• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2003년도 동계 학술대회 논문집
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• pp.209-214
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• 2003

바이오 센서는 생물학적 인식 반응(Biological recognition reaction)이나 생물 촉매 공정(Bio-catalytic process)을 측정 가능한 전기적 신호로 변환시켜주는 적절한 변환기(Transducer)와 같은 생물학적 인식요소로 이루어진 감지 장치를 의미한다. 1962년 효소를 이용한 Glucose 전극봉의 개발이후 이 분야에 대한 수많은 연구와 기기의 개발이 진행되어왔다. 분석도구로써 바이오 센서는 효소, 항체, 수용체, 세포, 조직 등과 같은 생물학적 인식 요소들에 광범위하게 적용 가능하다는 장점이 있는 반면, 위에 열거한 생물학적 인식 요소들의 불안정성으로 인해 신뢰성이 유지되지 못하는 단점을 동시에 지니고 있다. (중략)

• Korean Journal of Hydrosciences
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• 제10권
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• pp.59-72
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• 1999

FIAS(Flood Inundation Analysis System) using Arc/Info is developed and applied to the Namhan River basin. The DWOPER model is revised and expanded to handle simultaneous multiple overtopping and/or breaking, and to estimate the inundated depth and extents. The model is applied to an actual levee overtopping case, which occurred on August 23∼27, 1995 in the Namhan River. Stage hydrographs inside and outside of the levee are compared, then inundated discharges from overbank spilling are computed. The Graphic User interface is developed with AML. Two- and three-dimensional inundation map by Arc/Info are presented. The computed inundation extends agree with observations in terms of inundated depth and flooded area. The FIAS is useful for the analysis of flood hazards and preparation of inundation map for river basins.

• 한국수자원학회논문집
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• 제31권4호
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• pp.415-427
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• 1998

DWOPER 모형에 제방월류 및 붕괴에 따른 홍수해석, 제내지에서의 범람 해석등을 처리할 수 있도록 프로그램을 대폭적으로 개선, 보강한 모형을 개발하여 Arc/Info와 연계하여 처리할 수 있는 홍수범람해석시스템 FIAS(Flood Inundation Analysis System)를 구축하여 이를 남한강의 제방월류 및 붕괴에 대해서 적용하였다. 본 모형을 1995년 8월 23~27일에 남한강의 제방의 월류로 인해 발생한 범람홍수에 대해 적용하였다. 홍수파 해석에 의한 하천의 하도부에서의 수위와 제내지의 수위를 비교하여 하천제방의 월류로 인한 범람유량을 산정하였다. Arc/Info의 AML 을 이용한 GUT를 개발하여 2차원과 3차원 홍수범람도를 도시하였다. 본 연구모형으로부터 계산된 범람수위와 범람면적은 실제 현지 조사자료와도 잘 일치하는 것으로 나타났다.

• Korean Journal of Radiology
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• 제23권1호
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• pp.101-111
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• 2022

Objective: Familial intracranial aneurysms (FIAs) are found in approximately 6%-20% of patients with intracranial aneurysms (IAs), suggesting that genetic predisposition likely plays a role in its pathogenesis. The aim of this study was to identify possible IA-associated variants using whole exome sequencing (WES) in selected Korean families with FIA. Materials and Methods: Among the 26 families in our institutional database with two or more IA-affected first-degree relatives, three families that were genetically enriched (multiple, early onset, or common site involvement within the families) for IA were selected for WES. Filtering strategies, including a family-based approach and knowledge-based prioritization, were applied to derive possible IA-associated variants from the families. A chromosomal microarray was performed to detect relatively large chromosomal abnormalities. Results: Thirteen individuals from the three families were sequenced, of whom seven had IAs. We noted three rare, potentially deleterious variants (PLOD3 c.1315G>A, NTM c.968C>T, and CHST14 c.58C>T), which are the most promising candidates among the 11 potential IA-associated variants considering gene-phenotype relationships, gene function, co-segregation, and variant pathogenicity. Microarray analysis did not reveal any significant copy number variants in the families. Conclusion: Using WES, we found that rare, potentially deleterious variants in PLOD3, NTM, and CHST14 genes are likely responsible for the subsets of FIAs in a cohort of Korean families.

• Journal of Biosystems Engineering
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• 제28권5호
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• pp.465-468
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• 2003

A microdialysis coupled flow injection amperometric biosensor was calibrated to measure the concentration of glucose using 7 standard samples from 10ml to 70ml of glucose solution. The output of the sensor increased linearly with an increase in the glucose concentration with an $R^2$ correlation of 0.99. The amperometric biosensor was then applied to measure the. glucose concentration of 2 commercial samples(Orange and Pineapple juice) and the results compared with HPLC. Around 12% error was observed in glucose concentration measurements of the samples analyzed. The sensor has potential in rapid measurement once the calibration is done. Potential for on-line sensing is also discussed.

• 한국농공학회:학술대회논문집
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• 한국농공학회 1999년도 Proceedings of the 1999 Annual Conference The Korean Society of Agricutural Engineers
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• pp.454-458
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• 1999

This study is to analyze the causes of flood damage in Imjin river basin inAugust , 1999. and to propose the measure to reudce such flood damage. The northern part of Kyonggin Province in the basin was severely damaged by flood due to the heavy rainfall for 4 days from 31 July to 3 August, whioch was recordedas 1,032mm. The heavy rainfall worth recording was one of main cuasese of such damage, but unsuitable river improvement and basin management were also important causes. The flood proptection works such as flood control reservoir and riverlevee were not contructed or sufficient in spite of the unflavorable geographical conditions of Imjin reiver. In case of irrigatiion faciliteis, 43 pumping stations in 3 FIAs were severely damaged due to inundation of the pump and switch boxes. The protection works for pump room should be improved to reduce the damage due to inundation.

• 센서학회지
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• 제33권1호
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• pp.12-17
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• 2024

Floating inverter amplifiers (FIAs) have recently garnered considerable attention owing to their high energy efficiency and inherent resilience to input common-mode voltages and process-voltage-temperature variations. Since the voltage gain of a simple FIA is low, it is typically cascaded or cascoded to achieve a higher voltage gain. However, cascading poses stability concerns in closed-loop applications, while cascoding limits the output swing. This study introduces a gain-enhanced FIA that features cross-coupled body biasing. Through simulations, it is demonstrated that the proposed FIA designed using a 28-nm complementary metal-oxide-semiconductor technology with a 1-V power supply can achieve a high voltage gain (> 90 dB) suitable for dynamic open-loop applications. The proposed FIA can also be used as a closed-loop amplifier by adjusting the amount of positive feedback due to the cross-coupled body biasing. The capability of achieving a high gain with minimum-length devices makes the proposed FIA a promising candidate for low-power, high-speed sensor interface systems.

• Environmental Analysis Health and Toxicology
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• 제17권2호
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• pp.109-115
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• 2002

This study was conducted to investigate the reference value of mercury (Hg) in liver and kidney of Korean population. The mercury concentration in 244‘sudden and unexpected death’autopsies (male: 180, female: 64) aged from 0 to 87 years was analyzed. The concentration of mercury was measured by atomic absorption spectrophotometer (Perkin-Elmer Model 5100) with mercury/hydride generating system (FIAS 400). The contents of mercury in liver and kidney fitted well the log-normal distribution rather than normal distribution. Geometric mean concentration of mercury in liver and kidney was 0.115 $\mu\textrm{g}$/g wet weight and 0.149 $\mu\textrm{g}$/g wet weight, respectively. Geometric mean concentration of mercury in female was higher than in male (p < 0.01). The mercury content in liver and kidney increased with age up to the forties and slightly decreased there-after. The regression model of mercury deposit in liver and kidney by age was predicted as the following equation : Log LHg : -1.0576＋0.0045$.$Age-0.0001$.$Age$^2$＋0.0873$.$Sex, Log KHg = -1.0576＋0.0152$.$Age-0.0002$.$Age$^2$＋0.1935$.$Sex. The liver burden of mercury was estimated to be 158.3∼161.3 $\mu\textrm{g}$ in male and 163.0∼166.9 $\mu\textrm{g}$ in female. The kidney burden of mercury was estimated to be 42.0∼42.9 $\mu\textrm{g}$ in male and 55.5∼57.1 $\mu\textrm{g}$ in female.

• 한국환경보건학회지
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• 제41권5호
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• pp.289-298
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• 2015

Objectives: The method of analyzing urinary arsenic by flow injection hydride generation atomic absorption spectrometry (FI-HG-AAS) is generally used because it shows relatively greater sensitivity, low detection limits, low blocking action, and is simple to operate. In this study, the results of analysis according to three pre-reductants commonly used in the FI-HG-AAS method were compared with each other. Methods: To analyze urinary arsenic, nineteen urine samples were collected from adults aged 43-79 years old without occupational arsenic exposure. Analysis equipment was FI-HG-AAS (AAnalyst 800/FIAS 400, Perkin- Elmer Inc., USA). The three pre-reductants were potassium iodide (KI/AA), C3H7NO2S (L-cysteine), and a mixture of KI/AA and L-cysteine (KI/AA&L-cysteine). Results: In the results of the analysis, the recovery rate of the method using KI/AA was 82.3%, 95.7% for Lcysteine, and 123.5% for KI/AA and L-cysteine combined. When compared with the results by use of high performance liquid chromatography inductively-coupled plasma mass spectrometry (HPLC-ICP-MS), the method using L-cysteine was the closest to those using HPLC-ICP-MS ($98.57{\mu}g/L$ for HPLC-ICP-MS; $74.96{\mu}g/L$ for L-cysteine; $69.23{\mu}g/L$ for KI/AA and L-cysteine; $13.06{\mu}g/L$ for KI/AA) and were significantly correlated (R2=0.882). In addition, they showed the lowest coefficient of variation in the results between two laboratories that applied the same method. Conclusion: The efficiency of hydride generation is considered highly important to the analysis of urinary arsenic via FI-HG-AAS. This study suggests that using L-cysteine as a pre-reductant may be suitable and the most rational among the FI-Hg-AAS methods using pre-reductants.