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Inducible Nitric Oxide Synthase mRNA Expression and Nitric Oxide Production in Silica-Induced Acute Inflammatory Lung Injury

  • Lee, Ji-Hee
    • The Korean Journal of Physiology and Pharmacology
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    • v.2 no.2
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    • pp.233-239
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    • 1998
  • Stimulated alveolar macrophages and neutrophils produce nitric oxide, a free radical by an inducible nitric oxide synthase(iNOS), which reacts with superoxide anion to form peroxynitrite, a more highly reactive toxic species. The objectives of the present study were to evaluate acute inflammatory lung injury and to determine iNOS mRNA induction and nitric oxide production by rat broncho-alveolar lavage cells following intratracheal treatment of silica. After 4 h exposure to silica, differential counts of broncho-alveolar lavage cells and lactate dehydrogenase(LDH) activity as well as total protein in the broncho-alveolar lavage fluid were determined. Broncho-alveolar lavage cells were also assayed for iNOS mRNA and the productions of nitrite and nitrate measured in the cells cultured. Differential analysis of broncho-alveolar lavage cells showed that the number of alveolar macrophages slightly decreased following silica treatment; however, red blood cells, lymphocytes, and neutrophils significantly were increased by 9-, 14-, and 119-fold following silica treatment, respectively, compared with the saline control. It was also found significant increases in the LDH activity and total protein in the lavage fluid obtained from silica-treated rats, indicating silica-induced acute lung injury. Northern blot analysis demonstrated that the steady state levels of iNOS mRNA in broncho-alveolar lavage cells were increased following silica treatment. The productions of nitrite and nitrate in the cultured cells were significantly increased by 2-fold following silica treatment, respectively, which were attenuated by the NOS inhibitor $N{\omega}-nitro-L-arginine-methyl$ ester(L-NAME) and partially reversed by L-arginine. These findings suggest that nitric oxide production in alveolar macrophages and recruited neutrophils is increased in response to silica. Nitric oxide may contribute in part to acute inflammatory lung injury.

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Active Narrative of Digital Game and Improvisation (디지털 게임의 능동서사와 즉흥연기)

  • Yu, Hui-Beom;Sung, Jung-Hwan
    • Journal of Korea Game Society
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    • v.16 no.2
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    • pp.75-86
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    • 2016
  • Game studies of theatrical approach explained interactive property of game in humanistic background. Those studies analyze the game, and based on Aristoteles Poetic Attribute. But theatrical approach has a problem by user's unpredictable intervention in narrative (Active narrative). This paper intended to see in the glance of any impact on the Aristotelian model by active narrative. As a result of the active narrative remake the causality between materials of drama. Also, it can be seen to define a kind of the "Improvisation" in theatrical view. But it exposed a essential difference in the form an expression by substance and material of media. It was defined forms of improvisation in the gaming environment which are 'Self-generated Individuality', 'Self-definition Faction', 'Eccentric Behavior Contending', 'Trolling' and 'Bug Play'. Finally this paper proposes the characteristics of the improvisation of the game and the direction to be improved game analysis model in humanities through forms of improvisation in game environment.

Shock Tube and Modeling Study of Ignition in$NH_3-NO-Ar$Mixtures ($NH_3-NO-Ar$혼합기체의 점화 과정에 관한 충격관 실험 및 모델 연규)

  • Shin, Kuan Soo;Bae, Gyun Tack;Shim, Seung Bo;Ryu, Si Ok
    • Journal of the Korean Chemical Society
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    • v.45 no.2
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    • pp.111-115
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    • 2001
  • The ignition of NH$_3$-NO-Ar mixtures was examined in the temperature renge of 1675-2391 K behind reflected shock waves. The ignition delay times were measured by monitoring pressure profiles and the OH emissions at 1.0 cm from the end wall. A correlation between ignition delay times and concentrations of gases could be summarized in the form of mass-action expression, To complement the experiment, computer modeling study of the ignition of NH$_3$-NO-Ar mixtures was carried out using various mechanisms reported previously. The sensitivity analysis shows the reaction of NH$_2$+NO${\rightarrow}$NNH+OH is the most important step in the ignition of NH$_3$-NO-Ar mixtures.

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Study on the Hawaiian Bark Cloth Kapa (하와이 목질의복(木質衣服)(Bark Cloth) KAPA에 대한 연구(硏究))

  • Park, Meeg-Nee
    • Journal of the Korean Society of Costume
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    • v.17
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    • pp.137-148
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    • 1991
  • The use of bark cloth, made of the inner bark of certain trees, was widespread along tropical zones from the Africa to the Hawaii encompassing the globe. They include Malaysia, Indonesia, New Guinea, Polynesian Islands and South America. Among them the Hawaiian bark cloth, named Kapa(pronounced as tapa) was rated as the best quality and most admired. It has variety in designs and colors as well as the most sophistcated production methods. The distinct processes of kapa making are composed of two stages. The first is called first beating and it is a preparatory stage to beat the sea-water soaked bast. It was done with a round beater on a stone anvil. The second beating process was carried out with the squared beater and wooden anvil. The strips from the first beating was soaked again in the water and then beaten lightly to break up fibers. The craftmen laid a bundle of strips over the anvil and beat it into pieces of kapa. The second beater of Hawaii was the most characteristic one among bark cloth producing countries. On their surfaces were the engraved patterns, which were creation of theirs. These distinguished designs enabled them to produce the kapa with the thinner and finer texture and an elaboration of impressed designs known as "watermaks". The Hawaiian culture was self-sufficient one : Everything they used was of their own creation until 19th century. Among their inventions of printing designs on kapa are three most important and distinguished processes. They are the overlaying, the cord snapping and the block printing techniques. Their inventiveness as well as self sufficient environment made it possible to develop their fine art of the kapa making. It is said that the mass producing and cheap western technology of loom forced them to gradually abandon their traditional art and as a result this fine and valuable legacy of Hawaiian traditional kapa making technique is all but disappeared. However it is encouraging and heart warming to find that some of the people as well as specialized researchers pined together to form a group to try to reproduce the old kapa and study the traditional art. They consider the kapa as an expression of the ethnic identity with Hawaii's heritage as well as valuable art of human history.

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A Study on Ball Joint Doll's Symbolism and Clothing Design (구체 관절 인형의 상징성과 인형 패션 디자인에 관한 연구)

  • Son Yi-Jeong;Lee Un-Young;Lee In-Seong
    • Journal of the Korean Society of Costume
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    • v.56 no.7 s.106
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    • pp.42-53
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    • 2006
  • The purpose of this research is to study doll's symbolism representing our social culture and the characteristics of clothing design. The ball joint doll was selected, that are pretty much resembled to human body in terms of facial expression, body proportion, joint movement, etc. Results of research are summarized as follows: the ball joint doll is indicated a doll whose joints are free to move with a round shaped joint, which originated by Yochilya simon, who adopted German Hans Bellmer's method.'rho ball joint doll, first, there appeared state of human isolation due to the material civilization and industrial revolution, and trend of adhering to one's own world made human possess dolls. Second, according to the doll play became a representing play culture among Kidult culture, dolls, that are resembled with human being, were recognized as personalized objects. Third, along of expanding digital culture that makes easy to exchange information via Internet, so, ball joint doll market is growing fast, for which various levels of mania are being formed. Take a look at the doll fashion in modern society. In accordance to form of Look, it is largely categorized Young Casual look, Office look, Ethnic look and Military look. When take a look at design specialty, young casual look was presented as a comfortable silhouette and also made of elastic materials and expressed vivid bright tones. Office look image was expressed as a suit of jacket with skirt, and cotton wool polyester materials and acro-matic colors. Ethnic look was represented by Japanese traditional dress and Chinese traditional clothing. The Military look was generally emphasized army uniforms of straight silhouette and shoulder straps.

A Study on the Body Distortion and Deformation in Fashion Art (패션아트에 나타난 몸의 왜곡과 변형에 관한 연구)

  • 허정선;금기숙
    • Journal of the Korean Society of Costume
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    • v.54 no.3
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    • pp.145-158
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    • 2004
  • In modern art, body appears as artistic performer, material or producer. and is expressed as' social environment body' which is changed in the relationship with its society and culture. The correlation between body and clothing image appears in 'body as expression object' which directly borrows human body or sets up a section of human body, 'body as medium' in which clothing substitutes body, and 'body as image' in which image of body reappears along with clothing. The results of analysis are as follows : First, 'image of expansion and exaggeration' to expand the influence of clothing thereby disclosing illusion of material civilization prevalent in our society, and make metaphor of dwarfish human's lurking fear by transforming and exaggerating human body. Second, 'image of restriction and suppression' to express the loss of humanity, power and restriction of modern society with fixing and cruelty of body image through clothing which disregard body function. Third, 'image of open and fluidity to criticize the extinction of values of human existence and standardized figure of our society by reducing three-dimensional clothing and body to untypical form or introducing the image of absent of human body to clothing. Fourth, 'image of reversion and paradox' to express practical clothing object with unwearable material, or cause confusion of sex and identity by expressing dual aspects of body at the same time. In this study, which is focused on correlation between body and clothing and the meaning of them, I realized that, even though artistic clothing expressed image of distortion and deformation of human existence as essential subject of body, they, in most contents, were used as medium of communication to rediscover human dignity and identity, and consisted of a series of metaphoric network of meanings satirizing aspects of our society.

Tubular Jacquard Knit Wear Design through the Application of Keith Haring's Works (키스 해링[Keith Haring]의 작품을 응용한 니트웨어 디자인 - 튜블러 자카드 조직을 활용하여 -)

  • Lee, Ha-Jung;Lee, Youn-Hee
    • Journal of the Korean Society of Costume
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    • v.61 no.1
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    • pp.69-83
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    • 2011
  • This study applied cartoon-like simple and implicit symbol of Keith Haring works to tubular jacquard knit, designed woman casual knit wear with fun, explicit and activities using fluorescent yarns with explicit features. This study aimed to propose the directions for new market pioneering that meets the emotional requirements of modern people by raising the level of utilization and expression area of knit fashion, and to present the constructive directions for high value-added knit wear by designing highly effective knit wear. Methods of this study examined the lifetime and artistic background of Keith Haring and collected his works through searching of internet, scholastic publications or thesis. Formative types and colors of works collected were analyzed and classified according to characteristic standards of Haring and characteristic formativeness and color of works were extracted. The result of this study is as shown below: First, the feature of his works can be summarized into motif that has symbolic and implicit cartoon-like lines including narratives as well as enormous number of works. Such feature is very suitable for variation and recombination in realization of design and has unlimited potentials for development. Second, image colors can be extracted such as black and white, original color and fluorescent paints, which reflects the intention of artist who put focus on communication with the public. Such color feature is very suitable for design motif that has explicitness of reflecting the intention of artist through use of special fluorescent yarn. Third, I made it as reversible wear that has effects of increasing or decreasing the explicitness according to color area ratio using the feature of textures allowing use of both sides as well as form stability of tubular jacquard. Fourth, by adjusting the thickness of fabric with controlling of ply in fabric using poly yarn and wool union yarn, I could obtain good results of study in terms of technique that can express various materials with embossed dynamic effects of unevenness on flat surface.

The Formative Characteristic of Creative Fashion Design by the Checklist Method (체크리스트법에 의한 창의적인 패션디자인의 조형적 특성)

  • Nam, Mi-Young;Kim, Yoon-Kyoung;Lee, Kyoung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.36 no.8
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    • pp.849-859
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    • 2012
  • This study contributes to the development of a creative fashion design and provides concrete data regarding the process of creative ideas through an analysis of the characteristics of the fashion design idea and the characteristics of fashion design from a formative perspective according to Osborn's checklist method. The data collection involved 466 pages that focused on the work of 30 designers (2005 S/S-2009 F/W) extracted from the websites style.com and ifb.co.kr. In the cases of pictures collected, a content analysis was applied based on statistical analysis and design analysis criteria. First, as a result of the examination of the characteristics of ideas for fashion design based on the checklist, it turned out that elimination method is most frequently employed, followed by addition, conversion, limit and combination. In addition, every idea showed a significant difference in terms of the applied item, expression method, and balance. Second, due to the study of the formative characteristics of fashion design (based on the checklist), it turned out that square-shaped silhouette, achromatic and chromatic colors, combined tones, identical color combination, complex texture, and identical texture combination are frequently used. In addition, every idea showed a significant difference in terms of form, color, and fabric. We believe that the use of the checklist is useful for the development of a creative design because formative characteristics vary based on the characteristic of ideas of fashion design.

Design Development for Fashion Cultural Product Using Traditional Patterns by Tessellation

  • Park, Youshin
    • Journal of Fashion Business
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    • v.20 no.6
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    • pp.79-93
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    • 2016
  • Since the development of patterns using tessellation is applied to a wide range of fields such as clothing, architecture, environment, and products, etc. and its expression principle is also found in various fields such as mathematics and science, etc. However, this pattern is mostly used as a math material with little studies on fashion and culture. In addition, it is thought that Korean traditional culture products need more various and modern design development methods and pattern through preliminary investigation which is simple copy of traditional items, simple copy of Korean Alphabet, Chinese character, and folk paintings. Therefore, it will present the method to make more design cases using Tessellation. Tessellation that combines mathematics and art will be the infinite form of designing of designers as well as creative training way to understand the composition principles of old culture and to raise sense of modern design. Tessellation of regular triangle, regular square, and regular hexagon was performed on the patterns which have meaning of wealth and prosperity of Korean traditional patterns. As the concrete method, first, each side of the regular triangle is developed symmetrically with patterns of fish, turtle, and cicadas. Second, rotational movement after symmetry movement about middle point of one side ${\times}$ 1 symmetry movement about middle point ${\times}$ 1 using crane and cloud, of the regular triangle was performed. Third, the regular square was tessellated parallel movement ${\times}$ 2 with "Da(multi)" and dragon pattern as the source image. Fourth, the sitting tiger was tessellated with symmetry movement about middle point ${\times}$ 2 and parallel movement ${\times}$ 1. Fifth, three bat patterns are tessellated by again rotational movement of two sides after rotational movement of one side and rotational movement of the other side. In addition, It developed traditional culture product design of the scarf, umbrella, aprons, neckties.

An Analytical Model of the First Eigen Energy Level for MOSFETs Having Ultrathin Gate Oxides

  • Yadav, B. Pavan Kumar;Dutta, Aloke K.
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.10 no.3
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    • pp.203-212
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    • 2010
  • In this paper, we present an analytical model for the first eigen energy level ($E_0$) of the carriers in the inversion layer in present generation MOSFETs, having ultrathin gate oxides and high substrate doping concentrations. Commonly used approaches to evaluate $E_0$ make either or both of the following two assumptions: one is that the barrier height at the oxide-semiconductor interface is infinite (with the consequence that the wave function at this interface is forced to zero), while the other is the triangular potential well approximation within the semiconductor (resulting in a constant electric field throughout the semiconductor, equal to the surface electric field). Obviously, both these assumptions are wrong, however, in order to correctly account for these two effects, one needs to solve Schrodinger and Poisson equations simultaneously, with the approach turning numerical and computationally intensive. In this work, we have derived a closed-form analytical expression for $E_0$, with due considerations for both the assumptions mentioned above. In order to account for the finite barrier height at the oxide-semiconductor interface, we have used the asymptotic approximations of the Airy function integrals to find the wave functions at the oxide and the semiconductor. Then, by applying the boundary condition at the oxide-semiconductor interface, we developed the model for $E_0$. With regard to the second assumption, we proposed the inclusion of a fitting parameter in the wellknown effective electric field model. The results matched very well with those obtained from Li's model. Another unique contribution of this work is to explicitly account for the finite oxide-semiconductor barrier height, which none of the reported works considered.