• Journal of Korea Water Resources Association
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• v.54 no.5
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• pp.335-345
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• 2021

The one-dimensional solute transport models have been developed for recent decades to predict behavior and fate of solutes in rivers. Transient storage model (TSM) is the most popular model because of its simple conceptualization to consider the complexity of natural rivers. However, the TSM is highly dependent on its parameters which cannot be directly measured. In addition, the TSM interprets the late-time behavior of concentration curves in the shape of an exponential function, which has been evaluated as not suitable for actual solute behavior in natural rivers. In this study, we suggested a stochastic approach to the solute transport analysis. We delineated the model development and model application to a natural river, and compared the results of the proposed model to those of the TSM. To validate the proposed model, a tracer test was carried out in the 4.85 km reach of Gam Creek, one of the first-order tributaries of Nakdong River, South Korea. As a result of comparing the power-law slope of the tail of breakthrough curves, the simulation results from the stochastic storage model yielded the average error rate of 0.24, which is more accurate than the 14.03 and 1.87 from advection-dispersion model and TSM, respectively. This study demonstrated the appropriateness of the power-law residence time distribution to the hyporheic zone of the Gam Creek.

• The Journal of Bigdata
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• v.7 no.1
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• pp.213-224
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• 2022

In logistics and distribution, Market Basket Analysis (MBA) is used as an important means to analyze the correlation between major sales products and to increase internal operational efficiency. In particular, the results of market basket analysis are used as important reference data for decision-making processes such as product purchase prediction, product recommendation, and product display structure in stores. With the recent development of e-commerce, the number of items handled by a single distribution and logistics company has rapidly increased, And the existing analytical methods such as Apriori and FP-Growth have slowed down due to the exponential increase in the amount of calculation and applied to actual business. There is a limit to examining important association rules to overcome this limitation, In this study, at the Main-Category level, which is the highest classification system of products, the utility item set mining technique that can consider the sales volume of products together was used to first select a group of products mainly sold together. Then, at the sub-category level, the types of products sold together were identified using FP-Growth. By using this sequential layer filtering technique, it may be possible to reduce the unnecessary calculations and to find practically usable rules for enhancing the effectiveness and profitability.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.680-689
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• 2011

A dynamic analysis procedure is developed to provide a comprehensive estimation of the dynamic response spectrum for locomotive's wheels running over a Pre-Stressed Concrete (PSC) box girder bridge on the Korea high speed railway. The wheel force spectrum with the bridge behavior are analyzed as the dynamic procedure for various running speeds (50~450km/h). The high-speed railway locomotive (KTX) is used as 38-degree of freedom system. Three displacements(vertical, lateral, and longitudinal) and three rotational components (pitching, rolling, and yawing). For one car-body and two bogies as well as five movements except pitching rotation components for four wheel axes forces are considered in the 38-degree of freedom model. Three dimensional frame element is used to model of the PSC box girder bridges, simply supported span length of 40m. The irregulation of rail-way is derived using the exponential spectrum density function under assumption of twelve level tracks conditions based on the normal probability procedure. The dynamic responses of bridge passing through the railway locomotive with high-speed analyzed by Newmark-${\beta}$ method and Runge-Kutta method are compared and contrasted considering the developed models of bridge, track and locomotive comprehensively. The dynamic analyses of wheel forces by Runge-Kutta method which are able to analyze the forces with high frequency running on the bridge and ground rail-way are conducted. Additionally, wheel forces spectrum and three rotational components of vehicle body for three typical running speeds is also presented.

• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.170-172
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• 2013

The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In this study, we investigate the pharmacokinetic profile of uridine in rabbits, following topical ocular (8 mg/eye), oral (450 mg/kg) and intravenous (100 mg/kg) administration. Blood and urine samples were serially taken, and uridine was measured by high-performance liquid chromatography-tandem mass spectrometry. No symptoms were noted in the animals after uridine treatment. Uridine was not detected in either plasma or urine after topical ocular administration, indicating no systemic exposure to uridine with this treatment route. Following a single intravenous dose, the plasma concentration of uridine showed a bi-exponential decay, with a rapid decline over 10 min, followed by a slow decay with a terminal half-life of $0.36{\pm}0.05$ h. Clearance and volume of distribution were $1.8{\pm}0.6$ L/h/kg and $0.58{\pm}0.32$ L/kg, respectively. The area under the plasma concentration-time curves (AUC) was $59.7{\pm}18.2{\mu}g{\cdot}hr/ml$, and urinary excretion up to 12 hr was ~7.7% of the dose. Plasma uridine reached a peak of $25.8{\pm}4.1{\mu}g/ml$ at $2.3{\pm}0.8$ hr after oral administration. The AUC was $79.0{\pm}13.9{\mu}g{\cdot}hr/ml$, representing ~29.4% of absolute bioavailability. About 1% of the oral dose was excreted in the urine. These results should prove useful in the design of future clinical and nonclinical studies conducted with uridine.

• Journal of the Korean Data and Information Science Society
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• v.25 no.1
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• pp.1-10
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• 2014

In this paper, we study approximations of the ruin probability in a continuous time surplus process. First, we introduce the well-known approximation formulas of the ruin probability such as Cram$\acute{e}$r, Tijms' and De Vylder's methods. We, then, suggest new approximation formulas of two types, which improve the existing approximation formulas. One is Cram$\acute{e}$r and Tijms' type which makes use of the moment generating function of distribution of a claim size and the other is De Vylder's type which makes use of the surplus process with exponential claims. Finally, we compare, by illustrating numerical examples, the newly suggested approximation formulas with the existing approximation formulas of the ruin probability.

• Journal of IKEEE
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• v.3 no.1 s.4
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• pp.93-100
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• 1999

When providing MPEG-2 video service through the ATM network, the degradation of QoS caused by cell losses and cell errors occuring from ATM netwok was assessed by the end-users subjectively and then the relation between CLR, CER and subjective QoS of MPEG-2 video was analyzed. Cell losses and cell errors occuring from the ATM network were generated according to the normal and exponential distribution by NEM module. Video sources were divided into sports and drama by moving feature and were tested. The results of our experiments show that the excellent quality of subjective QoS grade 5 was achieved for a cell loss rate of $2{\times}10^{-7}$ and for a cell error rate of $2{\times}10^{-7}$ and the good quality of subjective QoS grade 4 was achieved for a cell loss rate of $2{\times}10^{-6}$ and for a cell error rate of $2{\times}10^{-6}$ When providing MPEC-2 video service through the ATM network, the results of our experiments will be used as valuable information to determine the network performance objectives for satisfying the QoS required by the end-users and to design the network.

• Journal of the Korea Society of Computer and Information
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• v.25 no.1
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• pp.131-140
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• 2020

In this study, we analyzed the effect of consumer's cognitive response, emotional response and behavioral response on online shopping stockouts (ISRI: Individual Stockout Response Index). And we try to show the heterogeneity of the degree of consumer response by subdivision market based on the regularity of distribution. The ISRI was developed by Kim and Lee in 2016 and 2018, which were based on the items and factors of cognitive, emotional and behavioral responses. The exponential stockouts response of consumers in this study will give an accurate picture of what consumers want when stockouts. further research should be done on how consumers' reactions are influenced by situational characteristics, consumer characteristics, store characteristics and brand / product characteristics. Especially, the price level of the product will affect the consumer 's response in the case of online fashion goods shopping.

• Geomechanics and Engineering
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• v.22 no.2
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• pp.119-132
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• 2020

In this study a new innovative three unknowns trigonometric shear deformation theory is proposed for the buckling and vibration responses of exponentially graded sandwich plates resting on elastic mediums under various boundary conditions. The key feature of this theoretical formulation is that, in addition to considering shear deformation effect, it has only three unknowns in the displacement field as in the case of the classical plate theory (CPT), contrary to five as in the first shear deformation theory (FSDT) and higher-order shear deformation theory (HSDT). Material characteristics of the sandwich plate faces are considered to vary within the thickness direction via an exponential law distribution as a function of the volume fractions of the constituents. Equations of motion are obtained by employing Hamilton's principle. Numerical results for buckling and free vibration analysis of exponentially graded sandwich plates under various boundary conditions are obtained and discussed. Verification studies confirmed that the present three -unknown shear deformation theory is comparable with higher-order shear deformation theories which contain a greater number of unknowns.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.4
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• pp.49-59
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• 2016

Naval combat system developed in-country is progressing at an alarming rate since 2000. ROK navy will be achieved all vessels that have combat system in the near future. The importance of System Engineering and Integrated Logistics Support based on reliability analysis is increasing. However, reliability analysis that everyone trusted and recognized is not enough and applied practically for development of Defense Acquisition Program. In particular, Existing Reliability Analysis is focusing on reliability index (Mean Time Between Failure (MTBF) etc.) for policy decision of defense improvement project. Most of the weapon system acquisition process applying in the exponential distribution simply persist unreality due to memoryless property. Critical failures are more important than simple faults to ship's operator. There are no confirmed cases of reliability analysis involved with critical failure that naval ship scheduler and operator concerned sensitively. Therefore, this study is focusing on Mean Time To Critical Failure (MTTCF), reliability on specific time and Operational Readiness Float (ORF) requirements related to critical failure of Patrol Killer Guided missile (PKG) combat system that is beginning of naval combat system developed in-country. Methods of analysis is applied parametric and non-parametric statistical techniques. It is compared to the estimates and proposed applications. The result of study shows that parametric and non-parametric estimators should be applied differently depending on purpose of utilization based on test of normality. For the first time, this study is offering Reliability of ROK Naval combat system to stakeholders involved with defense improvement project. Decision makers of defense improvement project have to active support and effort in this area for improvement of System Engineering.

• Korean Journal of Clinical Pharmacy
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• v.13 no.2
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• pp.55-58
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• 2003

Astromicin is an aminoglycoside antiviotic that is structually different from conventional aminoglycosides. Astromicin has been shown to be active against aerobic Gram-negative bacilli. The pharmacokinetics of astromicin were determined in 12 healthy volunteers ($65.5\pm5.23\;kg$ of body weight) following a 30-min continuous intravenous infusion at a dose of 200 mg. The plasma and urine samples were collected up to 24 h and drug concentrations were measured by a bioassay using Bacillus subtilis. Pharmacokinetic parameters were calculated by fitting individual concentration-time curve to a one-exponential decay model. The plasma levels were $16.9\pm1.68\;and\;1.05\pm0.346\l{\mu}g/ml$ at 0 h and 8 h after the infusion, respectively. The elimination half-life of astromicin was $1.86\pm0.360\;h$ The volume of distribution was $0.182\pm0.0164\;L/kg$, and the total body clearance was $5.25\pm1.74\;L/h$. These pharmacokinetic parameters were similar to these of gentamicin, tobramycin, and amikacin. Therefore, it is recommended that therapeutic drug monitoring of astromicin could be conducted in a similar fashion as the other aminoglycosides.