• Title/Summary/Keyword: FAVOR method

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3D-QSAR Study on the Influence of Alrylamino (R) Substituents on Herbicidal Activity of Thiourea Analogues

  • Soung, Min-Gyu;Park, Kwan-Yong;Sung, Nack-Do
    • Bulletin of the Korean Chemical Society
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    • v.31 no.6
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    • pp.1469-1473
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    • 2010
  • Influences of alrylamino (R) substituents on the herbicidal activity ($pI_{50}$) of 1-(4-chloro-2-fluoro-5-propargyloxypheny)-3-(R)-thiourea analogues (1 ~ 35) against the barnyard grass (Echinochloa crusgalli) in the pre-emergence step were discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) as the three dimensional quantitative structure-activity relationship (3D-QSAR) method. The statistically most satisfactory CoMFA models for the herbicidal activity against the barnyard grass had the better predictability ($r^2{_{cv.}}$) and correlativity ($r^2{_{ncv.}}$) than those of CoMSIA models. The optimized CoMFA model 1($r^2{_{cv.}}$ = 0.531 & $r^2{_{ncv.}}$ = 0.931) with the sensitivity to the perturbation (${d_q}^{2'}{dr^2}_{yy'}$ = 1.081) and the prediction ($q^2$ = 0.475) produced by a progressive scrambling analyses were not dependent on chance correlation. And statistical qualities with the atom based fit alignment (AF) were slightly higher than those of the field fit alignment (FF). According to the optimized CoMFA model 1, the contribution ratio (%) of the steric field (76.9%) on the herbicidal activity of the Thioureas was three-fold higher than that of the electrostatic field (20.1%) and the hydrophobic field (3.0%) had the least influence. A steric favor group is on the vicinity of the nitrogen atom in alrylamino (R) substituent, and a steric disfavor group is on the outer side of alrylamino (R) substituent. Thus, as the size of alrylamino (R) substituent increases, so does the herbicidal activity of the substituent.

A study on the Response Characteristics of Fuzzy Controller & Fuzzy Neural Network Controller (퍼지 제어기와 퍼지 신경망제어기의 응답 특성에 관한 연구)

  • Kim, Hyeong-Su;Lee, Sang-Bu;Kim, Heung-Gi
    • The Transactions of the Korea Information Processing Society
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    • v.3 no.6
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    • pp.1473-1482
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    • 1996
  • This study examines the response characteristics of the fuzzy controller and the fuzzy neural network controller. The former is excellent in terms of the overshoot at its values and has great advantages on the disturbance. But there exist some errors in its desired output. Many methods have been introduced that remove the errors of the desired state. This study is in more favor of the fuzzy neural network controller using the neural network than any other method. The fuzzy neural network controller complements the shortcomings of fuzzy controller and can be an accurate controller by being well-without any disturbance or error-converged to the desired output. And it is through simulation that the comparison of the two controllers is carried out in this study.

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Health Vulnerability Assessment for PM10 in Busan (부산지역 미세먼지에 대한 건강 취약성 평가)

  • Lee, Won-Jung;Hwang, Mi-Kyoung;Kim, Yoo-Keun
    • Journal of Environmental Health Sciences
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    • v.40 no.5
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    • pp.355-366
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    • 2014
  • Objectives: This study seeks to evaluate the vulnerability assessment of the human health sector for $PM_{10}$, which is reflected in the regional characteristics and related disease mortality rates for $PM_{10}$ in Busan over the period of 2006-2010. Methods: According to the vulnerability concept suggested by the Intergovernmental Panel on Climate Change (IPCC), vulnerability to $PM_{10}$ is comprised of the categories of exposure, sensitivity, and adaptive capacity. The indexes of the exposure and sensitivity categories indicate positive effects, while the adaptive capacity index indicates a negative effect on vulnerability to $PM_{10}$. Variables of each category were standardized by the rescaling method, and each regional relative vulnerability was computed through the vulnerability index calculation formula. Results: The regions with a high exposure index are Jung-Gu (transportation region) and Saha-Gu (industrial region). Major factors determining the exposure index are the $PM_{10}$ concentration, days of $PM_{10}{\geq}50$, ${\mu}g/m^3$, and $PM_{10}$ emissions. The regions that show a high sensitivity index are urban and rural regions; these commonly have a high mortality rate for related disease and vulnerable populations. The regions that have a high adaptive capacity index are Jung-Gu, Gangseo-Gu, and Busanjin-Gu, all of which have a high level of economic/welfare/health care factors. The high-vulnerability synthesis of the exposure, sensitivity, and adaptive capacity indexes show that Dong-Gu and Seo-Gu have a risk for $PM_{10}$ potential effects and a low adaptive capacity. Conclusions: This study presents the vulnerability index to $PM_{10}$ through a relative comparison using quantitative evaluation to draw regional priorities. Therefore, it provides basic data to reflect environmental health influences in favor of an adaptive policy limiting damage to human health caused by vulnerability to $PM_{10}$.

The Problem Analysis and Improvement Plans to the Bidding System of Construction Works (건설공사 입 ${\cdot}$ 낙찰제도의 문제점 및 개선방안;대한주택공사의 발주공사를 중심으로)

  • Jeong, Jin-Pal;Park, Moon-Sun;Kim, Yong-Su
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2007.11a
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    • pp.704-709
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    • 2007
  • The purpose of this study is to present both problems and improvement plans on the bidding system of the Korea National Housing Corporation, which orders apartment houses professionally. For data gathering, this study used data from electronic procurement system from 2001 to 2005. The research method of this study is to analyze the data categorized into four types: changes of ordering and contract price ration, the lowest-pricing bidding system, and permanent projects by grades. As a result of the analysis, the amount of ordering is biased in favor of particular level. Finally, this study present following improvement plans: 1) screening system and the lowest-pricing bidding system need to be supplemented, 2) the contract price ratio and the amount of ordering should be controlled, and 3) the improvement of PQ and the introduction of the list of Qualified companies by types need to be presented.

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Comparing the effectiveness of ultrasound guided versus blind genicular nerve block on pain, muscle strength with isokinetic device, physical function and quality of life in chronic knee osteoarthritis: a prospective randomized controlled study

  • Cankurtaran, Damla;Karaahmet, Ozgur Zeliha;Yildiz, Sadik Yigit;Eksioglu, Emel;Dulgeroglu, Deniz;Unlu, Ece
    • The Korean Journal of Pain
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    • v.33 no.3
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    • pp.258-266
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    • 2020
  • Background: The genicular nerve block (GNB) is demonstrated from several reports to alleviate pain and improve knee functionality in patients with chronic knee osteoarthritis (OA). Ultrasound (US)-guided GNB has been the most used imaging method. This study aimed to compare the effectiveness of US-guided versus blind GNB in the treatment of knee OA. Methods: This prospective, randomized clinical trial included patients with knee OA based on American College of Rheumatology diagnostic criteria. The patients were evaluated for clinical and dynamometer parameters at the baseline, 4 weeks after treatment, and 12 weeks after treatment. The patients underwent blind injection or US-guided injection. Results: When compared with the baseline, both groups showed significant improvement in pain, physical function, and quality of life parameters. Significant differences were observed between the groups for clinical parameters (30-second chair stand test, 6-minute walk test) in favor of the US-guided group. On the other hand, blind injection was more significantly effective on some parameters of the Nottingham Health Profile. There wasn't any significant improvement in isokinetic muscle strength for either group. Conclusions: This study demonstrated that both US-guided and blind GNB, in the treatment of knee OA, were effective in reducing symptoms and improving physical function. GNB wasn't an effective treatment for isokinetic muscle function. US-guided injections may yield more effective clinical results than blind injections.

A Research Trends for Domestic Public Design by Meta Analysis (국내 공공디자인 연구동향에 대한 메타분석)

  • Hwang, Mee-Young
    • Korean Institute of Interior Design Journal
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    • v.25 no.3
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    • pp.102-111
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    • 2016
  • There are various form of public elements in modern urban space. These public elements mingle with sociocultural elements which consist of each city, determining urban environment's image. Especially, since the social value of design becomes important, the social role of public design has been emphasized as an effective value for public interest and environment. It is just about 10 years since design mind in the public sector has been made domestically. Even though domestic public design has been studied not so long, it has developed with radical change of social culture and science technology. This study targets public environment in modern dense urban space. Also, it grasps the trend of public design studies through analysing and documentary survey of the existing studies, and based on that result, aims at presenting the direction that domestic public design studies should progress. This study selected 253 theses(1989.6~2015.11) by collecting primary, secondary data about public design studies, and implemented overall meta-analysing about the trend of domestic public design studies. As a result, public design has been studied intensively in the field of design about environment, architecture, etc. The trend analyzing of study purpose and keyword has a tendency which is weighted towards exploratory study focused on suggestion and development about object and realm of public design. The trend analyzing of study area tends to study overall part of public space or public facility rather than specific area and object. The most parts of studies analyze domestic area, especially Seoul metropolitan area. Also, the study method weighted in favor of some qualitative analysis has been utilized.

Application of the French Codes to the Pressurized Thermal Shocks Assessment

  • Chen, Mingya;Qian, Guian;Shi, Jinhua;Wang, Rongshan;Yu, Weiwei;Lu, Feng;Zhang, Guodong;Xue, Fei;Chen, Zhilin
    • Nuclear Engineering and Technology
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    • v.48 no.6
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    • pp.1423-1432
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    • 2016
  • The integrity of a reactor pressure vessel (RPV) related to pressurized thermal shocks (PTSs) has been extensively studied. This paper introduces an integrity assessment of an RPV subjected to a PTS transient based on the French codes. In the USA, the "screening criterion" for maximum allowable embrittlement of RPV material is developed based on the probabilistic fracture mechanics. However, in the French RCC-M and RSE-M codes, which are developed based on the deterministic fracture mechanics, there is no "screening criterion". In this paper, the methodology in the RCC-M and RSE-M codes, which are used for PTS analysis, are firstly discussed. The bases of the French codes are compared with ASME and FAVOR codes. A case study is also presented. The results show that the method in the RCC-M code that accounts for the influence of cladding on the stress intensity factor (SIF) may be nonconservative. The SIF almost doubles if the weld residual stress is considered. The approaches included in the codes differ in many aspects, which may result in significant differences in the assessment results. Therefore, homogenization of the codes in the long time operation of nuclear power plants is needed.

Studies on the Improvement of Moutainous Pasture II. Effect of existing vegetation on establishment and herbage production of oversown grasses in forest (산지초지 개량에 관한 연구 II. 임지의 선점식생이 겉뿌린 목초의 정착 및 수량에 미치는 영향)

  • 이인덕;윤익석
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.4 no.2
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    • pp.108-114
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    • 1983
  • This study was conducted to investigate the effects of existing vegetation on seedling establishment and herbage production of oversown grasses in the Pinus rigida forest. The dominant existing vegetations were Miscanthus sinensis, Festuca ovina, and Lycopodium serratum. In establishment year, seedling stands and herbage production were not affected in Miscanthus sinensis and Festuca ovina, while in Lycopodium serratum it was affected relatively seriously. The pattern of sown species response to the existing vegetations was trend to toward simplified two or three species as Dactylis glomerata, Lolium perenne, and Trifolium repens to advancing the time. Among sown species, Dactylis glomerata was a major dominant species in all existing vegetation area. The content of sown pasture grasses in the sward increased markedly, while the existing vegetations before seeding seriously decreased to advancing the cutting time. The above results shown that the improvement of forest pasture with a surface seeding was better in Miscanthus sinensis and Festuca ovina, but in Lycopodium serratum was found very difficult to improvement of pasture without surface treatment, also establishment method must favor the low herbage production potential.

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Improving the Dyeability of Cotton Fabric with Caesalpinia sappan through Pretreatment with Gelatin (면직물의 젤라틴 전처리에 의한 소목염색의 염색성 향상)

  • Lee, Ji Youn;Jang, Jeong Dae
    • Fashion & Textile Research Journal
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    • v.21 no.4
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    • pp.509-514
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    • 2019
  • Cotton fabrics were treated with gelatin to enhance dyeability and color strength when using Caesalpinia sappan dye. Gelatin was used as the protein and a pad-dry- cure method was used for the treatment process (2, 4, 6, 8, 10, 12, 14g/l concentration). Pretreated fabrics were mordanted with 10% alum. Fabrics were then dyed with freeze-dried sappan wood water extract powder form. Dyed samples were assessed in regards to dyeing behavior and color fastness. Comparing untreated and gelatin treated samples from the SEM images indicated that the Gelatin treatment (10g/l) resulted in an enhanced surface roughness that was relative to that of untreated cotton. Padding cotton with gelatin at 6g/l concentration afforded dyed fabrics with a 2 times increase in the K/S value over that of untreated fabrics. All dyed samples were red color with a significant enhancement in the sample color strength (K/S) being observed for pretreated samples. pH values favor dye absorption with pH 7 yielding the highest color strength. Dyeing at an elevated temperature resulted in a lower color strength and reddish-dull color. Longer dyeing times created greater color strengths for untreated and gelatin treated cotton. Increased dye concentrations resulted in higher K/S values for both gelatin treated and untreated cotton. As for color fastness, gelatin treated and untreated cotton fabrics dyed with sappan wood extract showed a relatively low rating in washing fastness (color change 1 rating), light fastness (1 rating), and rubbing fastness (wet:1-2, dry:3-4 rating).

Does transcutaneous electrical nerve stimulation affect pain, neuropathic pain, and sympathetic skin responses in the treatment of chronic low back pain? A randomized, placebo-controlled study

  • Yaksi, Elif;Ketenci, Aysegul;Baslo, Mehmet Baris;Orhan, Elif Kocasoy
    • The Korean Journal of Pain
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    • v.34 no.2
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    • pp.217-228
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    • 2021
  • Background: The purpose of this study was to assess the effectiveness of transcutaneous electrical nerve stimulation (TENS) in chronic low back pain and neuropathic pain. Methods: Seventy-four patients aged 18-65 with chronic low back pain were included in the study. Baseline measurements were performed, and patients were randomized into three groups. The first group received burst TENS (bTENS), the second group conventional TENS (cTENS), and the third group placebo TENS (pTENS), all over 15 sessions. Patients' visual analogue scale (VAS) scores were evaluated before treatment (preT), immediately after treatment (postT), and in the third month after treatment (postT3). Douleur Neuropathique 4 Questions (DN4), the Modified Oswestry Low Back Pain Disability Questionnaire (MOS), the Beck Depression Inventory (BDI), and sympathetic skin response (SSR) values were also evaluated preT and postT3. Results: A statistically significant improvement was observed in mean VAS scores postT compared to preT in all three groups. Intergroup comparison revealed a significant difference between preT and postT values, that difference being assessed in favor of bTENS at multiple comparison analysis. Although significant improvement was determined in neuropathic pain DN4 scores measured at postT3 compared to preT in all groups, there was no significant difference between the groups. No statistically significant difference was also observed between the groups in terms of MOS, BDI, or SSR values at postT3 (P > 0.05). Conclusions: bTENS therapy in patients with low back pain is an effective and safe method that can be employed in short-term pain control.