Journal of International Academy of Physical Therapy Research (국제물리치료학회지)

International Academy of Physical Therapy Research (국제물리치료연구학회)
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A Study on the Effects of Needle Electrode Electrical Stimulation on the Number of c-Fos Response Cells and c-Fos Expression in the Global Ischemic Rats

  • Kim, Sung Won (Department of Physical Therapy, Dongnam Health University) ;
  • Song, Young Wha (Department of Physical Therapy, Dongnam Health University) ;
  • Lee, Jung Sook (Department of Occupational Therapy, Dongju University College)
  • Received : 2016.06.28
  • Accepted : 2016.09.02
  • Published : 2016.10.30
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Abstract

c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.

Keywords

References

  1. Eldridge LL, Masterman D, Knowlton BJ. Intact implicit habit learning in Alzheimer's disease. Behavioral Neuroscience 2002; 116: 722-726. https://doi.org/10.1037/0735-7044.116.4.722
  2. Comelli MC, Guidolin D, Seren MS, Zanoni R, Canella R, Rubini R, Manev H. Time course, localization and pharmacological modulation of immediate early inducible genes, brainderived neurotrophic factor and trkB messenger RNAs in the rat brain following photochemical stroke. Neuroscience 1993; 55(2): 473-90. https://doi.org/10.1016/0306-4522(93)90517-J
  3. Dragunow M, Robertson HA. Brain injury induces c-fos protein(s) in nerve and glial-like cells in adult mammalian brain. Brain Res 1998; 455(2): 295-9. https://doi.org/10.1016/0006-8993(88)90088-1
  4. Shauran E. Karin M. AP-1 in cell proliferation and survival. Oncogene 2001; 20: 2390-2400. https://doi.org/10.1038/sj.onc.1204383
  5. Dony C, Gruss P. Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissue. Nature 1987; 328: 711-714. https://doi.org/10.1038/328711a0
  6. Caubet JF, Mitjavila MT, Dubart A, Roten D, Weil SC, Vainchenker W. Expression of the cfos protooncogene by human and murine erythroblasts. Blood 1989; 74: 947-951.
  7. Alitalo R, Partanen J, Pertovaara L, Holtta E, Andersson L, Alitalo K. Increased erythroid potentiating activity/tissue inhibitor of metakkoproteinases and jun/fos transcription factor complex characterize tumor promoterinduced megakaryoblastic differentiation of K562 leukemia cells. Blood 1990; 75: 1974-1982.
  8. Smeyne RJ, Curran T, Morgan JI. Temporal and spatial expression of a fos-lac Ztransgene in the developing nervous system. Mol Brain Res 1992; 16: 158-162. https://doi.org/10.1016/0169-328X(92)90206-Q
  9. Akins PT, Liu PK, Hsu CY. Immediate Early Gene Expression in Response to Cerebral Ischemia, Friend or Foe? Stroke 1996; 27(9): 1682-1687. https://doi.org/10.1161/01.STR.27.9.1682
  10. Morgan JI, Curran T. Stimulus-transcription coupling in the mervous system, Involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 1991; 14: 421-451. https://doi.org/10.1146/annurev.ne.14.030191.002225
  11. Herdengen T, Leah JD. Inducible and constitutive transcription factor in the mammalian nervous system, control of gene expression by Jun, Fos, and KREB and CREB/ATF proteins. Brain Res Rev 1998; 28: 370-390. https://doi.org/10.1016/S0165-0173(98)00018-6
  12. Sharp FR, Lu A, Tang Y, Millhorn DE. Multiple molecular penumbras after cerebral ischemia. J Cereb Blood Flow Metab 2000; 20: 1011-1032. https://doi.org/10.1097/00004647-200007000-00001
  13. Domanska-Janik, Bong KP, Bronisz-Kowalczyk A, Zajac H, Zablocka B. AP1 transcriptional factor activation and its relation to apoptosis of hippocampal CA1 pyramidal neurons after transient ischemia in gerbils. J Neurosci Res 1999; 57(6): 840-6. https://doi.org/10.1002/(SICI)1097-4547(19990915)57:6<840::AID-JNR9>3.0.CO;2-Z
  14. Shigeno T, Mima T, Takakura K, Graham DI, Kato G, Hashimoto Y, Furukawa S. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J Neurosci 1991; 11: 2914-9. https://doi.org/10.1523/JNEUROSCI.11-09-02914.1991
  15. Horn M, Schlote W. Delayed neuronal deat hand delayed neuronal recovery in the human brain following global ischemia. Acta Neuropathol 1992; 85: 79-87. https://doi.org/10.1007/BF00304636
  16. Kim JS. The Effects of Needle Electrode Electrical Stimulation on Blockage of Cell Death in SD Rat's Brain. Yongin University 2007.
  17. Seo BH. Diazoxide Prevents Neuronal Apoptosis in Animal Model of Focal Cerebral Ischemia. Eulji University 2007.
  18. Herdengen T, Leah JD. Inducible and constitutive transcription factor in the mammalian nervous system, control of gene expression by Jun, Fos, and KREB, and CREB/ATF proteins, Brain Res Rev 1998; 28: 370-390. https://doi.org/10.1016/S0165-0173(98)00018-6
  19. Shaulian E, Karin M. AP-1 as a regulator of cell life and death, Nat, Cell Biol 2002; 4: 131-136. https://doi.org/10.1038/ncb0502-e131
  20. Piechaczyk M, Blanchard J, c-Fos protooncogene regulation and function. Crit Rev Oncol Hematol 1994; 17: 93-131. https://doi.org/10.1016/1040-8428(94)90021-3
  21. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995; 270: 16483-16486. https://doi.org/10.1074/jbc.270.28.16483
  22. Sharp FR, Lu A, Tang Y, Millhorn DE. Multiple molecular penumbras after cerebral ischemia. J Cereb Blood Flow Metab 2000; 20: 1011-1032. https://doi.org/10.1097/00004647-200007000-00001
  23. Lee JS, Kim SW. Effect of NEES on the Occurrence of c-Fos in the Cerebrum of a Rat With Transient Global Ischemia. Physical Therapy Korea 2010; 17(1): 69-76.