• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1081-1084
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• 2002

In this study, we perform 3-D reconstruction of human proximal femur from DICOM files by using voxel mesh algorithm. After 3-D reconstruction, the model converted to Finite Element model which developed for automatically making not only 3-D geometrical model but also FE model from medical image dataset. During this job, trabecular pattern, one of characteristic of human bone can be added to the model by means of giving it's own elastic property calculated from intensity in CT scanned image to the each voxel. And then another model is made from same image dataset which have two material properties - one corresponds to cortical bone, another to trabecular bone. Finally, validity of voxel mesh technique is verified through comparing results of FE analysis, free vibration and stress analysis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1074-1077
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• 2002

Biomechanical behavior of the human femur is very important in various clinical situations. In this study, the data of FE models based on DICOM file exported from Computed tomography(CT). We generated FE models(voxel model, tetra model) of human femur using CT slide image. We compared them with Yon Mises stress results derived from finite element analysis(FEA). Comparing the two models, we found a correlation of them. As a result, the tetra model based proposed marching cube algorithm is a valid and accurate method to predict parameters of the complex biomechanical behavior of human femur.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.1641-1642
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• 2013

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.6 s.237
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• pp.913-920
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• 2005

Compared to previous in-vitro test, FE model showed reliable motion patterns. A finite element model of a 50th percentile male neck was developed to study the mechanics of whiplash injury while the rear impacts. The model was consisted of the whole cervical vertebrae including part of occipital, intervertebral discs. which were modeled using linear viscoelastic materials and posterior elements. The sliding interfaces were defined to simulate contact phenomena in facet joints and in odontoid process. All ligaments and atlanto-occipital membrane were modeled as nonlinear bar elements. Only muscle elements were not considered. Motion of each cervical vertebra was obtained from the dynamic simulation with a MADYMO model for 15 km/h $40\%$ rear end offset impacts. Soft tissue neck injury(STNI) was investigated with a developed FE model. In FE model analysis, the high stress was appeared at C3/C4 disc in offset impact. Further research is still needed in order to improve the developed neck FE model for many different crash patterns.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.11
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• pp.1202-1208
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• 2009

An inverse finite element (FE) model parameter estimation algorithm can be used to characterize mechanical properties of biological tissues. Using this algorithm, we can consider the influence of material nonlinearity, contact mechanics, complex boundary conditions, and geometrical constraints in the modeling. In this study, biomechanical experiments on macro and micro samples are conducted and characterized with the developed algorithm. Macro scale experiments were performed to measure the force response of porcine livers against mechanical loadings using one-dimensional indentation device. The force response of the human liver cancer cells was also measured by the atomic force microscope (AFM). The mechanical behavior of porcine livers (macro) and human liver cancer cells (micro) were characterized with the algorithm via hyperelastic and linear viscoelastic models. The developed models are suitable for computing accurate reaction force on tools and deformation of biomechanical tissues.

• Mycobiology
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• v.42 no.4
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• pp.427-431
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• 2014

Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.777-778
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• 2012

• Journal of Sensor Science and Technology
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• v.20 no.4
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• pp.249-253
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• 2011

This paper describes the fabrication and characteristics of vibration-driven electromagnetic energy harvester without spring to use at low frequency like a human body motion. The implemented energy harvester consists of NdFeB magnets, copper coil. The optimization of induced voltage was done by the various widths of coil, number of the turns, size of fixed and moving magnets and thicknesses of the cylinder. The fabricated energy harvester is capable of producing up to 15.0 $V_{pp}$ for basic model and 28.80 $V_{pp}$ for improved model at 5.0 Hz resonance frequency and 0.75 g acceleration level. The basic model and improved model are provided a maximum power of 6.375 mWand 25.831 mW at 1 KHz of load resistance in rectifier circuit.

• Toxicological Research
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• v.32 no.4
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• pp.311-316
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• 2016

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDerm$^{TM}$ skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time according to the test guidelines. Cell viabilities of EpiDerm$^{TM}$ skins were measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide based method. FeNPs, AlNPs, TNPs, and AgNPs were non-corrosive because the viability was more than 50% after 3 min exposure and more than 15% after 60 min exposure, which are the non-corrosive criteria. All NPs were also non-irritants, based on viability exceeding 50% after 60 min exposure and 42 hr post-incubation. Release of interleukin 1-alpha and histopathological analysis supported the cell viability results. These findings suggest that FeNPs, AlNPs, TNPs, and AgNPs are 'non-corrosive' and 'non-irritant' to human skin by a globally harmonized classification system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.12
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• pp.1563-1571
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• 2011

In this study, we developed a finite element model of the human middle ear has been developed to calculate itsfor sound transfer characteristics calculation. We usedThe geometric data forof ossicles, obtained byfrom micro-CT scanning, was used in order to develop the middle- ear FE model. A right- side temporal bone of a Korean cadaver was used for the micro-CT scanning. The developed FE model includes three ossicles, the tympanic membrane, ligaments, and muscles. We calculated theA sound transfer function from the tympanic membrane to the stapes footplate was calculated. The sound transfer function calculated vias of the FE model shows good agreement with measured responses over the 10- kHz frequency band. To measureidentify the sensitivityies of the middle- ear function due to material property variation, we studied several parameters studies have been fulfilled using the middle ear FE model. TAs a result the stiffness property of the incudostapedial joint had the greatest influence onwas the most influential to the middle- ear sound transfer function among the parameters.