2 level and it showed isointense on T1-weighted images and hyperintense on T2-weighted and FLAIR images. This lesion was considered as edematous lesion secondary to disc protrusion. The presumptive diagnosis was focal spinal cord edema associated with intervertebral disc protrusion. A traumatic aetiology was suspected. The cat was treated corticosteroids and analgesic and clinical sign improved following 9 days of treatment. Clinical relevance : Intervertebral disc protrusion is rare disease in a cat. However, it could be considered as a cause of paraparesis in cats.

Association between Characteristics of Brain Magnetic Resonance Imaging and Atypical Antipsychotics Use in Dementia Patients (치매 환자에서 뇌 자기공명영상의 특징과 비정형 항정신병 약제 사용여부의 상관 관계)

  • Choi, Jongtaek;Kim, Jiwon;Roh, Yangho;Rhu, Sukhwan;Woo, Sungil;Hahn, Sangwoo;Hwang, Jaeuk
    • Korean Journal of Biological Psychiatry
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    • v.20 no.3
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    • pp.97-103
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    • 2013
  • Objectives We aimed to identify the neuroimaging marker for prediction of the use of atypical antipsychotics (AAP) in dementia patients. Methods From April 2010 to March 2013, 31 patients who were diagnosed as dementia at the psychiatric department of Soonchunhyang University Hospital, completed the brain magnetic resonance imaging scan and cognitive test for dementia. Ten patients were treated with AAP for the improvement of behavioral and psychological symptoms of dementia (BPSD) and the other 21patients were not. Using T1 weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of brain, areas of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and white matter hyperintensities (WMH) have been segmented and measured. Multivariate logistic regression models were applied for assessment of association between AAP use and the GM/WM ratio, the WMH/whole brain (GM + WM + CSF) ratio. Results There was a significant association between AAP use and the GM/WM ratio (odds ratio, OR = 1.18, 95% confidence interval, CI 1.01-1.38, p = 0.037), while there was no association between AAP use and the WMH/whole brain ratio (OR = 0.82, 95% CI 0.27-2.48, p = 0.73). Conclusions The GM/WM ratio could be a biological marker for the prediction of AAP use and BPSD in patients with dementia. It was more likely to increase as dementia progress since atrophy of WM was more prominent than that of GM over aging.

A Case of Krabbe Disease with Infantile Spasm (영아 연축을 동반한 Krabbe병 1례)

  • Kim, Ja Kyoung;Kim, Dal Hyun;Kang, Bo Young;Kwon, Young Se;Hong, Young Jin;Son, Byong Kwan;Yoon, Hye Ran
    • Clinical and Experimental Pediatrics
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    • v.46 no.1
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    • pp.95-99
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    • 2003
  • Krabbe disease is a rare autosomal recessive disorder clinically characterized by retardation in motor development, prominent spasticity, seizures, and optic atrophy. Pathologically, there are many globoid cells in the white matter, in addition to the lack of myelin and the presence of severe gliosis. Hence Krabbe disease is known as globoid cell leukodystrophy. Biochemically, the primary enzymatic deficiency in Krabbe disease is galactocerebroside beta-galactosidase. Patients with Krabbe disease can be subdivided into the early-onset type and late-onset type, according to the onset of clinical manifestations. Most patients with early-onset type die before their second birthday. We describe a girl with Krabbe disease associated with uncontrolled seizures, which was confirmed with biochemical study and MRI. The clinical findings of this patient included hyperirritability, scissoring of the legs, flexion of arm, and clenching of the fists, and generalized tonic seizures. EEG showed hypsarrhythmia, and MRI demonstrated degenerative white matter changes in bilateral periventricular white matter, posterior rim of internal capsule, basal ganglia and brain stem on T2W1 and FLAIR image. The diagnosis was based on clinical features of progressive neurologic deterioration in conjunction with low galactocerebroside beta-galactosidase activity.

2016 KOREA STAR AWARDS (2016 미래패키징 신기술 정부포상)

  • (사)한국포장협회
    • The monthly packaging world
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    • s.277
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    • pp.45-66
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    • 2016
  • 산업통상자원부가 주최하고 한국생산기술연구원이 주관하는 "제10회 미래패키징 신기술 정부포상"시상식이 4월 26일 일산 킨텍스 그랜드볼룸에서 열렸다. 정부포상제도는 미래지식산업인 패키징산업 종사자의 긍지와 자부심 함양의 계기를 실천하고, 패키징산업 종사자의 사기진작과 패키징산업 활성화를 도모하는데 그 목적이 있다. 또한 한국국제포장기자재전(KOREA PACK)과의 동시개최로 패키징산업 종사자간 정보교류 극대화 및 공동체 의식 함양으로 일체감을 조성함은 물론, 패키징산업 기술인의 기술개발 의욕을 고취한다는 평가를 받고 있다. 제10회 미래패키징 신기술 정부포상 시상식에서는 코리아스타상 기업부문, 학생부문, 공로부문으로 구분하여 시상이 진행됐다. 기업부문은 패키징 완제품, 친환경패키징, 패키징관련기계(설비) 및 관련부품, 패키징인쇄(라벨링), 패키징원부자재 생산 및 가공공정, 패키징디자인 등의 분야에서 신기술 개발 또는 개선으로 수출 신장, 매출 수익 증대 및 발명특허 획득을 통해 패키징 기술력 발전에 기여한 기업의 패키징제품 또는 패키징디자인을 대상으로 진행되고 있으며 학생부문은 패키징 디자인 관련분야 전공자로 패키징과 연관된 컨셉으로 상품성, 창의성, 표현성, 친환경성, 지속가능성 등이 어우러진 독창적인 패키징제품 또는 패키징디자인을 대상으로 한다. 또한 공로부문은 패키징 산업 관련 산업계, 학계, 연구계, 유관기관에 종사하는 자로서 패키징 관련 핵심 기술개발, 경영, 마케팅 면에서 패키징 산업 발전에 기여한 공적이 뚜렷한 자, 패키징산업발전 정책연구 및 패키징산업 육성에 기여한 기업 또는 개인을 대상으로 하고 있다. 이번 행사에서는 기업부문 29개 제품과, 학생 14명, 공로 2명에 대한 포상이 진행, 국무총리상에는 (주)더우주의 '우주 페이스 마스크(OOZOO FACE MASK)'가 수상했으며, 산업통상자원부장관상에는 현대글로비스(주)외 2개사, 한국생산기술연구원장상에는 (주)풀무원 외 10개사가 수상했다. 학생부문에서는 안양대학교가 산업통상자원부장관상을 수상했다. 공로부문으로 진행된 시상식에서는 서영철 Flair Flexible Packaging 대표이사와 이명훈 한국포장시스템연구소장이 산업통상자원부장관 표창을 받았다. 본 고에서는 제10회 미래패키징 신기술 정부포상 수상작들을 살펴봄으로써 최신 패키징 경향에 대해 알아보도록 한다.

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Characteristics of Magnetic Resonance Imaging Findings in 32 Dogs Diagnosed with Meningoencephalitis of Unknown Etiology

  • Im, Chang-Gyu;Kim, Ah Reum;Han, Changhee;Hwang, Gunha;Kim, Rakhoon;An, Soyon;Hwang, Tae Sung;Lee, Hee Chun
    • Journal of Veterinary Clinics
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    • v.37 no.5
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    • pp.255-260
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    • 2020
  • The purpose of this retrospective study was to describe the characteristics of magnetic resonance imaging (MRI) findings in dogs with meningoencephalitis of unknown etiology (MUE), and to evaluate the usefulness of meningeal enhancement. Thirty-two dogs were included in MUE group on the basis of clinical signs, MRI findings and cerebrospinal fluid (CSF) results, and for comparison of the meningeal enhancement, twenty-three dogs with normal MRI, normal CSF and no clinical sign were included in the control group. The evaluated MRI findings included lesion site, lesion number, signal intensity of each MRI sequence, mass effect, perilesional edema, contrast enhancement, and meningeal enhancement. The MUE was most frequently associated with multiple lesions (50%) with perilesional edema (72%) in forebrain (66%) that were hyperintense (92%) in T2W and FLAIR images. Of the meningeal enhancement, there was no significant difference between the control group and the MUE groups in the pachymeningeal enhancement. However, leptomeningeal (or both) enhancement was found relatively high proportion in the MUE group than in the control group (P < 0.001, Odd ratio = 10.26), and based on this result, leptomeningeal (or both) enhancement is considered to be significant finding for indicating MUE.

A Comparative Study on Effective Leadership in Combat and Noncombat Situation (전투 및 비전투 상황에서의 효율적 리더십에 대한 비교 연구)

  • Lee, Jae-Yoon
    • Journal of National Security and Military Science
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    • s.5
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    • pp.203-239
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    • 2007
  • The current problems with the changing nature of the battlefield of the future point up the serious need for more and better research on the nature of effective military leadership. The purpose of this study was to examine effective leadership traits and behaviors of junior officers in combat situation. During times of peace, leader study battles and imagine themselves in all sorts of combat situations while at the same time, they must cope with numerous challenges and fill a variety of roles that they perceive are not battle related. This illustrates one of the fundamental paradoxes of the peacetime environment. Early studies, showing that combat leadership and noncombat leadership needed different talents, produced some clusters of traits which good combat leader were said to possess. Good combat leaders, for example, were described as possessing courage(e.g., bravery, fearlessness, daring, prowess, gallantry, guts, intrepidity, undaunted courage, fighting spirit, aggressive action), personal integrity(e.g., sincerity, flair, calmness, modesty), adaptability(e.g., flexibility, rapidity in action, speedy decision-making, clarity of thought) and so on. Behaviors found to be important in both combat and noncombat situations bore some relation to role requirements common to both situations. Behaviors important in one situation but not the other could be explained in terms of situational differences in role requirements for effective leadership. In order to achieve this purpose, a number of literature reviews were analysed. These results, though obtained in a somewhat rough and ready fashion, were useful not because they pointed to different leaders in war and in peace, but because they showed leaders the different things that were expected of them in different situations. It was also worth knowing how develop combat leadership. While these findings clearly suggest combat and noncombat differences, they do not necessarily confirm the complete study on effective leadership in combat situation. In conclusion, this study would be useful basis for further improvement on effective combat leadership and some further researches were recommended.

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An MRI-Based Quantification for Correlation of Imaging Biomarker and Clinical Performance in Chronic Phase of Carbon Monoxide Poisoning

  • Lee, Aleum;Hwang, Ji-sun;Bae, Won-kyung;Park, Jai-soung;Goo, Dong Erk;Park, Sung-Tae
    • Investigative Magnetic Resonance Imaging
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    • v.23 no.3
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    • pp.241-250
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    • 2019
  • Purpose: The purpose of this study was to determine the relation between quantitative magnetic resonance imaging biomarkers, and clinical performances in chronic phase of carbon monoxide intoxication. Materials and Methods: Eighteen magnetic resonance scans and cognitive evaluations were performed, on patients with carbon monoxide intoxication in chronic phase. Apparent diffusion coefficient (ADC) ratios of affected versus unaffected centrum semiovale, and corpus callosum were obtained. Signal intensity (SI) ratios between affected centrum semiovale, and normal pons in T2-FLAIR (fluid-attenuated inversion recovery) images were obtained. The Mini-Mental State Exam, and clinical outcome scores were assessed. Correlation coefficients were calculated, between MRI and clinical markers. Patients were further classified into poor-outcome and good-outcome groups based on clinical performance, and imaging parameters were compared. T2-SI ratio of centrum semiovale was compared, with that of 18 sex-matched and age-matched controls. Results: T2-SI ratio of centrum semiovale was significantly higher in the poor-outcome group, than that in the good-outcome group and was strongly inversely correlated, with results from the Mini-Mental State Exam. ADC ratios of centrum semiovale were significantly lower in the poor outcome group than in the good outcome group, and were moderately correlated with the Mini-Mental State Exam score. Conclusion: A higher T2-SI and a lower ratio of ADC values in the centrum semiovale, may indicate presence of more severe white matter injury and clinical impairment. T2-SI ratio and ADC values in the centrum semiovale, are useful quantitative imaging biomarkers for correlation with clinical performance in individuals with carbon monoxide intoxication.

Delayed Post-Hypoxic Leukoencephalopathy Induced by an Overdose with Fentanyl Patches: A Case Report (펜타닐 첩포 남용으로 인한 지연성 저산소성 백색질뇌증: 증례 보고)

  • Jin Sol Choi;Eun Ae Yoo;Jin Ok Choi;Soo Jung Kim
    • Journal of the Korean Society of Radiology
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    • v.81 no.4
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    • pp.972-978
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    • 2020
  • Fentanyl intoxication has occasionally been reported since fentanyl patches became available for medical use. Delayed post-hypoxic leukoencephalopathy is a complication of hypoxia. However, its neuropsychiatric symptoms can be delayed, and it can progress to leukoencephalopathy even after full recovery from coma due to acute intoxication. Herein, we report a case of fentanyl intoxication in a 65-year-old man who was presented to the hospital because of unconsciousness for 13 hours after using ten fentanyl patches simultaneously. Initial brain CT findings were non-specific. Twenty days later, delayed neuropathologic symptoms manifested, and MRI showed bilaterally symmetrical, heterogeneous, confluent high signal intensities on T2-weighted/fluid attenuated inversion recovery MRI in the cerebral white matter with diffusion restriction. This was followed by rapid exacerbation of neuropathological symptoms with diffuse severe cerebral atrophy over 1 year.

Gerstmann-Sträussler-Scheinker Disease: A Case Report (Gerstmann-Sträussler-Scheinker병: 증례 보고)

  • Minji Shin;Donghyun Kim;Young Jin Heo;Jin Wook Baek;Suyoung Yun;Hae Woong Jeong
    • Journal of the Korean Society of Radiology
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    • v.84 no.3
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    • pp.745-749
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    • 2023
  • Gerstmann-Sträussler-Scheinker (GSS) disease is a rare hereditary prion disease which is clinically characterized by a progressive cerebellar ataxia followed by cognitive impairment. We report a rare case of GSS disease in a 39-year-old male patient who complained of a progressive gait disturbance followed by dysarthria with cognitive impairment, after five months from the onset of initial symptom. His brain MRI scan revealed multifocal symmetric diffusion restricted lesions with T2/FLAIR hyperintensities in bilateral cerebral cortices, basal ganglia, and thalami. His family members also manifested similar symptoms in their 40-50s, suggesting the possibility of a genetic disease. Finally, he was genetically diagnosed with GSS disease by real-time quaking-induced conversion and prion protein (PRNP) gene sequencing test.