생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제20권3호
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  • Pages.97-103
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  • 2013
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

치매 환자에서 뇌 자기공명영상의 특징과 비정형 항정신병 약제 사용여부의 상관 관계

Association between Characteristics of Brain Magnetic Resonance Imaging and Atypical Antipsychotics Use in Dementia Patients

  • 최종택 (순천향대학교 서울병원 정신건강의학과) ;
  • 김지원 (순천향대학교 서울병원 정신건강의학과) ;
  • 노양호 (순천향대학교 서울병원 정신건강의학과) ;
  • 류석환 (순천향대학교 구미병원 정신건강의학과) ;
  • 우성일 (순천향대학교 서울병원 정신건강의학과) ;
  • 한상우 (순천향대학교 서울병원 정신건강의학과) ;
  • 황재욱 (순천향대학교 서울병원 정신건강의학과)
  • Choi, Jongtaek (Department of Psychiatry, Soonchunhyang University Hospital Seoul) ;
  • Kim, Jiwon (Department of Psychiatry, Soonchunhyang University Hospital Seoul) ;
  • Roh, Yangho (Department of Psychiatry, Soonchunhyang University Hospital Seoul) ;
  • Rhu, Sukhwan (Department of Psychiatry, Soonchunhyang University Gumi Hospital) ;
  • Woo, Sungil (Department of Psychiatry, Soonchunhyang University Hospital Seoul) ;
  • Hahn, Sangwoo (Department of Psychiatry, Soonchunhyang University Hospital Seoul) ;
  • Hwang, Jaeuk (Department of Psychiatry, Soonchunhyang University Hospital Seoul)
  • 투고 : 2013.05.16
  • 심사 : 2013.06.20
  • 발행 : 2013.08.31
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초록

Objectives We aimed to identify the neuroimaging marker for prediction of the use of atypical antipsychotics (AAP) in dementia patients. Methods From April 2010 to March 2013, 31 patients who were diagnosed as dementia at the psychiatric department of Soonchunhyang University Hospital, completed the brain magnetic resonance imaging scan and cognitive test for dementia. Ten patients were treated with AAP for the improvement of behavioral and psychological symptoms of dementia (BPSD) and the other 21patients were not. Using T1 weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of brain, areas of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and white matter hyperintensities (WMH) have been segmented and measured. Multivariate logistic regression models were applied for assessment of association between AAP use and the GM/WM ratio, the WMH/whole brain (GM + WM + CSF) ratio. Results There was a significant association between AAP use and the GM/WM ratio (odds ratio, OR = 1.18, 95% confidence interval, CI 1.01-1.38, p = 0.037), while there was no association between AAP use and the WMH/whole brain ratio (OR = 0.82, 95% CI 0.27-2.48, p = 0.73). Conclusions The GM/WM ratio could be a biological marker for the prediction of AAP use and BPSD in patients with dementia. It was more likely to increase as dementia progress since atrophy of WM was more prominent than that of GM over aging.

키워드

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