• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1993년도 가을 학술발표회논문집
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• pp.240-247
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• 1993

The precise prediction of reserved carrying capacity of bridge as a system is extremely difficult especially when the bridges are highly redundant and significantly deteriorated or damaged. This paper is intended to propose a new approach for the evaluation of reserved system carrying capacity of bridges in terms of equivalent system-strength, which may be defined as a bridge system-strength corresponding to the system reliability of the bridge. This can be derived from an inverse process based on the concept of FOSM form of system reliability index. It may be emphasized that this approach is very useful for the evaluation of the deterministic system redundancy and reserve strength which are measured in terms of either probabilistic system redundancy factor and reserve factor or deterministic system redundancy factor and reserve factor. The system reliability of bridges is formulated as a parallel-series model obtained from the FAM(Failure Mode Approach) based on the major failure mechanisms. AFOSM and IST methods are used for the reliability analysis of the proposed models. The proposed approach and method for the system redundancy and reserve safety/strength are applied to the safety assessment of actual RC and steel box-girder bridges. The results of the evaluation of reserved system safety or bridge system-strength in terms of the system redundancy and the system safety/strength are significantly different from those of element reliability-based or conventional methods.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2002년도 추계국제학술대회
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• pp.164-164
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• 2002

에스트로젠을 처리한 송사리의 간으로부터 choriogenin vitellogenin estrogen receptor의 발현량을 전사수준에서 Real-time을 사용하여 정량.비교하였다. 시험어종으로는 부화 후 5개월 이상된 성숙한 수컷 송사리(Oryzias latipes)를(체중 약 250mg/마리)를 사용하여 17$\beta$-estradiol(25ppt, 50ppt, 100ppt)에 24시간 노출시켰다. Fluorescence dye는 choriogenin vitellogenin estrogen receptor의 경우 FAM (6-carboxyfluorescein)을 사용하였으며, $\beta$-actin의 경우는 VIC를 사용하였다. 프로브에 사용하는 quencher dye는 TAMRA(6-carboxy-N',N',N',N'-tetramethyl rhodamine)을 사용하였다. Internal control로 사용된 $\beta$-actin은 17$\beta$-estradiol의 농도에 상관 없이 0~10pM 범위에서 일정하게 발현됨을 보여주었다. vitellogenin choriogenin L 및 choriogenin H는 17$\beta$-estradiol의 농도에 의존하여 발현이 증가되는 용량-반응양상(Dose-dependent)을 나타내었다. 반면, estrogen receptor는 모든 처리군에서 $10^{-2}$pM 정도로 발혐됨에 따라 본 시험농도의 17$\beta$-estradiol에 의해서는 거의 유도발현이 되지 않음을 보여주었다. choriogenin L, choriogenin H, vitellogenin I 및 estrogen receptor 발현감수성을 비교한 결과, 25ppt 및 50ppt의 17$\beta$-esoadiol 농도에서는 ChgL > ChgH > VTG I >ER의 순으로 감수성이 높았으며, 100ppt 노출에서는 ChgL > VTG I > Chg H > ER의 순으로 감수성이 높게 나타났다. 결론적으로 choriogenin이 에스트로젠물질에 의한 가장 민감한 생체지표임을 알 수 있었다.

• 한국동물위생학회지
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• 제24권1호
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• pp.89-94
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• 2001

In order to investigate the relationship between milk hygienic quality and some environmental factors such as the herd size and types of milking machines, we sampled and examined the level of total bacterial count, coliforms, Staphyococcus aureus, somatic cell counts(SCC) and fat rates in raw milk. of the 84 dairy farms, the prevalence of level on number of standard plate count over 100,000cfu/$m\ell$ and coliforms over 1,000cfu/$m\ell$ in bulk milk were 25.0% and 15.6%, respectively. Also, 2 farms(2.4%) were exceed the level on number of 500cfu/$m\ell$ S aureus in raw milk. The prevalence of dairy herd with first grade of total bacterial count(TBC) according to bucket, pipe line and parlour milking system was 40.0%, 74.0% and 84.0%, respectively. The prevalence of dairy herd with first grade of TBC according to grade 1, 2 and 3 by SCC was 77.8%, 83.2%. and 69.2%, respectively. Therefore, the relationships between hygienic quality in raw milk and the herd size, types of milking machines, were significant. In conclusion, this study could be overemphasized the importance of herd management condition for milk hygienic qualify.

• 대한한방소아과학회지
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• 제21권1호
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• pp.11-26
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• 2007

Objectives : The purpose of this study is to investigate the recent tendency of clinical researches of obese children for finding better oriental medicine treatments. Methods : This study was focused on diagnoses, treatments, prognoses and cures of obese children based on 37 of other papers which are J Korean Oriental Med, J Korean Oriental Pediatrics, J Korean Acd Fam Med, J Korean society for the study of obesity, Korea Sport Research, J Korean Academy of Pediatric Allergy and Respiratory Disease, J Korean Society for Health Education and Promotion, Korean J Pediatric, and Korean J Oriental Physiology and Pathology. Results : The rate of obese children has been increased continuously. There are several reasons for increased rate : For example, inadequate eating habit, lack of exercise, and genetic factors such as inherited diseases, and the disorder of the endocrine system. The obesity in childhood or adolescent can cause not only the physical problems but also the mental problems. It is necessary for children to diet, change life style, exercise continuously, and being active in order to prevent child obesity and keep healthy. Obesity can be treated through therapy diet, exercise, behavior modification, drug therapy and operation. Conclusion : It is important to recognize the children obesity, and make better treatments for that in the way of oriental cure. Moreover, additional reports should be keeping up based on continuing clinical researches.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.191-193
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• 2005

This paper presents Hybrid PI controller of IPMSM drive using fuzzy adaptive mechanism(FAM) control. To increase the robustness, fixed gam PI controller, Hybrid PI controller proposes a new method based self tuning PI controller. Hybrid PI controller is developed to minimize overshoot and settling time following sudden parameter changes such as speed, load torque, inertia, rotor resistance and self inductance. The results on a speed controller of IPMSM are presented to show the effectiveness of the proposed gain tuner. And this controller is better than the fixed gains one in terms of robustness, even under great variations of operating conditions and load disturbance.

• 동의신경정신과학회지
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• 제27권1호
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• pp.1-9
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• 2016

Objectives The purpose of this research is to study the Psychological Characteristics of Korean Medical Students focusing on the Minnesota Multiphasic Personality Inventory-2 and the Beck Depression Inventory.Methods The survey was conducted on 101 Korean Medicine Students to investigate psychological characteristics focusing on the Minnesota Multiphasic Personality Inventory-2 and the Beck Depression Inventory.Results 29.7% of students scored more than 10 points in the Beck Depression Inventory. Students with depression according to the Beck Depression Inventory showed the higher scores in the Pd, Si, RC4, WRK, FAM, Mt and MDS scales as compared to the students without depression tendencies (p<.05). Students with depression according to the Beck Depression Inventory showed the higher scores in the Pt, RC7, ANX, A and PK scales as compared to the students without depressive tendencies (p<.05).Conclusions Students with depressive tendencies seem to have more difficulty adjusting socially compared to students without depressive tendencies. In addition, students with depressive tendencies will likely have other psychological problems compared to the students without depressive tendencies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5799-5804
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• 2012

Family with sequence similarity 189, member B (FAM189B), alias COTE1, a putative oncogene selected by microarray, for the first time was here found to be significantly up-regulated in hepatocellular carcinoma (HCC) specimens and HCC cell lines. mRNA expression of COTE1 in HCC samples and cell lines was detected by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR, while protein expression of COTE1 in HCC tissues was assessed by immunohistochemistry. In addition, invasion of HCC cells was observed after overexpressing or silencing COTE1. In the total of 48 paired HCC specimens, compared with the adjacent non-cancer tissues, the expression of COTE1 was up-regulated in 31 (p<0.01). In HCC cell lines, COTE1 expression was significantly higher than in normal human adult liver (p<0.01). Overexpression of COTE1 enhanced HCC-derived LM6 and MHCC-L cellular invasion in vitro. In contrast, COTE1 knockdown via RNAi markedly suppressed these phenotypes, as documented in LM3 and MHCC-H HCC cells. Mechanistic analyses indicated that COTE1 could physically associate with WW domain oxidoreductase (WWOX), a tumor suppressor. COTE1 may be closely correlated with invasion of hepatocellular carcinoma (HCC) cells and thus may serve as an effective target for gene therapy.

• 한국정보과학회논문지:소프트웨어및응용
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• 제31권8호
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• pp.1054-1061
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• 2004

최근 인터넷의 발전으로 정보의 접근이 용이할 뿐 아니라 그 양 또한 기하급수적으로 증가하고 있다. 정보의 홍수 속에서 원하는 정보만을 자동으로 추출할 수 있는 기술은 정보검색에 소요되는 시간과 노력을 절약할 수 있는 매우 중요한 연구이다. 본 논문에서는 관심 범위가 유사한 사용자에게 양질의 정보를 자동으로 추천하기 위하여 협력적 여과방법에 관하여 제안한다. 제안하는 방법의 기본적인 배경은 사용자는 선택항목의 선호도를 입력하고, 여과 장치는 이 선호도에 근거하여 추천집합을 자동으로 생성하는 것이다. 선호도로부터 추천집합을 추론하기 위하여 본 논문에서 퍼지 연상기억장치에 기반한 방법을 제안한다. 제안된 방법은 웹 서버상에서 기술문서 특히, 정보기술문서를 검색하는 분야에 대하여 구현하였으며 그 결과를 보인다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제31권9호
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• pp.1171-1179
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• 2004

본 논문에서는 음성인식의 전처리 단계로서 음성 영역과 비음성 영역 사이의 경계를 검출하는 음성경계 추출에 대하여 기술한다. 본 논문에서는 음성경계 추출을 위해 두 가지의 특징벡터를 사용한다. 첫 번째는 백색잡음(white noise)에 강건한 시간 영역의 정보인 정규화된 RMS이고, 두 번째는 주파수 영역의 정보인 정규화된 멜주파수 대역 최대 에너지(met-frequency band maximum energy)이다. 본 논문에서 사용하는 음성경계 추출 알고리즘은 학습을 통해 규칙을 생성하고 음성의 시간 정보를 적용하기 위해 순환노드를 추가한 순환 퍼지연상기억장치이다. 퍼지부의 가중치 학습은 헤비안 학습 방법을 사용하고, 순환부의 가중치 학습을 위해서는 오류 역전파(error back-propagation) 알고리즘을 사용한다. 실험에서는 KAIST에서 제공한 연령과 성별로 구분된 음성 자료를 사용하였다.

• 한국미생물·생명공학회지
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• 제47권4호
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• pp.645-650
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• 2019

Despite differences in virulence between strains of Toxoplasma gondii, rapid and accurate genotyping methods are lacking. In this study, a method was developed to detect and genotype T. gondii in food and environmental samples using PCR and a novel peptide nucleic acid (PNA) melting array. An alignment of genome sequences for T. gondii type I, II, and III obtained from NCBI was generated, and a single nucleotide polymorphism analysis was performed to identify targets for PCR amplification and a PNA melting array. Prior to the PNA melting array, conventional PCR was used to amplify GRA6 of T. gondii. After amplification, the PNA melting array was performed using two different PNA hybridization probes with fluorescent labels (FAM and HEX) and quenchers. Melting curves for each probe were used to determine genotypes and identify mutations. A 214-bp region of the GRA6 gene of T. gondii was successfully amplified by PCR. For all T. gondii strains (type I, II, and III) used to evaluate specificity, the correct genotypes were determined by the PNA melting array. Non-T. gondii strains, including 14 foodborne pathogens and 3 protozoan parasites, such as Giardia lamblia, Cryptosporidium parvum, and Entamoeba histolytica, showed no signal, suggesting that the assay has a high specificity. Although this is only a proof-of-concept study, the assay is promising for the fast and reliable genotyping of T. gondii from food and environmental samples.