• 국제물리치료학회지
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• 제7권2호
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• pp.1031-1036
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• 2016

c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.

• Korean Journal of Acupuncture
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• 제19권1호
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• pp.15-23
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• 2002

This study was carried to identify the component of Large Intestine Meridian Muscle in human, dividing into outer, middle, and inner part. Brachium and antebrachium were opened widely to demonstrate muscles, nerve, blood vessels and the others, displaying the inner structure of Large Intestine Meridian Muscle. We obtained the results as follows; 1. Meridian Muscle is composed of the muscle, nerve and blood vessels. 2. In human anatomy, it is present the difference between a term of nerve or blood vessels which control the muscle of Meridian Muscle and those which pass near by Meridian Muscle. 3. The inner composition of meridian muscle in human arm is as follows. 1) Muscle; extensor digitorum tendon(LI-1), lumbrical tendon(LI-2), 1st dosal interosseous muscle(LI-3), 1st dosal interosseous muscle and adductor pollicis muscle(LI-4), extensor pollicis longus tendon and extensor pollicis brevis tendon(LI-5), adductor pollicis longus muscle and extensor carpi radialis brevis tendon(LI-6), extensor digitorum muscle and extensor carpi radialis brevis mucsle and abductor pollicis longus muscle(LI-7), extensor carpi radialis brevis muscle and pronator teres muscle(LI-8), extensor carpi radialis brevis muscle and supinator muscle(LI-9), extensor carpi radialis longus muscle and extensor carpi radialis brevis muscle and supinator muscle(LI-10), brachioradialis muscle(LI-11), triceps brachii muscle and brachioradialis muscle(LI-12), brachioradialis muscle and brachialis muscle(LI-13), deltoid muscle(LI-14, LI-15), trapezius muscle and supraspinous muscle(LI-16), platysma muscle and sternocleidomastoid muscle and scalenous muscle(LI-17, LI-18), orbicularis oris superior muscle(LI-19, LI-20) 2) Nerve; superficial branch of radial nerve and branch of median nerve(LI-1, LI-2, LI-3), superficial branch of radial nerve and branch of median nerve and branch of ulna nerve(LI-4), superficial branch of radial nerve(LI-5), branch of radial nerve(LI-6), posterior antebrachial cutaneous nerve and branch of radial nerve(LI-7), posterior antebrachial cutaneous nerve(LI-8), posterior antebrachial cutaneous nerve and radial nerve(LI-9, LI-12), lateral antebrachial cutaneous nerve and deep branch of radial nerve(LI-10), radial nerve(LI-11), lateral antebrachial cutaneous nerve and branch of radial nerve(LI-13), superior lateral cutaneous nerve and axillary nerve(LI-14), 1st thoracic nerve and suprascapular nerve and axillary nerve(LI-15), dosal rami of C4 and 1st thoracic nerve and suprascapular nerve(LI-16), transverse cervical nerve and supraclavicular nerve and phrenic nerve(LI-17), transverse cervical nerve and 2nd, 3rd cervical nerve and accessory nerve(LI-18), infraorbital nerve(LI-19), facial nerve and infraorbital nerve(LI-20). 3) Blood vessels; proper palmar digital artery(LI-1, LI-2), dorsal metacarpal artery and common palmar digital artery(LI-3), dorsal metacarpal artery and common palmar digital artery and branch of deep palmar aterial arch(LI-4), radial artery(LI-5), branch of posterior interosseous artery(LI-6, LI-7), radial recurrent artery(LI-11), cephalic vein and radial collateral artery(LI-13), cephalic vein and posterior circumflex humeral artery(LI-14), thoracoacromial artery and suprascapular artery and posterior circumflex humeral artery and anterior circumflex humeral artery(LI-15), transverse cervical artery and suprascapular artery(LI-16), transverse cervical artery(LI-17), SCM branch of external carotid artery(LI-18), facial artery(LI-19, LI-20)

• The Korean Journal of Physiology
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• 제19권2호
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• pp.139-153
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• 1985

기립 및 도립의 체위면화가 두부 및 하지의 혈액순환계에 미치는 영향을 관찰하고, atropine의 정주에 의한 부교감신경의 차단이 체위변화에 대한 심맥관계의 내성을 증가시키는 지를 보기위하여 개를 경사대에 수평위로 고정하여 수동적으로 기립 및 도립위로 체위를 변화시키고, 각 체위에서 10분간 유지시켜 경동맥, 외경정맥, 고동맥 및 고정맥의 분시 혈류량, 분시 심박수 및 분시 호흡수, 그리고 혈액의 pH, $PCO_2$, $PO_2$ 및 Hct를 측정하였다. 다시 수평위에서 atropine 0.5mg을 1회 정주한 후 위의 실험과정을 반복하여 시행하고 atropine투여전과 비교 관찰하였던 바 다음과 같은 결과를 얻었다. 기립시 두부 및 하지 동정맥혈의 분시 혈류량은 감소하였고, 특히 두부로 가는 혈류량의 감소가 더 컸으나, atropine의 투여는 경동맥의 분시 혈류량의 감소를 억제하였다. 도립시 두부 및 하지의 분시 혈류량은 유의한 변화를 보이지 않았고, 개체에 따라 변화양상도 다르게 나타났다. atropine의 투여는 투여전에 비하여 유의한 차이를 보이지 않았다. 분시 심박수는 기립 및 도립시 모두 증가하였다. atropine의 투여는 수평위에서 분시 심박수는 투여전 보다 증가하나, 체위변화에 의한 분시 심박수의 증가를 경감시켰다. 분시 호흡수는 개체에 따라 변화양상에 차이가 있으나, 대체로 기립시는 감소하고 도립시는 증가하였다. atropine의 투여는 기립 및 도립시 다 같이 분시 호흡수의 변화를 억제하였다. 혈액소견은 기립시 정맥철의 pH 및 $PO_2$는 감소하였고, $PCO_2$는 증가하나 동맥혈의 $PCO_2$는 감소하였다. 도립시 동정맥혈의 소견은 수평위에 비해 별 변화가 없었으며 , atropine의 투여후도 기립 및 도립시 모두에서 투여전에 비하러 유의한 변하는 없었다. Hct는 기립 및 도립시 증가하였으며 atropine투여에 의한 변화는 관찰할 수 없었다. 이상에서와 같이 atropine의 투여는 기립시 두부로 가는 혈류량을 증가시키며, 기립 및 도립시 발생할 수 있는 분시 심박수의 과도한 증가를 억제함으로서 체위변화에 대한 심맥관계의 내성을 증가시키는데 어느정도 효과가 있다고 하겠다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2009년도 추계학술대회
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• pp.183-185
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• 2009

As imaging technology develops, magnetic resonance imaging (MRI) techniques have contributed to the understanding of brain function by providing anatomical structure of the brain and functional imaging related to information processing. Manganese-enhanced MRI (MEMRI) techniques can provide useful information about functions of the nervous system. However, systematic studies regarding information processing of pain have not been conducted. The purpose of this study was to detect brain activation during painful electrical stimulation using MEMRI with high spatial resolution. Male Sprague-Dawley rats (250-300 g) were divided into 3 groups: normal control, sham stimulation, and electric stimulation. Rats were anesthetized with 2.5% isoflurane for surgery. Polyethylene catheter (PE-10) was placed in the external carotid artery to administrate mannitol and MnCl2. The blood brain barrier (BBB) was broken by 20% D-mannitol under anesthesia mixed with urethane and a-chloralose. The hind limb was electrically stimulated with a 2Hz (10V) frequency while MnCl2 was infused. Brain activation induced by electrical stimulation was detected using a 4.7 T MRI. Remarkable signal enhancement was observed in the primary sensory that corresponds to sensory tactile stimulation at the hind limb region. These results suggest that signal enhancement is related to functional activation following electrical stimulation of the peripheral receptive field.

• Bulletin of the Korean Chemical Society
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• 제34권6호
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• pp.1663-1667
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• 2013

Neointimal hyperplasia causes vascular access dysfunction in hemodialysis patients with synthetic arteriovenous (AV) grafts. Several studies have reported that paclitaxel- or sirolimus-eluting AV grafts inhibit neointimal hyperplasia and display lower rates of stenosis compared with control grafts. However, there have been few comparative studies of the efficacy of paclitaxel- and sirolimus-eluting grafts. We compared the neointimal hyperplasia of paclitaxel- and sirolimus-eluting grafts. AV grafts were implanted laterally between the common carotid artery and the external jugular vein in 12 female Landrace pigs. The animals were sacrificed six weeks after surgery. The neointimal hyperplasia at the anastomosis sites of the grafts was quantified using the ratio of the intragraft hyperplasia to the graft area (H/G ratio) at the graft-vessel interface. The area of intimal hyperplasia at the venous (paclitaxel 1.06 [0.72-1.56] vs sirolimus 2.40 [1.72-3.0] $mm^2$, P = 0.04) and arterial anastomosis sites (paclitaxel 0.93 [0.57-1.48] vs sirolimus 2.40 [1.72-3.0] $mm^2$, P = 0.04) was significantly different between the two groups. However, the H/G ratios for the venous anastomosis site (paclitaxel 0.25 (0.17-0.38) vs sirolimus 0.38 (0.2-0.66), P = 0.4) and the arterial anastomosis site (paclitaxel 0.19 (0.08-0.39) vs sirolimus 0.41 (0.34-0.50), P = 0.1) did not differ significantly between the groups. In conclusion, there was no significant difference in the inhibition of neointimal hyperplasia by sirolimus- and paclitaxel-eluting AV grafts.

• 대한전자공학회논문지SP
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• 제44권4호통권316호
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• pp.86-92
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• 2007

2D 영상의 특징점을 추적하는 이산동적 모델을 고안한다. 종래의 스네이크 접근은 내외 추진력으로 구성된 에너지함수를 최소화하도록 구획을 변형시켜가면서 영상 내의 원하는 특징에 밀착시켜간다. 이 때 스네이크화소를 중심한 인접화소군은 사각형 같은 평면 2차 행렬이다. 본 논문에서는 유사 특성점들을 상호 연결하는 모델 구조를 제시한다. 에너지모델은 그 국부최소점이 활성처리에 유용한 교차 해법에 적합하도록 설계한다. 추적시 선 형태의 1차 행렬 블록을 사용한다. 진행 방향의 반대 끝 라인으로부터 굴곡상태를 만족하는 시발점들을 선정하고 에너지 최소처리를 통해 이웃 라인으로 순차 자동 이동한다. 추적 경로는 상승 하강점 또는 극대 극소점과 같은 굴곡 한계에 의존한다. 이와 같은 층위적 접근은 인접데이터 라인 사이에 수직 또는 수평 방향으로 높은 상관성을 갖는 일방향 특성이 있는 디지털 영상의 특징점 추적에 유용하다. 그리고 인체 경동맥초음파영상에서 그 내 외막 시점을 추적하는 실험으로 알고리즘의 효과를 확인하였다.

• 한국한의학연구원논문집
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• 제16권2호
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• pp.143-157
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• 2010

Objectives : The objective of this study was to access the effect of Artemisiae capillaris herba Extracts on the organogenetic reproductive toxicity of New Zealand White rabbits when administered by oral gavage. Methods : Gestational New Zealand White rabbits were dosed from 6 days of gestation to 18 days of gestation. It was conducted in accordance with the recommendations of the KFDA Guideline for Detection of Toxicity to Reproduction for Medicinal Products. In addition, serum AST, ALT, LDH and ALP levels were detected with their necropsy and histopathological observation Results: No significant changes of body weights, gains and food consumption were demonstrated in all dosed groups compared to those of vehicle control group except for 2,000mg/kg-dosing group, which showed significantly increase of body weight compared to that of vehicle control group. Normal gross findings were demonstrated in all tested groups. No significant changes of number of corpora lutea, implantation, implantation rate, number of fetal death, loss rate of post-implantation, number of live youngs at C-section, survival rate of post-implantation, number of male live youngs at C-section, number of female live youngs, sex ratio of live young, external anomalies of live youngs and body weight of live youngs were demonstrated in all dosed groups compared to those of vehicle control group. Although some visceral variations such as thymic reminant in the neck, dilation of renal pelvis, dilated ureter and malpositioned left common carotid artery, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. Some malformations and variation were demonstrated with retardations. However, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. In addition, similar ossification numbers were detected in sternebrae, metacarpals, metatarsals, phalanges, cervical vertebrae, and sacral and caudal vertebrae. No Artemisiae capillaris herba Extracts treatment-related changes of serum AST, ALT, LDH and ALP levels were demonstrated in all dosed levels in this study. Conclusions : We could conclude that oral administration of Artemisiae capillaris herba Extracts hasn't an influence on the organogenetic reproductive toxicity.

• 대한약리학회지
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• 제19권1호
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• pp.61-69
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• 1983

Hypothermia is an essential preparatory procedure for cardiac surgery, which lows the metabolic rate and myocardial oxygen demand. However, hypothermia itself is a stress enough to change the tonus of sympathoadrenal system, especially the cardiovascular responses to the catecholamines. It is reported that the positive chronotropic and inotropic response of catecholamines is exaggerated during hypothermia because of decreased norepinephrine uptake at the junctional cleft or decreased catecholamine metabolism. On the other hand, there are evidences of diminished catecholamines responses in low temperature ana further, interconversion of adrenergic receptors is also suggested. Present investigation was planned to observe the cardiovascular changes and its responses to catecholamines during surface hypothermia in cat. Healthy mongrel cats, weighing $2{\sim}3\;kg$, anesthetized with secobarbital(30 mg/kg), were permitted to hypothermia by external cooling technic. Esophageal temperature, ECG (lead II), heart rate, left ventricular pressure with dP/dt, carotid artery pressure and left ventricular contractile force were monitored with Polygragh (Model 7, Grass), and the respiration was maintained with artificial respirator (V 5 KG, Narco). Followings are summarized results. 1) Surface cooling caused progressive decrease of body temperature and reached $l8.8{\pm}0.8^{\circ}C$ and $16.9{\pm}0.6^{\circ}C$ in 120 and 150 min respectively, after immersion into ice water, and ventricular fibrillation was developed at $20.4{\pm}0.65^{\circ}C$. 2) Heart rate, blood pressure and myocardial contractility were decreased after initial increase as the body temperature falls. 3) Systolic and diastolicdd P/dt of left ventricular pressure were decreased and that the decrement of diastolic dP/dt was more marked. 4) On ECG, ST depression, Twave inversion and prolongation of PR interval were prominent in hypothermia, and moreover, the prolongation of PR interval was marked just prior to the development of ventricular fibrillation. 5) The cardiovascular responses to catecholamines, especially to isoproterenol, were suppressed under hypothermia.

• 한국산학기술학회논문지
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• 제14권12호
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• pp.6340-6345
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• 2013

본 연구는 열 자극으로 유도된 신경성 염증 상태에서 혈류량의 변화와 histamine의 치수혈류 조절에 관해 유기적 관계를 연구함으로써 치수혈류 조절기전을 밝히고자 하였다. 연구방법은 열 마리의 고양이를 전신마취 하에 사용되었으며, 치수혈류의 변화는 레이저 도플러 측정계(Periflux 4001, Stockholm, Sweden)을 사용하여 측정 하였다. 레이저 도플러 측정하는 프로브는 하악 견치의 치면에 위치하였다. 열 자극은 입력/출력 장치와 열 자극 제어 스크립트 파일을 사용하여 치아에 적용하였다. 열($40-65^{\circ}C$)에 따라 치수 혈류량이 증가를 확인하였으며, $55^{\circ}C$에서 가장 큰 변화가 나타났다. 열 자극의 변화가 없는 $45^{\circ}C$에서 Histamine($5{\mu}g/kg/1ml$)를 치아와 가까운 설 동맥으로 주입 시 열 자극만 처치한 그룹보다 현저한 증가가 나타났다. 본 연구는 열적 자극에 의해 발생된 신경성 염증상태에서 치수혈류 변화와 이에 히스타민의 기능적으로 관여함을 나타내주며, 치아 염증 상태의 기전을 밝힐 수 있는 가능성을 보여준다.

• The Korean Journal of Physiology
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• 제16권2호
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• pp.165-175
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• 1982

Changes in handling of $Li^+$ by contralateral kidney during acute $Li^+$ loading were investigated immediately after unilateral ureteral obstruction. Carotid artery, jugular vein, renal vein and ureter of experimental animal were catheterized and renal venous flow was shunted to .external jugular vein. In experimental group right ureter was ligated. One to two hours after operation a single shot of LiCl solution (2 mEq/kg) was intravenously injected and then .arterial, renal venous blood and urine samples were taken sequentially for 1 to $1{\frac{1}{2}}$ hours. Urine volume, plasma and urinary concentrations of $Li^+$, $Na^+$ and $K^+$ were measured and urinary excretion of them were calculated. Results obtained were as follows: 1) In experimental group urine volume, urinary excretion of $Na^+$, and $K^+$ by contralateral kidney after unilateral ureteral obstruction were slightly larger than mean value of both kidney in control group. 2) During acute $Li^+$ loading contralateral kidney in experimental group showed limited $K^+$ excretion, but urinary flow and $Na^+$ excretion were comparable to mean value of both kidney in control group. 3) Urinary osmolar concentration in experimental group was much lower than that in control group, and it was maintained at low level even after Li loading. 4) In experimental group plasma$Li^+$ concentration decreased more slowly than in control group after a single shot of LiCl solution. 5) Urinary excretion of $Li^+$ in experimental group was markedly decreased, even lesseer than mean of both kidney in control group. 6) From the above results it was concluded that immediately after unilateral ureteral obstruction contralateral kidney showed normal water and $Na^+$ diuretic response to Li load but urinay $Li^+$ excretion was decreased and reclaimed $Li^+$ to systemic circulation.