• Title/Summary/Keyword: Expression profile

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Mathematical expression for the Prediction of Strip Profile in hot rolling mill (열연 판형상 예측 수식모델 개발)

  • Cho Y.S.;Hwang S.M.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2004.05a
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    • pp.70-73
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    • 2004
  • The approach in this thesis is for prediction of deformed strip profile in hot rolling mill. This approach shows how to make an expression as a mathematical form in predicting strip profile. This approach is based on the velocity field, shear stress and material flow on the strip edge along width direction and lateral displacement and stress along width are analytically calculated. Roll force is calculated in each section and then combined together to show roll force distribution along width. All the assumptions to make equation form for this approach are supported by FEM simulation result and the result of model is verified by FEM result. So, this model will supply very useful tool to the researcher and engineers which takes less time and has similar accuracy in predicting roll force profile comparing to FEM simulation. This model has to be combined with deformed roll profile model, which include thermal crown prediction and wear prediction model to predict deformed strip profile.

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Gene Expression Analysis of Acetaminophen-induced Liver Toxicity in Rat (아세트아미노펜에 의해 간손상이 유발된 랫드의 유전자 발현 분석)

  • Chung, Hee-Kyoung
    • Toxicological Research
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    • v.22 no.4
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    • pp.323-328
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    • 2006
  • Global gene expression profile was analyzed by microarray analysis of rat liver RNA after acute acetaminophen (APAP) administration. A single dose of 1g/kg body weight of APAP was given orally, and the liver samples were obtained after 24, 48 h, and 2 weeks. Histopathologic and biochemical studies enabled the classification of the APAP effect into injury (24 and 48 h) and regeneration (2 weeks) stages. The expression levels of 4900 clones on a custom rat gene microarray were analyzed and 484 clones were differentially expressed with more than a 1.625-fold difference(which equals 0.7 in log2 scale) at one or more time points. Two hundred ninety seven clones were classified as injury-specific clones, while 149 clones as regeneration-specific ones. Characteristic gene expression profiles could be associated with APAP-induced gene expression changes in lipid metabolism, stress response, and protein metabolism. We established a global gene expression profile utilizing microarray analysis in rat liver upon acute APAP administration with a full chronological profile that not only covers injury stage but also later point of regeneration stage.

Program Development of Integrated Expression Profile Analysis System for DNA Chip Data Analysis (DNA칩 데이터 분석을 위한 유전자발연 통합분석 프로그램의 개발)

  • 양영렬;허철구
    • KSBB Journal
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    • v.16 no.4
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    • pp.381-388
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    • 2001
  • A program for integrated gene expression profile analysis such as hierarchical clustering, K-means, fuzzy c-means, self-organizing map(SOM), principal component analysis(PCA), and singular value decomposition(SVD) was made for DNA chip data anlysis by using Matlab. It also contained the normalization method of gene expression input data. The integrated data anlysis program could be effectively used in DNA chip data analysis and help researchers to get more comprehensive analysis view on gene expression data of their own.

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Dipole Model to Predict the Rectangular Defect on Ferromagnetic Pipe

  • Suresh, V.;Abudhair, A.
    • Journal of Magnetics
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    • v.21 no.3
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    • pp.437-441
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    • 2016
  • Dipole model based analytical expression is proposed to estimate the length and depth of the rectangular defect on ferromagnetic pipe. Among the three leakage profiles of Magnetic Flux Leakage (MFL), radial and axial leakage profiles are considered in this work. Permeability variation of the specimen is ignored by considering the flux density as close to saturation level of the inspected specimen. Comparing the profile of both the components, radial leakage profile furnishes the better estimation of defect parameter. This is evident from the results of error percentage of length and depth of the defect. Normalized pattern of the proposed analytical model radial leakage profile is good agreement with the experimentally obtained profile support the performance of proposed expression.

Anger Expression and Health Behavior in Patients with Coronary Arteries Disease (관상동맥질환자의 분노표현유형과 건강행위)

  • Hong, Eun-Mi;Park, Jin-Hee
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.21 no.2
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    • pp.101-109
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    • 2014
  • Purpose: The purpose of this study was to identify the difference in health behavior according to the anger expression styles in patients with coronary arteries disease. Methods: Participants included 99 patients with coronary artery disease who were treated with a percutaneous coronary intervention in K University Hospital in Seoul, from January to March 2012. The survey data were collected using the Anger Expression Inventory Korea Version and the Health Promoting Lifestyle Profile Version 2. The data were analyzed using descriptive statistics, acluster analysis, chi-square test,and ANOVA with the PASW 19.0program. Results: The anger expression styles identified from the cluster analysis were anger-control type(43.3%), anger-in/out type(42.4%), and high anger expression type(14.4%). The total score of the Health Promoting Life style Profile for the anger-control type was significantly higher than the other two types. Additionally, anger-control type showed significantly higher scores than the other two types in all domains of the Health Promoting Life style Profile. Conclusion: These results indicated that higher levels of anger-in and anger-out increased the risk of adverse health behavior and that anger control strategies could have some benefit in reinforcing healthy behavior in patients with coronary artery disease.

Searching for Optimal Ensemble of Feature-classifier Pairs in Gene Expression Profile using Genetic Algorithm (유전알고리즘을 이용한 유전자발현 데이타상의 특징-분류기쌍 최적 앙상블 탐색)

  • 박찬호;조성배
    • Journal of KIISE:Software and Applications
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    • v.31 no.4
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    • pp.525-536
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    • 2004
  • Gene expression profile is numerical data of gene expression level from organism, measured on the microarray. Generally, each specific tissue indicates different expression levels in related genes, so that we can classify disease with gene expression profile. Because all genes are not related to disease, it is needed to select related genes that is called feature selection, and it is needed to classify selected genes properly. This paper Proposes GA based method for searching optimal ensemble of feature-classifier pairs that are composed with seven feature selection methods based on correlation, similarity, and information theory, and six representative classifiers. In experimental results with leave-one-out cross validation on two gene expression Profiles related to cancers, we can find ensembles that produce much superior to all individual feature-classifier fairs for Lymphoma dataset and Colon dataset.

A Study of Semiotic Analysis of Body Expression Image Shown in the Body Profile of Female Influencer's SNS (여성 인플루언서의 SNS 바디프로필에 나타난 신체표현 이미지의 기호학적 분석 연구)

  • Jung Hwa Chae;Kyeong Sook Cho
    • Journal of the Korea Fashion and Costume Design Association
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    • v.25 no.1
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    • pp.65-81
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    • 2023
  • The purpose of this study is to interpret the semantic actions of body image symbolized in body expression images shown by micro-influencers body profiles to understand the body profile phenomenon of the MZ generation. As a result of collecting body profile data from micro-influencers, the body profile image types of female influencers on SNS were classified into four types, Athletic, Slim body, Natural, and, Glamorous. Images representing each type were analyzed using the Roland Barthes' Myth model analysis frame. As a result of the semantic analysis, influencers were found to be very active and bold, emphasizing certain body parts according to the type of body image they pursue. Fashion is strategically used to emphasize these aspects. It was found that the ideology of a 'subjective modern woman' was commonly expressed through emphasis on visual signs. This study is meaningful in that it can indirectly lead to the understanding the fashion culture expressed by the MZ generation and provide consumer information and essential data that can be used for communication strategies in the fashion market.

An Analytical Model of Corona Discharge Plasmas in Coaxial Cylindrical Reactor (동축 원통형 코로나 방전 플라즈마의 해석적 모델)

  • 고욱희
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.53 no.3
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    • pp.157-161
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    • 2004
  • We present a simple analytical expression of plasma density by making use of the electron density equation to study the dynamic behavior of the corona discharge plasma. It assumes that a specified voltage profile is fed through the inner conductor of the reactor chamber consisting of two coaxial conducting cylinders. The analytical description is based on the electron continuity equation with ionization and attachment by electrons. It is found that the electron density profile calculated between two coaxial cylindrical electrodes depends very sensitively on the Profile of applied voltage. The analytical expression of plasma density and its generation will provide important scaling laws in the corona discharge plasma.

Insulin Resistance Does Not Influence Gene Expression in Skeletal Muscle

  • Nguyen, Lisa L.;Kriketos, Adamandia D.;Hancock, Dale P.;Caterson, Ian D.;Denyer, Gareth S.
    • BMB Reports
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    • v.39 no.4
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    • pp.457-463
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    • 2006
  • Insulin resistance is commonly observed in patients prior to the development of type 2 diabetes and may predict the onset of the disease. We tested the hypothesis that impairment in insulin stimulated glucose-disposal in insulin resistant patients would be reflected in the gene expression profile of skeletal muscle. We performed gene expression profiling on skeletal muscle of insulin resistant and insulin sensitive subjects using microarrays. Microarray analysis of 19,000 genes in skeletal muscle did not display a significant difference between insulin resistant and insulin sensitive muscle. This was confirmed with real-time PCR. Our results suggest that insulin resistance is not reflected by changes in the gene expression profile in skeletal muscle.

Molecular Prognostic Profile of Egyptian HCC Cases Infected with Hepatitis C Virus

  • Zekri, Abdel-Rahman N.;Hassan, Zeinab K.;Bahnassy, Abeer A.;Sherif, Ghada M.;ELdahshan, Dina;Abouelhoda, Mohamed;Ali, Ahmed;Hafez, Mohamed M.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5433-5438
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    • 2012
  • Background: Hepatocellular carcinoma (HCC) is a common and aggressive malignancy. Despite of the improvements in its treatment, HCC prognosis remains poor due to its recurrence after resection. This study provides complete genetic profile for Egyptian HCC. Genome-wide analyses were performed to identify the predictive signatures. Patients and Methods: Liver tissue was collected from 31 patients with diagnosis of HCC and gene expression levels in the tumours and their adjacent non-neoplastic tissues samples were studied by analyzing changes by microarray then correlate these with the clinico-pathological parameters. Genes were validated in an independent set by qPCR. The genomic profile was associated with genetic disorders and cancer focused on gene expression, cell cycle and cell death. Molecular profile analysis revealed cell cycle progression and arrest at G2/M, but progression to mitosis; unregulated DNA damage check-points, and apoptosis. Result: Nine hundred fifty eight transcripts out of the 25,000 studied cDNAs were differentially expressed; 503 were up-regulated and 455 were down-regulated. A total of 19 pathways were up-regulated through 27 genes and 13 pathways were down-regulated through 19 genes. Thirty-seven genes showed significant differences in their expression between HCC cases with high and low Alpha Feto Protein ($AFP{\geq}600$ IU/ml). The validation for the microarray was done by real time PCR assay in which PPP3CA, ATG-5, BACE genes showed down-regulation and ABCG2, RXRA, ELOVL2, CXR3 genes showed up-regulation. cDNA microarrays showed that among the major upregulated genes in HCC are sets. Conclusion: The identified genes could provide a panel of new diagnostic and prognostic aids for HCC.